GREMLIN Database
MAA - Maltose O-acetyltransferase
UniProt: P77791 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG14239
Length: 183 (156)
Sequences: 6211 (4426)
Seq/√Len: 354.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
88_M94_I4.2301.00
85_D105_G3.1531.00
75_F95_R3.0341.00
108_I130_V2.9961.00
134_N152_D2.8831.00
79_N99_N2.7921.00
133_G152_D2.6521.00
78_N98_D2.6321.00
135_N153_N2.4451.00
145_N158_S2.1891.00
77_G98_D2.1781.00
109_Y140_G2.1561.00
131_T149_T2.1471.00
24_D72_Y2.1181.00
110_T129_P2.0261.00
56_Q75_F2.0251.00
42_E45_L1.9701.00
33_H37_H1.9421.00
138_I144_I1.8581.00
28_A31_L1.8541.00
47_Q51_A1.8161.00
58_T78_N1.7821.00
76_L80_F1.7771.00
33_H40_A1.7491.00
133_G149_T1.7431.00
75_F93_P1.6801.00
108_I111_A1.6611.00
111_A127_G1.6461.00
80_F100_C1.6361.00
63_E81_F1.5941.00
80_F98_D1.5271.00
82_A86_C1.4691.00
92_C127_G1.4631.00
37_H58_T1.4481.00
57_V60_A1.4291.00
95_R131_T1.4111.00
45_L48_Q1.3881.00
73_N93_P1.3831.00
108_I132_I1.3731.00
96_I102_L1.3711.00
102_L108_I1.3681.00
97_G115_I1.3561.00
74_I88_M1.3421.00
99_N135_N1.3381.00
34_R39_L1.3031.00
115_I155_V1.2871.00
138_I142_A1.2851.00
56_Q76_L1.2821.00
31_L52_D1.2721.00
30_Q41_E1.2611.00
28_A53_L1.2431.00
82_A88_M1.2401.00
142_A160_A1.2371.00
143_V158_S1.2321.00
56_Q59_E1.2171.00
116_D119_A1.2141.00
71_G74_I1.2111.00
132_I138_I1.2001.00
76_L96_I1.1851.00
130_V148_V1.1771.00
97_G134_N1.1701.00
60_A76_L1.1501.00
77_G97_G1.1451.00
132_I136_V1.1431.00
27_R31_L1.1421.00
87_V105_G1.1301.00
145_N163_T1.0961.00
49_I53_L1.0951.00
150_I154_V1.0921.00
83_N101_M1.0881.00
98_D134_N1.0841.00
98_D115_I1.0721.00
121_N135_N1.0501.00
50_L54_F1.0471.00
19_E23_R1.0431.00
95_R112_T1.0391.00
120_R137_W1.0171.00
20_T24_D1.0061.00
107_H141_R0.9981.00
99_N116_D0.9971.00
102_L138_I0.9931.00
136_V154_V0.9851.00
13_L126_L0.9831.00
76_L82_A0.9771.00
48_Q52_D0.9761.00
107_H140_G0.9731.00
116_D135_N0.9691.00
136_V152_D0.9671.00
28_A32_I0.9591.00
89_L109_Y0.9401.00
112_T131_T0.9361.00
37_H40_A0.9291.00
59_E78_N0.9281.00
115_I134_N0.9231.00
133_G154_V0.9231.00
81_F101_M0.9231.00
117_P152_D0.9041.00
6_E10_A0.9001.00
96_I100_C0.8921.00
157_A160_A0.8861.00
30_Q39_L0.8841.00
135_N152_D0.8831.00
34_R38_S0.8811.00
33_H39_L0.8771.00
51_A57_V0.8701.00
6_E13_L0.8681.00
96_I108_I0.8651.00
49_I52_D0.8551.00
77_G80_F0.8531.00
31_L53_L0.8531.00
39_L58_T0.8421.00
114_P134_N0.8381.00
82_A102_L0.8361.00
68_C74_I0.8331.00
83_N89_L0.8311.00
132_I144_I0.8251.00
77_G115_I0.8161.00
155_V158_S0.8121.00
100_C152_D0.8041.00
34_R45_L0.7991.00
34_R52_D0.7961.00
136_V151_G0.7881.00
150_I156_V0.7851.00
112_T128_K0.7841.00
