GREMLIN Database
YBFO - Putative uncharacterized protein YbfO
UniProt: P77779 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13661
Length: 477 (382)
Sequences: 558 (516)
Seq/√Len: 26.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
106_G110_D5.6741.00
18_D22_R5.6121.00
107_W111_R4.9571.00
282_Y287_Y4.8011.00
106_G109_G4.6131.00
108_D112_L4.0951.00
126_Y297_T4.0281.00
272_Q284_R4.0061.00
249_D253_N3.5581.00
127_Q133_P3.5411.00
272_Q283_N3.5071.00
94_M98_R3.4281.00
312_Y322_S3.4141.00
225_H236_V3.2341.00
158_Q277_E3.1861.00
300_P325_L3.1351.00
48_D52_R2.9591.00
155_T158_Q2.9421.00
108_D111_R2.8921.00
106_G112_L2.8531.00
106_G111_R2.8211.00
73_D77_R2.8121.00
107_W112_L2.6960.99
176_M179_R2.6480.99
270_P283_N2.6170.99
272_Q282_Y2.6090.99
230_G271_G2.4980.99
109_G112_L2.4470.99
284_R323_M2.4130.99
382_L386_D2.3950.99
22_R51_H2.1900.97
111_R114_T2.1600.97
277_E287_Y2.1390.97
237_S241_A2.1330.97
316_P321_D2.1290.97
224_Y265_Q2.0890.97
134_L137_V2.0380.96
312_Y321_D1.9750.95
397_P403_P1.9570.95
231_L270_P1.9340.95
150_R154_D1.9280.95
283_N295_Y1.8610.94
283_N303_L1.8600.94
396_K401_C1.8570.93
268_R281_Y1.8500.93
22_R77_R1.8460.93
103_T111_R1.8150.93
110_D130_S1.8140.93
283_N305_G1.8130.93
312_Y316_P1.7690.92
275_D287_Y1.7570.91
269_L283_N1.7420.91
408_Q412_M1.7410.91
272_Q295_Y1.7200.91
316_P322_S1.6990.90
272_Q323_M1.6910.90
284_R295_Y1.6750.89
315_N318_Q1.6450.88
56_Y250_E1.6370.88
47_Y248_Y1.6220.88
246_A249_D1.6090.87
70_Y78_R1.5960.87
285_H323_M1.5620.86
149_R155_T1.5400.85
333_N380_R1.5370.85
98_R101_Q1.5330.85
351_K355_I1.5170.84
301_I309_F1.5090.84
230_G300_P1.5000.83
272_Q281_Y1.4920.83
377_T385_Y1.4920.83
177_L181_E1.4870.83
380_R401_C1.4780.82
244_W283_N1.4770.82
272_Q325_L1.4750.82
270_P295_Y1.4710.82
16_R25_E1.4650.82
244_W272_Q1.4650.82
404_Q408_Q1.4580.81
349_P353_P1.4580.81
406_D413_D1.4340.80
71_L80_A1.4060.79
285_H325_L1.4020.79
155_T287_Y1.3990.79
350_S355_I1.3820.78
363_Y367_Q1.3790.78
246_A269_L1.3630.77
251_W284_R1.3600.77
272_Q301_I1.3530.76
109_G113_T1.3530.76
302_G309_F1.3510.76
301_I325_L1.3440.76
336_G340_R1.3330.75
355_I359_L1.3310.75
21_G72_Y1.3280.75
397_P404_Q1.3110.74
333_N347_P1.3050.73
362_P377_T1.3030.73
227_D231_L1.2990.73
272_Q303_L1.2930.73
274_Y281_Y1.2920.73
379_F383_S1.2910.73
388_T392_R1.2710.71
268_R287_Y1.2660.71
295_Y323_M1.2570.71
269_L281_Y1.2500.70
183_E186_A1.2330.69
282_Y323_M1.2270.69
108_D114_T1.2240.68
250_E273_Q1.2230.68
