GREMLIN Database
FEAB - Phenylacetaldehyde dehydrogenase
UniProt: P80668 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13179
Length: 499 (455)
Sequences: 36421 (21937)
Seq/√Len: 1028.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
316_A415_A4.9941.00
260_R264_D3.9391.00
316_A413_R3.1401.00
288_Q325_G3.0981.00
319_F413_R2.9001.00
38_A50_S2.8231.00
376_N386_A2.7821.00
67_W242_H2.7701.00
283_K315_E2.7131.00
394_D397_L2.6621.00
351_R355_D2.6061.00
363_D398_R2.5741.00
292_E329_A2.5721.00
208_R211_E2.5411.00
362_D366_A2.5301.00
323_V411_L2.4921.00
283_K317_P2.4461.00
97_H100_E2.3941.00
95_E129_R2.3671.00
437_T443_A2.3361.00
38_A47_E2.3341.00
67_W244_A2.2291.00
214_S220_D2.2221.00
55_N58_D2.2011.00
361_L385_V2.1941.00
98_S122_G2.1561.00
99_E117_R2.1541.00
358_C362_D2.1341.00
90_F213_A2.1171.00
93_L215_E2.1021.00
428_E474_Q2.0421.00
417_G442_Q1.9981.00
370_E392_N1.9971.00
201_T350_S1.9871.00
239_S261_T1.9821.00
162_E493_K1.9801.00
363_D367_Q1.9751.00
358_C377_G1.9731.00
235_A239_S1.9641.00
327_E331_K1.9411.00
100_E208_R1.9191.00
445_E449_R1.9151.00
279_A294_L1.9101.00
358_C385_V1.9021.00
161_K487_D1.8971.00
321_T325_G1.8931.00
365_Q371_L1.8881.00
348_L357_V1.8821.00
86_I218_I1.8591.00
372_I391_V1.8561.00
257_G260_R1.8231.00
64_M242_H1.7971.00
256_K474_Q1.7861.00
93_L96_Q1.7661.00
60_D236_A1.7641.00
284_D442_Q1.7611.00
97_H215_E1.7541.00
313_Y423_L1.7521.00
93_L216_A1.7401.00
400_T412_V1.7321.00
451_Q473_K1.7271.00
161_K490_C1.7131.00
60_D64_M1.6871.00
47_E50_S1.6741.00
327_E372_I1.6521.00
315_E414_V1.6521.00
395_A423_L1.6351.00
330_V389_L1.6311.00
390_V399_L1.6251.00
104_L208_R1.6241.00
88_L129_R1.6231.00
210_A225_V1.6231.00
419_E422_Q1.6201.00
370_E391_V1.6181.00
93_L212_L1.6181.00
313_Y420_A1.6091.00
417_G445_E1.6071.00
71_V74_R1.5881.00
113_I117_R1.5841.00
415_A419_E1.5821.00
95_E125_L1.5811.00
319_F323_V1.5741.00
324_S328_Q1.5651.00
79_L82_E1.5641.00
294_L322_L1.5631.00
299_F330_V1.5531.00
128_M185_M1.5511.00
398_R402_E1.5351.00
359_S398_R1.5341.00
92_D96_Q1.5271.00
325_G328_Q1.5261.00
229_S232_V1.5241.00
193_S222_V1.5201.00
351_R383_Y1.5091.00
287_P325_G1.5031.00
89_R92_D1.4961.00
320_D413_R1.4771.00
312_I409_V1.4771.00
60_D240_H1.4751.00
291_I325_G1.4731.00
371_L390_V1.4671.00
36_R50_S1.4671.00
82_E85_R1.4671.00
46_Q381_E1.4471.00
282_L442_Q1.4441.00
88_L136_T1.4371.00
98_S117_R1.4361.00
77_G449_R1.4331.00
