GREMLIN Database
YNJE - Thiosulfate sulfurtransferase YnjE
UniProt: P78067 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG14007
Length: 435 (408)
Sequences: 138 (98)
Seq/√Len: 4.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
152_H156_Q4.8990.96
345_S351_E4.2290.92
338_A409_Y4.0540.90
237_A253_L3.6520.84
387_T410_D3.1590.74
31_T100_A3.1250.73
395_F408_V3.0980.72
91_H365_D3.0630.71
411_G415_E3.0570.71
66_L136_L2.8640.66
387_T411_G2.8360.65
317_P322_T2.7480.62
71_L103_G2.5840.57
189_A228_L2.5820.57
329_I411_G2.5160.55
331_P340_W2.4990.54
147_Y266_L2.4260.52
194_T198_E2.3980.51
123_I249_K2.3870.51
204_N387_T2.3140.49
150_W387_T2.3080.48
93_L120_L2.3020.48
193_D293_M2.2500.46
97_A273_P2.2490.46
212_K216_A2.2400.46
204_N410_D2.2380.46
329_I387_T2.2350.46
229_Y411_G2.2110.45
326_Y412_G2.1920.45
229_Y329_I2.1460.43
43_I69_L2.1210.42
150_W229_Y2.1180.42
284_V288_A2.1160.42
150_W411_G2.0970.42
28_K126_L2.0780.41
361_R365_D2.0700.41
70_N362_S2.0190.39
157_G160_V2.0170.39
229_Y387_T2.0070.39
174_A191_Y1.9620.38
110_A123_I1.9380.37
213_A353_F1.9320.37
208_D369_M1.9180.36
150_W186_I1.8960.36
33_D405_N1.8960.36
153_D158_K1.8860.35
84_L311_V1.8840.35
104_N107_D1.8740.35
126_L334_E1.8670.35
319_F322_T1.8260.34
171_I335_I1.8150.33
139_L392_S1.8110.33
91_H300_R1.7880.32
204_N329_I1.7820.32
354_H393_E1.7810.32
126_L339_R1.7770.32
26_L31_T1.7740.32
101_L169_K1.7640.32
205_K295_D1.7460.31
93_L167_D1.7370.31
138_K228_L1.7360.31
184_S379_Q1.7210.31
229_Y410_D1.7120.30
51_Y76_L1.6900.30
335_I414_Y1.6660.29
203_W328_Y1.6600.29
224_T387_T1.6480.29
246_A290_P1.6310.28
334_E417_S1.6180.28
266_L334_E1.6120.28
48_S355_N1.6040.28
215_L243_M1.5990.27
283_G412_G1.5980.27
43_I99_V1.5570.26
203_W326_Y1.5420.26
150_W329_I1.5400.26
208_D360_M1.5230.26
42_A98_P1.5090.25
266_L303_L1.5040.25
329_I410_D1.5010.25
104_N161_T1.4940.25
154_L227_I1.4920.25
108_V379_Q1.4860.25
45_T111_V1.4840.25
268_V396_M1.4710.24
322_T371_K1.4660.24
121_T159_E1.4640.24
28_K427_G1.4600.24
172_E225_T1.4570.24
48_S70_N1.4570.24
269_E273_P1.4380.24
283_G290_P1.4360.23
304_H368_A1.4200.23
236_A408_V1.4190.23
246_A312_S1.4150.23
206_V340_W1.4110.23
384_Y411_G1.4070.23
186_I224_T1.4060.23
65_E255_D1.4030.23
186_I229_Y1.4010.23
53_G63_G1.4000.23
44_D63_G1.4000.23
329_I414_Y1.3920.22
115_L407_S1.3910.22
243_M392_S1.3880.22
176_G391_A1.3810.22
316_W320_I1.3780.22
62_S138_K1.3720.22
208_D382_S1.3640.22
215_L350_M1.3630.22
50_F136_L1.3620.22
55_P115_L1.3580.22
50_F66_L1.3550.22
394_T400_A1.3530.22
28_K429_R1.3520.22
139_L246_A1.3460.21
70_N356_P1.3330.21
150_W204_N1.3270.21