350_S359_L1.2220.68
155_T275_D1.2190.68
396_K402_T1.2030.67
95_S98_R1.2030.67
175_Q180_L1.2020.67
366_D370_S1.1950.67
270_P316_P1.1880.66
409_Y412_M1.1830.66
15_Y77_R1.1750.65
373_N376_K1.1720.65
103_T109_G1.1720.65
129_G133_P1.1700.65
176_M181_E1.1620.64
372_P379_F1.1610.64
334_N339_A1.1580.64
269_L301_I1.1520.64
349_P360_R1.1500.64
113_T116_Q1.1490.63
89_D93_W1.1470.63
394_W402_T1.1450.63
396_K404_Q1.1350.63
150_R155_T1.1310.62
404_Q409_Y1.1290.62
402_T410_P1.1220.62
347_P353_P1.1190.61
295_Y325_L1.1150.61
268_R274_Y1.1050.60
315_N321_D1.1010.60
299_D324_G1.0910.59
411_G414_T1.0900.59
335_G339_A1.0890.59
78_R251_W1.0870.59
301_I306_G1.0870.59
359_L362_P1.0850.59
396_K409_Y1.0850.59
410_P413_D1.0820.59
372_P376_K1.0750.58
268_R282_Y1.0730.58
371_A379_F1.0710.58
346_T369_S1.0680.58
406_D409_Y1.0670.58
294_R314_L1.0650.58
175_Q178_D1.0620.57
176_M180_L1.0620.57
224_Y235_L1.0600.57
398_N405_D1.0560.57
398_N410_P1.0540.57
333_N368_A1.0530.57
406_D411_G1.0420.56
283_N325_L1.0400.56
368_A393_K1.0320.55
395_V402_T1.0250.55
108_D130_S1.0250.55
334_N338_G1.0240.54
270_P284_R1.0230.54
227_D309_F1.0210.54
364_P387_Y1.0180.54
400_T412_M1.0150.54
338_G343_K1.0150.54
352_L356_A1.0150.54
409_Y413_D1.0080.53
367_Q374_V1.0040.53
339_A345_P1.0020.53
231_L265_Q1.0000.53
391_C402_T0.9990.53
180_L183_E0.9990.53
360_R363_Y0.9980.53
359_L363_Y0.9930.52
366_D380_R0.9890.52
22_R315_N0.9870.52
103_T106_G0.9850.52
332_L346_T0.9830.51
411_G415_K0.9820.51
267_I273_Q0.9780.51
377_T381_A0.9760.51
408_Q411_G0.9750.51
389_L403_P0.9680.50
295_Y313_P0.9640.50
103_T112_L0.9620.50
405_D409_Y0.9610.50
336_G343_K0.9550.49
364_P369_S0.9540.49
110_D267_I0.9500.49
402_T414_T0.9480.49
14_L46_H0.9460.49
392_R399_L0.9450.49
403_P406_D0.9430.48
22_R26_K0.9420.48
400_T404_Q0.9400.48
334_N337_Y0.9370.48
368_A377_T0.9360.48
353_P365_I0.9340.48
227_D296_I0.9310.48
362_P383_S0.9240.47
347_P366_D0.9220.47
244_W305_G0.9210.47
372_P383_S0.9210.47
404_Q411_G0.9190.47
150_R156_L0.9180.47
399_L405_D0.9120.46
340_R344_P0.9100.46
303_L306_G0.9100.46
398_N408_Q0.9070.46
359_L377_T0.9060.46
396_K400_T0.9040.46
231_L248_Y0.9020.45
107_W110_D0.8970.45
232_P270_P0.8970.45
244_W265_Q0.8930.45
305_G325_L0.8920.45
106_G114_T0.8910.45
328_K331_H0.8860.44
21_G284_R0.8830.44
399_L406_D0.8820.44
359_L374_V0.8810.44
137_V278_S0.8800.44
368_A372_P0.8800.44
345_P369_S0.8770.44
244_W273_Q0.8750.43
107_W113_T0.8750.43
407_S413_D0.8740.43
397_P412_M0.8740.43