313_Y414_V1.4281.00
211_E215_E1.4271.00
45_G381_E1.4221.00
293_G436_W1.4141.00
103_Q107_L1.4141.00
78_R82_E1.4131.00
418_E449_R1.4021.00
99_E103_Q1.4001.00
329_A332_S1.3991.00
419_E423_L1.3961.00
433_A452_A1.3941.00
314_I322_L1.3931.00
294_L312_I1.3901.00
321_T324_S1.3891.00
91_A129_R1.3871.00
283_K442_Q1.3831.00
134_L137_K1.3831.00
160_R448_D1.3721.00
128_M181_M1.3681.00
362_D365_Q1.3661.00
40_F47_E1.3651.00
319_F391_V1.3651.00
92_D129_R1.3621.00
334_Q342_V1.3541.00
97_H208_R1.3441.00
259_A477_T1.3421.00
169_G194_I1.3401.00
357_V406_G1.3391.00
103_Q339_M1.3391.00
58_D61_N1.3331.00
360_F404_V1.3231.00
106_T116_S1.3201.00
367_Q398_R1.3201.00
35_K53_D1.3191.00
354_C358_C1.3191.00
245_K270_T1.3051.00
414_V423_L1.2931.00
180_G196_I1.2901.00
41_D44_T1.2831.00
282_L414_V1.2771.00
355_D359_S1.2761.00
416_D419_E1.2721.00
320_D324_S1.2691.00
328_Q331_K1.2601.00
354_C385_V1.2591.00
210_A223_F1.2561.00
282_L446_Y1.2561.00
323_V327_E1.2551.00
354_C377_G1.2511.00
331_K373_R1.2491.00
91_A95_E1.2271.00
280_I420_A1.2241.00
351_R354_C1.2241.00
315_E416_D1.2231.00
336_G343_A1.2151.00
421_L446_Y1.2131.00
318_L321_T1.2091.00
235_A261_T1.1981.00
369_A390_V1.1961.00
334_Q344_Q1.1951.00
315_E318_L1.1921.00
396_K401_R1.1921.00
484_D487_D1.1891.00
239_S264_D1.1881.00
59_V233_C1.1791.00
64_M68_R1.1781.00
53_D229_S1.1731.00
483_P487_D1.1691.00
359_S363_D1.1681.00
158_W444_L1.1671.00
161_K492_T1.1671.00
101_L208_R1.1661.00
213_A223_F1.1651.00
325_G329_A1.1641.00
103_Q113_I1.1601.00
63_V240_H1.1591.00
200_E229_S1.1561.00
326_F409_V1.1531.00
78_R86_I1.1531.00
63_V242_H1.1471.00
63_V243_V1.1411.00
433_A455_V1.1391.00
395_A426_D1.1391.00
322_L326_F1.1331.00
447_S495_V1.1311.00
235_A257_G1.1261.00
141_K483_P1.1221.00
257_G261_T1.1181.00
254_T257_G1.1151.00
106_T338_G1.1121.00
56_E236_A1.1111.00
89_R93_L1.1101.00
328_Q332_S1.1091.00
221_G224_N1.1081.00
323_V391_V1.1071.00
418_E445_E1.1071.00
364_A390_V1.1041.00
443_A457_V1.1021.00
88_L133_G1.0911.00
164_V245_K1.0901.00
184_V223_F1.0901.00
253_A257_G1.0901.00
323_V372_I1.0861.00
207_L227_T1.0851.00
37_L53_D1.0821.00
90_F212_L1.0821.00
41_D337_P1.0801.00
401_R428_E1.0761.00
65_S224_N1.0751.00
401_R426_D1.0751.00
418_E422_Q1.0751.00
279_A309_S1.0751.00
378_P386_A1.0721.00
470_G479_R1.0721.00
484_D492_T1.0711.00
90_F218_I1.0711.00
236_A240_H1.0681.00
280_I446_Y1.0661.00
327_E373_R1.0661.00
479_R491_E1.0641.00
