GREMLIN Database
NUDG - CTP pyrophosphohydrolase
UniProt: P77788 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG14009
Length: 135 (120)
Sequences: 5931 (4306)
Seq/√Len: 393.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
12_E16_K3.6971.00
54_R60_E3.6751.00
21_Q100_A2.9711.00
44_S47_Q2.9481.00
39_V48_A2.8711.00
21_Q99_Q2.5521.00
105_S108_E2.3481.00
19_L112_Y2.2341.00
53_L61_A2.1201.00
19_L104_C2.0941.00
104_C112_Y2.0401.00
16_K105_S2.0361.00
18_L101_L2.0081.00
31_L113_P2.0021.00
62_T87_P1.9431.00
19_L114_L1.8501.00
5_E80_H1.8121.00
25_Q29_A1.8111.00
50_V54_R1.7621.00
68_A124_A1.7561.00
59_I88_D1.6551.00
64_G87_P1.6271.00
60_E90_H1.5991.00
45_Q84_W1.5581.00
71_Q78_I1.5091.00
5_E82_H1.4921.00
108_E111_Q1.4851.00
58_G96_H1.4471.00
66_Y82_H1.4321.00
66_Y69_S1.4261.00
39_V45_Q1.4001.00
88_D91_G1.3701.00
20_A98_H1.3681.00
20_A101_L1.3461.00
15_G106_P1.2891.00
58_G94_Q1.2791.00
69_S80_H1.2671.00
62_T89_F1.2651.00
50_V63_V1.2651.00
23_P29_A1.2591.00
8_A83_A1.2281.00
95_A98_H1.2221.00
102_V112_Y1.2071.00
7_V48_A1.1981.00
73_E78_I1.1971.00
61_A86_V1.1551.00
21_Q30_G1.1541.00
93_L101_L1.1361.00
8_A49_L1.1261.00
69_S82_H1.1191.00
28_Q31_L1.1171.00
9_A49_L1.1091.00
30_G99_Q1.0821.00
71_Q80_H1.0821.00
59_I93_L1.0681.00
54_R58_G1.0431.00
9_A53_L1.0271.00
46_R50_V1.0121.00
120_P123_E1.0111.00
23_P99_Q1.0031.00
65_E85_H1.0021.00
73_E76_G0.9971.00
11_I53_L0.9971.00
24_A29_A0.9871.00
67_V85_H0.9821.00
52_E56_E0.9791.00
7_V45_Q0.9651.00
49_L86_V0.9561.00
12_E15_G0.9521.00
66_Y84_W0.9371.00
119_I123_E0.9311.00
114_L118_D0.9281.00
47_Q50_V0.9201.00
95_A101_L0.9161.00
45_Q82_H0.9051.00
31_L115_A0.9051.00
115_A118_D0.8981.00
31_L116_P0.8931.00
63_V86_V0.8741.00
102_V108_E0.8721.00
50_V61_A0.8511.00
110_L123_E0.8461.00
53_L86_V0.8411.00
49_L84_W0.8161.00
10_I67_V0.8151.00
24_A99_Q0.8111.00
62_T88_D0.8061.00
18_L59_I0.8051.00
22_R33_E0.8041.00
86_V89_F0.8021.00
68_A71_Q0.8001.00
21_Q32_W0.7951.00
83_A121_L0.7871.00
27_D77_R0.7861.00
13_R16_K0.7851.00
61_A64_G0.7791.00
24_A30_G0.7741.00
72_R75_S0.7731.00
32_W102_V0.7731.00
74_V77_R0.7721.00
77_R81_L0.7691.00
50_V60_E0.7531.00
49_L53_L0.7501.00
33_E98_H0.7301.00
50_V64_G0.7251.00
12_E85_H0.7221.00
16_K108_E0.7201.00
5_E9_A0.7201.00
23_P97_E0.7181.00
22_R98_H0.7061.00
12_E17_I0.7001.00
72_R79_I0.6880.99
50_V62_T0.6800.99
64_G85_H0.6720.99
63_V87_P0.6700.99
85_H125_F0.6700.99
28_Q115_A0.6690.99
22_R38_K0.6630.99
63_V88_D0.6600.99
60_E89_F0.6440.99
90_H93_L0.6420.99
34_F118_D0.6400.99
10_I83_A0.6380.99
53_L59_I0.6370.99
68_A121_L0.6370.99
34_F83_A0.6350.99
95_A99_Q0.6320.99
9_A86_V0.6300.99
9_A12_E0.6260.99
52_E55_E0.6250.99
57_L101_L0.6220.99
7_V11_I0.6200.99
72_R77_R0.6030.99
32_W104_C0.6030.99
33_E79_I0.5970.99
22_R25_Q0.5960.99
32_W100_A0.5950.99
105_S109_A0.5930.98
7_V10_I0.5870.98
27_D76_G0.5850.98
6_V118_D0.5820.98
46_R84_W0.5820.98
95_A100_A0.5810.98
43_E48_A0.5800.98
29_A99_Q0.5780.98
35_A57_L0.5720.98
104_C110_L0.5660.98
110_L119_I0.5650.98
63_V89_F0.5630.98
118_D121_L0.5600.98
59_I91_G0.5560.98
63_V84_W0.5530.98
13_R87_P0.5520.98
20_A49_L0.5520.98
9_A61_A0.5520.98
6_V22_R0.5510.98
13_R91_G0.5500.98
13_R92_T0.5490.98
114_L122_L0.5490.98
79_I82_H0.5470.97
21_Q31_L0.5370.97
19_L32_W0.5350.97
67_V124_A0.5350.97
63_V66_Y0.5320.97
49_L63_V0.5310.97
17_I34_F0.5300.97
15_G105_S0.5250.97
23_P30_G0.5250.97
33_E118_D0.5240.97
20_A57_L0.5230.97
54_R96_H0.5220.97
54_R57_L0.5210.97
70_H81_L0.5160.96
33_E115_A0.5130.96
78_I81_L0.5120.96
33_E36_G0.5050.96
20_A38_K0.5050.96
20_A103_W0.5040.96
38_K79_I0.5040.96
64_G86_V0.5000.96
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2rrkA 1 1 99.9 0.266 Contact Map
3gwyA 2 0.963 99.9 0.288 Contact Map
1mutA 1 0.9481 99.9 0.292 Contact Map
3eesA 2 0.9704 99.9 0.314 Contact Map
3hhjA 1 0.9333 99.9 0.321 Contact Map
4v14A 1 0.9185 99.9 0.329 Contact Map
3fk9A 2 0.9556 99.9 0.33 Contact Map
3grnA 2 0.963 99.9 0.331 Contact Map
3r03A 2 0.9407 99.9 0.331 Contact Map
3i7uA 4 0.9556 99.9 0.332 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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