GREMLIN Database
SSUE - FMN reductase (NADPH)
UniProt: P80644 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13708
Length: 191 (171)
Sequences: 6732 (4525)
Seq/√Len: 346.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
35_Y63_Q4.1461.00
4_I67_A3.1111.00
2_R33_E3.0841.00
80_A120_A2.8241.00
81_Y124_V2.8131.00
55_P59_T2.5891.00
62_E66_Q2.5461.00
102_V130_A2.4361.00
26_K162_D2.3691.00
17_S21_E2.2531.00
125_L130_A2.2471.00
147_Y151_P2.2261.00
5_T20_L2.1931.00
103_L164_A2.0361.00
86_K90_D2.0311.00
58_K62_E1.9431.00
7_A17_S1.9371.00
59_T63_Q1.8361.00
16_S107_T1.8111.00
60_F88_L1.7971.00
20_L73_A1.7711.00
120_A123_P1.7481.00
104_P117_V1.7401.00
80_A124_V1.7221.00
106_A114_L1.7201.00
158_Q162_D1.7181.00
2_R66_Q1.6751.00
25_E151_P1.6291.00
3_V69_G1.6121.00
5_T24_R1.5551.00
46_D49_Y1.5441.00
17_S38_N1.5231.00
98_Q129_K1.5101.00
21_E24_R1.5081.00
141_D144_V1.5011.00
155_P159_T1.5001.00
69_G168_F1.4731.00
24_R36_H1.4641.00
7_A20_L1.4431.00
38_N41_N1.4261.00
72_V102_V1.4141.00
135_H167_T1.3831.00
3_V32_V1.3671.00
64_L92_L1.3501.00
23_A105_L1.3491.00
89_L128_L1.3461.00
4_I37_W1.3351.00
56_A59_T1.3281.00
133_I171_A1.3121.00
32_V169_W1.3071.00
157_L160_R1.3071.00
72_V125_L1.2911.00
76_V116_A1.2751.00
74_T121_L1.2701.00
2_R35_Y1.2691.00
77_Y83_G1.2661.00
62_E65_Q1.2571.00
102_V125_L1.2371.00
103_L168_F1.2281.00
23_A71_I1.2261.00
70_L97_L1.2151.00
131_Q171_A1.2121.00
83_G90_D1.2081.00
74_T106_A1.1971.00
60_F92_L1.1851.00
81_Y120_A1.1841.00
16_S73_A1.1821.00
137_V164_A1.1651.00
55_P58_K1.1361.00
43_A56_A1.1321.00
35_Y67_A1.1291.00
64_L70_L1.1281.00
69_G172_L1.1171.00
57_L91_L1.1061.00
6_L72_V1.0651.00
24_R28_N1.0551.00
26_K158_Q1.0531.00
61_T92_L1.0291.00
13_P18_S1.0231.00
169_W173_H1.0201.00
112_A115_L1.0181.00
21_E36_H1.0171.00
162_D166_E1.0141.00
159_T163_T1.0121.00
72_V85_L1.0051.00
22_Y25_E0.9941.00
47_L50_A0.9931.00
23_A161_L0.9861.00
19_L107_T0.9831.00
26_K165_L0.9811.00
27_L34_V0.9791.00
74_T117_V0.9771.00
164_A168_F0.9761.00
5_T36_H0.9741.00
26_K29_G0.9651.00
126_S132_E0.9611.00
48_L52_F0.9541.00
72_V89_L0.9511.00
139_A157_L0.9291.00
7_A16_S0.9271.00
5_T34_V0.9231.00
59_T62_E0.9191.00
159_T162_D0.9141.00
166_E170_Q0.9081.00
61_T96_A0.9061.00
133_I168_F0.9051.00
15_R142_S0.8981.00
168_F172_L0.8961.00
37_W63_Q0.8951.00
83_G86_K0.8921.00
115_L118_D0.8891.00
27_L165_L0.8851.00
71_I103_L0.8851.00
64_L88_L0.8841.00
4_I63_Q0.8791.00
108_G138_F0.8781.00
155_P158_Q0.8711.00
19_L139_A0.8711.00
46_D50_A0.8691.00
81_Y86_K0.8581.00
28_N31_D0.8571.00
41_N59_T0.8561.00
106_A118_D0.8541.00
156_N159_T0.8491.00
12_F40_Q0.8481.00
78_K93_P0.8461.00
3_V172_L0.8441.00
114_L118_D0.8401.00
70_L100_K0.8401.00
109_G143_Q0.8291.00
74_T82_S0.8241.00
63_Q66_Q0.8221.00
37_W60_F0.8191.00
80_A86_K0.8171.00
65_Q96_A0.8151.00
86_K124_V0.8101.00