49_A204_L1.0631.00
259_A269_V1.0611.00
200_E230_G1.0601.00
90_F128_M1.0561.00
53_D232_V1.0531.00
169_G247_S1.0511.00
331_K386_A1.0501.00
141_K484_D1.0491.00
367_Q397_L1.0451.00
421_L449_R1.0431.00
184_V194_I1.0321.00
101_L212_L1.0221.00
74_R78_R1.0191.00
333_L345_I1.0191.00
168_A243_V1.0161.00
374_G388_T1.0141.00
70_F76_A1.0141.00
286_D438_Q1.0101.00
43_A338_G1.0031.00
280_I424_A1.0021.00
45_G383_Y0.9981.00
414_V420_A0.9981.00
439_N442_Q0.9971.00
354_C383_Y0.9961.00
175_F305_V0.9921.00
69_A193_S0.9881.00
84_E136_T0.9841.00
256_K266_L0.9831.00
124_T181_M0.9811.00
276_K310_S0.9771.00
33_S55_N0.9741.00
417_G446_Y0.9741.00
168_A237_L0.9741.00
97_H212_L0.9721.00
166_V193_S0.9691.00
96_Q215_E0.9671.00
286_D289_W0.9661.00
374_G386_A0.9641.00
207_L225_V0.9631.00
135_T189_A0.9611.00
97_H211_E0.9601.00
71_V422_Q0.9591.00
211_E214_S0.9591.00
337_P340_S0.9491.00
472_M491_E0.9481.00
393_P397_L0.9461.00
357_V408_V0.9461.00
160_R495_V0.9461.00
289_W293_G0.9441.00
295_M329_A0.9431.00
100_E103_Q0.9431.00
107_L339_M0.9431.00
164_V268_R0.9421.00
102_A117_R0.9411.00
360_F363_D0.9391.00
88_L132_A0.9381.00
259_A263_A0.9351.00
288_Q321_T0.9341.00
434_S460_H0.9311.00
157_A467_L0.9301.00
297_G309_S0.9291.00
363_D366_A0.9281.00
56_E232_V0.9261.00
56_E60_D0.9211.00
67_W71_V0.9201.00
422_Q426_D0.9141.00
278_P433_A0.9131.00
162_E448_D0.9101.00
244_A451_Q0.9101.00
359_S362_D0.9091.00
93_L97_H0.9051.00
167_V245_K0.9011.00
298_S310_S0.9011.00
85_R89_R0.8981.00
320_D323_V0.8941.00
111_K120_E0.8931.00
41_D107_L0.8911.00
84_E88_L0.8871.00
80_P84_E0.8871.00
109_Q202_T0.8861.00
76_A451_Q0.8811.00
124_T177_L0.8811.00
70_F193_S0.8801.00
166_V243_V0.8791.00
365_Q390_V0.8791.00
287_P291_I0.8781.00
360_F398_R0.8781.00
59_V168_A0.8781.00
368_Q397_L0.8771.00
201_T352_A0.8771.00
357_V404_V0.8731.00
279_A436_W0.8711.00
412_V423_L0.8681.00
61_N65_S0.8681.00
259_A262_A0.8671.00
77_G448_D0.8661.00
94_V124_T0.8651.00
40_F383_Y0.8631.00
291_I329_A0.8631.00
291_I326_F0.8621.00
282_L417_G0.8621.00
41_D46_Q0.8611.00
319_F411_L0.8591.00
91_A132_A0.8591.00
444_L448_D0.8591.00
162_E472_M0.8581.00
71_V451_Q0.8581.00
355_D358_C0.8571.00
210_A214_S0.8551.00
74_R77_G0.8541.00
256_K260_R0.8531.00
282_L437_T0.8511.00
467_L494_S0.8451.00
433_A450_L0.8451.00
84_E132_A0.8451.00
43_A384_Y0.8431.00
251_S254_T0.8361.00
183_K480_D0.8351.00
395_A412_V0.8251.00
69_A222_V0.8251.00
