GREMLIN Database
YBDL - Methionine aminotransferase
UniProt: P77806 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13531
Length: 386 (346)
Sequences: 43527 (29710)
Seq/√Len: 1597.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
53_A57_A3.2721.00
117_E138_I3.0561.00
97_T103_A2.9011.00
75_A282_R2.8651.00
112_V137_G2.6821.00
296_R300_D2.6741.00
297_Q373_E2.6521.00
182_Q186_A2.5911.00
81_E87_Q2.5841.00
312_E325_D2.5781.00
116_D165_R2.4941.00
301_I377_L2.4351.00
71_A278_A2.3851.00
157_A194_G2.3731.00
250_A255_S2.3611.00
340_W344_E2.2441.00
117_E140_K2.2191.00
46_R50_E2.1971.00
105_Y109_T2.1441.00
181_Q184_D2.1341.00
378_A382_R2.0791.00
303_V307_N2.0761.00
303_V315_P2.0581.00
122_D141_R1.9471.00
74_E90_A1.9341.00
245_V277_L1.9261.00
75_A78_Q1.9171.00
305_A308_E1.8831.00
305_A381_E1.8651.00
186_A190_Q1.8601.00
155_E159_L1.8231.00
78_Q282_R1.8181.00
301_I305_A1.8151.00
305_A309_S1.7991.00
372_K375_T1.7841.00
77_A90_A1.7591.00
82_R285_P1.7561.00
200_I231_V1.7451.00
70_Q74_E1.7411.00
50_E54_H1.7391.00
93_D252_A1.7081.00
305_A380_A1.7081.00
49_Q53_A1.7071.00
132_I137_G1.7031.00
333_D336_E1.7011.00
152_D155_E1.6921.00
192_I199_V1.6841.00
157_A187_A1.6801.00
345_H382_R1.6791.00
129_A133_A1.6721.00
54_H279_D1.6651.00
307_N313_I1.6451.00
150_R184_D1.6431.00
155_E158_A1.6381.00
74_E78_Q1.6321.00
107_A229_V1.6291.00
270_N273_A1.6291.00
301_I373_E1.6181.00
117_E163_R1.6101.00
196_E227_R1.6071.00
204_V233_S1.6061.00
304_N308_E1.5861.00
300_D304_N1.5831.00
75_A278_A1.5791.00
118_V132_I1.5521.00
108_I132_I1.5391.00
129_A141_R1.5331.00
122_D143_A1.5191.00
182_Q216_A1.5171.00
153_W187_A1.5161.00
119_I164_T1.5121.00
107_A200_I1.5081.00
336_E340_W1.5031.00
373_E377_L1.5021.00
154_Q187_A1.4991.00
76_I247_Y1.4961.00
187_A190_Q1.4931.00
117_E161_S1.4861.00
378_A381_E1.4731.00
248_C258_I1.4711.00
50_E53_A1.4541.00
100_A231_V1.4361.00
303_V313_I1.4351.00
302_L322_L1.4301.00
184_D187_A1.4281.00
69_V275_L1.4191.00
145_Q184_D1.4181.00
67_T259_R1.4111.00
35_L379_A1.4101.00
166_L200_I1.4061.00
307_N315_P1.3981.00
305_A377_L1.3961.00
88_P249_V1.3951.00
51_R279_D1.3901.00
294_F373_E1.3891.00
294_F297_Q1.3891.00
234_F277_L1.3811.00
349_A365_I1.3801.00
309_S381_E1.3771.00
117_E164_T1.3771.00
114_N136_G1.3651.00
334_D353_S1.3621.00
289_L293_D1.3591.00
80_T249_V1.3571.00
120_C139_V1.3501.00
49_Q57_A1.3491.00
70_Q90_A1.3391.00
303_V322_L1.3321.00
278_A282_R1.3141.00
78_Q82_R1.3111.00
336_E339_Q1.3061.00
52_L276_A1.2991.00
91_D252_A1.2971.00
335_V353_S1.2971.00
160_L191_A1.2921.00
192_I197_I1.2881.00
323_L352_L1.2851.00
157_A161_S1.2851.00
71_A282_R1.2811.00
51_R54_H1.2801.00
325_D364_L1.2781.00
143_A155_E1.2721.00
191_A195_H1.2721.00
375_T378_A1.2711.00
186_A221_H1.2641.00
30_H346_G1.2601.00
325_D363_K1.2561.00
