GREMLIN Database
CINAL - NMN amidohydrolase-like protein YfaY
UniProt: P77808 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG14087
Length: 400 (374)
Sequences: 1744 (1366)
Seq/√Len: 70.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
308_T328_S3.4181.00
200_T242_V3.2951.00
260_S292_L3.1831.00
372_N376_R3.1811.00
89_G123_A3.0801.00
271_T321_A3.0661.00
326_A338_A2.9951.00
47_L84_T2.8851.00
5_E60_H2.7291.00
29_F32_H2.7271.00
232_M235_L2.6231.00
47_L81_A2.6201.00
313_T345_T2.6171.00
4_V35_L2.5901.00
65_I150_T2.5821.00
372_N375_R2.5061.00
19_V24_A2.4381.00
281_L327_V2.4241.00
309_A347_A2.4151.00
88_E124_S2.3791.00
284_Q367_A2.3761.00
67_N157_F2.3611.00
268_F323_L2.3351.00
51_V84_T2.3071.00
92_L120_E2.2821.00
316_R340_A2.2181.00
256_P284_Q2.2101.00
131_P164_E2.1911.00
91_V123_A2.1821.00
29_F162_E2.1451.00
315_R324_A2.1251.00
236_W240_K2.1011.00
8_S42_T2.0751.00
270_L374_L2.0451.00
20_D23_A1.9851.00
80_L117_K1.9731.00
278_G286_S1.9721.00
139_A168_R1.9541.00
182_L236_W1.9211.00
268_F322_G1.8491.00
25_W162_E1.8421.00
238_D241_R1.8061.00
340_A345_T1.8021.00
39_R56_E1.7991.00
294_A321_A1.7951.00
299_P304_T1.7681.00
98_K101_E1.7681.00
299_P311_W1.7581.00
295_C319_H1.7531.00
93_H96_W1.7441.00
94_E98_K1.7171.00
27_A40_R1.6951.00
271_T315_R1.6731.00
336_N347_A1.6540.99
20_D40_R1.6470.99
54_L85_A1.6450.99
115_N192_S1.6310.99
325_L374_L1.6100.99
131_P163_H1.5990.99
309_A313_T1.5910.99
288_A334_H1.5890.99
282_A298_V1.5840.99
58_S147_M1.5680.99
283_L363_Q1.5680.99
240_K247_V1.5640.99
148_F165_I1.5490.99
270_L285_L1.5480.99
5_E57_R1.5420.99
121_L127_F1.5400.99
101_E105_H1.5340.99
280_L367_A1.5340.99
58_S145_C1.5270.99
92_L97_L1.5250.99
101_E116_R1.5240.99
316_R342_P1.5020.99
352_F369_M1.4990.99
141_Q172_R1.4930.99
35_L169_L1.4820.99
375_R379_N1.4790.99
272_L293_L1.4650.99
283_L287_R1.4440.99
82_A149_F1.4330.99
206_G224_G1.4290.98
253_E257_A1.4290.98
327_V370_A1.4220.98
46_N49_D1.4140.98
88_E123_A1.4060.98
309_A345_T1.4020.98
5_E41_N1.4000.98
58_S85_A1.3850.98
97_L101_E1.3830.98
336_N349_R1.3820.98
322_G342_P1.3790.98
228_E231_A1.3730.98
26_L161_V1.3720.98
62_D145_C1.3640.98
302_E330_F1.3630.98
240_K250_E1.3570.98
211_Y220_L1.3520.98
113_P116_R1.3360.98
194_L243_A1.3300.98
304_T319_H1.3230.97
182_L233_E1.3170.97
104_F115_N1.3130.97
153_V159_V1.3020.97
222_L236_W1.2990.97
262_E379_N1.2960.97
195_A199_D1.2930.97
300_S305_L1.2840.97
54_L66_V1.2820.97
259_I371_L1.2780.97
294_A303_E1.2770.97
92_L116_R1.2740.97
262_E375_R1.2730.97
271_T319_H1.2700.97
51_V55_R1.2690.97
5_E61_A1.2650.97
3_K36_P1.2650.97
36_P225_P1.2590.97
128_I139_A1.2560.97
97_L116_R1.2550.97
66_V149_F1.2510.96
189_R194_L1.2500.96
272_L282_A1.2380.96
47_L51_V1.2360.96
33_Q166_L1.2270.96
98_K102_R1.2270.96
100_M119_A1.2240.96
137_G160_M1.2230.96
256_P287_R1.2220.96
316_R324_A1.2180.96
184_L247_V1.2040.96
48_D52_T1.1980.95
282_A293_L1.1930.95
291_P305_L1.1820.95
181_C223_T1.1800.95
232_M236_W1.1760.95
308_T326_A1.1700.95
