GREMLIN Database
PUUA - Gamma-glutamylputrescine synthetase PuuA
UniProt: P78061 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13908
Length: 472 (422)
Sequences: 6375 (3279)
Seq/√Len: 159.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
428_I450_N5.1261.00
312_A398_L4.7951.00
207_D262_H3.9621.00
285_I310_M3.9331.00
150_R395_D3.8751.00
392_H396_N3.7851.00
310_M390_I3.7631.00
123_T141_N3.5111.00
146_Q395_D3.5061.00
145_Q149_Q3.3611.00
309_K397_E3.3601.00
126_D130_A3.0451.00
316_D396_N2.9031.00
29_R33_R2.8291.00
439_E443_H2.8051.00
143_L388_A2.7461.00
204_V208_I2.7421.00
139_V441_F2.6951.00
320_S430_N2.6901.00
434_R439_E2.6691.00
462_E466_E2.6101.00
320_S433_L2.5651.00
238_T247_D2.5281.00
145_Q148_R2.5191.00
255_V266_A2.5061.00
289_N293_E2.4861.00
295_V306_L2.4811.00
156_V383_M2.4651.00
207_D261_K2.4401.00
305_P397_E2.3771.00
317_L430_N2.3641.00
163_Y227_S2.3531.00
285_I386_I2.3431.00
317_L392_H2.2741.00
238_T243_E2.2631.00
425_G450_N2.2551.00
324_L385_A2.2451.00
419_R422_D2.2181.00
308_K399_P2.2041.00
243_E247_D2.1991.00
309_K312_A2.1651.00
148_R153_F2.1561.00
144_W242_L2.1271.00
421_S457_E2.1211.00
30_Y35_P2.0521.00
325_L382_V2.0501.00
323_A427_F2.0381.00
239_D243_E2.0121.00
59_S213_Q1.9971.00
164_L204_V1.9881.00
144_W241_V1.9861.00
212_A254_L1.9801.00
208_I255_V1.9541.00
418_I422_D1.9401.00
215_Q254_L1.9121.00
42_V122_L1.8691.00
165_L273_Y1.8671.00
427_F442_C1.8571.00
426_E429_E1.8511.00
147_L154_P1.8301.00
38_Q210_E1.8291.00
133_D440_R1.8291.00
218_P236_Y1.8181.00
455_Q467_W1.8161.00
25_Q29_R1.7851.00
377_A382_V1.7781.00
309_K398_L1.7751.00
306_L394_L1.7701.00
312_A400_L1.7391.00
163_Y279_S1.6901.00
305_P309_K1.6891.00
424_L446_H1.6841.00
144_W239_D1.6751.00
245_C383_M1.6571.00
301_G308_K1.6501.00
251_L255_V1.6461.00
211_L258_M1.6371.00
64_L104_L1.6361.00
317_L389_G1.6281.00
421_S425_G1.6271.00
324_L427_F1.6231.00
422_D425_G1.5991.00
141_N242_L1.5981.00
319_P426_E1.5941.00
155_V237_H1.5941.00
106_S121_L1.5881.00
155_V288_Q1.5811.00
147_L391_L1.5791.00
160_L248_A1.5671.00
428_I446_H1.5601.00
139_V384_A1.5521.00
154_P387_F1.5461.00
316_D398_L1.5411.00
101_V125_V1.5391.00
31_L58_V1.5301.00
388_A436_Y1.5291.00
432_H436_Y1.5291.00
211_L214_L1.5021.00
37_T109_P1.4881.00
43_L119_Q1.4471.00
143_L384_A1.4321.00
164_L259_A1.4201.00
212_A217_I1.4141.00
152_L295_V1.4101.00
309_K399_P1.3811.00
143_L146_Q1.3811.00
119_Q250_A1.3791.00
235_L244_A1.3791.00
244_A247_D1.3751.00
323_A424_L1.3671.00
45_T249_L1.3561.00
431_D435_R1.3441.00
26_E29_R1.3341.00
308_K400_L1.3301.00
305_P399_P1.3261.00
31_L61_L1.3211.00
454_L457_E1.3071.00
425_G429_E1.3061.00
370_Y386_I1.3041.00
285_I390_I1.2881.00
141_N145_Q1.2701.00
