GREMLIN Database
SSUD - Alkanesulfonate monooxygenase
UniProt: P80645 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13706
Length: 381 (308)
Sequences: 13859 (8688)
Seq/√Len: 495.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
236_N311_T5.6791.00
151_N156_H3.3741.00
37_Q68_V3.3111.00
236_N308_D3.1261.00
133_A189_E2.6921.00
38_A41_R2.6091.00
38_A339_Y2.6031.00
235_T238_E2.5851.00
236_N240_W2.5341.00
73_K104_L2.4911.00
209_E213_A2.4891.00
40_D71_R2.4721.00
62_A74_F2.4541.00
315_R318_E2.4141.00
310_P348_L2.3831.00
185_E214_K2.3701.00
208_I224_F2.2671.00
233_R238_E2.2571.00
130_E153_K2.2521.00
184_Q210_Q2.2301.00
317_N321_A2.2041.00
66_I99_S2.1991.00
308_D311_T2.1841.00
313_A348_L2.1611.00
341_V345_L2.1401.00
339_Y343_E2.0701.00
30_G100_N2.0651.00
33_Q37_Q2.0351.00
237_D241_Q2.0031.00
234_E344_L2.0021.00
42_L342_G1.9941.00
205_K209_E1.9901.00
37_Q41_R1.9861.00
137_Q190_Q1.9751.00
36_A65_M1.9591.00
208_I212_R1.9551.00
213_A217_A1.9321.00
124_D127_E1.9311.00
210_Q214_K1.9271.00
34_Q37_Q1.9171.00
336_E339_Y1.8921.00
215_A222_I1.8841.00
188_A214_K1.8671.00
96_D101_G1.8541.00
244_E248_S1.8161.00
33_Q68_V1.7951.00
127_E153_K1.7921.00
66_I74_F1.7631.00
144_Q171_Y1.7401.00
38_A335_L1.6871.00
34_Q335_L1.6711.00
47_V72_L1.6621.00
65_M74_F1.6511.00
92_A103_A1.6361.00
305_L312_V1.6211.00
38_A42_L1.6101.00
185_E217_A1.5881.00
137_Q141_R1.5631.00
210_Q213_A1.5411.00
140_R171_Y1.5351.00
57_D91_Q1.5261.00
149_D159_G1.5101.00
127_E130_E1.5071.00
33_Q64_S1.5061.00
48_L75_L1.5061.00
24_S27_V1.4971.00
232_V312_V1.4851.00
206_E209_E1.4831.00
234_E336_E1.4741.00
238_E242_A1.4701.00
36_A47_V1.4681.00
344_L348_L1.4681.00
336_E340_R1.4541.00
310_P314_A1.4511.00
178_G194_Y1.4381.00
290_L293_G1.4271.00
130_E154_H1.4241.00
41_R70_Q1.4191.00
311_T314_A1.3961.00
141_R145_R1.3911.00
185_E189_E1.3891.00
214_K217_A1.3851.00
140_R190_Q1.3781.00
313_A317_N1.3661.00
226_I324_I1.3571.00
34_Q38_A1.3551.00
331_G335_L1.3521.00
36_A69_T1.3481.00
311_T315_R1.3431.00
64_S67_P1.3431.00
140_R174_L1.3301.00
83_T91_Q1.3231.00
241_Q244_E1.3151.00
30_G34_Q1.2921.00
340_R344_L1.2841.00
309_G340_R1.2741.00
317_N320_A1.2661.00
215_A220_R1.2651.00
57_D60_L1.2591.00
233_R239_A1.2521.00
113_P117_A1.2481.00
27_V31_Y1.2411.00
34_Q331_G1.2401.00
137_Q150_F1.2361.00
133_A190_Q1.2281.00
231_I242_A1.2251.00
151_N158_R1.2201.00
318_E321_A1.2141.00
314_A318_E1.2131.00
92_A105_F1.2121.00
232_V309_G1.2011.00
49_I65_M1.1971.00
188_A218_H1.1961.00
