GREMLIN Database
YNFF - Probable dimethyl sulfoxide reductase chain YnfF
UniProt: P77783 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13844
Length: 807 (665)
Sequences: 8725 (5404)
Seq/√Len: 209.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
117_Y132_R5.8921.00
727_I746_A4.7041.00
140_D565_R4.5181.00
734_R805_E4.2201.00
553_K561_E3.6871.00
734_R741_E3.4281.00
296_E361_R3.3851.00
288_A345_A3.3071.00
721_D755_G3.2971.00
145_N148_R3.2861.00
343_E353_A3.2171.00
686_L725_R3.1561.00
557_W561_E3.1281.00
544_P547_S3.1121.00
292_V296_E2.9901.00
720_I754_P2.9401.00
500_G512_C2.9081.00
141_T514_I2.9001.00
301_Q305_D2.8691.00
122_V131_E2.8631.00
142_I514_I2.8481.00
139_L565_R2.8021.00
291_W295_T2.7571.00
309_V638_S2.7421.00
134_S137_E2.7361.00
736_F803_Q2.7191.00
148_R152_D2.7061.00
736_F805_E2.6781.00
346_A353_A2.6401.00
733_V746_A2.6401.00
285_L349_T2.6191.00
149_I157_A2.6181.00
717_I746_A2.6161.00
290_A396_L2.6141.00
737_N802_V2.5921.00
117_Y551_E2.5701.00
713_Q745_A2.5571.00
227_F286_A2.5111.00
273_E358_Q2.5031.00
133_I514_I2.4941.00
722_A748_V2.4871.00
120_K141_T2.4841.00
222_K368_P2.4711.00
352_P355_K2.4451.00
255_R362_E2.4321.00
717_I804_I2.4271.00
355_K358_Q2.4251.00
120_K133_I2.4151.00
120_K514_I2.3851.00
139_L561_E2.3501.00
353_A357_I2.3291.00
341_T344_W2.3041.00
290_A326_Y2.2881.00
297_N301_Q2.2881.00
736_F741_E2.2551.00
299_V304_L2.2521.00
146_L466_F2.2501.00
481_D786_H2.2451.00
724_A754_P2.2291.00
725_R803_Q2.2171.00
258_V271_E2.2151.00
729_H748_V2.1661.00
638_S642_E2.1571.00
302_P306_K2.1421.00
141_T145_N2.1421.00
221_T224_V2.1361.00
220_N403_N2.0951.00
149_I466_F2.0701.00
358_Q362_E2.0651.00
727_I733_V2.0621.00
132_R551_E2.0481.00
142_I499_V2.0261.00
715_V757_T2.0211.00
561_E565_R2.0061.00
744_I759_I2.0041.00
715_V733_V2.0011.00
549_K552_R1.9611.00
732_T743_L1.9601.00
133_I141_T1.9591.00
223_L362_E1.9481.00
275_L359_L1.9291.00
465_K496_E1.9281.00
273_E355_K1.9241.00
275_L351_I1.9121.00
734_R743_L1.8971.00
70_R85_T1.8941.00
223_L257_I1.8721.00
729_H747_K1.8681.00
717_I757_T1.8611.00
603_E607_T1.8571.00
715_V759_I1.8541.00
291_W342_P1.8511.00
120_K131_E1.8481.00
715_V735_V1.8371.00
285_L356_I1.8231.00
600_D603_E1.8201.00
686_L757_T1.8121.00
281_T348_I1.8051.00
294_I330_I1.7911.00
292_V361_R1.7711.00
487_E490_Q1.7571.00
505_M509_A1.7541.00
296_E357_I1.7471.00
116_K550_F1.7341.00
561_E564_K1.7281.00
298_M364_G1.7241.00
728_R731_D1.7211.00
328_A331_L1.7171.00
140_D144_D1.6861.00
343_E357_I1.6841.00
363_I397_T1.6771.00
294_I311_Y1.6731.00
720_I723_Q1.6681.00
363_I369_A1.6671.00
346_A356_I1.6571.00
292_V342_P1.6521.00
468_W501_I1.6521.00
525_E544_P1.6461.00
346_A352_P1.6201.00
259_I285_L1.6171.00
292_V357_I1.6141.00
716_W749_T1.6071.00
732_T745_A1.5941.00
497_M514_I1.5931.00
273_E362_E1.5901.00
519_L554_P1.5891.00
757_T802_V1.5881.00
396_L643_I1.5851.00
119_M515_L1.5801.00
147_R151_K1.5711.00
133_I137_E1.5691.00
