GREMLIN Database
HYFC - Hydrogenase-4 component C
UniProt: P77858 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG14211
Length: 315 (294)
Sequences: 5427 (2609)
Seq/√Len: 152.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
162_S167_M4.7921.00
186_L242_F4.1631.00
36_R283_N3.7921.00
190_G277_L3.6951.00
29_T50_D3.6311.00
240_S267_T3.5961.00
39_M283_N3.3881.00
243_V267_T2.9411.00
240_S271_V2.7821.00
131_A217_T2.7681.00
51_Y54_I2.5511.00
247_L274_I2.5001.00
167_M170_N2.4521.00
189_C242_F2.4341.00
194_F281_A2.4151.00
62_E223_G2.3731.00
83_M234_K2.2661.00
171_T177_N2.2561.00
197_M278_A2.2461.00
160_A177_N2.2351.00
179_P247_L2.2241.00
179_P186_L2.1701.00
239_A274_I2.1551.00
236_V275_F2.1351.00
83_M233_L2.1231.00
213_E216_L2.1161.00
71_M121_L2.0981.00
109_I150_I2.0581.00
79_L118_F2.0451.00
21_L233_L2.0351.00
262_T266_V2.0111.00
170_N173_A1.9941.00
158_L313_T1.9641.00
86_L237_V1.9251.00
190_G194_F1.9121.00
123_G135_A1.9041.00
193_C238_M1.8961.00
58_F225_A1.8571.00
252_A266_V1.8551.00
191_F301_F1.8551.00
185_A246_F1.8521.00
85_V107_T1.7941.00
79_L230_G1.7931.00
35_I276_V1.7731.00
273_L277_L1.7581.00
28_F275_F1.7501.00
25_T233_L1.7361.00
56_K60_R1.7321.00
155_V185_A1.7071.00
31_I276_V1.7001.00
107_T111_L1.6991.00
27_L50_D1.6471.00
164_H167_M1.5841.00
89_A107_T1.5321.00
39_M280_I1.5281.00
38_R43_R1.5041.00
97_S166_E1.4901.00
216_L224_L1.4861.00
138_E205_A1.4641.00
182_T312_L1.4371.00
108_L112_L1.4321.00
176_W270_K1.4231.00
141_L293_I1.4221.00
49_Q53_D1.4181.00
15_L19_V1.4161.00
204_V293_I1.4121.00
193_C242_F1.4111.00
252_A261_L1.4041.00
207_A211_L1.3931.00
35_I279_S1.3861.00
149_L192_A1.3861.00
204_V288_G1.3751.00
224_L228_K1.3671.00
148_M192_A1.3581.00
185_A308_W1.3401.00
156_L168_I1.3381.00
25_T229_W1.3351.00
207_A210_E1.3241.00
153_L245_L1.3211.00
101_G107_T1.3151.00
160_A171_T1.3111.00
72_F76_P1.3041.00
166_E170_N1.2981.00
159_I182_T1.2961.00
19_V22_L1.2921.00
35_I39_M1.2911.00
151_L309_V1.2841.00
242_F274_I1.2831.00
195_I202_F1.2741.00
148_M305_A1.2681.00
88_M107_T1.2591.00
34_Q38_R1.2591.00
183_V187_L1.2581.00
160_A168_I1.2581.00
175_G180_L1.2541.00
262_T265_V1.2511.00
120_A139_L1.2501.00
280_I284_T1.2491.00
78_V82_S1.2451.00
235_Q275_F1.2421.00
128_S131_A1.2301.00
23_M51_Y1.2251.00
212_Q217_T1.2151.00
134_G205_A1.2111.00
189_C238_M1.2081.00
296_V301_F1.2041.00
24_L236_V1.2011.00
73_R223_G1.1971.00
87_A237_V1.1901.00
243_V247_L1.1841.00
100_A166_E1.1671.00
167_M171_T1.1651.00
75_M121_L1.1641.00
75_M122_S1.1631.00
30_G47_I1.1591.00
148_M297_T1.1581.00
51_Y55_H1.1531.00
172_L248_P1.1521.00
290_F294_H1.1321.00
276_V280_I1.1321.00
85_V111_L1.1221.00
180_L183_V1.1211.00
100_A164_H1.1110.99
155_V305_A1.1070.99
24_L272_L1.1030.99
235_Q278_A1.0920.99
32_S282_E1.0910.99
55_H59_K1.0830.99
243_V271_V1.0750.99
65_P72_F1.0690.99
261_L265_V1.0600.99
58_F222_A1.0590.99
173_A251_R1.0560.99
204_V292_L1.0550.99
105_L157_A1.0520.99
162_S168_I1.0410.99
183_V186_L1.0400.99
211_L215_P1.0360.99
155_V309_V1.0360.99
240_S244_A1.0340.99
170_N174_M1.0290.99
32_S199_K1.0270.99
31_I35_I1.0270.99
116_R142_G1.0230.99
204_V211_L1.0200.99
188_A304_A1.0150.99
122_S125_D1.0140.99