54_W417_S1.3260.21
360_M397_Y1.3190.21
44_D53_G1.3170.21
205_K354_H1.3140.21
24_A249_K1.3130.21
246_A403_W1.3110.21
150_W410_D1.3100.21
316_W346_D1.3090.21
130_L136_L1.2910.20
119_G283_G1.2870.20
169_K176_G1.2680.20
364_D368_A1.2600.20
142_F257_G1.2550.20
142_F298_Q1.2540.20
49_A129_A1.2520.19
242_I408_V1.2510.19
109_D140_P1.2490.19
43_I291_Q1.2480.19
348_T363_A1.2410.19
204_N411_G1.2340.19
208_D397_Y1.2290.19
26_L34_Q1.2250.19
187_P336_A1.2240.19
104_N273_P1.2200.19
352_D411_G1.2190.19
328_Y412_G1.2150.19
248_V282_F1.2130.19
58_L281_D1.2120.19
94_K249_K1.2110.19
126_L129_A1.2100.19
281_D380_Q1.1890.18
315_S411_G1.1790.18
172_E397_Y1.1780.18
191_Y195_N1.1780.18
101_L201_P1.1770.18
151_L265_G1.1770.18
27_A140_P1.1750.18
61_P136_L1.1630.18
289_Q294_L1.1630.18
352_D414_Y1.1560.18
170_V228_L1.1540.18
207_S377_P1.1530.18
245_Y393_E1.1440.17
50_F56_Q1.1400.17
201_P341_G1.1380.17
255_D374_N1.1340.17
188_G229_Y1.1340.17
302_L380_Q1.1340.17
66_L138_K1.1290.17
363_A369_M1.1250.17
103_G193_D1.1240.17
249_K421_K1.1230.17
173_A340_W1.1160.17
332_K427_G1.1160.17
142_F374_N1.1120.17
192_I218_H1.1100.17
192_I239_V1.1030.17
45_T101_L1.1020.17
187_P303_L1.0990.17
384_Y415_E1.0960.17
150_W224_T1.0930.17
329_I352_D1.0900.16
331_P336_A1.0850.16
105_D190_D1.0840.16
277_K297_E1.0770.16
245_Y360_M1.0760.16
169_K313_I1.0750.16
119_G325_G1.0730.16
383_F412_G1.0700.16
46_R63_G1.0700.16
92_N132_E1.0700.16
313_I352_D1.0620.16
129_A311_V1.0580.16
324_S386_G1.0580.16
204_N229_Y1.0570.16
360_M393_E1.0520.16
88_I263_D1.0470.16
157_G235_A1.0470.16
215_L312_S1.0440.16
51_Y290_P1.0430.16
422_N427_G1.0260.15
104_N227_I1.0250.15
384_Y410_D1.0240.15
61_P429_R1.0230.15
229_Y352_D1.0220.15
94_K277_K1.0210.15
228_L291_Q1.0210.15
300_R322_T1.0180.15
105_D108_V1.0170.15
352_D387_T1.0060.15
46_R53_G0.9970.15
158_K311_V0.9950.15
312_S392_S0.9940.15
300_R303_L0.9930.15
194_T417_S0.9900.15
238_R389_W0.9890.15
282_F290_P0.9880.15
343_A382_S0.9820.15
224_T377_P0.9760.15
362_S395_F0.9690.14
67_A76_L0.9680.14
177_A273_P0.9660.14
320_I427_G0.9630.14
203_W412_G0.9610.14
248_V325_G0.9590.14
260_T311_V0.9570.14
96_D115_L0.9560.14
257_G370_W0.9500.14
172_E239_V0.9480.14
28_K31_T0.9470.14
355_N393_E0.9470.14
309_S384_Y0.9390.14
310_L337_G0.9370.14
286_I332_K0.9350.14
60_G123_I0.9350.14
103_G191_Y0.9330.14
311_V426_T0.9330.14
132_E364_D0.9310.14
194_T412_G0.9280.14
158_K165_A0.9260.14
309_S379_Q0.9250.14
111_V399_R0.9240.14
344_G387_T0.9170.14
209_E404_K0.9160.14
41_K168_W0.9150.14
115_L341_G0.9140.14
310_L341_G0.9120.14
99_V292_L0.9110.14
146_V402_G0.9110.14