38_Q213_Q1.2681.00
321_S325_L1.2661.00
238_T244_A1.2611.00
305_P308_K1.2541.00
135_E138_N1.2521.00
166_D264_M1.2491.00
290_N293_E1.2481.00
167_R260_E1.2481.00
425_G428_I1.2461.00
310_M391_L1.2441.00
356_L368_V1.2381.00
29_R32_E1.2311.00
311_L368_V1.2311.00
306_L309_K1.2291.00
27_V107_L1.2271.00
225_E232_E1.2221.00
449_K452_E1.2181.00
126_D133_D1.2181.00
434_R442_C1.2101.00
319_P322_M1.2091.00
320_S426_E1.2091.00
428_I443_H1.2031.00
312_A401_Q1.2021.00
434_R443_H1.1981.00
146_Q388_A1.1951.00
201_F231_F1.1881.00
51_F121_L1.1861.00
321_S385_A1.1851.00
227_S277_A1.1851.00
411_Q414_L1.1811.00
298_D301_G1.1671.00
207_D211_L1.1671.00
37_T118_G1.1581.00
456_F463_T1.1521.00
164_L266_A1.1521.00
147_L150_R1.1481.00
326_A331_S1.1471.00
221_G234_N1.1461.00
322_M372_V1.1451.00
100_C124_M1.1411.00
283_I386_I1.1411.00
258_M262_H1.1381.00
430_N433_L1.1381.00
319_P422_D1.1321.00
317_L396_N1.1321.00
321_S389_G1.1291.00
298_D302_E1.1181.00
107_L118_G1.1181.00
254_L258_M1.1181.00
311_L356_L1.1161.00
28_K62_K1.1121.00
228_P276_H1.1121.00
454_L458_R1.1041.00
318_M355_A1.1021.00
269_M330_N1.1011.00
100_C122_L1.1011.00
310_M386_I1.0900.99
451_D455_Q1.0810.99
289_N295_V1.0810.99
131_P138_N1.0800.99
165_L267_T1.0690.99
163_Y277_A1.0670.99
331_S374_G1.0650.99
103_V123_T1.0600.99
211_L261_K1.0600.99
315_I356_L1.0460.99
332_Y420_Q1.0410.99
446_H450_N1.0380.99
152_L306_L1.0380.99
427_F433_L1.0260.99
140_L241_V1.0250.99
312_A399_P1.0210.99
220_D236_Y1.0190.99
232_E282_H1.0180.99
283_I382_V1.0170.99
274_E460_I1.0150.99
211_L254_L1.0080.99
319_P345_A1.0080.99
226_A277_A1.0070.99
309_K394_L1.0040.99
40_V61_L1.0010.99
259_A266_A1.0000.99
153_F239_D0.9970.99
453_L457_E0.9970.99
443_H447_A0.9900.99
323_A445_Y0.9900.99
354_V408_G0.9890.99
333_R464_E0.9760.99
108_T119_Q0.9740.99
460_I464_E0.9720.99
94_G407_N0.9680.99
427_F446_H0.9660.99
225_E282_H0.9650.99
27_V120_M0.9640.99
430_N434_R0.9620.99
51_F249_L0.9490.99
321_S433_L0.9460.99
215_Q250_A0.9410.98
355_A372_V0.9390.98
296_L307_L0.9360.98
456_F461_T0.9360.98
46_D52_R0.9320.98
248_A281_M0.9320.98
235_L251_L0.9320.98
270_A376_D0.9300.98
204_V258_M0.9300.98
113_D117_I0.9270.98
62_K65_E0.9240.98
324_L442_C0.9230.98
428_I439_E0.9210.98
38_Q115_E0.9210.98
314_M356_L0.9180.98
450_N454_L0.9140.98
270_A374_G0.9120.98
204_V264_M0.9110.98
27_V104_L0.9070.98
424_L450_N0.8970.98
26_E30_Y0.8960.98
35_P109_P0.8960.98
139_V143_L0.8950.98
433_L437_L0.8950.98
24_T65_E0.8950.98
233_I251_L0.8920.98
349_H403_E0.8920.98
24_T28_K0.8890.98
392_H435_R0.8840.98
209_D222_A0.8830.98
428_I431_D0.8820.98
308_K312_A0.8820.98
135_E139_V0.8810.98
424_L453_L0.8800.98
147_L287_M0.8770.98
159_E232_E0.8750.98
40_V58_V0.8740.98
156_V310_M0.8740.98