40_D70_Q1.1941.00
141_R150_F1.1941.00
223_R325_D1.1691.00
238_E241_Q1.1671.00
117_A158_R1.1641.00
127_E154_H1.1631.00
185_E218_H1.1561.00
75_L104_L1.1551.00
234_E238_E1.1541.00
333_P336_E1.1521.00
189_E218_H1.1511.00
60_L63_A1.1471.00
49_I62_A1.1401.00
64_S98_L1.1381.00
36_A72_L1.1371.00
88_A135_F1.1291.00
157_V160_A1.1241.00
140_R192_D1.1191.00
147_T159_G1.1171.00
107_L136_T1.1161.00
175_Y225_G1.1151.00
59_W91_Q1.1131.00
40_D69_T1.1051.00
138_V155_I1.1031.00
138_V150_F1.0931.00
134_E152_G1.0851.00
185_E210_Q1.0831.00
37_Q70_Q1.0781.00
131_A134_E1.0741.00
62_A76_V1.0721.00
64_S68_V1.0661.00
243_A247_I1.0661.00
41_R339_Y1.0611.00
232_V340_R1.0581.00
243_A306_V1.0561.00
201_P318_E1.0521.00
133_A137_Q1.0461.00
42_L338_A1.0451.00
238_E333_P1.0431.00
182_V185_E1.0421.00
111_S115_E1.0321.00
240_W244_E1.0241.00
139_W143_L1.0161.00
136_T190_Q1.0151.00
287_S290_L1.0071.00
242_A340_R1.0031.00
181_D210_Q1.0021.00
39_A338_A1.0001.00
175_Y193_L0.9931.00
96_D170_P0.9921.00
138_V141_R0.9901.00
307_G312_V0.9871.00
87_V91_Q0.9811.00
228_L316_I0.9771.00
26_P30_G0.9761.00
214_K218_H0.9761.00
105_F139_W0.9721.00
241_Q245_R0.9701.00
205_K322_L0.9631.00
230_V329_L0.9621.00
262_F265_T0.9621.00
228_L305_L0.9611.00
95_L103_A0.9601.00
329_L341_V0.9591.00
242_A333_P0.9481.00
141_R146_E0.9451.00
195_L225_G0.9441.00
150_F153_K0.9431.00
96_D169_Q0.9371.00
138_V157_V0.9371.00
184_Q188_A0.9311.00
233_R242_A0.9311.00
31_Y331_G0.9301.00
203_L206_E0.9301.00
46_G75_L0.9291.00
313_A345_L0.9231.00
44_Y342_G0.9221.00
134_E153_K0.9201.00
23_G31_Y0.9171.00
29_H98_L0.9151.00
66_I103_A0.9091.00
130_E182_V0.9081.00
31_Y34_Q0.9031.00
245_R248_S0.9011.00
97_R170_P0.9001.00
184_Q214_K0.8881.00
186_L190_Q0.8871.00
249_H252_D0.8851.00
206_E210_Q0.8801.00
60_L95_L0.8761.00
314_A317_N0.8751.00
146_E149_D0.8731.00
240_W301_A0.8731.00
140_R144_Q0.8721.00
337_E340_R0.8671.00
232_V345_L0.8661.00
338_A342_G0.8641.00
67_P99_S0.8631.00
335_L339_Y0.8581.00
237_D240_W0.8541.00
176_F183_A0.8531.00
168_Q171_Y0.8511.00
131_A135_F0.8481.00
41_R343_E0.8471.00
234_E340_R0.8441.00
200_P203_L0.8411.00
110_G115_E0.8391.00
30_G33_Q0.8381.00
143_L172_P0.8351.00
215_A218_H0.8331.00
114_Q117_A0.8321.00
136_T176_F0.8321.00
264_R267_S0.8311.00
34_Q41_R0.8291.00
176_F187_A0.8261.00
248_S252_D0.8181.00
342_G346_F0.8151.00
244_E247_I0.8111.00
35_I338_A0.8031.00
22_E25_R0.8011.00
133_A186_L0.8001.00
305_L315_R0.7971.00
142_L148_V0.7971.00
290_L295_G0.7841.00