275_Q305_L1.1700.95
88_E142_L1.1670.95
30_F65_I1.1660.95
269_S294_A1.1660.95
297_V315_R1.1600.95
118_Q134_T1.1590.95
272_L296_E1.1580.95
249_F253_E1.1570.95
286_S290_A1.1520.94
339_L377_W1.1460.94
260_S290_A1.1420.94
291_P300_S1.1420.94
280_L283_L1.1410.94
50_L81_A1.1410.94
193_D197_S1.1410.94
141_Q144_R1.1400.94
185_T217_I1.1380.94
281_L370_A1.1370.94
104_F111_M1.1330.94
27_A37_L1.1280.94
54_L64_L1.1250.94
275_Q300_S1.1240.94
184_L236_W1.1220.94
55_R85_A1.1200.94
55_R59_Q1.1180.93
122_P138_F1.1170.93
323_L341_T1.1100.93
272_L281_L1.1100.93
164_E168_R1.1090.93
276_F302_E1.1050.93
300_S331_E1.1030.93
128_I165_I1.1030.93
186_T243_A1.1010.93
276_F327_V1.0980.93
283_L367_A1.0970.93
259_I375_R1.0910.93
64_L147_M1.0830.92
161_V166_L1.0820.92
287_R363_Q1.0760.92
74_S199_D1.0670.92
93_H121_L1.0620.92
41_N60_H1.0610.92
94_E101_E1.0600.92
150_T165_I1.0570.91
303_E307_Q1.0500.91
300_S332_N1.0490.91
300_S333_E1.0460.91
121_L136_C1.0450.91
261_R265_N1.0400.91
313_T316_R1.0380.91
324_A340_A1.0360.91
18_I24_A1.0360.91
186_T247_V1.0360.91
276_F330_F1.0330.90
354_T362_R1.0290.90
161_V165_I1.0280.90
4_V63_V1.0270.90
271_T324_A1.0270.90
226_A232_M1.0200.90
300_S329_G1.0170.90
114_S196_Q1.0110.89
13_V18_I1.0100.89
284_Q368_M1.0060.89
64_L145_C1.0030.89
149_F153_V1.0030.89
313_T317_A1.0000.89
305_L331_E0.9950.89
253_E261_R0.9890.88
66_V82_A0.9880.88
129_N164_E0.9870.88
25_W161_V0.9840.88
128_I164_E0.9820.88
348_L373_M0.9810.88
259_I262_E0.9810.88
280_L363_Q0.9760.88
189_R246_S0.9730.88
339_L373_M0.9720.88
247_V250_E0.9720.88
275_Q331_E0.9700.87
316_R341_T0.9640.87
150_T157_F0.9640.87
148_F168_R0.9630.87
186_T194_L0.9600.87
310_H314_E0.9520.86
346_F377_W0.9510.86
291_P329_G0.9500.86
325_L339_L0.9480.86
305_L332_N0.9440.86
341_T344_G0.9430.86
275_Q329_G0.9420.86
7_L57_R0.9420.86
99_E129_N0.9380.86
46_N208_T0.9270.85
7_L53_I0.9190.84
121_L138_F0.9190.84
51_V81_A0.9170.84
295_C304_T0.9140.84
269_S321_A0.9130.84
276_F335_L0.9100.84
297_V319_H0.9090.84
102_R106_E0.9070.84
29_F166_L0.9060.84
222_L232_M0.9050.84
335_L362_R0.9050.84
112_A196_Q0.9030.83
307_Q320_F0.8990.83
115_N118_Q0.8990.83
305_L333_E0.8980.83
132_V159_V0.8960.83
253_E258_Q0.8950.83
291_P333_E0.8930.83
327_V366_C0.8910.83
289_G300_S0.8900.83
297_V304_T0.8900.83
186_T189_R0.8890.82
63_V148_F0.8880.82
5_E39_R0.8850.82
20_D42_T0.8760.82
138_F149_F0.8760.82
204_P209_M0.8760.82
52_T59_Q0.8750.81
43_V53_I0.8690.81
201_L239_V0.8680.81
51_V85_A0.8620.80
275_Q291_P0.8590.80
86_K140_V0.8590.80
323_L374_L0.8580.80
88_E122_P0.8550.80
261_R264_Q0.8540.80
8_S23_A0.8540.80
194_L220_L0.8530.80
217_I248_I0.8520.80
185_T219_E0.8500.80
305_L329_G0.8480.79
159_V163_H0.8470.79
9_T50_L0.8470.79
329_G333_E0.8430.79
291_P331_E0.8420.79
103_Y107_R0.8400.79
314_E318_N0.8390.79
90_L120_E0.8390.79
229_Q233_E0.8370.78
126_E141_Q0.8350.78
275_Q332_N0.8350.78
86_K142_L0.8290.78
302_E314_E0.8280.78
139_A146_L0.8280.78
11_D49_D0.8260.78
338_A347_A0.8250.77
37_L40_R0.8230.77