410_P414_T0.8690.43
158_Q229_R0.8690.43
232_P325_L0.8690.43
248_Y295_Y0.8680.43
174_V177_L0.8680.43
353_P364_P0.8670.43
232_P244_W0.8630.43
280_L296_I0.8610.42
337_Y348_D0.8570.42
273_Q281_Y0.8570.42
398_N404_Q0.8550.42
412_M415_K0.8540.42
126_Y134_L0.8540.42
358_Q370_S0.8510.42
351_K360_R0.8460.41
396_K407_S0.8440.41
342_N380_R0.8390.41
244_W303_L0.8340.40
398_N402_T0.8320.40
351_K357_K0.8300.40
363_Y372_P0.8270.40
355_I358_Q0.8260.40
407_S411_G0.8260.40
348_D374_V0.8210.40
399_L407_S0.8210.40
126_Y300_P0.8200.39
337_Y344_P0.8190.39
404_Q415_K0.8180.39
273_Q283_N0.8140.39
401_C408_Q0.8120.39
369_S376_K0.8080.39
246_A268_R0.8060.38
358_Q380_R0.8050.38
338_G341_P0.8010.38
174_V179_R0.7990.38
383_S399_L0.7980.38
368_A401_C0.7920.38
369_S378_F0.7910.37
327_S330_G0.7900.37
336_G341_P0.7880.37
231_L246_A0.7870.37
267_I285_H0.7860.37
394_W400_T0.7850.37
370_S385_Y0.7850.37
333_N341_P0.7840.37
402_T406_D0.7830.37
148_Q157_Q0.7810.37
77_R98_R0.7810.37
246_A265_Q0.7800.37
372_P384_P0.7790.37
357_K377_T0.7750.36
235_L265_Q0.7740.36
405_D412_M0.7730.36
353_P359_L0.7720.36
15_Y26_K0.7720.36
283_N323_M0.7700.36
347_P387_Y0.7700.36
386_D394_W0.7650.36
379_F387_Y0.7630.35
283_N314_L0.7620.35
232_P248_Y0.7600.35
353_P369_S0.7590.35
349_P356_A0.7590.35
388_T396_K0.7580.35
390_Y393_K0.7570.35
288_Y293_G0.7560.35
18_D275_D0.7530.35
319_Y327_S0.7520.35
94_M100_P0.7520.35
345_P352_L0.7510.35
228_H300_P0.7500.35
351_K390_Y0.7500.35
402_T405_D0.7490.35
170_P173_L0.7490.35
210_Q213_P0.7480.34
381_A385_Y0.7470.34
174_V178_D0.7440.34
301_I319_Y0.7430.34
366_D391_C0.7430.34
379_F386_D0.7420.34
366_D381_A0.7380.34
407_S410_P0.7350.34
402_T413_D0.7350.34
348_D372_P0.7350.34
353_P367_Q0.7340.34
399_L404_Q0.7340.34
93_W312_Y0.7320.33
359_L365_I0.7320.33
171_P176_M0.7310.33
396_K403_P0.7310.33
302_G306_G0.7310.33
204_V208_Q0.7300.33
398_N401_C0.7300.33
302_G305_G0.7300.33
346_T376_K0.7300.33
78_R273_Q0.7290.33
153_A158_Q0.7270.33
400_T403_P0.7230.33
176_M186_A0.7190.33
235_L246_A0.7180.32
367_Q384_P0.7170.32
395_V403_P0.7150.32
384_P388_T0.7090.32
352_L385_Y0.7080.32
126_Y130_S0.7070.32
103_T107_W0.7070.32
206_Q214_V0.7060.32
395_V398_N0.7050.32
373_N383_S0.7050.32
401_C404_Q0.7050.32
126_Y158_Q0.7050.32
232_P295_Y0.7040.32
247_E268_R0.7040.32
285_H322_S0.7000.31
390_Y402_T0.6980.31
334_N340_R0.6980.31
353_P376_K0.6960.31
351_K371_A0.6960.31
394_W406_D0.6950.31
355_I362_P0.6940.31
275_D278_S0.6920.31
390_Y401_C0.6920.31
