GREMLIN Database
DDPX - D-alanyl-D-alanine dipeptidase
UniProt: P77790 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13791
Length: 193 (173)
Sequences: 1414 (929)
Seq/√Len: 70.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
22_K27_D3.6141.00
65_V115_I3.4321.00
131_A166_F3.2721.00
40_C69_A3.1531.00
56_I153_G3.0301.00
146_L150_I2.8631.00
42_L46_A2.7701.00
131_A158_G2.5081.00
137_P140_A2.4681.00
56_I154_G2.4621.00
57_A150_I2.4401.00
65_V107_T2.3391.00
32_K78_M2.3101.00
107_T118_M2.2341.00
53_S154_G2.2091.00
34_I79_L2.2051.00
49_A168_L2.0551.00
52_K154_G2.0261.00
110_D114_N1.9921.00
65_V109_R1.9771.00
57_A108_L1.9251.00
14_F17_L1.9211.00
77_A81_Q1.8861.00
64_L106_L1.8691.00
124_E128_R1.8591.00
66_I69_A1.8481.00
136_V140_A1.8441.00
10_L19_I1.8341.00
9_D39_R1.8251.00
9_D12_V1.8241.00
44_K48_T1.8221.00
103_A167_E1.7301.00
119_G144_R1.6611.00
21_L40_C1.6410.99
13_I51_A1.6190.99
62_L116_L1.5910.99
27_D88_Y1.5660.99
17_L66_I1.5600.99
9_D41_L1.5510.99
30_T34_I1.5330.99
10_L17_L1.5280.99
60_S146_L1.5240.99
151_M156_F1.5190.99
120_A128_R1.4900.99
53_S150_I1.4880.99
16_D58_Q1.4820.99
117_D140_A1.4720.99
21_L38_A1.4690.99
54_I63_Q1.4650.99
148_N158_G1.4520.99
53_S151_M1.4300.99
46_A156_F1.4280.98
131_A148_N1.3990.98
67_Y115_I1.3920.98
152_T158_G1.3880.98
73_Q77_A1.3780.98
27_D87_Q1.3670.98
97_N167_E1.2920.97
116_L143_N1.2880.97
139_A142_R1.2420.96
138_P142_R1.2230.96
75_A99_S1.2130.96
11_A19_I1.1960.95
78_M81_Q1.1950.95
136_V141_Q1.1820.95
43_H102_T1.1780.95
63_Q109_R1.1640.95
54_I64_L1.1310.94
53_S64_L1.1080.93
10_L14_F1.1020.93
34_I75_A1.1010.93
23_Y123_D1.0860.92
80_W95_G1.0800.92
135_S145_L1.0750.92
48_T52_K1.0740.92
125_M129_S1.0700.92
18_E109_R1.0690.92
88_Y130_H1.0650.92
26_A33_A1.0530.91
30_T78_M1.0490.91
18_E65_V1.0480.91
53_S56_I1.0460.91
7_L43_H1.0450.91
61_G109_R1.0410.91
111_E114_N1.0140.90
43_H46_A0.9970.89
151_M154_G0.9940.89
148_N166_F0.9910.89
144_R168_L0.9900.88
97_N171_A0.9760.88
120_A129_S0.9640.87
45_D49_A0.9610.87
108_L118_M0.9500.86
28_N35_Y0.9430.86
121_G124_E0.9390.86
75_A79_L0.9290.85
52_K56_I0.9260.85
119_G136_V0.9250.85
100_R175_P0.9230.85
47_I51_A0.9130.84
72_P75_A0.9130.84
68_D123_D0.9120.84
42_L104_I0.9120.84
111_E153_G0.9110.84
131_A144_R0.9080.84
9_D19_I0.9070.84
21_L69_A0.9010.83
13_I17_L0.8970.83
51_A55_S0.8970.83
141_Q145_L0.8860.82
73_Q96_S0.8840.82
24_A33_A0.8840.82
14_F19_I0.8800.82
22_K122_F0.8700.81
10_L66_I0.8660.81
42_L69_A0.8580.80
132_Y166_F0.8440.79
12_V18_E0.8340.78
80_W94_V0.8270.78
49_A169_P0.8260.78
108_L116_L0.8200.77
33_A36_Q0.8190.77
64_L147_L0.7990.75
29_I125_M0.7840.74
122_F125_M0.7810.74
57_A64_L0.7800.73
16_D54_I0.7780.73
87_Q130_H0.7710.73
53_S57_A0.7700.72
96_S99_S0.7690.72
54_I109_R0.7590.71
13_I47_I0.7590.71
26_A32_K0.7520.71
139_A143_N0.7480.70
95_G99_S0.7460.70
109_R115_I0.7430.70
21_L102_T0.7410.70
167_E170_Q0.7390.69