21_E25_E0.8041.00
24_R34_V0.7991.00
122_K136_G0.7981.00
47_L52_F0.7981.00
99_G131_Q0.7921.00
54_S91_L0.7911.00
89_L121_L0.7881.00
129_K167_T0.7871.00
79_A127_A0.7851.00
25_E28_N0.7761.00
5_T73_A0.7751.00
95_R98_Q0.7741.00
125_L132_E0.7731.00
69_G101_V0.7721.00
39_L88_L0.7711.00
44_P83_G0.7691.00
89_L124_V0.7681.00
131_Q134_L0.7661.00
17_S36_H0.7601.00
70_L102_V0.7571.00
10_P84_A0.7541.00
79_A116_A0.7461.00
122_K126_S0.7461.00
41_N56_A0.7431.00
163_T167_T0.7411.00
104_P125_L0.7401.00
120_A124_V0.7401.00
63_Q67_A0.7360.99
97_L130_A0.7300.99
73_A105_L0.7260.99
31_D169_W0.7250.99
170_Q174_R0.7230.99
18_S21_E0.7180.99
8_G74_T0.7160.99
39_L84_A0.7160.99
10_P83_G0.7140.99
80_A90_D0.7010.99
153_F156_N0.6870.99
72_V121_L0.6760.99
142_S146_D0.6730.99
27_L169_W0.6730.99
89_L125_L0.6720.99
81_Y121_L0.6710.99
154_T157_L0.6670.99
25_E29_G0.6670.99
7_A36_H0.6660.99
70_L130_A0.6560.99
18_S146_D0.6550.99
112_A116_A0.6540.99
23_A165_L0.6470.99
71_I105_L0.6450.99
44_P87_T0.6440.99
133_I167_T0.6420.99
87_T91_L0.6420.99
145_I154_T0.6380.99
165_L169_W0.6380.99
146_D152_Q0.6360.99
76_V113_H0.6330.98
3_V27_L0.6330.98
102_V132_E0.6310.98
99_G129_K0.6300.98
19_L105_L0.6290.98
139_A145_I0.6220.98
145_I157_L0.6170.98
92_L97_L0.6170.98
75_P82_S0.6160.98
23_A73_A0.6140.98
127_A134_L0.6140.98
61_T65_Q0.6120.98
35_Y66_Q0.6040.98
106_A117_V0.6030.98
22_Y158_Q0.6000.98
88_L92_L0.5990.98
4_I70_L0.5930.98
5_T71_I0.5890.98
14_S17_S0.5870.98
166_E169_W0.5860.98
143_Q154_T0.5850.97
111_V141_D0.5840.97
76_V79_A0.5810.97
145_I152_Q0.5810.97
55_P62_E0.5790.97
145_I153_F0.5770.97
54_S57_L0.5770.97
7_A39_L0.5740.97
94_E98_Q0.5680.97
79_A115_L0.5680.97
103_L133_I0.5620.97
29_G162_D0.5590.97
48_L87_T0.5580.97
58_K61_T0.5560.97
15_R18_S0.5530.96
20_L34_V0.5520.96
19_L142_S0.5470.96
84_A88_L0.5400.96
31_D166_E0.5380.96
64_L96_A0.5370.96
14_S107_T0.5360.96
49_Y57_L0.5330.96
103_L137_V0.5320.96
8_G85_L0.5250.95
14_S38_N0.5240.95
99_G167_T0.5240.95
126_S134_L0.5240.95
27_L32_V0.5220.95
101_V172_L0.5200.95
74_T85_L0.5180.95
93_P96_A0.5150.95
4_I64_L0.5150.95
17_S40_Q0.5140.95
159_T166_E0.5120.95
170_Q173_H0.5100.95
6_L60_F0.5100.95
31_D173_H0.5080.94
46_D51_R0.5070.94
48_L53_D0.5060.94
47_L51_R0.5040.94
147_Y153_F0.5020.94
146_D150_R0.5010.94
85_L121_L0.5000.94
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2fzvA 5 0.9895 100 0.348 Contact Map
2q62A 4 0.9843 100 0.378 Contact Map
3u7rA 4 0.9215 100 0.394 Contact Map
3svlA 4 0.9058 100 0.394 Contact Map
4ptzC 4 0.911 100 0.401 Contact Map
1rttA 1 0.8848 100 0.416 Contact Map
4hs4A 6 0.9162 100 0.419 Contact Map
3fvwA 1 0.8953 100 0.426 Contact Map
4ltnA 4 0.9634 100 0.433 Contact Map
3k1yA 4 0.8953 100 0.446 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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