GREMLIN Database
FSAA - Fructose-6-phosphate aldolase 1
UniProt: P78055 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13471
Length: 220 (207)
Sequences: 3867 (2082)
Seq/√Len: 144.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
73_L102_E6.1171.00
64_T67_G4.6551.00
69_V98_M2.8781.00
68_M86_V2.6491.00
205_A209_Q2.5181.00
96_I108_G2.4201.00
43_L46_L2.3001.00
30_S210_D2.2781.00
150_H162_V2.2591.00
150_H154_K2.2501.00
15_A192_Q2.2241.00
88_V111_V2.1811.00
117_G149_L2.1431.00
97_K101_A2.1271.00
66_E70_N2.0991.00
23_A122_L2.0201.00
98_M102_E2.0091.00
202_A206_K1.9981.00
136_D172_Q1.9551.00
65_A94_A1.8721.00
189_D193_Q1.8581.00
209_Q213_G1.8401.00
42_V45_Q1.8311.00
94_A97_K1.7851.00
97_K126_E1.7101.00
65_A98_M1.6881.00
63_T91_E1.6721.00
42_V46_L1.6391.00
126_E161_K1.6331.00
114_A152_L1.6191.00
128_V153_L1.6161.00
11_V14_K1.6061.00
86_V99_L1.5951.00
73_L98_M1.5901.00
181_C184_I1.5901.00
14_K18_R1.5701.00
9_D35_G1.5401.00
86_V96_I1.5251.00
70_N74_K1.5241.00
180_G184_I1.5101.00
72_A99_L1.4951.00
209_Q212_Q1.4891.00
32_I39_L1.4791.00
100_K126_E1.4761.00
69_V95_A1.4611.00
143_I176_C1.4471.00
63_T204_V1.4471.00
58_A75_L1.4411.00
144_Q148_D1.4191.00
116_Q200_V1.4171.00
63_T208_E1.4091.00
141_S144_Q1.3881.00
12_A188_L1.3561.00
44_P48_E1.3501.00
38_P41_V1.3491.00
135_I140_G1.3411.00
202_A205_A1.3401.00
57_F107_L1.3371.00
62_A67_G1.3361.00
147_T151_Q1.3251.00
40_D44_P1.3181.00
73_L104_I1.3131.00
118_L152_L1.3131.00
74_K77_S1.2871.00
173_A190_V1.2861.00
65_A91_E1.2801.00
60_V68_M1.2801.00
206_K209_Q1.2781.00
201_D205_A1.2751.00
100_K124_G1.2731.00
9_D12_A1.2441.00
40_D74_K1.2431.00
15_A19_I1.2401.00
37_K42_V1.2301.00
105_P126_E1.2301.00
121_A152_L1.2111.00
161_K183_S1.2101.00
59_Q131_Y1.2081.00
114_A148_D1.2061.00
115_A174_L1.1971.00
65_A69_V1.1891.00
164_A167_F1.1591.00
16_L188_L1.1591.00
186_L191_A1.1470.99
72_A84_V1.1460.99
136_D142_G1.1390.99
56_L79_I1.1360.99
107_L129_A1.1310.99
18_R94_A1.1290.99
106_T126_E1.1230.99
41_V45_Q1.1160.99
72_A86_V1.1130.99
171_R175_D1.1100.99
93_L119_L1.1080.99
88_V108_G1.1080.99
197_Y201_D1.1050.99
76_R104_I1.0850.99
5_L191_A1.0790.99
199_A203_A1.0600.99
121_A153_L1.0580.99
143_I175_D1.0550.99
61_M208_E1.0470.99
90_A195_I1.0440.99
91_E94_A1.0440.99
76_R82_I1.0310.99
203_A207_F1.0160.99
193_Q196_S1.0130.99
33_A213_G0.9920.99
69_V73_L0.9890.98
163_L183_S0.9870.98
170_P193_Q0.9790.98
22_L191_A0.9760.98
137_A168_K0.9710.98
10_V45_Q0.9650.98
34_A189_D0.9620.98
65_A95_A0.9550.98
96_I106_T0.9470.98
16_L192_Q0.9440.98
83_V127_Y0.9380.98
66_E98_M0.9320.98
110_A203_A0.9320.98
111_V153_L0.9310.98
141_S175_D0.9260.98
133_N168_K0.9230.98
164_A176_C0.9230.98
14_K45_Q0.9190.98
37_K45_Q0.9190.98
173_A186_L0.9150.97
205_A208_E0.9140.97
70_N73_L0.9130.97
76_R105_P0.9110.97
5_L16_L0.9100.97
36_K42_V0.9090.97
110_A131_Y0.9090.97
133_N137_A0.9080.97
138_Q198_P0.9050.97
122_L158_P0.8900.97
67_G70_N0.8900.97
144_Q147_T0.8900.97
75_L78_I0.8890.97
198_P202_A0.8890.97
35_G38_P0.8890.97
37_K40_D0.8840.97
179_A184_I0.8840.97
74_K78_I0.8770.97
69_V99_L0.8720.97
98_M101_A0.8680.97
147_T179_A0.8670.97
59_Q129_A0.8650.96
90_A192_Q0.8640.96
188_L192_Q0.8610.96
73_L77_S0.8600.96
68_M95_A0.8560.96
88_V96_I0.8440.96
176_C181_C0.8430.96
12_A192_Q0.8410.96
58_A82_I0.8360.96
149_L153_L0.8360.96
41_V44_P0.8350.96
72_A76_R0.8340.96
11_V15_A0.8320.96
199_A202_A0.8300.96