127_E131_A0.7841.00
251_D254_T0.7831.00
25_R28_D0.7831.00
223_R326_S0.7791.00
160_A164_F0.7771.00
215_A221_K0.7741.00
211_V215_A0.7741.00
185_E213_A0.7731.00
196_T207_K0.7701.00
211_V222_I0.7691.00
96_D171_Y0.7681.00
194_Y211_V0.7661.00
135_F139_W0.7661.00
235_T239_A0.7631.00
141_R148_V0.7631.00
62_A66_I0.7621.00
242_A245_R0.7611.00
62_A95_L0.7601.00
212_R216_A0.7601.00
240_W243_A0.7561.00
295_G298_R0.7551.00
230_V341_V0.7541.00
129_Y182_V0.7521.00
63_A67_P0.7481.00
78_L108_V0.7441.00
202_E205_K0.7441.00
126_S182_V0.7431.00
150_F155_I0.7411.00
112_D115_E0.7401.00
33_Q65_M0.7391.00
107_L174_L0.7331.00
134_E138_V0.7321.00
208_I322_L0.7271.00
263_A267_S0.7261.00
141_R144_Q0.7251.00
317_N348_L0.7251.00
317_N349_L0.7221.00
137_Q140_R0.7211.00
59_W79_R0.7171.00
109_T128_R0.7141.00
147_T161_K0.7061.00
239_A243_A0.7051.00
93_A166_A0.7021.00
231_I243_A0.7001.00
92_A143_L0.7001.00
49_I61_V0.7001.00
260_A263_A0.6991.00
209_E323_G0.6971.00
176_F186_L0.6951.00
85_P138_V0.6941.00
292_A296_L0.6941.00
137_Q189_E0.6941.00
212_R325_D0.6941.00
162_L165_P0.6941.00
181_D214_K0.6921.00
62_A103_A0.6911.00
35_I335_L0.6881.00
133_A182_V0.6861.00
52_G55_C0.6851.00
289_N293_G0.6841.00
75_L175_Y0.6821.00
28_D31_Y0.6801.00
149_D158_R0.6791.00
46_G326_S0.6781.00
218_H221_K0.6771.00
201_P205_K0.6761.00
189_E214_K0.6761.00
212_R323_G0.6741.00
29_H64_S0.6721.00
33_Q67_P0.6721.00
263_A266_D0.6711.00
83_T87_V0.6701.00
31_Y35_I0.6701.00
89_A166_A0.6691.00
84_S87_V0.6691.00
151_N154_H0.6681.00
38_A342_G0.6671.00
66_I95_L0.6671.00
181_D185_E0.6661.00
29_H33_Q0.6661.00
291_W294_V0.6651.00
52_G56_E0.6611.00
138_V142_L0.6611.00
332_Y335_L0.6611.00
234_E309_G0.6611.00
254_T257_K0.6601.00
74_F99_S0.6601.00
288_P291_W0.6561.00
44_Y346_F0.6521.00
233_R340_R0.6521.00
252_D256_A0.6521.00
63_A99_S0.6491.00
245_R249_H0.6481.00
104_L175_Y0.6461.00
161_K165_P0.6451.00
296_L300_G0.6431.00
85_P135_F0.6421.00
39_A72_L0.6371.00
189_E217_A0.6351.00
30_G70_Q0.6301.00
73_K173_P0.6291.00
78_L88_A0.6271.00
230_V305_L0.6251.00
227_R328_V0.6241.00
96_D166_A0.6241.00
88_A139_W0.6221.00
184_Q211_V0.6191.00
184_Q194_Y0.6191.00
86_T142_L0.6191.00
291_W295_G0.6181.00
292_A295_G0.6171.00
53_R90_R0.6171.00
187_A194_Y0.6161.00
48_L77_A0.6151.00
240_W306_V0.6141.00
76_V103_A0.6141.00
83_T88_A0.6130.99
42_L335_L0.6080.99
232_V341_V0.6080.99
247_I250_L0.6070.99
109_T132_S0.6050.99
78_L177_G0.6050.99
232_V308_D0.6050.99
313_A349_L0.6050.99
257_K260_A0.6040.99
224_F324_I0.6030.99