103_A159_I0.7360.69
124_E129_S0.7360.69
6_E21_L0.7290.68
100_R171_A0.7280.68
18_E63_Q0.7190.67
56_I59_L0.7170.67
70_Y156_F0.7100.66
97_N102_T0.7090.66
29_I35_Y0.7040.66
19_I38_A0.7020.65
30_T33_A0.6940.64
60_S150_I0.6890.64
76_Q89_V0.6890.64
88_Y161_S0.6880.64
16_D63_Q0.6870.64
37_Q139_A0.6860.64
20_E27_D0.6800.63
67_Y122_F0.6750.62
80_W84_P0.6730.62
52_K66_I0.6700.62
119_G171_A0.6700.62
73_Q99_S0.6690.62
132_Y160_S0.6620.61
148_N152_T0.6590.60
157_V167_E0.6580.60
14_F51_A0.6580.60
100_R174_Y0.6550.60
46_A168_L0.6510.60
22_K25_C0.6460.59
130_H161_S0.6430.59
119_G129_S0.6420.58
16_D55_S0.6410.58
77_A93_T0.6400.58
70_Y100_R0.6390.58
79_L123_D0.6370.58
41_L65_V0.6320.57
63_Q112_H0.6250.56
167_E171_A0.6230.56
92_V107_T0.6160.55
11_A18_E0.6130.55
19_I39_R0.6130.55
151_M168_L0.6120.55
35_Y68_D0.6090.55
133_H159_I0.6080.54
128_R133_H0.6060.54
54_I79_L0.6020.54
48_T51_A0.6010.54
6_E44_K0.6010.54
59_L141_Q0.5990.53
35_Y72_P0.5980.53
53_S62_L0.5970.53
68_D79_L0.5960.53
23_Y29_I0.5920.52
110_D116_L0.5920.52
18_E160_S0.5880.52
108_L143_N0.5840.52
8_V44_K0.5830.51
76_Q90_V0.5830.51
132_Y148_N0.5830.51
82_A175_P0.5800.51
159_I167_E0.5720.50
11_A16_D0.5670.49
55_S139_A0.5660.49
42_L47_I0.5660.49
170_Q173_S0.5640.49
46_A49_A0.5620.49
142_R146_L0.5610.49
17_L54_I0.5610.49
133_H136_V0.5600.49
58_Q63_Q0.5590.48
102_T171_A0.5580.48
13_I48_T0.5580.48
88_Y91_D0.5570.48
11_A39_R0.5570.48
75_A90_V0.5560.48
23_Y28_N0.5560.48
14_F21_L0.5540.48
52_K55_S0.5500.47
79_L96_S0.5480.47
102_T167_E0.5480.47
101_G156_F0.5420.46
48_T139_A0.5420.46
137_P141_Q0.5400.46
151_M166_F0.5400.46
45_D169_P0.5390.46
132_Y135_S0.5370.46
150_I154_G0.5340.45
117_D136_V0.5330.45
9_D13_I0.5330.45
137_P143_N0.5320.45
67_Y96_S0.5310.45
119_G126_H0.5310.45
157_V169_P0.5310.45
56_I150_I0.5300.45
92_V95_G0.5280.45
45_D48_T0.5260.44
32_K113_G0.5250.44
60_S131_A0.5240.44
36_Q55_S0.5230.44
73_Q76_Q0.5220.44
18_E26_A0.5210.44
80_W91_D0.5180.43
60_S141_Q0.5180.43
116_L146_L0.5160.43
64_L109_R0.5160.43
119_G168_L0.5150.43
158_G166_F0.5140.43
72_P118_M0.5130.43
117_D137_P0.5100.43
142_R145_L0.5100.43
117_D143_N0.5080.42
102_T168_L0.5070.42
131_A134_P0.5060.42
62_L146_L0.5050.42
6_E174_Y0.5050.42
60_S142_R0.5040.42
79_L93_T0.5020.42
171_A175_P0.5010.41
72_P129_S0.5010.41
64_L151_M0.5010.41
119_G124_E0.5000.41
20_E24_A0.5000.41
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1r44A 1 0.9223 100 0.257 Contact Map
4ox3A 1 0.886 99.9 0.629 Contact Map
4mphA 2 0.7876 99.9 0.644 Contact Map
4murA 2 0.8238 99.9 0.652 Contact Map
4muqA 1 0.8912 99.9 0.668 Contact Map
4nt9B 3 0.7927 99.9 0.69 Contact Map
2vo9A 1 0.7202 99.7 0.747 Contact Map
2mxzA 1 0.6788 96.8 0.897 Contact Map
3n1gB 1 0.658 91.3 0.923 Contact Map
2ibgE 1 0.5544 90.6 0.924 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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