286_I290_P0.9100.14
345_S349_H0.9100.14
181_Y402_G0.9080.13
92_N242_I0.9050.13
54_W184_S0.9040.13
125_I166_G0.8970.13
346_D349_H0.8940.13
324_S412_G0.8940.13
218_H381_V0.8930.13
193_D259_Q0.8890.13
321_G416_W0.8880.13
344_G370_W0.8880.13
298_Q340_W0.8880.13
224_T410_D0.8880.13
240_A393_E0.8860.13
298_Q336_A0.8850.13
302_L305_R0.8800.13
54_W181_Y0.8800.13
149_Q153_D0.8790.13
229_Y315_S0.8790.13
384_Y387_T0.8780.13
206_V331_P0.8740.13
248_V359_T0.8720.13
283_G328_Y0.8680.13
204_N384_Y0.8680.13
66_L379_Q0.8640.13
212_K286_I0.8630.13
212_K285_K0.8620.13
27_A322_T0.8590.13
133_P317_P0.8520.13
327_S414_Y0.8520.13
208_D394_T0.8490.13
67_A153_D0.8490.13
37_Q159_E0.8490.13
95_T143_E0.8460.13
116_Q398_A0.8440.13
22_W51_Y0.8440.13
65_E100_A0.8430.13
156_Q209_E0.8410.13
377_P410_D0.8400.13
55_P307_D0.8390.12
54_W245_Y0.8390.12
188_G329_I0.8380.12
264_A281_D0.8320.12
207_S343_A0.8300.12
343_A352_D0.8280.12
151_L207_S0.8280.12
164_P209_E0.8230.12
99_V115_L0.8220.12
58_L112_K0.8210.12
255_D289_Q0.8180.12
73_A110_A0.8170.12
376_K379_Q0.8140.12
23_A30_L0.8120.12
411_G414_Y0.8110.12
81_T338_A0.8100.12
312_S381_V0.8060.12
194_T337_G0.8000.12
170_V353_F0.7990.12
174_A195_N0.7980.12
54_W240_A0.7970.12
127_S132_E0.7950.12
139_L191_Y0.7950.12
203_W325_G0.7940.12
31_T136_L0.7940.12
283_G326_Y0.7930.12
130_L265_G0.7890.12
41_K99_V0.7890.12
106_K131_S0.7870.12
319_F364_D0.7860.12
230_G355_N0.7860.12
58_L62_S0.7850.12
145_L237_A0.7840.12
370_W390_R0.7840.12
117_K275_K0.7830.12
30_L34_Q0.7800.12
283_G325_G0.7780.12
298_Q331_P0.7770.12
216_A280_P0.7760.12
343_A362_S0.7740.12
172_E254_L0.7740.12
381_V403_W0.7740.12
150_W352_D0.7730.12
318_E390_R0.7720.12
191_Y312_S0.7720.12
67_A186_I0.7700.12
332_K419_D0.7700.12
279_E429_R0.7700.12
27_A76_L0.7680.12
199_S387_T0.7680.12
94_K221_R0.7670.12
138_K259_Q0.7660.12
59_N66_L0.7650.11
150_W415_E0.7640.11
204_N346_D0.7630.11
66_L424_V0.7600.11
188_G281_D0.7590.11
42_A95_T0.7590.11
370_W398_A0.7570.11
154_L163_K0.7570.11
109_D125_I0.7560.11
249_K275_K0.7550.11
245_Y355_N0.7530.11
70_N397_Y0.7520.11
223_D228_L0.7510.11
254_L403_W0.7500.11
148_P217_K0.7490.11
169_K397_Y0.7490.11
212_K409_Y0.7470.11
72_S175_W0.7470.11
148_P266_L0.7440.11
154_L226_V0.7440.11
52_N194_T0.7430.11
138_K173_A0.7430.11
61_P320_I0.7420.11
145_L220_I0.7410.11
297_E422_N0.7410.11
242_I293_M0.7400.11
316_W341_G0.7400.11
131_S319_F0.7380.11
239_V243_M0.7360.11
146_V252_R0.7330.11
295_D387_T0.7320.11
26_L135_R0.7310.11
120_L163_K0.7310.11
205_K313_I0.7300.11
49_A147_Y0.7280.11
74_S217_K0.7260.11
43_I215_L0.7260.11
146_V186_I0.7250.11
282_F325_G0.7230.11