268_R491_E0.8241.00
246_I262_A0.8231.00
420_A423_L0.8211.00
421_L425_N0.8201.00
57_A61_N0.8191.00
37_L229_S0.8191.00
435_V446_Y0.8181.00
290_V294_L0.8181.00
190_A490_C0.8111.00
71_V77_G0.8111.00
196_I206_M0.8091.00
164_V491_E0.8091.00
57_A60_D0.8081.00
291_I322_L0.8071.00
440_L443_A0.8061.00
281_V322_L0.8061.00
186_P485_W0.8051.00
414_V419_E0.8041.00
207_L211_E0.8031.00
65_S221_G0.8011.00
246_I258_I0.8011.00
75_W222_V0.8001.00
164_V192_C0.7991.00
61_N64_M0.7991.00
324_S327_E0.7981.00
54_A58_D0.7961.00
187_A194_I0.7941.00
375_S388_T0.7901.00
259_A266_L0.7881.00
369_A397_L0.7841.00
361_L408_V0.7841.00
66_A224_N0.7841.00
88_L92_D0.7831.00
335_V378_P0.7821.00
180_G184_V0.7791.00
255_G273_L0.7731.00
114_A344_Q0.7721.00
48_I107_L0.7711.00
198_P227_T0.7711.00
452_A455_V0.7671.00
109_Q349_V0.7661.00
81_A136_T0.7661.00
357_V385_V0.7651.00
181_M209_V0.7621.00
106_T113_I0.7601.00
234_G238_T0.7581.00
95_E98_S0.7581.00
255_G271_L0.7571.00
326_F389_L0.7551.00
87_L189_A0.7551.00
228_G233_C0.7541.00
277_N310_S0.7511.00
107_L204_L0.7491.00
352_A355_D0.7461.00
256_K264_D0.7441.00
86_I216_A0.7431.00
218_I222_V0.7431.00
315_E417_G0.7421.00
252_T474_Q0.7421.00
102_A113_I0.7421.00
278_P424_A0.7411.00
95_E122_G0.7381.00
54_A62_A0.7371.00
169_G183_K0.7361.00
287_P318_L0.7361.00
262_A269_V0.7351.00
113_I339_M0.7311.00
248_F254_T0.7301.00
333_L344_Q0.7301.00
177_L205_T0.7291.00
94_V125_L0.7291.00
291_I295_M0.7281.00
238_T258_I0.7281.00
319_F392_N0.7271.00
218_I223_F0.7261.00
117_R341_P0.7251.00
360_F402_E0.7251.00
290_V322_L0.7251.00
168_A246_I0.7241.00
391_V413_R0.7231.00
438_Q441_S0.7221.00
102_A106_T0.7201.00
180_G206_M0.7181.00
288_Q329_A0.7181.00
238_T261_T0.7181.00
41_D339_M0.7161.00
340_S343_A0.7131.00
89_R216_A0.7121.00
330_V373_R0.7081.00
71_V76_A0.7081.00
99_E113_I0.7071.00
196_I223_F0.7041.00
168_A234_G0.7031.00
201_T349_V0.7031.00
164_V244_A0.7021.00
157_A494_S0.7011.00
66_A193_S0.7011.00
40_F45_G0.7001.00
327_E330_V0.6971.00
282_L315_E0.6911.00
314_I318_L0.6911.00
232_V235_A0.6901.00
295_M326_F0.6881.00
60_D242_H0.6831.00
171_V180_G0.6831.00
356_K359_S0.6821.00
68_R71_V0.6801.00
75_W86_I0.6801.00
260_R263_A0.6781.00
330_V333_L0.6761.00
104_L204_L0.6751.00
69_A74_R0.6751.00
200_E356_K0.6751.00
312_I322_L0.6741.00
350_S353_H0.6721.00
313_Y400_T0.6711.00
302_Q345_I0.6701.00
100_E211_E0.6691.00
416_D422_Q0.6691.00
192_C490_C0.6691.00
