GREMLIN Database
MENI - 1,4-dihydroxy-2-naphthoyl-CoA hydrolase
UniProt: P77781 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13968
Length: 136 (119)
Sequences: 3208 (2123)
Seq/√Len: 194.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
39_T97_R3.3801.00
83_L111_H2.4781.00
30_H37_E2.4691.00
27_R39_T2.4391.00
38_A65_I2.4291.00
29_E39_T2.4121.00
91_R124_R2.2481.00
65_I100_G2.2151.00
30_H35_T2.2031.00
101_V119_F2.1811.00
106_H111_H2.0681.00
62_A129_S2.0161.00
120_D124_R2.0161.00
117_E125_L1.9981.00
66_G131_L1.9421.00
32_G35_T1.9371.00
35_T101_V1.9171.00
37_E101_V1.8991.00
104_P107_L1.8801.00
40_M57_A1.8731.00
39_T99_R1.8191.00
59_V85_I1.8171.00
20_M57_A1.8121.00
70_G133_T1.7821.00
35_T103_K1.7091.00
66_G116_I1.6731.00
75_E78_Q1.6591.00
70_G112_Q1.6481.00
20_M60_V1.6411.00
59_V87_A1.5221.00
87_A127_C1.4791.00
62_A116_I1.4461.00
84_E88_N1.4141.00
37_E99_R1.3991.00
117_E128_S1.3951.00
44_S47_K1.3341.00
52_L81_V1.3241.00
58_S126_C1.3061.00
119_F123_G1.2841.00
115_Q128_S1.2781.00
103_K117_E1.2701.00
58_S118_I1.2271.00
26_I38_A1.2191.00
105_L128_S1.2141.00
50_F71_Y1.1991.00
103_K115_Q1.1741.00
58_S127_C1.1681.00
93_A126_C1.1641.00
69_A114_W1.1511.00
88_N113_V1.0971.00
41_P97_R1.0811.00
43_D46_T1.0741.00
56_G60_V1.0491.00
25_D45_R1.0431.00
29_E37_E1.0361.00
90_V113_V1.0311.00
42_V53_L1.0221.00
17_E22_G1.0141.00
34_D72_L1.0041.00
28_F38_A0.9921.00
58_S89_H0.9880.99
53_L98_V0.9860.99
71_Y80_V0.9750.99
90_V106_H0.9730.99
63_E82_G0.9590.99
86_N130_R0.9540.99
21_V64_S0.9520.99
61_L100_G0.9230.99
23_F45_R0.9140.99
52_L92_S0.9070.99
74_T80_V0.9000.99
71_Y79_K0.9000.99
99_R119_F0.8970.99
90_V125_L0.8950.99
73_C107_L0.8890.99
100_G116_I0.8840.99
24_L60_V0.8810.99
47_K95_E0.8750.99
62_A118_I0.8740.99
34_D104_P0.8580.99
105_L115_Q0.8570.99
88_N132_T0.8560.99
101_V123_G0.8370.98
27_R97_R0.8330.98
99_R121_E0.8270.98
97_R121_E0.8220.98
90_V128_S0.8190.98
85_I89_H0.8120.98
70_G80_V0.7970.98
116_I131_L0.7970.98
69_A102_C0.7950.98
106_H113_V0.7930.98
84_E130_R0.7860.97
26_I40_M0.7750.97
31_I72_L0.7700.97
87_A129_S0.7690.97
115_Q130_R0.7690.97
55_G89_H0.7530.97
28_F68_V0.7500.97
40_M61_L0.7420.96
104_P114_W0.7340.96
112_Q133_T0.7320.96
26_I60_V0.7260.96
53_L58_S0.7180.96
16_G22_G0.7100.95
91_R106_H0.7070.95
93_A98_V0.6950.95
41_P46_T0.6930.95
91_R120_D0.6920.95
102_C114_W0.6840.94
98_V126_C0.6840.94
42_V98_V0.6760.94
119_F125_L0.6750.94
33_D73_C0.6740.94
50_F79_K0.6730.94
57_A98_V0.6720.94
40_M53_L0.6700.94
111_H134_A0.6690.94
36_L69_A0.6610.93
46_T53_L0.6580.93
83_L88_N0.6570.93
113_V132_T0.6550.93
19_N47_K0.6530.93
52_L94_R0.6530.93
59_V89_H0.6490.93
36_L72_L0.6490.93
63_E67_S0.6460.93
81_V134_A0.6450.93
59_V129_S0.6190.91
26_I61_L0.6170.91
46_T57_A0.6170.91
47_K94_R0.6170.91
19_N22_G0.6150.91
100_G118_I0.6060.90
31_I68_V0.6020.90
33_D107_L0.5900.89
93_A120_D0.5900.89
113_V130_R0.5890.89
59_V131_L0.5870.89
83_L134_A0.5820.88
74_T77_E0.5810.88
65_I116_I0.5730.87
48_Q66_G0.5710.87
69_A104_P0.5680.87
19_N23_F0.5670.87
73_C112_Q0.5660.87
58_S63_E0.5660.87
73_C104_P0.5650.87
31_I36_L0.5640.87
18_G22_G0.5630.86
28_F31_I0.5620.86
34_D73_C0.5610.86
114_W133_T0.5590.86
83_L132_T0.5460.85
67_S82_G0.5430.84
70_G114_W0.5400.84
99_R123_G0.5370.84
99_R120_D0.5360.84
29_E38_A0.5360.84
27_R41_P0.5360.84
33_D72_L0.5330.83
34_D107_L0.5310.83
98_V118_I0.5250.82
38_A64_S0.5240.82
101_V117_E0.5230.82
49_P67_S0.5220.82
48_Q52_L0.5210.82
103_K119_F0.5190.82
50_F81_V0.5190.82
88_N130_R0.5190.82
66_G133_T0.5170.81
62_A100_G0.5170.81
42_V46_T0.5110.81
25_D43_D0.5080.80
78_Q107_L0.5060.80
65_I102_C0.5060.80
48_Q67_S0.5020.80
20_M23_F0.5000.79
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4k4cA 2 1 100 0.323 Contact Map
1vh5A 2 1 100 0.325 Contact Map
4qd8A 3 1 100 0.334 Contact Map
3lmbA 2 0.9853 100 0.34 Contact Map
4rmmA 2 0.9559 99.9 0.351 Contact Map
1sc0A 1 0.9926 99.9 0.356 Contact Map
1yocA 4 0.9853 99.9 0.357 Contact Map
3gekA 3 0.875 99.9 0.362 Contact Map
1t82A 2 0.9632 99.9 0.366 Contact Map
3e8pA 3 1 99.9 0.366 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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