337_G361_R0.7230.11
71_L75_W0.7220.11
170_V402_G0.7220.11
36_Q168_W0.7190.11
233_V408_V0.7150.11
71_L268_V0.7150.11
326_Y383_F0.7150.11
35_L170_V0.7140.11
107_D193_D0.7120.11
207_S419_D0.7120.11
211_L398_A0.7070.11
93_L174_A0.7070.11
332_K345_S0.7030.11
324_S328_Y0.7000.11
235_A269_E0.7000.11
37_Q51_Y0.6990.11
198_E311_V0.6990.11
26_L37_Q0.6970.11
265_G337_G0.6950.11
139_L312_S0.6930.11
265_G301_G0.6930.11
52_N265_G0.6920.11
75_W357_D0.6910.11
96_D121_T0.6910.11
38_Q122_H0.6890.11
211_L337_G0.6890.11
332_K346_D0.6870.11
37_Q140_P0.6870.11
289_Q391_A0.6860.11
344_G352_D0.6850.10
295_D313_I0.6840.10
293_M394_T0.6830.10
200_E384_Y0.6820.10
246_A286_I0.6820.10
172_E269_E0.6810.10
211_L422_N0.6810.10
198_E251_V0.6780.10
213_A285_K0.6770.10
93_L122_H0.6770.10
247_G357_D0.6760.10
346_D411_G0.6760.10
42_A209_E0.6740.10
340_W384_Y0.6740.10
360_M395_F0.6720.10
35_L281_D0.6720.10
154_L315_S0.6700.10
386_G416_W0.6700.10
138_K405_N0.6690.10
173_A268_V0.6660.10
387_T415_E0.6660.10
229_Y313_I0.6650.10
102_Y282_F0.6650.10
321_G417_S0.6640.10
204_N224_T0.6630.10
251_V318_E0.6610.10
119_G391_A0.6600.10
329_I384_Y0.6580.10
173_A194_T0.6580.10
261_W333_G0.6560.10
175_W193_D0.6560.10
26_L366_I0.6550.10
111_V409_Y0.6550.10
60_G285_K0.6540.10
281_D296_M0.6510.10
355_N398_A0.6500.10
148_P223_D0.6500.10
155_Q281_D0.6490.10
300_R422_N0.6480.10
83_Q209_E0.6480.10
235_A343_A0.6470.10
31_T41_K0.6450.10
215_L392_S0.6450.10
33_D37_Q0.6450.10
103_G139_L0.6440.10
23_A26_L0.6410.10
68_A389_W0.6380.10
175_W327_S0.6350.10
79_M403_W0.6340.10
100_A190_D0.6330.10
199_S410_D0.6300.10
298_Q372_A0.6290.10
89_K404_K0.6250.10
71_L89_K0.6240.10
26_L29_P0.6240.10
115_L167_D0.6240.10
40_G137_Q0.6230.10
175_W391_A0.6220.10
277_K285_K0.6200.10
102_Y247_G0.6200.10
190_D268_V0.6200.10
22_W25_E0.6200.10
350_M394_T0.6190.10
224_T245_Y0.6160.10
193_D336_A0.6160.10
312_S329_I0.6150.10
324_S346_D0.6140.10
312_S403_W0.6130.10
232_D384_Y0.6130.10
240_A245_Y0.6130.10
56_Q227_I0.6070.10
24_A34_Q0.6070.10
171_I290_P0.6070.10
155_Q188_G0.6060.10
245_Y354_H0.6060.10
150_W344_G0.6040.10
245_Y398_A0.6030.10
21_S35_L0.6030.10
247_G389_W0.6030.10
329_I346_D0.6030.10
91_H361_R0.6010.10
159_E297_E0.5990.10
319_F323_T0.5980.09
205_K230_G0.5970.09
367_T401_M0.5950.09
172_E201_P0.5950.09
224_T392_S0.5940.09
325_G386_G0.5890.09
188_G406_V0.5890.09
246_A392_S0.5870.09
258_W275_K0.5860.09
225_T346_D0.5860.09
147_Y403_W0.5850.09
256_G359_T0.5840.09
54_W393_E0.5830.09
224_T411_G0.5830.09
313_I394_T0.5820.09
151_L286_I0.5810.09
33_D39_N0.5810.09
143_E292_L0.5810.09
118_A139_L0.5790.09