45_G351_R0.6671.00
180_G209_V0.6671.00
261_T264_D0.6661.00
92_D95_E0.6651.00
351_R377_G0.6641.00
35_K232_V0.6621.00
440_L444_L0.6621.00
353_H356_K0.6611.00
105_E108_E0.6611.00
364_A404_V0.6591.00
268_R488_G0.6591.00
361_L390_V0.6581.00
233_C236_A0.6581.00
284_D437_T0.6581.00
354_C378_P0.6571.00
59_V63_V0.6561.00
365_Q376_N0.6561.00
59_V236_A0.6561.00
156_Q444_L0.6551.00
80_P135_T0.6551.00
367_Q396_K0.6551.00
76_A449_R0.6541.00
395_A400_T0.6541.00
281_V290_V0.6521.00
295_M333_L0.6521.00
385_V388_T0.6511.00
138_I490_C0.6511.00
313_Y395_A0.6511.00
393_P399_L0.6491.00
160_R493_K0.6481.00
417_G421_L0.6481.00
91_A125_L0.6481.00
75_W188_L0.6471.00
443_A447_S0.6471.00
287_P321_T0.6471.00
36_R52_A0.6461.00
423_L426_D0.6461.00
213_A218_I0.6451.00
200_E257_G0.6451.00
238_T246_I0.6441.00
447_S457_V0.6441.00
487_D490_C0.6431.00
294_L326_F0.6421.00
76_A162_E0.6411.00
451_Q472_M0.6401.00
487_D492_T0.6391.00
326_F411_L0.6391.00
393_P400_T0.6371.00
289_W438_Q0.6341.00
106_T339_M0.6321.00
352_A356_K0.6311.00
101_L177_L0.6311.00
373_R389_L0.6291.00
335_V345_I0.6281.00
358_C361_L0.6271.00
195_V224_N0.6251.00
360_F364_A0.6231.00
82_E86_I0.6231.00
270_T488_G0.6231.00
98_S102_A0.6211.00
289_W292_E0.6211.00
111_K175_F0.6201.00
52_A227_T0.6191.00
259_A271_L0.6171.00
39_I49_A0.6171.00
437_T442_Q0.6161.00
111_K115_I0.6161.00
65_S220_D0.6151.00
284_D438_Q0.6151.00
76_A163_P0.6141.00
157_A496_C0.6131.00
121_V125_L0.6121.00
348_L353_H0.6121.00
105_E205_T0.6121.00
208_R212_L0.6091.00
337_P343_A0.6091.00
138_I486_L0.6091.00
183_K247_S0.6081.00
39_I108_E0.6071.00
184_V196_I0.6041.00
56_E239_S0.6031.00
177_L209_V0.6031.00
441_S444_L0.6011.00
284_D439_N0.5991.00
64_M67_W0.5991.00
105_E116_S0.5991.00
103_Q106_T0.5991.00
51_T203_P0.5981.00
54_A226_V0.5971.00
421_L445_E0.5971.00
390_V393_P0.5961.00
375_S386_A0.5961.00
80_P189_A0.5951.00
371_L388_T0.5941.00
435_V443_A0.5931.00
228_G234_G0.5921.00
94_V209_V0.5911.00
404_V408_V0.5911.00
167_V192_C0.5901.00
158_W495_V0.5901.00
297_G460_H0.5891.00
279_A312_I0.5881.00
441_S445_E0.5871.00
105_E120_E0.5861.00
62_A226_V0.5841.00
94_V177_L0.5811.00
48_I204_L0.5801.00
335_V344_Q0.5791.00
193_S224_N0.5781.00
91_A128_M0.5761.00
252_T256_K0.5741.00
314_I411_L0.5741.00
279_A434_S0.5731.00
245_K488_G0.5701.00
392_N413_R0.5701.00
56_E235_A0.5701.00
361_L388_T0.5691.00
377_G386_A0.5691.00
235_A238_T0.5681.00