257_E260_K1.2531.00
232_S247_Y1.2531.00
89_D93_D1.2501.00
190_Q194_G1.2461.00
109_T135_S1.2451.00
324_V367_L1.2381.00
52_L56_V1.2301.00
183_A186_A1.2281.00
153_W191_A1.2211.00
119_I142_M1.2131.00
182_Q220_A1.2051.00
95_T255_S1.2021.00
226_E251_P1.1971.00
183_A187_A1.1951.00
302_L380_A1.1911.00
157_A195_H1.1901.00
103_A248_C1.1891.00
191_A197_I1.1881.00
67_T73_R1.1881.00
145_Q155_E1.1851.00
294_F298_K1.1841.00
190_Q193_A1.1761.00
108_I112_V1.1751.00
108_I168_I1.1731.00
98_A102_E1.1681.00
113_R116_D1.1661.00
289_L292_P1.1621.00
256_A260_K1.1561.00
299_R369_F1.1551.00
279_D282_R1.1531.00
71_A275_L1.1491.00
293_D296_R1.1421.00
79_K285_P1.1381.00
193_A225_R1.1321.00
211_S317_E1.1291.00
157_A191_A1.1261.00
182_Q221_H1.1251.00
73_R77_A1.1211.00
299_R303_V1.1161.00
285_P289_L1.1161.00
54_H58_Q1.1131.00
279_D283_A1.1091.00
298_K301_I1.1081.00
102_E262_H1.1081.00
229_V250_A1.1061.00
145_Q152_D1.1001.00
377_L381_E1.0911.00
167_V197_I1.0901.00
198_F229_V1.0831.00
47_Y50_E1.0811.00
110_A261_V1.0771.00
338_C349_A1.0751.00
186_A224_L1.0621.00
76_I96_V1.0611.00
301_I304_N1.0581.00
46_R49_Q1.0541.00
54_H57_A1.0541.00
293_D297_Q1.0521.00
47_Y283_A1.0511.00
158_A162_E1.0441.00
275_L278_A1.0411.00
290_A294_F1.0381.00
161_S164_T1.0311.00
341_L349_A1.0231.00
71_A74_E1.0181.00
72_L96_V1.0181.00
89_D252_A1.0171.00
333_D362_H1.0151.00
262_H266_T1.0131.00
112_V118_V1.0121.00
160_L197_I1.0111.00
80_T247_Y1.0101.00
327_S363_K1.0101.00
217_S220_A1.0091.00
334_D363_K1.0081.00
189_W228_A1.0041.00
312_E327_S0.9991.00
304_N307_N0.9971.00
210_F296_R0.9961.00
229_V248_C0.9941.00
286_E290_A0.9871.00
340_W345_H0.9831.00
132_I139_V0.9821.00
161_S195_H0.9811.00
335_V339_Q0.9811.00
193_A226_E0.9801.00
31_Q346_G0.9761.00
76_I94_I0.9731.00
42_F294_F0.9661.00
300_D315_P0.9651.00
341_L383_L0.9641.00
311_L326_Y0.9591.00
198_F227_R0.9571.00
153_W157_A0.9431.00
77_A94_I0.9371.00
93_D255_S0.9371.00
118_V166_L0.9371.00
106_A262_H0.9351.00
154_Q158_A0.9301.00
142_M159_L0.9221.00
193_A227_R0.9211.00
255_S259_R0.9181.00
50_E57_A0.9151.00
124_S170_N0.9111.00
287_H290_A0.9091.00
94_I249_V0.9081.00
112_V166_L0.9061.00
229_V254_I0.9021.00
111_L198_F0.8981.00
198_F254_I0.8941.00
209_N215_H0.8931.00
128_Y168_I0.8931.00
78_Q81_E0.8921.00
153_W188_L0.8911.00
133_A139_V0.8911.00
77_A89_D0.8891.00
103_A231_V0.8891.00
111_L166_L0.8881.00
290_A293_D0.8861.00
250_A258_I0.8851.00
299_R316_C0.8841.00
286_E289_L0.8711.00
49_Q56_V0.8701.00
231_V248_C0.8681.00
252_A256_A0.8641.00
121_F151_V0.8621.00
95_T258_I0.8611.00
98_A270_N0.8611.00
119_I159_L0.8591.00
326_Y365_I0.8591.00
193_A224_L0.8511.00
70_Q73_R0.8501.00
304_N377_L0.8491.00
302_L305_A0.8481.00
69_V278_A0.8481.00
164_T197_I0.8431.00
100_A233_S0.8431.00
337_F341_L0.8431.00
29_Q346_G0.8421.00