691_F758_A1.5671.00
248_A254_A1.5631.00
345_A356_I1.5581.00
402_I405_G1.5521.00
68_L91_Y1.5401.00
142_I516_L1.5391.00
72_H82_E1.5391.00
249_R272_D1.5381.00
225_V259_I1.5381.00
298_M361_R1.5351.00
55_V73_V1.5291.00
495_C498_I1.5281.00
293_L299_V1.5251.00
107_R706_V1.5221.00
122_V129_K1.5221.00
361_R365_S1.5171.00
686_L721_D1.5061.00
153_Y465_K1.4981.00
146_L499_V1.4971.00
299_V311_Y1.4831.00
285_L359_L1.4821.00
681_R738_N1.4791.00
304_L311_Y1.4661.00
119_M132_R1.4651.00
294_I327_K1.4601.00
308_C643_I1.4591.00
742_M759_I1.4451.00
469_C498_I1.4441.00
284_A348_I1.4431.00
137_E141_T1.4411.00
543_Q605_K1.4391.00
71_L78_V1.4291.00
486_H490_Q1.4211.00
295_T357_I1.4201.00
327_K331_L1.4141.00
223_L359_L1.4131.00
181_M186_G1.4081.00
160_V181_M1.4051.00
444_G447_M1.4011.00
725_R804_I1.3961.00
225_V359_L1.3911.00
144_D148_R1.3891.00
292_V298_M1.3891.00
295_T331_L1.3891.00
56_W70_R1.3851.00
141_T497_M1.3841.00
581_H585_K1.3821.00
719_P750_P1.3821.00
54_A70_R1.3801.00
118_P135_W1.3791.00
500_G509_A1.3771.00
340_K348_I1.3681.00
147_R150_L1.3621.00
553_K557_W1.3471.00
686_L803_Q1.3461.00
293_L364_G1.3461.00
57_S71_L1.3441.00
302_P305_D1.3411.00
505_M515_L1.3291.00
646_E650_K1.3281.00
258_V267_A1.3281.00
277_I351_I1.3251.00
78_V109_M1.3231.00
309_V642_E1.3221.00
340_K344_W1.3211.00
503_H520_M1.3211.00
261_P274_W1.3141.00
602_E606_T1.3121.00
275_L355_K1.2961.00
310_G313_E1.2961.00
350_S753_L1.2931.00
159_H464_I1.2921.00
294_I299_V1.2921.00
564_K569_D1.2871.00
442_D446_E1.2781.00
263_Y268_A1.2721.00
71_L81_V1.2651.00
150_L158_V1.2641.00
139_L553_K1.2601.00
313_E328_A1.2601.00
715_V744_I1.2591.00
554_P557_W1.2581.00
344_W347_K1.2561.00
247_Q250_E1.2551.00
56_W84_D1.2521.00
143_S565_R1.2481.00
292_V295_T1.2461.00
340_K345_A1.2461.00
289_I363_I1.2371.00
431_Q435_F1.2361.00
137_E514_I1.2351.00
615_P619_Y1.2291.00
273_E359_L1.2291.00
121_R130_F1.2261.00
281_T349_T1.2251.00
582_E585_K1.2141.00
222_K367_K1.2091.00
718_N754_P1.2071.00
501_I558_M1.2061.00
150_L155_N1.2051.00
292_V356_I1.2011.00
54_A72_H1.2001.00
366_A369_A1.1981.00
289_I360_A1.1981.00
377_P390_I1.1931.00
70_R82_E1.1901.00
326_Y330_I1.1901.00
113_D703_N1.1891.00
481_D484_H1.1841.00
298_M365_S1.1821.00
70_R84_D1.1811.00
157_A465_K1.1711.00
636_T642_E1.1711.00
624_A627_E1.1691.00
749_T752_I1.1691.00
557_W564_K1.1621.00
301_Q327_K1.1621.00
247_Q251_R1.1591.00
585_K588_H1.1571.00
759_I780_I1.1561.00
122_V127_E1.1561.00
289_I359_L1.1531.00
286_A390_I1.1491.00
575_T582_E1.1481.00
85_T90_V1.1411.00
293_L397_T1.1381.00
150_L184_C1.1381.00
501_I518_D1.1331.00
225_V289_I1.1321.00
288_A356_I1.1321.00
277_I281_T1.1321.00
289_I293_L1.1311.00
466_F499_V1.1311.00
399_N405_G1.1291.00
716_W747_K1.1271.00
77_T110_N1.1251.00
158_V466_F1.1251.00
735_V759_I1.1211.00
683_T803_Q1.1201.00
257_I359_L1.1171.00
217_D220_N1.1151.00
226_M229_N1.1151.00
222_K366_A1.1131.00
519_L552_R1.1071.00
268_A751_R1.1071.00
363_I371_I1.1061.00