459_L463_T0.8730.98
204_V262_H0.8730.98
156_V244_A0.8730.98
445_Y449_K0.8720.98
105_G243_E0.8710.97
287_M295_V0.8700.97
134_V440_R0.8690.97
150_R391_L0.8680.97
28_K32_E0.8630.97
159_E225_E0.8610.97
461_T464_E0.8570.97
342_P371_R0.8570.97
200_H260_E0.8560.97
346_S408_G0.8530.97
143_L436_Y0.8500.97
310_M314_M0.8480.97
362_D365_N0.8470.97
433_L442_C0.8450.97
421_S453_L0.8450.97
421_S450_N0.8420.97
285_I370_Y0.8340.97
318_M356_L0.8310.97
92_E95_E0.8290.97
329_V420_Q0.8290.97
328_N376_D0.8290.97
353_T408_G0.8290.97
346_S354_V0.8280.97
158_V248_A0.8260.97
202_A206_N0.8240.97
324_L437_L0.8230.96
314_M368_V0.8180.96
147_L152_L0.8170.96
431_D439_E0.8160.96
351_N409_L0.8130.96
125_V138_N0.8110.96
144_W154_P0.8080.96
442_C446_H0.8080.96
384_A437_L0.7950.96
207_D258_M0.7930.96
338_G341_V0.7930.96
152_L287_M0.7920.96
59_S218_P0.7900.96
125_V131_P0.7860.95
426_E430_N0.7850.95
460_I463_T0.7830.95
353_T409_L0.7830.95
192_V223_V0.7830.95
424_L449_K0.7830.95
359_P367_R0.7820.95
322_M416_F0.7820.95
156_V245_C0.7800.95
388_A433_L0.7800.95
138_N142_R0.7770.95
154_P285_I0.7770.95
265_H469_L0.7760.95
320_S432_H0.7730.95
131_P141_N0.7720.95
143_L147_L0.7720.95
154_P287_M0.7720.95
52_R194_S0.7680.95
325_L430_N0.7680.95
210_E214_L0.7670.95
203_D262_H0.7650.95
162_F208_I0.7630.95
288_Q295_V0.7600.95
39_Y209_D0.7600.95
402_E405_E0.7570.94
455_Q458_R0.7560.94
351_N407_N0.7560.94
217_I235_L0.7520.94
159_E284_H0.7500.94
336_Q343_T0.7490.94
161_E225_E0.7490.94
60_S63_K0.7480.94
286_S367_R0.7480.94
274_E459_L0.7480.94
123_T135_E0.7430.94
133_D138_N0.7420.94
337_P343_T0.7400.94
168_Q174_Y0.7400.94
210_E213_Q0.7380.94
303_D349_H0.7370.94
385_A437_L0.7360.94
451_D454_L0.7310.93
317_L320_S0.7300.93
61_L120_M0.7240.93
153_F290_N0.7230.93
392_H398_L0.7230.93
35_P107_L0.7210.93
269_M333_R0.7210.93
31_L37_T0.7200.93
133_D438_G0.7190.93
283_I383_M0.7190.93
317_L321_S0.7180.93
150_R295_V0.7160.93
317_L398_L0.7160.93
164_L208_I0.7140.92
324_L445_Y0.7130.92
212_A251_L0.7130.92
69_Y99_T0.7120.92
444_V447_A0.7120.92
55_R113_D0.7110.92
205_L222_A0.7100.92
218_P247_D0.7090.92
456_F467_W0.7090.92
217_I250_A0.7080.92
219_A233_I0.7060.92
226_A340_Y0.7040.92
31_L40_V0.7020.92
39_Y210_E0.7000.92
456_F459_L0.6970.92
138_N141_N0.6970.92
54_K193_Y0.6970.92
392_H432_H0.6950.91
139_V142_R0.6930.91
439_E442_C0.6920.91
113_D203_D0.6880.91
329_V461_T0.6880.91
187_N190_S0.6850.91
270_A331_S0.6850.91
209_D219_A0.6850.91
285_I314_M0.6850.91
199_N257_L0.6830.91
48_N448_C0.6820.91
225_E284_H0.6820.91
382_V385_A0.6810.91
329_V456_F0.6800.91
153_F288_Q0.6800.91
327_P331_S0.6780.90
108_T250_A0.6740.90
103_V141_N0.6740.90
406_G409_L0.6730.90
367_R371_R0.6710.90
348_G354_V0.6680.90