199_V218_V0.8401.00
297_Q301_I0.8371.00
31_Q375_T0.8351.00
347_V383_L0.8351.00
245_V269_V0.8331.00
245_V273_A0.8331.00
335_V351_P0.8311.00
130_P133_A0.8311.00
337_F365_I0.8301.00
287_H291_L0.8261.00
298_K373_E0.8241.00
154_Q157_A0.8231.00
121_F142_M0.8231.00
309_S380_A0.8181.00
102_E266_T0.8151.00
334_D351_P0.8121.00
93_D225_R0.8111.00
79_K207_H0.8101.00
69_V274_Q0.8071.00
47_Y279_D0.8061.00
122_D358_D0.8021.00
100_A204_V0.8021.00
209_N212_Q0.8021.00
110_A258_I0.8001.00
300_D303_V0.7981.00
60_A275_L0.7961.00
311_L324_V0.7871.00
216_A220_A0.7861.00
332_L336_E0.7811.00
106_A258_I0.7801.00
153_W184_D0.7781.00
349_A367_L0.7751.00
338_C351_P0.7721.00
207_H237_T0.7651.00
107_A258_I0.7641.00
102_E106_A0.7571.00
339_Q344_E0.7561.00
189_W199_V0.7561.00
147_P184_D0.7551.00
86_Y219_L0.7531.00
51_R55_H0.7521.00
302_L369_F0.7511.00
101_T127_S0.7511.00
140_K159_L0.7481.00
95_T248_C0.7451.00
47_Y287_H0.7451.00
218_V228_A0.7451.00
142_M155_E0.7441.00
323_L364_L0.7431.00
374_S377_L0.7431.00
43_D49_Q0.7421.00
144_L173_H0.7421.00
160_L164_T0.7411.00
52_L272_P0.7401.00
218_V221_H0.7371.00
40_P295_Y0.7371.00
109_T261_V0.7361.00
297_Q300_D0.7341.00
219_L230_A0.7331.00
122_D356_C0.7321.00
201_S218_V0.7301.00
288_Y292_P0.7281.00
237_T288_Y0.7261.00
73_R90_A0.7251.00
173_H176_S0.7231.00
105_Y135_S0.7201.00
189_W224_L0.7181.00
119_I156_F0.7171.00
79_K84_Y0.7141.00
55_H58_Q0.7101.00
371_K375_T0.7101.00
352_L355_F0.7091.00
117_E165_R0.7081.00
79_K238_Y0.7071.00
211_S296_R0.7041.00
120_C132_I0.6991.00
118_V137_G0.6931.00
308_E377_L0.6861.00
271_T275_L0.6841.00
77_A88_P0.6821.00
203_E230_A0.6781.00
332_L340_W0.6761.00
55_H276_A0.6751.00
119_I167_V0.6741.00
334_D338_C0.6731.00
75_A281_L0.6731.00
275_L279_D0.6721.00
140_K164_T0.6711.00
112_V116_D0.6701.00
160_L195_H0.6691.00
250_A254_I0.6681.00
296_R299_R0.6671.00
291_L295_Y0.6651.00
193_A223_Q0.6601.00
299_R315_P0.6601.00
35_L376_L0.6571.00
97_T248_C0.6571.00
150_R181_Q0.6571.00
253_P256_A0.6561.00
151_V184_D0.6551.00
84_Y206_E0.6511.00
292_P296_R0.6501.00
121_F173_H0.6501.00
145_Q150_R0.6491.00
44_G47_Y0.6481.00
324_V364_L0.6411.00
224_L227_R0.6391.00
180_W184_D0.6381.00
156_F191_A0.6371.00
234_F247_Y0.6371.00
128_Y132_I0.6361.00
169_L185_F0.6331.00
105_Y265_L0.6331.00
178_T317_E0.6301.00
95_T259_R0.6291.00
206_E232_S0.6281.00
99_G244_K0.6271.00
313_I322_L0.6241.00
259_R262_H0.6241.00
108_I166_L0.6191.00
306_L324_V0.6181.00
115_G138_I0.6151.00
58_Q279_D0.6141.00
68_G73_R0.6131.00
105_Y131_A0.6121.00
44_G48_L0.6121.00
145_Q148_H0.6121.00
140_K161_S0.6091.00
210_F299_R0.6081.00
158_A161_S0.6051.00
65_P70_Q0.6041.00
146_P312_E0.6041.00
205_Y321_F0.6031.00
347_V382_R0.6001.00
120_C141_R0.6001.00
302_L376_L0.6001.00
156_F167_V0.5991.00
95_T250_A0.5981.00
332_L337_F0.5951.00