262_S276_V0.5780.09
205_K224_T0.5780.09
62_S300_R0.5770.09
203_W283_G0.5760.09
136_L302_L0.5750.09
144_Q207_S0.5750.09
68_A383_F0.5740.09
23_A95_T0.5730.09
188_G220_I0.5690.09
310_L369_M0.5670.09
29_P32_L0.5670.09
59_N123_I0.5670.09
43_I127_S0.5660.09
315_S415_E0.5650.09
241_Q396_M0.5640.09
313_I401_M0.5620.09
140_P155_Q0.5620.09
245_Y257_G0.5610.09
244_L396_M0.5610.09
396_M410_D0.5600.09
99_V120_L0.5600.09
52_N255_D0.5600.09
60_G125_I0.5600.09
245_Y407_S0.5590.09
188_G228_L0.5590.09
198_E389_W0.5570.09
66_L137_Q0.5570.09
332_K422_N0.5570.09
119_G248_V0.5560.09
248_V412_G0.5560.09
52_N310_L0.5560.09
186_I320_I0.5560.09
198_E417_S0.5550.09
169_K175_W0.5540.09
350_M400_A0.5540.09
229_Y384_Y0.5540.09
171_I307_D0.5530.09
69_L127_S0.5530.09
42_A401_M0.5500.09
70_N339_R0.5490.09
194_T203_W0.5490.09
28_K61_P0.5480.09
109_D249_K0.5470.09
195_N395_F0.5460.09
191_Y231_R0.5460.09
159_E322_T0.5460.09
163_K168_W0.5450.09
222_H284_V0.5450.09
26_L55_P0.5450.09
27_A306_Q0.5420.09
329_I415_E0.5410.09
330_K379_Q0.5390.09
198_E361_R0.5390.09
39_N305_R0.5390.09
348_T408_V0.5380.09
31_T254_L0.5370.09
201_P352_D0.5370.09
198_E266_L0.5360.09
313_I353_F0.5360.09
66_L288_A0.5340.09
112_K136_L0.5330.09
75_W391_A0.5320.09
124_S350_M0.5280.09
201_P204_N0.5280.09
160_V429_R0.5270.09
186_I387_T0.5260.09
185_H416_W0.5260.09
255_D354_H0.5260.09
344_G411_G0.5250.09
171_I348_T0.5250.09
136_L306_Q0.5250.09
195_N205_K0.5250.09
282_F328_Y0.5220.09
340_W411_G0.5210.09
329_I344_G0.5210.09
194_T310_L0.5200.09
195_N244_L0.5190.09
65_E71_L0.5190.09
303_L361_R0.5160.09
277_K353_F0.5160.09
72_S192_I0.5160.09
52_N311_V0.5160.09
218_H270_R0.5150.09
257_G271_G0.5150.09
23_A31_T0.5140.09
222_H249_K0.5130.09
118_A381_V0.5110.09
67_A151_L0.5110.09
230_G293_M0.5100.09
35_L105_D0.5100.09
87_W365_D0.5090.09
194_T311_V0.5090.09
315_S378_E0.5090.09
345_S353_F0.5090.09
370_W388_G0.5070.09
84_L115_L0.5060.09
204_N344_G0.5050.09
27_A33_D0.5040.09
95_T398_A0.5030.08
39_N47_P0.5030.08
224_T295_D0.5010.08
197_V239_V0.5000.08
167_D227_I0.5000.08
181_Y240_A0.5000.08
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2wlrA 1 0.9356 100 0.573 Contact Map
1rhsA 1 0.6391 100 0.732 Contact Map
1urhA 1 0.5747 100 0.733 Contact Map
1yt8A 1 0.8 100 0.734 Contact Map
3aayA 1 0.6184 100 0.738 Contact Map
1uarA 1 0.6161 100 0.739 Contact Map
1e0cA 1 0.6138 100 0.741 Contact Map
3hzuA 2 0.6529 100 0.744 Contact Map
3utnX 1 0.6391 100 0.744 Contact Map
4jgtA 1 0.6161 100 0.744 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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