GREMLIN Database
YFCH - Epimerase family protein YfcH
UniProt: P77775 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG14111
Length: 297 (274)
Sequences: 64767 (45601)
Seq/√Len: 2754.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
8_G29_V3.0841.00
236_A289_E2.8931.00
19_R206_N2.6131.00
207_G222_M2.5431.00
86_Q90_N2.5401.00
2_N26_Q2.5361.00
62_A212_L2.3631.00
112_G208_I2.3311.00
19_R209_L2.2601.00
218_G275_R2.2361.00
80_Q83_R2.1921.00
54_Q101_A2.1661.00
220_F278_E2.1461.00
19_R23_L2.1191.00
65_N111_S2.1021.00
108_V157_R2.1011.00
30_V45_V2.0731.00
206_N284_R2.0071.00
231_E235_H1.9961.00
28_T60_V1.9871.00
127_T130_E1.9841.00
239_H289_E1.9821.00
49_Q52_A1.9601.00
148_A158_V1.9511.00
4_V60_V1.9391.00
64_I212_L1.9221.00
2_N28_T1.9191.00
93_Q147_I1.9181.00
6_T65_N1.8941.00
45_V52_A1.8581.00
277_E282_A1.8561.00
236_A239_H1.8451.00
163_T208_I1.8331.00
229_R232_Q1.8241.00
23_L209_L1.7731.00
161_L211_L1.7541.00
50_G97_D1.7481.00
206_N210_W1.7391.00
225_P277_E1.7261.00
28_T43_P1.7161.00
142_A146_E1.7131.00
5_I17_I1.7071.00
167_L291_A1.6891.00
85_C143_R1.6861.00
54_Q98_L1.6551.00
93_Q97_D1.6271.00
90_N93_Q1.6061.00
209_L213_D1.5901.00
273_P277_E1.5491.00
236_A240_A1.5481.00
23_L213_D1.5371.00
16_L64_I1.5241.00
3_I25_H1.5211.00
48_W86_Q1.5191.00
19_R22_E1.5091.00
61_D107_S1.5061.00
16_L205_V1.4921.00
92_T144_W1.4911.00
108_V159_C1.4861.00
82_E86_Q1.4731.00
16_L66_L1.4721.00
179_P183_L1.4661.00
210_W214_N1.4431.00
63_V99_I1.4381.00
17_I29_V1.4331.00
52_A55_S1.4261.00
276_L279_A1.4151.00
132_P142_A1.4141.00
50_G54_Q1.4131.00
12_I166_V1.4101.00
163_T204_M1.4031.00
128_E275_R1.3881.00
19_R205_V1.3871.00
66_L112_G1.3721.00
112_G163_T1.3421.00
100_N154_D1.3411.00
137_T141_C1.3351.00
50_G94_K1.3341.00
250_P253_A1.3281.00
113_S117_Y1.3201.00
146_E149_C1.3111.00
54_Q102_S1.3111.00
195_Y227_P1.3051.00
180_P185_L1.3021.00
149_C160_L1.2981.00
96_V151_A1.2911.00
232_Q235_H1.2891.00
25_H213_D1.2791.00
164_G271_A1.2761.00
58_N102_S1.2761.00
18_P170_D1.2741.00
200_H291_A1.2641.00
201_I205_V1.2531.00
8_G17_I1.2481.00
111_S144_W1.2431.00
97_D100_N1.2171.00
62_A108_V1.2131.00
139_K143_R1.2121.00
64_I208_I1.2081.00
47_L91_I1.2031.00
199_I204_M1.1931.00
161_L208_I1.1931.00
88_R140_L1.1861.00
147_I150_R1.1861.00
65_N92_T1.1851.00
4_V30_V1.1751.00
275_R278_E1.1741.00
127_T272_L1.1671.00
20_L209_L1.1611.00
76_W80_Q1.1431.00
111_S148_A1.1331.00
3_I62_A1.1321.00
126_V130_E1.1231.00
3_I20_L1.1191.00
19_R202_D1.1131.00
210_W279_A1.1071.00