114_P203_D0.6680.90
299_A303_D0.6660.90
191_Q194_S0.6650.90
144_W148_R0.6630.89
130_A133_D0.6610.89
154_P241_V0.6600.89
161_E282_H0.6590.89
43_L51_F0.6590.89
437_L442_C0.6590.89
465_I469_L0.6550.89
322_M326_A0.6540.89
352_R371_R0.6530.89
191_Q197_N0.6530.89
314_M370_Y0.6530.89
103_V106_S0.6500.89
373_A382_V0.6490.88
110_S119_Q0.6490.88
270_A328_N0.6490.88
47_L441_F0.6480.88
25_Q28_K0.6470.88
287_M387_F0.6450.88
156_V285_I0.6450.88
309_K400_L0.6440.88
156_V241_V0.6430.88
333_R456_F0.6430.88
157_A234_N0.6420.88
161_E232_E0.6420.88
160_L235_L0.6420.88
395_D398_L0.6420.88
248_A383_M0.6420.88
41_D53_G0.6380.88
304_S307_L0.6370.88
320_S431_D0.6370.88
147_L387_F0.6370.88
56_I68_C0.6370.88
303_D308_K0.6360.87
320_S427_F0.6360.87
314_M386_I0.6340.87
44_L100_C0.6330.87
71_P340_Y0.6320.87
342_P353_T0.6320.87
159_E282_H0.6300.87
347_W358_I0.6280.87
119_Q215_Q0.6270.87
327_P377_A0.6260.87
391_L395_D0.6250.87
160_L251_L0.6240.86
126_D132_F0.6230.86
153_F289_N0.6220.86
341_V409_L0.6210.86
373_A377_A0.6210.86
208_I233_I0.6200.86
201_F264_M0.6190.86
345_A355_A0.6150.86
324_L381_L0.6150.86
316_D320_S0.6140.86
112_A254_L0.6130.85
427_F430_N0.6130.85
273_Y276_H0.6130.85
252_K256_R0.6120.85
223_V226_A0.6110.85
287_M306_L0.6100.85
322_M417_P0.6100.85
245_C379_P0.6100.85
441_F445_Y0.6100.85
140_L384_A0.6090.85
463_T467_W0.6080.85
164_L201_F0.6070.85
142_R145_Q0.6060.85
351_N404_V0.6050.85
271_K278_G0.6040.85
296_L387_F0.6040.85
329_V464_E0.6040.85
438_G441_F0.6040.85
289_N292_G0.6020.84
278_G334_R0.6010.84
313_G394_L0.6000.84
239_D242_L0.5990.84
157_A223_V0.5990.84
299_A302_E0.5970.84
390_I393_G0.5960.84
50_C256_R0.5960.84
220_D237_H0.5960.84
104_L120_M0.5950.84
284_H367_R0.5930.84
232_E369_E0.5930.84
399_P402_E0.5920.83
237_H286_S0.5920.83
114_P117_I0.5860.83
460_I465_I0.5850.83
435_R439_E0.5850.83
403_E406_G0.5850.83
148_R290_N0.5840.83
441_F444_V0.5840.83
208_I254_L0.5830.83
404_V408_G0.5820.82
61_L104_L0.5820.82
298_D303_D0.5810.82
307_L311_L0.5790.82
70_F100_C0.5790.82
322_M345_A0.5780.82
163_Y276_H0.5770.82
253_R257_L0.5760.82
455_Q463_T0.5760.82
257_L260_E0.5750.82
318_M372_V0.5730.81
237_H241_V0.5720.81
336_Q339_M0.5720.81
117_I206_N0.5720.81
41_D253_R0.5710.81
387_F391_L0.5700.81
30_Y109_P0.5700.81
121_L250_A0.5700.81
429_E432_H0.5700.81
38_Q214_L0.5690.81
289_N306_L0.5690.81
427_F437_L0.5690.81
425_G446_H0.5680.81
30_Y107_L0.5680.81
164_L264_M0.5680.81
219_A222_A0.5670.81
102_P120_M0.5670.81
289_N294_N0.5670.81
456_F464_E0.5670.81
142_R146_Q0.5660.81
279_S375_A0.5650.81
60_S218_P0.5650.81
42_V68_C0.5640.80
168_Q173_G0.5640.80
93_M340_Y0.5620.80
115_E210_E0.5620.80
220_D234_N0.5620.80
163_Y271_K0.5620.80
330_N464_E0.5620.80