470_Y559_L1.0991.00
149_I496_E1.0981.00
224_V245_V1.0961.00
201_A791_L1.0911.00
541_L605_K1.0881.00
683_T738_N1.0871.00
484_H487_E1.0861.00
426_N429_K1.0811.00
291_W331_L1.0741.00
146_L566_L1.0741.00
339_A344_W1.0711.00
83_S96_V1.0681.00
202_A387_S1.0671.00
223_L366_A1.0661.00
757_T804_I1.0651.00
460_L484_H1.0651.00
688_L802_V1.0611.00
622_F625_F1.0591.00
224_V254_A1.0521.00
223_L369_A1.0511.00
149_I497_M1.0461.00
311_Y327_K1.0461.00
218_I370_Y1.0451.00
304_L643_I1.0431.00
289_I393_L1.0421.00
72_H80_W1.0411.00
116_K132_R1.0411.00
145_N149_I1.0401.00
249_R270_R1.0381.00
109_M546_T1.0371.00
585_K602_E1.0371.00
623_R627_E1.0311.00
154_G157_A1.0301.00
81_V106_R1.0231.00
54_A82_E1.0161.00
443_H446_E1.0161.00
116_K549_K1.0151.00
715_V804_I1.0151.00
351_I356_I1.0141.00
115_L515_L1.0131.00
604_M609_I1.0121.00
346_A349_T1.0121.00
441_I444_G1.0081.00
286_A389_A1.0071.00
131_E137_E1.0041.00
446_E449_A1.0041.00
227_F259_I1.0031.00
142_I497_M1.0021.00
309_V640_K1.0001.00
278_R753_L0.9991.00
516_L558_M0.9981.00
469_C508_S0.9941.00
354_E357_I0.9931.00
135_W516_L0.9931.00
716_W751_R0.9921.00
139_L557_W0.9891.00
684_Y803_Q0.9891.00
259_I359_L0.9881.00
345_A349_T0.9861.00
684_Y737_N0.9831.00
74_K79_Y0.9821.00
342_P357_I0.9811.00
584_I588_H0.9801.00
487_E494_K0.9801.00
130_F515_L0.9761.00
219_A244_Y0.9751.00
444_G448_T0.9731.00
689_T756_V0.9721.00
525_E541_L0.9691.00
392_M643_I0.9681.00
681_R801_L0.9671.00
458_E463_P0.9661.00
68_L84_D0.9661.00
457_K484_H0.9641.00
685_P803_Q0.9621.00
369_A399_N0.9611.00
331_L339_A0.9611.00
259_I277_I0.9611.00
291_W341_T0.9571.00
231_P245_V0.9571.00
483_N487_E0.9561.00
717_I727_I0.9561.00
327_K330_I0.9531.00
53_K76_D0.9531.00
292_V360_A0.9521.00
146_L468_W0.9510.99
525_E581_H0.9460.99
299_V396_L0.9460.99
720_I750_P0.9450.99
522_T545_A0.9450.99
279_P756_V0.9440.99
259_I275_L0.9420.99
311_Y396_L0.9390.99
518_D558_M0.9390.99
76_D547_S0.9370.99
288_A292_V0.9370.99
395_V641_I0.9350.99
206_M388_R0.9350.99
468_W562_V0.9330.99
717_I722_A0.9330.99
422_P432_I0.9270.99
346_A351_I0.9270.99
226_M256_M0.9270.99
718_N752_I0.9250.99
357_I361_R0.9240.99
180_L566_L0.9240.99
686_L804_I0.9230.99
466_F497_M0.9190.99
257_I362_E0.9160.99
459_K462_V0.9160.99
255_R273_E0.9160.99
308_C395_V0.9140.99
312_D327_K0.9130.99
475_L486_H0.9120.99
509_A515_L0.9120.99
351_I355_K0.9120.99
742_M783_L0.9110.99
249_R256_M0.9080.99
255_R272_D0.9080.99
283_G386_T0.9070.99
263_Y751_R0.9060.99
353_A356_I0.9050.99
71_L522_T0.9050.99
158_V184_C0.9030.99
257_I273_E0.9000.99
519_L548_A0.8990.99
441_I446_E0.8990.99
326_Y396_L0.8980.99
467_L495_C0.8970.99
739_N800_N0.8950.99
581_H601_Y0.8940.99
135_W558_M0.8940.99
532_S538_Y0.8910.99
261_P276_P0.8900.99
263_Y750_P0.8890.99
300_D402_I0.8860.99
358_Q361_R0.8840.99
718_N748_V0.8810.99
344_W348_I0.8800.99
142_I562_V0.8790.99
473_N699_S0.8790.99
581_H605_K0.8780.99
91_Y94_H0.8770.99
368_P402_I0.8760.99
444_G449_A0.8750.99