398_N407_S0.6910.31
392_R395_V0.6900.31
388_T398_N0.6880.31
387_Y392_R0.6870.30
152_L232_P0.6860.30
351_K379_F0.6850.30
151_S174_V0.6840.30
79_V137_V0.6830.30
109_G114_T0.6820.30
272_Q287_Y0.6810.30
350_S374_V0.6800.30
342_N363_Y0.6790.30
230_G325_L0.6780.30
355_I369_S0.6780.30
133_P147_T0.6760.30
250_E265_Q0.6750.30
268_R306_G0.6740.30
399_L402_T0.6740.30
343_K347_P0.6730.30
237_S240_G0.6680.29
272_Q305_G0.6660.29
345_P355_I0.6640.29
251_W314_L0.6630.29
94_M99_K0.6600.29
229_R273_Q0.6600.29
178_D181_E0.6580.29
356_A359_L0.6570.29
354_D366_D0.6560.29
341_P345_P0.6530.28
355_I366_D0.6510.28
326_A329_Y0.6490.28
231_L251_W0.6480.28
401_C405_D0.6450.28
224_Y246_A0.6450.28
222_H243_E0.6450.28
176_M185_L0.6440.28
72_Y76_G0.6440.28
357_K379_F0.6430.28
346_T386_D0.6400.28
359_L375_F0.6390.28
363_Y376_K0.6380.27
327_S331_H0.6380.27
77_R308_N0.6360.27
347_P361_L0.6340.27
275_D282_Y0.6340.27
397_P406_D0.6330.27
390_Y400_T0.6300.27
346_T361_L0.6290.27
20_H45_Y0.6280.27
363_Y375_F0.6270.27
222_H254_L0.6270.27
365_I383_S0.6260.27
407_S414_T0.6260.27
348_D384_P0.6240.27
357_K366_D0.6220.27
367_Q387_Y0.6210.26
392_R400_T0.6160.26
54_V69_R0.6150.26
103_T108_D0.6150.26
408_Q414_T0.6140.26
389_L401_C0.6120.26
401_C410_P0.6120.26
158_Q272_Q0.6120.26
343_K354_D0.6110.26
285_H321_D0.6110.26
224_Y236_V0.6100.26
265_Q268_R0.6090.26
224_Y266_L0.6080.26
301_I305_G0.6070.26
246_A270_P0.6050.26
295_Y303_L0.6050.26
338_G345_P0.6050.26
369_S374_V0.6040.26
222_H266_L0.6030.25
373_N381_A0.6000.25
18_D308_N0.5980.25
271_G282_Y0.5980.25
394_W404_Q0.5970.25
232_P283_N0.5960.25
130_S146_K0.5960.25
356_A377_T0.5960.25
275_D290_P0.5950.25
356_A374_V0.5940.25
337_Y340_R0.5930.25
402_T409_Y0.5930.25
204_V207_M0.5920.25
105_Y111_R0.5920.25
269_L309_F0.5920.25
208_Q213_P0.5880.25
268_R295_Y0.5880.25
105_Y137_V0.5870.25
379_F382_L0.5870.25
267_I272_Q0.5860.25
372_P375_F0.5850.24
401_C412_M0.5850.24
403_P410_P0.5840.24
20_H51_H0.5820.24
270_P282_Y0.5820.24
376_K393_K0.5810.24
284_R321_D0.5810.24
350_S358_Q0.5780.24
46_H55_H0.5780.24
383_S386_D0.5770.24
331_H353_P0.5750.24
174_V181_E0.5750.24
405_D408_Q0.5740.24
375_F391_C0.5740.24
332_L372_P0.5720.24
235_L282_Y0.5720.24
362_P412_M0.5720.24
203_T206_Q0.5710.24
350_S398_N0.5710.24
357_K396_K0.5700.24
283_N302_G0.5700.24
147_T158_Q0.5700.24
389_L392_R0.5680.24
231_L272_Q0.5680.24
338_G354_D0.5650.23
103_T114_T0.5640.23
343_K351_K0.5620.23
284_R316_P0.5610.23
387_Y395_V0.5600.23