197_M238_M1.0040.99
247_L270_K0.9930.99
64_A73_R0.9920.99
82_S111_L0.9910.99
31_I279_S0.9840.99
79_L227_A0.9830.99
203_D287_R0.9760.99
27_L47_I0.9750.99
65_P68_S0.9730.99
80_I84_L0.9680.99
274_I277_L0.9680.99
30_G50_D0.9660.99
222_A225_A0.9610.98
34_Q60_R0.9550.98
277_L281_A0.9540.98
29_T232_G0.9500.98
267_T271_V0.9420.98
151_L306_L0.9420.98
186_L246_F0.9410.98
80_I230_G0.9380.98
136_S205_A0.9370.98
75_M118_F0.9260.98
190_G278_A0.9220.98
264_L268_L0.9210.98
89_A108_L0.9210.98
37_A43_R0.9170.98
152_S188_A0.9130.98
75_M125_D0.9070.98
80_I226_L0.9050.98
289_R294_H0.9030.98
122_S219_Y0.9010.98
249_F270_K0.8990.98
308_W312_L0.8980.98
288_G292_L0.8950.98
207_A287_R0.8930.98
187_L191_F0.8850.97
152_S192_A0.8840.97
173_A177_N0.8800.97
155_V182_T0.8730.97
157_A163_T0.8730.97
54_I58_F0.8730.97
109_I153_L0.8680.97
36_R282_E0.8680.97
122_S227_A0.8670.97
148_M302_S0.8640.97
54_I59_K0.8640.97
280_I285_L0.8620.97
40_H45_P0.8600.97
92_L98_P0.8600.97
190_G242_F0.8580.97
117_F290_F0.8550.97
57_L228_K0.8530.97
79_L115_F0.8520.97
200_I285_L0.8500.97
176_W179_P0.8490.97
104_D164_H0.8480.97
73_R77_W0.8420.96
108_L165_I0.8400.96
89_A104_D0.8390.96
124_L127_G0.8370.96
19_V23_M0.8330.96
54_I229_W0.8320.96
12_I16_A0.8180.96
252_A262_T0.8090.96
30_G38_R0.8090.96
169_S250_G0.8060.95
141_L145_V0.8050.95
199_K203_D0.8040.95
189_C246_F0.7950.95
148_M301_F0.7940.95
57_L225_A0.7930.95
22_L84_L0.7930.95
203_D210_E0.7910.95
141_L198_G0.7860.95
261_L264_L0.7830.95
27_L51_Y0.7790.95
189_C193_C0.7730.94
138_E207_A0.7680.94
304_A308_W0.7670.94
101_G227_A0.7640.94
216_L228_K0.7640.94
176_W249_F0.7640.94
48_W51_Y0.7630.94
105_L165_I0.7620.94
152_S155_V0.7620.94
85_V167_M0.7620.94
225_A229_W0.7620.94
97_S100_A0.7590.94
203_D206_E0.7590.94
165_I241_L0.7580.94
83_M237_V0.7560.94
30_G36_R0.7550.94
128_S278_A0.7540.94
169_S249_F0.7530.93
11_V15_L0.7520.93
195_I293_I0.7430.93
105_L168_I0.7400.93
175_G181_T0.7390.93
179_P183_V0.7360.93
33_R42_R0.7350.93
221_G225_A0.7350.93
205_A215_P0.7280.92
68_S72_F0.7270.92
98_P229_W0.7260.92
302_S305_A0.7240.92
182_T308_W0.7210.92
33_R53_D0.7200.92
271_V275_F0.7200.92
248_P270_K0.7180.92
243_V270_K0.7170.92
46_G52_R0.7170.92
155_V308_W0.7150.92
243_V263_S0.7140.92
168_I245_L0.7130.92
101_G108_L0.7120.91
94_I170_N0.7120.91
49_Q56_K0.7110.91
287_R291_L0.7110.91
64_A69_G0.7110.91
210_E287_R0.7100.91
29_T32_S0.7090.91
71_M75_M0.7080.91
196_E199_K0.7070.91
238_M242_F0.7070.91
190_G274_I0.7060.91
53_D56_K0.7040.91
291_L294_H0.7010.91
26_P54_I0.6990.91
64_A68_S0.6990.91
141_L144_L0.6980.91
72_F219_Y0.6980.91
194_F278_A0.6960.91
203_D211_L0.6940.90
184_L188_A0.6930.90
149_L152_S0.6930.90
209_Q213_E0.6880.90
90_L240_S0.6880.90
295_H299_L0.6870.90
26_P36_R0.6870.90
23_M26_P0.6790.89
209_Q212_Q0.6770.89
172_L249_F0.6740.89
144_L294_H0.6740.89
9_Y13_F0.6730.89
152_S185_A0.6720.89
34_Q47_I0.6700.89
81_S311_W0.6670.89
131_A213_E0.6660.89
76_P219_Y0.6660.89
40_H44_G0.6650.88
74_L77_W0.6640.88
200_I209_Q0.6630.88
188_A191_F0.6600.88
9_Y310_F0.6580.88
78_V81_S0.6580.88
82_S114_L0.6550.88
32_S232_G0.6540.88
250_G270_K0.6530.88
149_L297_T0.6510.87
60_R299_L0.6490.87