180_L559_L0.8730.99
368_P405_G0.8680.99
735_V802_V0.8680.99
442_D448_T0.8670.99
224_V248_A0.8610.99
285_L289_I0.8600.99
223_L255_R0.8550.99
139_L562_V0.8540.99
621_A624_A0.8520.99
744_I780_I0.8520.99
277_I285_L0.8500.99
246_E249_R0.8490.99
142_I145_N0.8480.99
146_L184_C0.8480.99
119_M505_M0.8470.99
136_D565_R0.8470.99
287_C340_K0.8440.99
610_F614_C0.8430.99
118_P134_S0.8430.99
226_M266_T0.8420.99
460_L494_K0.8420.99
55_V545_A0.8420.99
346_A354_E0.8390.99
539_V599_P0.8370.99
604_M607_T0.8360.99
546_T549_K0.8360.99
460_L487_E0.8360.99
506_T509_A0.8360.99
342_P345_A0.8350.99
601_Y605_K0.8340.99
146_L150_L0.8330.99
71_L545_A0.8320.99
278_R350_S0.8310.99
753_L756_V0.8310.99
292_V353_A0.8280.99
284_A288_A0.8270.99
525_E580_Q0.8260.99
341_T345_A0.8260.99
354_E358_Q0.8260.99
719_P723_Q0.8260.99
276_P753_L0.8230.99
120_K137_E0.8190.98
739_N784_T0.8180.98
295_T342_P0.8160.98
58_S540_I0.8160.98
304_L396_L0.8160.98
65_S237_S0.8150.98
69_L98_A0.8140.98
429_K432_I0.8140.98
361_R364_G0.8130.98
625_F628_D0.8130.98
475_L482_I0.8100.98
163_G188_L0.8080.98
375_W379_R0.8070.98
435_F438_T0.8050.98
355_K362_E0.8040.98
717_I733_V0.8030.98
288_A347_K0.8000.98
59_C63_C0.7990.98
634_L641_I0.7990.98
585_K589_A0.7970.98
483_N782_I0.7970.98
594_R597_E0.7950.98
143_S147_R0.7940.98
288_A344_W0.7940.98
428_V431_Q0.7930.98
145_N497_M0.7900.98
135_W553_K0.7900.98
619_Y622_F0.7890.98
622_F626_R0.7880.98
721_D754_P0.7870.98
59_C67_C0.7840.98
735_V744_I0.7840.98
704_I707_L0.7830.98
637_P642_E0.7830.98
714_E763_A0.7800.98
722_A727_I0.7800.98
288_A342_P0.7790.98
442_D449_A0.7790.98
371_I394_S0.7790.98
432_I435_F0.7780.98
232_A266_T0.7780.98
117_Y134_S0.7780.98
433_S436_T0.7750.98
111_H504_F0.7750.98
469_C500_G0.7740.98
293_L393_L0.7730.98
720_I724_A0.7700.98
263_Y276_P0.7690.98
569_D572_Q0.7690.98
63_C67_C0.7670.98
288_A341_T0.7670.98
222_K251_R0.7630.98
109_M520_M0.7620.98
144_D147_R0.7610.98
556_Y583_W0.7610.98
153_Y157_A0.7600.98
576_E582_E0.7590.98
110_N549_K0.7590.98
202_A391_A0.7580.98
291_W330_I0.7540.97
678_D681_R0.7540.97
173_N176_V0.7530.97
225_V371_I0.7520.97
432_I436_T0.7500.97
326_Y643_I0.7500.97
560_S564_K0.7490.97
73_V546_T0.7480.97
377_P386_T0.7480.97
56_W90_V0.7470.97
681_R685_P0.7450.97
475_L489_L0.7440.97
267_A274_W0.7440.97
525_E543_Q0.7410.97
74_K77_T0.7400.97
133_I138_A0.7390.97
381_S796_P0.7370.97
290_A330_I0.7360.97
796_P799_S0.7360.97
260_D264_N0.7340.97
443_H447_M0.7340.97
141_T144_D0.7330.97
76_D79_Y0.7310.97
116_K119_M0.7300.97
457_K461_D0.7280.97
553_K558_M0.7270.97
739_N801_L0.7250.97
342_P346_A0.7230.97
183_S186_G0.7220.97
681_R684_Y0.7210.97
143_S566_L0.7210.97
597_E600_D0.7190.97
223_L363_I0.7190.97
519_L524_Q0.7180.97
507_A764_W0.7180.97
55_V71_L0.7180.97
125_R128_G0.7180.97
304_L308_C0.7170.97
95_Q247_Q0.7160.96
727_I748_V0.7150.96
110_N546_T0.7150.96
147_R566_L0.7150.96
538_Y611_K0.7140.96
286_A393_L0.7140.96
156_E186_G0.7110.96
717_I748_V0.7100.96