118_Y221_N1.1061.00
57_L60_V1.1041.00
95_L109_L1.0981.00
193_R231_E1.0971.00
110_I161_L1.0921.00
207_G276_L1.0911.00
9_T31_T1.0851.00
206_N281_F1.0841.00
129_E275_R1.0841.00
123_E127_T1.0801.00
149_C158_V1.0801.00
218_G278_E1.0781.00
162_R219_P1.0761.00
200_H285_W1.0751.00
94_K97_D1.0751.00
111_S160_L1.0741.00
15_H201_I1.0731.00
123_E130_E1.0711.00
193_R229_R1.0701.00
99_I109_L1.0691.00
15_H202_D1.0651.00
188_P248_R1.0631.00
55_S58_N1.0561.00
197_A225_P1.0551.00
47_L67_A1.0521.00
273_P283_F1.0481.00
238_G245_A1.0481.00
149_C219_P1.0481.00
18_P22_E1.0471.00
235_H238_G1.0441.00
228_V288_L1.0351.00
96_V109_L1.0301.00
97_D101_A1.0261.00
11_L168_A1.0261.00
98_L101_A1.0241.00
238_G244_P1.0231.00
223_V271_A1.0171.00
69_E87_S1.0151.00
90_N94_K1.0141.00
54_Q58_N1.0131.00
173_I177_M1.0091.00
145_E162_R1.0091.00
53_D98_L1.0091.00
98_L102_S1.0081.00
89_W143_R1.0071.00
85_C89_W1.0071.00
6_T95_L1.0041.00
227_P270_R0.9971.00
228_V232_Q0.9961.00
14_R170_D0.9851.00
57_L98_L0.9811.00
166_V204_M0.9731.00
33_N36_K0.9701.00
85_C90_N0.9701.00
30_V56_N0.9661.00
195_Y229_R0.9651.00
84_L140_L0.9651.00
11_L201_I0.9611.00
99_I106_P0.9561.00
87_S91_I0.9561.00
220_F275_R0.9561.00
247_L250_P0.9551.00
100_N156_T0.9481.00
206_N209_L0.9471.00
227_P268_G0.9361.00
28_T59_G0.9341.00
109_L148_A0.9311.00
15_H18_P0.9301.00
66_L208_I0.9231.00
57_L63_V0.9211.00
96_V148_A0.9201.00
162_R221_N0.9181.00
143_R146_E0.9111.00
2_N25_H0.9101.00
167_L200_H0.9091.00
210_W213_D0.9081.00
200_H203_D0.9061.00
2_N60_V0.9031.00
51_L55_S0.8961.00
157_R216_L0.8921.00
15_H19_R0.8841.00
2_N61_D0.8821.00
94_K98_L0.8791.00
195_Y268_G0.8781.00
159_C211_L0.8781.00
285_W290_E0.8741.00
51_L54_Q0.8721.00
176_K179_P0.8681.00
21_L27_I0.8671.00
50_G101_A0.8661.00
203_D224_S0.8651.00
202_D285_W0.8641.00
16_L20_L0.8631.00
30_V52_A0.8631.00
69_E83_R0.8611.00
17_I27_I0.8581.00
238_G243_R0.8541.00
52_A56_N0.8501.00
43_P56_N0.8481.00
100_N155_K0.8441.00
161_L222_M0.8431.00
34_P44_R0.8401.00
33_N44_R0.8351.00
57_L102_S0.8341.00
186_G248_R0.8311.00
166_V199_I0.8251.00
248_R251_A0.8221.00
149_C152_Q0.8211.00
232_Q236_A0.8211.00
115_T164_G0.8201.00
160_L219_P0.8181.00
6_T67_A0.8181.00
124_V130_E0.8091.00
223_V273_P0.8051.00
96_V147_I0.8051.00
63_V95_L0.8051.00
3_I64_I0.8041.00
146_E150_R0.8021.00
176_K180_P0.8021.00
113_S145_E0.8011.00
192_G231_E0.7971.00
81_K139_K0.7961.00
92_T148_A0.7951.00
49_Q53_D0.7951.00
240_A289_E0.7911.00
30_V53_D0.7911.00
274_K277_E0.7911.00
186_G246_I0.7911.00
39_S42_G0.7881.00