69_V72_A0.8290.96
208_E212_Q0.8260.95
107_L131_Y0.8240.95
206_K210_D0.8230.95
107_L110_A0.8180.95
192_Q196_S0.8160.95
130_P149_L0.8110.95
57_F129_A0.8100.95
114_A118_L0.8080.95
39_L43_L0.8060.95
37_K41_V0.8040.95
180_G183_S0.8020.95
170_P190_V0.7970.94
47_H56_L0.7970.94
135_I145_T0.7890.94
164_A179_A0.7890.94
150_H179_A0.7780.94
77_S102_E0.7760.94
132_V142_G0.7690.93
8_S27_T0.7680.93
88_V93_L0.7660.93
59_Q107_L0.7610.93
41_V46_L0.7600.93
12_A15_A0.7590.93
30_S34_A0.7560.93
10_V42_V0.7550.93
166_S185_T0.7500.92
85_K185_T0.7470.92
111_V128_V0.7460.92
199_A207_F0.7440.92
134_R166_S0.7400.92
71_D74_K0.7390.92
51_G54_G0.7380.92
61_M67_G0.7340.92
108_G125_A0.7330.92
135_I138_Q0.7310.91
170_P174_L0.7250.91
129_A203_A0.7240.91
47_H79_I0.7060.90
99_L102_E0.7060.90
151_Q155_M0.7050.90
179_A182_E0.7020.90
15_A18_R0.6990.90
39_L211_W0.6970.89
140_G171_R0.6950.89
57_F131_Y0.6940.89
34_A206_K0.6830.88
76_R84_V0.6830.88
28_N109_T0.6780.88
148_D151_Q0.6760.88
89_T204_V0.6750.88
45_Q48_E0.6720.88
90_A119_L0.6670.87
27_T31_I0.6640.87
19_I191_A0.6560.86
112_Y203_A0.6510.86
12_A19_I0.6500.86
150_H182_E0.6500.86
120_S125_A0.6470.86
105_P127_Y0.6390.85
14_K49_A0.6360.85
10_V56_L0.6330.84
100_K105_P0.6330.84
85_K109_T0.6310.84
51_G79_I0.6300.84
138_Q202_A0.6260.84
75_L82_I0.6220.83
76_R80_A0.6190.83
207_F214_A0.6160.83
24_G29_P0.6120.82
19_I195_I0.6110.82
153_L160_A0.6090.82
147_T175_D0.6040.82
86_V95_A0.6010.81
33_A210_D0.5940.80
17_S22_L0.5930.80
28_N165_A0.5920.80
43_L58_A0.5910.80
164_A184_I0.5880.80
59_Q203_A0.5870.80
55_R183_S0.5870.80
16_L22_L0.5860.80
73_L99_L0.5850.79
145_T149_L0.5840.79
148_D174_L0.5840.79
110_A129_A0.5830.79
117_G153_L0.5820.79
89_T98_M0.5820.79
132_V145_T0.5810.79
4_Y107_L0.5810.79
112_Y131_Y0.5800.79
143_I179_A0.5790.79
196_S201_D0.5780.79
83_V106_T0.5760.78
200_V203_A0.5760.78
17_S49_A0.5760.78
44_P78_I0.5750.78
64_T70_N0.5750.78
4_Y83_V0.5710.78
10_V13_V0.5690.78
151_Q154_K0.5680.77
35_G42_V0.5630.77
86_V92_G0.5610.77
15_A195_I0.5610.77
138_Q199_A0.5580.76
30_S33_A0.5550.76
47_H82_I0.5550.76
26_T185_T0.5530.76
55_R83_V0.5530.76
174_L194_M0.5510.75
154_K175_D0.5500.75
131_Y168_K0.5500.75
167_F172_Q0.5480.75
15_A90_A0.5450.75
55_R105_P0.5400.74
6_D26_T0.5400.74
107_L203_A0.5400.74
59_Q110_A0.5400.74
116_Q130_P0.5400.74
124_G159_Q0.5390.74
3_L194_M0.5350.73
48_E51_G0.5320.73
19_I192_Q0.5290.72
121_A135_I0.5270.72
109_T165_A0.5270.72
32_I43_L0.5250.72
99_L104_I0.5240.72
91_E95_A0.5230.72
57_F168_K0.5230.72
169_T172_Q0.5230.72
68_M87_P0.5230.72
192_Q195_I0.5220.71
207_F210_D0.5210.71
89_T92_G0.5160.71
131_Y165_A0.5150.70
108_G120_S0.5110.70
27_T185_T0.5100.70
198_P207_F0.5090.69
109_T131_Y0.5090.69
13_V46_L0.5070.69
139_G171_R0.5060.69
93_L211_W0.5050.69
118_L151_Q0.5040.69
90_A196_S0.5030.69
85_K166_S0.5030.69
132_V164_A0.5010.68
130_P146_V0.5010.68
55_R127_Y0.5000.68
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1l6wA 6 1 100 0.027 Contact Map
3r8rA 5 0.9591 100 0.03 Contact Map
1wx0A 6 0.9182 100 0.036 Contact Map
1vpxA 6 0.9818 100 0.037 Contact Map
3s1xA 6 0.9909 100 0.038 Contact Map
3cq0A 2 0.9636 100 0.184 Contact Map
3cwnA 2 0.9636 100 0.185 Contact Map
3m16A 2 0.9636 100 0.191 Contact Map
3tkfA 2 0.9636 100 0.193 Contact Map
3hjzA 1 0.9636 100 0.195 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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