66_A195_V0.5681.00
358_C365_Q0.5671.00
288_Q328_Q0.5671.00
298_S409_V0.5641.00
94_V128_M0.5641.00
130_Y134_L0.5631.00
420_A424_A0.5631.00
395_A422_Q0.5621.00
305_V308_A0.5621.00
33_S58_D0.5621.00
67_W166_V0.5611.00
421_L450_L0.5601.00
133_G136_T0.5591.00
102_A121_V0.5591.00
287_P322_L0.5571.00
435_V457_V0.5561.00
30_P52_A0.5531.00
134_L483_P0.5531.00
68_R74_R0.5531.00
80_P139_A0.5521.00
314_I319_F0.5521.00
190_A486_L0.5511.00
277_N432_T0.5501.00
121_V177_L0.5501.00
209_V213_A0.5491.00
287_P290_V0.5491.00
71_V449_R0.5481.00
283_K414_V0.5481.00
424_A450_L0.5481.00
200_E253_A0.5471.00
455_V493_K0.5451.00
327_E389_L0.5451.00
90_F93_L0.5431.00
417_G449_R0.5421.00
39_I203_P0.5421.00
316_A319_F0.5421.00
167_V194_I0.5411.00
348_L385_V0.5411.00
285_A290_V0.5401.00
230_G234_G0.5401.00
367_Q394_D0.5391.00
169_G184_V0.5391.00
35_K55_N0.5381.00
81_A85_R0.5361.00
86_I90_F0.5361.00
62_A224_N0.5361.00
238_T265_H0.5361.00
66_A166_V0.5351.00
131_T186_P0.5351.00
451_Q491_E0.5331.00
334_Q340_S0.5331.00
101_L121_V0.5321.00
166_V244_A0.5321.00
309_S434_S0.5311.00
299_F333_L0.5311.00
74_R193_S0.5311.00
456_W459_S0.5301.00
269_V477_T0.5291.00
51_T204_L0.5291.00
85_R88_L0.5291.00
120_E175_F0.5281.00
65_S69_A0.5271.00
162_E451_Q0.5271.00
33_S57_A0.5271.00
178_M182_W0.5271.00
253_A352_A0.5271.00
399_L404_V0.5251.00
109_Q301_N0.5231.00
188_L223_F0.5221.00
247_S489_W0.5211.00
312_I411_L0.5211.00
450_L455_V0.5211.00
371_L375_S0.5201.00
123_C178_M0.5201.00
62_A195_V0.5181.00
94_V101_L0.5161.00
372_I392_N0.5161.00
182_W481_F0.5151.00
188_L218_I0.5141.00
291_I318_L0.5141.00
53_D200_E0.5141.00
122_G125_L0.5131.00
98_S125_L0.5111.00
214_S221_G0.5091.00
232_V236_A0.5091.00
168_A195_V0.5071.00
30_P34_E0.5031.00
389_L409_V0.5021.00
446_Y450_L0.5021.00
432_T456_W0.5011.00
155_Y459_S0.5011.00
360_F399_L0.5011.00
65_S68_R0.5011.00
324_S331_K0.5001.00
88_L91_A0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4o5hA 4 0.998 100 0.048 Contact Map
4yweA 5 0.9419 100 0.051 Contact Map
4qf6A 4 0.982 100 0.052 Contact Map
4pz2A 4 0.9539 100 0.055 Contact Map
4pxlA 4 0.9599 100 0.056 Contact Map
1a4sA 4 0.9679 100 0.058 Contact Map
4wj9A 4 0.9719 100 0.058 Contact Map
3ek1A 5 0.9679 100 0.058 Contact Map
4lihA 5 0.9679 100 0.059 Contact Map
4qtoA 4 0.9699 100 0.061 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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