261_A264_R0.6030.99
40_D72_L0.6010.99
253_E257_K0.6000.99
188_A215_A0.5970.99
131_A155_I0.5960.99
225_G326_S0.5930.99
46_G328_V0.5930.99
251_D255_I0.5920.99
69_T102_R0.5900.99
259_Q263_A0.5890.99
176_F191_V0.5890.99
79_R110_G0.5890.99
230_V312_V0.5820.99
165_P168_Q0.5820.99
211_V224_F0.5810.99
181_D206_E0.5800.99
61_V94_T0.5790.99
117_A120_G0.5790.99
297_V300_G0.5780.99
208_I211_V0.5780.99
225_G328_V0.5780.99
198_G204_V0.5740.99
116_L121_V0.5720.99
64_S99_S0.5690.99
45_T71_R0.5690.99
60_L94_T0.5680.99
199_E203_L0.5670.99
30_G67_P0.5660.99
193_L223_R0.5660.99
305_L319_Y0.5650.99
309_G343_E0.5650.99
262_F266_D0.5650.99
212_R224_F0.5640.99
47_V65_M0.5620.99
309_G344_L0.5590.99
62_A99_S0.5590.99
54_S112_D0.5590.99
105_F174_L0.5590.99
96_D99_S0.5580.99
229_H330_S0.5580.99
45_T73_K0.5580.99
107_L139_W0.5570.99
303_T315_R0.5570.99
212_R215_A0.5550.99
229_H304_A0.5550.99
134_E137_Q0.5540.99
175_Y326_S0.5530.99
59_W92_A0.5510.99
310_P344_L0.5500.99
316_I329_L0.5450.99
253_E256_A0.5450.99
107_L176_F0.5440.99
60_L64_S0.5440.99
57_D94_T0.5420.99
249_H253_E0.5390.99
296_L299_G0.5370.99
35_I331_G0.5350.99
179_S198_G0.5340.99
182_V186_L0.5340.99
27_V30_G0.5340.99
173_P223_R0.5330.99
93_A97_R0.5320.99
63_A95_L0.5300.99
89_A143_L0.5300.99
51_T83_T0.5290.99
125_H128_R0.5290.99
183_A186_L0.5280.99
179_S197_W0.5270.98
32_L35_I0.5270.98
289_N292_A0.5250.98
33_Q36_A0.5230.98
289_N294_V0.5220.98
86_T160_A0.5210.98
138_V152_G0.5190.98
242_A336_E0.5170.98
59_W87_V0.5170.98
106_N177_G0.5170.98
202_E302_G0.5160.98
69_T72_L0.5150.98
235_T308_D0.5150.98
23_G27_V0.5140.98
143_L174_L0.5120.98
202_E299_G0.5110.98
111_S116_L0.5110.98
88_A92_A0.5100.98
110_G113_P0.5080.98
293_G296_L0.5070.98
310_P313_A0.5070.98
216_A221_K0.5060.98
246_L250_L0.5060.98
42_L343_E0.5060.98
298_R301_A0.5050.98
258_A262_F0.5030.98
60_L91_Q0.5030.98
239_A306_V0.5030.98
32_L65_M0.5010.98
294_V298_R0.5010.98
99_S103_A0.5010.98
320_A324_I0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1nqkA 4 0.8924 100 0.245 Contact Map
3sdoA 2 0.9895 100 0.251 Contact Map
1tvlA 2 0.9081 100 0.257 Contact Map
3b9oA 2 0.9738 100 0.261 Contact Map
3raoA 2 0.8819 100 0.291 Contact Map
2wgkA 2 0.8714 100 0.304 Contact Map
1ezwA 3 0.8556 100 0.312 Contact Map
2i7gA 2 0.8478 100 0.312 Contact Map
1lucA 1 0.811 100 0.32 Contact Map
1z69A 4 0.8373 100 0.329 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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