325_L370_Y0.5600.80
25_Q32_E0.5600.80
159_E369_E0.5590.80
217_I247_D0.5590.80
167_R265_H0.5580.80
303_D403_E0.5570.80
352_R369_E0.5550.79
300_E303_D0.5550.79
308_K347_W0.5550.79
212_A219_A0.5540.79
430_N439_E0.5540.79
30_Y36_N0.5530.79
420_Q424_L0.5530.79
298_D308_K0.5530.79
48_N445_Y0.5520.79
39_Y55_R0.5520.79
274_E458_R0.5520.79
155_V286_S0.5520.79
93_M96_P0.5510.79
220_D286_S0.5510.79
448_C451_D0.5510.79
44_L124_M0.5510.79
217_I251_L0.5500.79
408_G415_P0.5500.79
333_R461_T0.5480.79
419_R457_E0.5480.79
159_E352_R0.5480.79
339_M458_R0.5480.79
217_I248_A0.5450.78
226_A339_M0.5450.78
410_E414_L0.5450.78
321_S324_L0.5440.78
322_M423_A0.5440.78
206_N210_E0.5430.78
284_H352_R0.5430.78
44_L75_F0.5430.78
155_V239_D0.5430.78
389_G393_G0.5420.78
24_T104_L0.5410.78
349_H405_E0.5410.78
230_Q279_S0.5400.78
73_S340_Y0.5360.77
150_R397_E0.5360.77
146_Q150_R0.5350.77
192_V226_A0.5350.77
431_D434_R0.5340.77
142_R438_G0.5340.77
71_P74_V0.5340.77
162_F233_I0.5340.77
158_V281_M0.5330.77
225_E280_G0.5330.77
329_V453_L0.5330.77
182_G260_E0.5320.76
60_S236_Y0.5310.76
60_S220_D0.5300.76
41_D55_R0.5300.76
325_L389_G0.5290.76
275_E458_R0.5290.76
346_S414_L0.5290.76
293_E364_H0.5280.76
157_A237_H0.5270.76
43_L250_A0.5270.76
91_Q132_F0.5260.76
33_R36_N0.5250.76
269_M464_E0.5250.76
195_V253_R0.5240.75
419_R453_L0.5240.75
258_M261_K0.5230.75
431_D443_H0.5220.75
421_S428_I0.5220.75
186_R190_S0.5210.75
455_Q459_L0.5210.75
435_R438_G0.5200.75
53_G195_V0.5200.75
47_L448_C0.5170.74
64_L120_M0.5160.74
157_A272_P0.5160.74
165_L272_P0.5160.74
327_P381_L0.5150.74
205_L231_F0.5140.74
45_T51_F0.5140.74
329_V463_T0.5140.74
349_H358_I0.5130.74
56_I61_L0.5130.74
166_D184_D0.5120.74
234_N367_R0.5120.74
29_R35_P0.5120.74
94_G350_N0.5120.74
287_M390_I0.5110.74
111_A211_L0.5100.73
325_L385_A0.5100.73
194_S197_N0.5090.73
111_A215_Q0.5090.73
39_Y206_N0.5080.73
39_Y113_D0.5080.73
282_H369_E0.5080.73
318_M321_S0.5080.73
396_N399_P0.5050.73
47_L381_L0.5050.73
38_Q58_V0.5050.73
232_E280_G0.5040.73
320_S323_A0.5040.73
157_A286_S0.5030.72
318_M345_A0.5030.72
293_E306_L0.5030.72
158_V383_M0.5020.72
336_Q458_R0.5010.72
456_F460_I0.5010.72
107_L120_M0.5000.72
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4lniA 5 0.9089 100 0.148 Contact Map
4s17A 5 0.8898 100 0.157 Contact Map
4acfA 5 0.9216 100 0.158 Contact Map
3ng0A 5 0.9131 100 0.166 Contact Map
1f52A 5 0.9195 100 0.166 Contact Map
4hppA 3 0.8686 100 0.17 Contact Map
2j9iA 5 0.8708 100 0.208 Contact Map
3o6xA 3 0.8326 100 0.358 Contact Map
3fkyA 8 0.6886 100 0.373 Contact Map
4baxA 5 0.6992 100 0.38 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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