146_P325_D0.5951.00
96_V245_V0.5951.00
256_A259_R0.5951.00
274_Q278_A0.5931.00
74_E77_A0.5931.00
147_P155_E0.5931.00
116_D163_R0.5901.00
73_R259_R0.5891.00
180_W185_F0.5891.00
171_T203_E0.5871.00
143_A159_L0.5861.00
101_T125_Y0.5861.00
34_N39_F0.5851.00
234_F281_L0.5851.00
374_S378_A0.5851.00
216_A221_H0.5851.00
203_E206_E0.5831.00
187_A191_A0.5821.00
291_L294_F0.5811.00
179_V209_N0.5811.00
104_L131_A0.5801.00
276_A279_D0.5781.00
72_L76_I0.5781.00
53_A56_V0.5761.00
168_I200_I0.5751.00
342_T348_A0.5751.00
55_H275_L0.5741.00
238_Y285_P0.5741.00
172_P318_G0.5741.00
71_A75_A0.5731.00
80_T230_A0.5731.00
64_A69_V0.5731.00
208_I295_Y0.5731.00
262_H269_V0.5731.00
203_E217_S0.5711.00
108_I137_G0.5701.00
353_S362_H0.5681.00
32_A348_A0.5661.00
251_P254_I0.5651.00
113_R165_R0.5641.00
157_A160_L0.5641.00
48_L280_M0.5631.00
213_Q317_E0.5631.00
47_Y51_R0.5601.00
223_Q226_E0.5601.00
108_I135_S0.5601.00
325_D328_A0.5591.00
110_A257_E0.5581.00
45_P48_L0.5581.00
34_N37_Q0.5571.00
72_L277_L0.5561.00
216_A219_L0.5551.00
211_S299_R0.5541.00
29_Q32_A0.5531.00
47_Y286_E0.5511.00
98_A269_V0.5501.00
46_R57_A0.5501.00
159_L162_E0.5481.00
225_R228_A0.5481.00
253_P257_E0.5481.00
316_C319_T0.5441.00
352_L364_L0.5441.00
150_R178_T0.5441.00
108_I131_A0.5421.00
167_V192_I0.5421.00
120_C129_A0.5381.00
302_L367_L0.5361.00
151_V156_F0.5361.00
192_I196_E0.5351.00
161_S194_G0.5341.00
31_Q378_A0.5341.00
33_I382_R0.5341.00
367_L376_L0.5331.00
166_L198_F0.5331.00
347_V379_A0.5321.00
143_A152_D0.5311.00
338_C341_L0.5311.00
147_P181_Q0.5301.00
185_F218_V0.5301.00
103_A246_G0.5281.00
126_D354_V0.5271.00
48_L240_M0.5261.00
226_E253_P0.5261.00
44_G49_Q0.5261.00
79_K206_E0.5251.00
88_P93_D0.5251.00
314_L325_D0.5241.00
36_S348_A0.5221.00
215_H218_V0.5211.00
69_V271_T0.5201.00
171_T179_V0.5201.00
220_A223_Q0.5201.00
301_I374_S0.5191.00
164_T167_V0.5191.00
45_P49_Q0.5191.00
333_D337_F0.5181.00
146_P314_L0.5171.00
75_A79_K0.5161.00
338_C342_T0.5161.00
42_F45_P0.5161.00
312_E328_A0.5151.00
338_C365_I0.5121.00
208_I292_P0.5101.00
217_S230_A0.5091.00
333_D353_S0.5091.00
106_A261_V0.5071.00
109_T265_L0.5061.00
51_R276_A0.5061.00
141_R357_A0.5051.00
191_A194_G0.5051.00
39_F62_Q0.5051.00
201_S230_A0.5041.00
121_F144_L0.5011.00
107_A231_V0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1u08A 2 0.987 100 0.256 Contact Map
1yizA 2 0.987 100 0.276 Contact Map
3e2yA 2 0.9793 100 0.277 Contact Map
2o0rA 2 0.9845 100 0.285 Contact Map
4my5A 2 0.9845 100 0.287 Contact Map
2o1bA 2 0.9482 100 0.288 Contact Map
1vp4A 2 0.9793 100 0.288 Contact Map
1gd9A 2 0.9767 100 0.291 Contact Map
2x5dA 3 0.9482 100 0.293 Contact Map
3piuA 2 0.9585 100 0.295 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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