156_L245_L0.6440.87
36_R41_S0.6440.87
206_E214_G0.6430.87
89_A191_F0.6430.87
126_T219_Y0.6420.87
27_L30_G0.6400.86
24_L275_F0.6400.86
45_P49_Q0.6370.86
145_V195_I0.6360.86
119_F138_E0.6350.86
17_Q92_L0.6340.86
305_A312_L0.6340.86
204_V207_A0.6340.86
89_A92_L0.6330.86
186_L247_L0.6330.86
112_L115_F0.6290.86
267_T270_K0.6270.85
82_S115_F0.6270.85
21_L25_T0.6250.85
65_P76_P0.6240.85
67_S221_G0.6160.84
228_K282_E0.6140.84
263_S266_V0.6140.84
279_S282_E0.6140.84
187_L309_V0.6140.84
150_I153_L0.6130.84
14_A99_F0.6120.84
90_L98_P0.6100.84
17_Q98_P0.6090.84
176_W248_P0.6090.84
22_L26_P0.6070.83
80_I217_T0.6050.83
12_I186_L0.6050.83
37_A42_R0.6050.83
9_Y12_I0.6040.83
243_V274_I0.6040.83
18_A22_L0.6020.83
38_R279_S0.5980.83
79_L119_F0.5960.82
10_L13_F0.5960.82
118_F121_L0.5940.82
171_T174_M0.5930.82
53_D287_R0.5920.82
32_S36_R0.5920.82
242_F247_L0.5890.82
134_G138_E0.5890.82
239_A243_V0.5890.82
94_I97_S0.5860.81
100_A104_D0.5860.81
98_P103_G0.5840.81
92_L240_S0.5840.81
32_S279_S0.5830.81
184_L308_W0.5820.81
40_H218_E0.5820.81
83_M230_G0.5810.81
42_R214_G0.5800.81
180_L184_L0.5780.80
114_L300_G0.5780.80
275_F279_S0.5780.80
134_G212_Q0.5780.80
112_L234_K0.5770.80
119_F198_G0.5760.80
154_L157_A0.5730.80
176_W180_L0.5720.80
105_L153_L0.5710.80
208_E228_K0.5700.79
112_L242_F0.5690.79
33_R40_H0.5680.79
14_A17_Q0.5670.79
38_R150_I0.5670.79
33_R206_E0.5610.78
86_L234_K0.5610.78
26_P30_G0.5600.78
172_L177_N0.5580.78
138_E211_L0.5540.78
213_E228_K0.5540.78
288_G297_T0.5540.78
121_L125_D0.5520.77
105_L163_T0.5520.77
232_G282_E0.5520.77
175_G272_L0.5500.77
55_H58_F0.5490.77
215_P228_K0.5490.77
190_G280_I0.5490.77
126_T206_E0.5480.77
90_L237_V0.5480.77
199_K232_G0.5470.77
155_V312_L0.5470.77
54_I225_A0.5470.77
84_L233_L0.5450.76
269_L272_L0.5440.76
296_V300_G0.5430.76
293_I298_W0.5420.76
252_A263_S0.5410.76
144_L302_S0.5390.76
244_A249_F0.5370.75
118_F150_I0.5360.75
50_D279_S0.5310.75
177_N181_T0.5310.75
142_G150_I0.5300.74
273_L276_V0.5300.74
289_R292_L0.5300.74
171_T175_G0.5270.74
25_T36_R0.5270.74
141_L195_I0.5260.74
137_R214_G0.5260.74
12_I187_L0.5250.74
154_L309_V0.5230.73
168_I244_A0.5230.73
16_A269_L0.5210.73
62_E72_F0.5180.73
204_V287_R0.5160.72
52_R129_P0.5160.72
10_L16_A0.5150.72
109_I118_F0.5150.72
156_L182_T0.5140.72
112_L142_G0.5130.72
79_L86_L0.5130.72
24_L28_F0.5120.72
126_T131_A0.5120.72
33_R208_E0.5120.72
106_I290_F0.5110.72
170_N251_R0.5080.71
14_A18_A0.5080.71
265_V269_L0.5060.71
211_L216_L0.5060.71
183_V308_W0.5060.71
197_M234_K0.5050.71
26_P50_D0.5050.71
293_I302_S0.5050.71
272_L276_V0.5030.71
118_F135_A0.5020.70
13_F17_Q0.5000.70
198_G234_K0.5000.70
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4he8H 1 0.8159 100 0.069 Contact Map
1q2fA 1 0.0952 16.7 0.964 Contact Map
1qleD 1 0.1365 4 0.973 Contact Map
3dacP 1 0.0413 3.3 0.974 Contact Map
2jpkA 1 0.0984 3.1 0.975 Contact Map
3mp7A 1 0.1587 3 0.975 Contact Map
2yevB 1 0.2063 2.6 0.976 Contact Map
4he8M 1 0.7937 2.4 0.976 Contact Map
1vryA 1 0.1778 2.4 0.976 Contact Map
4c7rA 3 0.2952 2.1 0.977 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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