409_Y414_T0.5600.23
351_K374_V0.5570.23
409_Y415_K0.5570.23
71_L138_E0.5570.23
104_W127_Q0.5560.23
355_I363_Y0.5550.23
23_L238_T0.5530.23
334_N342_N0.5530.23
394_W403_P0.5530.23
392_R396_K0.5520.23
360_R369_S0.5510.23
407_S412_M0.5510.23
338_G342_N0.5500.23
356_A370_S0.5500.23
397_P400_T0.5460.22
249_D283_N0.5460.22
227_D246_A0.5450.22
342_N357_K0.5440.22
360_R380_R0.5420.22
368_A384_P0.5420.22
206_Q209_N0.5410.22
353_P360_R0.5400.22
347_P367_Q0.5390.22
46_H333_N0.5390.22
235_L274_Y0.5390.22
378_F385_Y0.5380.22
391_C413_D0.5360.22
371_A381_A0.5360.22
301_I304_K0.5360.22
56_Y77_R0.5360.22
356_A365_I0.5350.22
270_P325_L0.5340.22
134_L280_L0.5340.22
234_A244_W0.5340.22
343_K359_L0.5340.22
353_P356_A0.5330.22
406_D414_T0.5330.22
365_I368_A0.5330.22
355_I375_F0.5320.22
11_A273_Q0.5320.22
392_R403_P0.5310.22
227_D303_L0.5310.22
380_R404_Q0.5290.22
108_D126_Y0.5280.21
95_S99_K0.5280.21
286_R299_D0.5280.21
147_T153_A0.5270.21
54_V339_A0.5260.21
22_R298_Q0.5260.21
341_P349_P0.5250.21
82_R88_R0.5250.21
327_S333_N0.5250.21
373_N387_Y0.5250.21
272_Q277_E0.5250.21
375_F379_F0.5240.21
43_H81_K0.5230.21
384_P389_L0.5230.21
77_R89_D0.5220.21
110_D251_W0.5210.21
354_D380_R0.5210.21
398_N413_D0.5200.21
335_G338_G0.5180.21
361_L375_F0.5180.21
379_F408_Q0.5180.21
109_G290_P0.5170.21
105_Y110_D0.5170.21
374_V402_T0.5170.21
206_Q216_T0.5160.21
240_G280_L0.5160.21
17_Y25_E0.5160.21
334_N341_P0.5150.21
358_Q365_I0.5150.21
179_R269_L0.5140.21
107_W114_T0.5140.21
397_P402_T0.5140.21
391_C408_Q0.5120.21
207_M210_Q0.5110.21
192_E196_W0.5110.21
390_Y396_K0.5110.21
380_R387_Y0.5100.21
336_G345_P0.5100.21
355_I378_F0.5100.21
359_L370_S0.5090.21
379_F409_Y0.5090.21
173_L176_M0.5090.21
232_P273_Q0.5080.20
246_A303_L0.5080.20
403_P411_G0.5070.20
283_N306_G0.5060.20
405_D415_K0.5050.20
18_D155_T0.5040.20
344_P350_S0.5040.20
395_V401_C0.5040.20
406_D415_K0.5010.20
356_A363_Y0.5010.20
155_T282_Y0.5000.20
19_R23_L0.5000.20
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4o9xA 1 0.6625 100 0.399 Contact Map
4iglB 1 0.6352 100 0.4 Contact Map
4iglA 1 0.4927 99.4 0.848 Contact Map
4ghbA 5 0.4612 85.4 0.951 Contact Map
4r03A 1 0.2096 80 0.954 Contact Map
4r8oA 2 0.1866 36.9 0.965 Contact Map
2mxwA 1 0.1782 29.3 0.967 Contact Map
3mswA 1 0.26 28.6 0.967 Contact Map
3fvzA 1 0.5786 27.1 0.967 Contact Map
3wknE 1 0.0797 17.6 0.97 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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