601_Y604_M0.7090.96
441_I448_T0.7080.96
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381_S787_R0.5540.88
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687_Q799_S0.5530.87
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448_T452_D0.5500.87
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693_Y711_C0.5490.87
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367_K402_I0.5310.85
585_K601_Y0.5310.85
384_E792_A0.5300.85
594_R599_P0.5300.85
244_Y247_Q0.5300.85
260_D267_A0.5300.85
148_R151_K0.5290.85
594_R601_Y0.5290.85
73_V79_Y0.5290.85
611_K614_C0.5290.85
718_N725_R0.5290.85
115_L505_M0.5280.85
291_W344_W0.5280.85
702_G705_D0.5280.85
377_P387_S0.5280.85
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510_K766_K0.5260.85
447_M453_G0.5260.85
443_H449_A0.5250.85
225_V393_L0.5240.85
441_I447_M0.5240.85
469_C489_L0.5230.84
197_A794_G0.5230.84
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243_Y247_Q0.5220.84
261_P277_I0.5220.84
468_W499_V0.5220.84
261_P689_T0.5210.84
436_T441_I0.5210.84
111_H703_N0.5210.84
355_K359_L0.5200.84
426_N435_F0.5200.84
393_L397_T0.5200.84
436_T440_A0.5190.84
621_A628_D0.5190.84
201_A792_A0.5190.84
605_K609_I0.5190.84
499_V514_I0.5180.84
436_T442_D0.5180.84
688_L735_V0.5180.84
196_T411_E0.5170.84
117_Y550_F0.5170.84
142_I146_L0.5160.84
133_I497_M0.5160.84
556_Y560_S0.5160.84
727_I804_I0.5160.84
384_E789_S0.5160.84
154_G465_K0.5150.84
289_I369_A0.5150.84
399_N402_I0.5140.83
82_E85_T0.5140.83
445_T449_A0.5130.83
635_K639_G0.5130.83
84_D90_V0.5120.83
289_I361_R0.5110.83
737_N800_N0.5110.83
248_A256_M0.5110.83
564_K575_T0.5110.83
215_P218_I0.5100.83
248_A251_R0.5100.83
73_V76_D0.5100.83
576_E580_Q0.5090.83
619_Y625_F0.5090.83
425_E428_V0.5080.83
645_S648_L0.5080.83
456_G488_V0.5070.83
256_M270_R0.5070.83
343_E347_K0.5060.83
220_N368_P0.5060.83
597_E601_Y0.5060.83
305_D312_D0.5060.83
287_C330_I0.5050.82
229_N410_R0.5050.82
199_I373_Q0.5050.82
737_N801_L0.5050.82
594_R600_D0.5050.82
84_D91_Y0.5040.82
785_S796_P0.5040.82
713_Q732_T0.5040.82
345_A348_I0.5040.82
457_K460_L0.5040.82
490_Q511_Y0.5040.82
422_P433_S0.5030.82
229_N372_C0.5030.82
169_G470_Y0.5030.82
477_N699_S0.5030.82
196_T199_I0.5030.82
350_S755_G0.5020.82
523_E552_R0.5020.82
193_S196_T0.5020.82
165_G190_R0.5020.82
501_I555_I0.5020.82
375_W378_Q0.5020.82
724_A755_G0.5010.82
368_P399_N0.5000.82
260_D274_W0.5000.82
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1kqfA 3 0.8922 100 0.221 Contact Map
2vpzA 1 0.855 100 0.224 Contact Map
2ivfA 1 0.8947 100 0.238 Contact Map
1q16A 2 0.9554 100 0.255 Contact Map
1h0hA 1 0.8922 100 0.258 Contact Map
2e7zA 1 0.8414 100 0.261 Contact Map
2iv2X 1 0.7968 100 0.279 Contact Map
1tmoA 1 0.8736 100 0.283 Contact Map
3ml1A 1 0.8798 100 0.285 Contact Map
2napA 1 0.834 100 0.286 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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