281_L367_A0.8220.77
254_G257_A0.8210.77
82_A147_M0.8200.77
44_G49_D0.8190.77
24_A27_A0.8180.77
102_R105_H0.8180.77
337_F350_V0.8120.76
276_F286_S0.8120.76
25_W158_K0.8070.76
52_T56_E0.8070.76
329_G359_L0.8020.75
74_S202_Q0.8020.75
17_Q212_R0.8000.75
186_T246_S0.7970.75
272_L325_L0.7950.75
275_Q311_W0.7940.75
150_T153_V0.7910.74
275_Q333_E0.7900.74
128_I137_G0.7890.74
183_R219_E0.7880.74
329_G332_N0.7870.74
126_E168_R0.7860.74
198_L239_V0.7860.74
300_S311_W0.7850.74
286_S293_L0.7850.74
311_W314_E0.7850.74
323_L342_P0.7830.74
314_E317_A0.7800.73
300_S359_L0.7800.73
146_L168_R0.7780.73
285_L293_L0.7770.73
362_R366_C0.7770.73
328_S336_N0.7760.73
210_G221_K0.7760.73
361_I365_V0.7750.73
197_S242_V0.7750.73
350_V369_M0.7750.73
57_R64_L0.7740.73
128_I168_R0.7730.73
38_S49_D0.7720.73
238_D242_V0.7640.72
9_T66_V0.7640.72
305_L311_W0.7630.72
258_Q261_R0.7620.72
139_A148_F0.7610.72
15_H221_K0.7610.72
195_A211_Y0.7600.71
291_P332_N0.7580.71
312_I340_A0.7550.71
49_D208_T0.7530.71
104_F190_S0.7510.71
150_T160_M0.7490.70
9_T212_R0.7470.70
311_W329_G0.7450.70
57_R61_A0.7430.70
41_N53_I0.7380.69
182_L250_E0.7370.69
301_Q304_T0.7350.69
350_V373_M0.7350.69
236_W250_E0.7340.69
233_E237_L0.7330.69
86_K122_P0.7310.68
131_P159_V0.7290.68
316_R343_D0.7280.68
360_A363_Q0.7270.68
111_M116_R0.7250.68
268_F342_P0.7230.68
305_L359_L0.7210.67
24_A158_K0.7200.67
262_E265_N0.7180.67
146_L172_R0.7160.67
96_W121_L0.7160.67
300_S328_S0.7140.67
88_E140_V0.7130.67
33_Q161_V0.7110.66
289_G333_E0.7100.66
273_S311_W0.7090.66
260_S285_L0.7090.66
280_L284_Q0.7080.66
190_S218_I0.7050.66
179_P225_P0.7050.66
187_F369_M0.7050.66
307_Q318_N0.7010.65
125_A140_V0.6980.65
42_T211_Y0.6980.65
260_S264_Q0.6950.65
269_S316_R0.6950.65
281_L371_L0.6920.64
181_C208_T0.6920.64
333_E359_L0.6890.64
289_G305_L0.6860.64
15_H31_F0.6850.63
328_S332_N0.6810.63
112_A193_D0.6810.63
186_T217_I0.6770.63
153_V157_F0.6760.62
358_S361_I0.6760.62
79_A212_R0.6730.62
11_D208_T0.6720.62
11_D213_S0.6660.61
93_H127_F0.6660.61
257_A261_R0.6640.61
6_M30_F0.6600.61
341_T377_W0.6590.60
22_N157_F0.6580.60
49_D207_V0.6570.60
190_S193_D0.6560.60
286_S300_S0.6550.60
328_S333_E0.6540.60
331_E359_L0.6540.60
22_N153_V0.6530.60
325_L370_A0.6510.60
29_F161_V0.6500.59
291_P359_L0.6490.59
15_H49_D0.6480.59
127_F136_C0.6420.58
283_L360_A0.6410.58
335_L366_C0.6400.58
9_T153_V0.6400.58
14_L212_R0.6400.58
328_S331_E0.6390.58
57_R60_H0.6390.58
201_L242_V0.6370.58
249_F252_T0.6360.58
74_S211_Y0.6320.57
282_A296_E0.6310.57
299_P314_E0.6300.57
98_K343_D0.6280.57
79_A138_F0.6270.57
289_G331_E0.6270.57
311_W331_E0.6260.57
23_A40_R0.6240.56
41_N57_R0.6240.56
297_V314_E0.6230.56
308_T336_N0.6230.56
11_D211_Y0.6220.56
240_K243_A0.6220.56
99_E103_Y0.6210.56
275_Q359_L0.6210.56
83_A90_L0.6210.56
13_V42_T0.6180.56
198_L220_L0.6170.55
54_L82_A0.6170.55
40_R44_G0.6160.55
275_Q328_S0.6150.55
234_K238_D0.6150.55
47_L80_L0.6140.55
122_P149_F0.6140.55
97_L111_M0.6120.55