108_I144_I0.7741.00
107_H143_V0.7701.00
112_T126_L0.7661.00
97_G100_C0.7611.00
117_P136_V0.7451.00
35_Y50_L0.7431.00
52_D55_G0.7431.00
80_F134_N0.7411.00
62_I82_A0.7351.00
38_S45_L0.7351.00
67_R84_F0.7341.00
60_A80_F0.7321.00
96_I132_I0.7311.00
105_G141_R0.7210.99
109_Y128_K0.7180.99
74_I94_I0.7110.99
142_A156_V0.7090.99
35_Y38_S0.7080.99
102_L106_V0.7020.99
142_A158_S0.6960.99
67_R85_D0.6840.99
57_V78_N0.6800.99
126_L141_R0.6790.99
80_F96_I0.6740.99
13_L124_A0.6690.99
133_G151_G0.6680.99
80_F97_G0.6680.99
71_G89_L0.6670.99
144_I150_I0.6650.99
55_G75_F0.6640.99
12_E15_R0.6640.99
22_S25_R0.6590.99
89_L107_H0.6580.99
118_V137_W0.6540.99
46_R53_L0.6500.99
124_A141_R0.6440.99
46_R64_P0.6420.99
45_L49_I0.6420.99
44_T48_Q0.6410.99
50_L53_L0.6370.99
130_V147_G0.6370.99
20_T23_R0.6360.99
31_L49_I0.6360.99
140_G143_V0.6330.99
127_G130_V0.6290.99
149_T152_D0.6270.99
80_F115_I0.6250.98
35_Y64_P0.6200.98
114_P131_T0.6180.98
39_L42_E0.6170.98
26_L29_R0.6160.98
106_V142_A0.6150.98
38_S61_Y0.6120.98
34_R37_H0.6110.98
113_H119_A0.6090.98
38_S49_I0.6050.98
137_W155_V0.6030.98
155_V159_G0.5990.98
144_I148_V0.5960.98
66_F74_I0.5960.98
112_T115_I0.5950.98
113_H117_P0.5950.98
29_R63_E0.5940.98
77_G100_C0.5850.98
87_V107_H0.5800.98
160_A163_T0.5800.98
47_Q50_L0.5780.97
108_I113_H0.5760.97
87_V104_P0.5750.97
155_V160_A0.5740.97
138_I150_I0.5720.97
106_V138_I0.5720.97
26_L31_L0.5720.97
35_Y44_T0.5710.97
101_M118_V0.5700.97
70_Y74_I0.5660.97
100_C134_N0.5660.97
23_R26_L0.5650.97
119_A124_A0.5620.97
32_I68_C0.5620.97
43_H47_Q0.5600.97
21_L25_R0.5600.97
48_Q66_F0.5590.97
24_D27_R0.5540.97
117_P120_R0.5520.97
129_P147_G0.5460.96
18_D22_S0.5440.96
105_G124_A0.5430.96
157_A163_T0.5420.96
84_F87_V0.5390.96
86_C106_V0.5370.96
127_G132_I0.5350.96
93_P110_T0.5300.96
55_G62_I0.5250.96
18_D21_L0.5230.95
85_D107_H0.5210.95
63_E84_F0.5190.95
107_H120_R0.5190.95
69_D85_D0.5180.95
9_I92_C0.5170.95
27_R52_D0.5160.95
27_R30_Q0.5150.95
86_C105_G0.5130.95
31_L34_R0.5120.95
99_N115_I0.5120.95
30_Q34_R0.5110.95
93_P129_P0.5070.95
14_Y111_A0.5050.95
46_R54_F0.5040.95
71_G94_I0.5000.94
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3hjjA 3 1 100 0.209 Contact Map
2p2oA 3 0.9945 100 0.211 Contact Map
3srtA 3 0.9945 100 0.215 Contact Map
3nz2A 4 0.9891 100 0.226 Contact Map
3fttA 3 0.9945 100 0.227 Contact Map
1krrA 3 1 100 0.234 Contact Map
1ocxA 3 0.9945 100 0.241 Contact Map
4g3qA 3 0.9781 99.9 0.452 Contact Map
2v0hA 3 0.9781 99.9 0.457 Contact Map
3vbiA 3 0.776 99.9 0.476 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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