82_A140_V0.6120.55
77_L117_K0.6110.55
315_R319_H0.6110.55
178_P226_A0.6090.55
132_V155_S0.6080.54
207_V224_G0.6080.54
239_V318_N0.6050.54
328_S338_A0.6040.54
26_L65_I0.6030.54
263_L270_L0.6020.54
153_V213_S0.6010.54
246_S376_R0.6000.53
313_T340_A0.5990.53
72_P115_N0.5990.53
53_I57_R0.5990.53
58_S143_N0.5980.53
332_N359_L0.5980.53
122_P134_T0.5970.53
214_S219_E0.5970.53
206_G223_T0.5970.53
26_L166_L0.5970.53
321_A324_A0.5970.53
207_V222_L0.5970.53
239_V243_A0.5960.53
275_Q289_G0.5900.52
289_G359_L0.5880.52
348_L376_R0.5880.52
311_W332_N0.5870.52
311_W328_S0.5870.52
259_I378_L0.5860.52
262_E266_R0.5840.51
53_I56_E0.5840.51
20_D149_F0.5810.51
273_S300_S0.5790.51
141_Q146_L0.5780.51
187_F255_L0.5780.51
25_W29_F0.5780.51
259_I285_L0.5780.51
8_S157_F0.5760.51
273_S305_L0.5750.50
153_V211_Y0.5730.50
24_A28_D0.5710.50
14_L210_G0.5710.50
295_C299_P0.5700.50
11_D38_S0.5690.50
160_M164_E0.5680.50
284_Q364_E0.5680.50
259_I374_L0.5660.49
26_L157_F0.5660.49
118_Q192_S0.5650.49
157_F161_V0.5640.49
185_T248_I0.5630.49
237_L240_K0.5630.49
369_M372_N0.5600.49
182_L251_G0.5600.49
198_L209_M0.5580.48
211_Y218_I0.5570.48
177_Q225_P0.5560.48
273_S329_G0.5550.48
79_A210_G0.5550.48
74_S195_A0.5520.48
63_V377_W0.5520.48
164_E167_P0.5520.48
277_T305_L0.5510.47
273_S291_P0.5500.47
126_E171_E0.5500.47
65_I127_F0.5500.47
260_S263_L0.5490.47
276_F300_S0.5490.47
308_T311_W0.5480.47
7_L66_V0.5480.47
189_R243_A0.5470.47
210_G223_T0.5450.47
130_N135_A0.5440.47
294_A297_V0.5440.47
185_T251_G0.5440.47
89_G317_A0.5430.46
83_A124_S0.5430.46
189_R218_I0.5420.46
367_A370_A0.5410.46
286_S305_L0.5390.46
100_M116_R0.5390.46
305_L328_S0.5390.46
258_Q262_E0.5370.46
256_P260_S0.5360.46
19_V40_R0.5350.46
278_G336_N0.5330.45
128_I160_M0.5310.45
15_H181_C0.5310.45
323_L377_W0.5300.45
272_L299_P0.5290.45
184_L222_L0.5290.45
181_C211_Y0.5270.45
189_R197_S0.5220.44
283_L286_S0.5220.44
273_S289_G0.5220.44
360_A364_E0.5220.44
354_T365_V0.5210.44
83_A89_G0.5200.44
9_T78_S0.5190.44
289_G332_N0.5190.44
153_V160_M0.5190.44
337_F370_A0.5180.43
365_V372_N0.5180.43
273_S331_E0.5170.43
74_S79_A0.5160.43
28_D158_K0.5150.43
5_E56_E0.5130.43
15_H210_G0.5120.43
11_D161_V0.5110.43
56_E59_Q0.5110.43
311_W359_L0.5100.43
49_D181_C0.5090.42
258_Q375_R0.5090.42
309_A338_A0.5080.42
98_K105_H0.5070.42
130_N133_G0.5060.42
96_W138_F0.5050.42
96_W136_C0.5040.42
285_L290_A0.5030.42
50_L157_F0.5030.42
304_T307_Q0.5020.42
36_P46_N0.5020.42
304_T315_R0.5000.41
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4uuwA 2 0.915 100 0.299 Contact Map
3kbqA 2 0.42 100 0.68 Contact Map
2a9sA 2 0.335 100 0.751 Contact Map
2is8A 3 0.3975 100 0.766 Contact Map
1y5eA 4 0.3875 100 0.77 Contact Map
2g2cA 1 0.37 100 0.773 Contact Map
3iwtA 4 0.3825 100 0.774 Contact Map
3pzyA 3 0.3725 100 0.775 Contact Map
3rfqA 5 0.38 100 0.777 Contact Map
1mkzA 2 0.4025 100 0.778 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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