115_T271_A0.7881.00
207_G281_F0.7871.00
249_V253_A0.7851.00
206_N285_W0.7811.00
285_W291_A0.7761.00
179_P182_R0.7691.00
83_R86_Q0.7631.00
48_W87_S0.7571.00
85_C140_L0.7561.00
203_D206_N0.7561.00
65_N95_L0.7481.00
91_I94_K0.7461.00
225_P273_P0.7451.00
103_D106_P0.7431.00
100_N151_A0.7391.00
97_D151_A0.7361.00
151_A154_D0.7361.00
211_L276_L0.7361.00
169_P200_H0.7341.00
53_D94_K0.7321.00
181_F238_G0.7311.00
249_V252_T0.7311.00
33_N38_S0.7281.00
135_E138_H0.7261.00
133_H138_H0.7251.00
16_L208_I0.7211.00
143_R147_I0.7201.00
210_W281_F0.7201.00
195_Y270_R0.7161.00
3_I212_L0.7131.00
77_T84_L0.7111.00
69_E84_L0.7101.00
38_S41_L0.7081.00
172_G175_G0.7031.00
38_S42_G0.7021.00
32_R46_T0.6991.00
228_V233_F0.6981.00
188_P250_P0.6961.00
14_R18_P0.6941.00
136_F139_K0.6931.00
15_H205_V0.6911.00
108_V215_E0.6901.00
63_V109_L0.6901.00
25_H61_D0.6871.00
83_R87_S0.6851.00
92_T96_V0.6841.00
210_W280_G0.6841.00
211_L279_A0.6821.00
57_L99_I0.6811.00
231_E249_V0.6781.00
107_S157_R0.6761.00
139_K146_E0.6761.00
144_W148_A0.6761.00
128_E276_L0.6751.00
222_M276_L0.6731.00
147_I151_A0.6721.00
164_G223_V0.6711.00
277_E283_F0.6691.00
125_V270_R0.6681.00
150_R153_S0.6681.00
125_V272_L0.6651.00
12_I204_M0.6621.00
235_H239_H0.6591.00
81_K136_F0.6521.00
122_G130_E0.6471.00
247_L251_A0.6411.00
236_A288_L0.6371.00
163_T166_V0.6351.00
46_T49_Q0.6311.00
102_S106_P0.6271.00
20_L212_L0.6271.00
25_H62_A0.6271.00
184_G187_G0.6251.00
62_A110_I0.6211.00
99_I102_S0.6191.00
127_T274_K0.6181.00
116_G138_H0.6141.00
205_V209_L0.6141.00
15_H170_D0.6121.00
182_R185_L0.6101.00
78_H136_F0.6081.00
183_L186_G0.6051.00
117_Y145_E0.6051.00
85_C139_K0.6031.00
110_I212_L0.6021.00
117_Y132_P0.6011.00
110_I208_I0.6001.00
102_S107_S0.5991.00
45_V53_D0.5981.00
50_G98_L0.5981.00
177_M181_F0.5971.00
238_G241_L0.5961.00
17_I21_L0.5961.00
121_L126_V0.5931.00
4_V56_N0.5911.00
68_G88_R0.5891.00
65_N109_L0.5861.00
177_M180_P0.5841.00
228_V236_A0.5841.00
11_L15_H0.5831.00
233_F288_L0.5821.00
89_W93_Q0.5821.00
204_M208_I0.5791.00
151_A156_T0.5791.00
11_L170_D0.5781.00
2_N59_G0.5771.00
178_L237_L0.5741.00
178_L182_R0.5711.00
5_I20_L0.5701.00
9_T33_N0.5691.00
133_H142_A0.5681.00
165_V196_L0.5671.00
4_V63_V0.5671.00
4_V57_L0.5651.00
194_Q230_N0.5641.00
62_A107_S0.5621.00
23_L210_W0.5611.00
140_L144_W0.5601.00
234_A238_G0.5601.00
124_V268_G0.5581.00
184_G243_R0.5571.00
266_L269_Q0.5571.00
114_A141_C0.5561.00
161_L207_G0.5561.00
21_L24_G0.5541.00
276_L283_F0.5501.00
4_V45_V0.5481.00
157_R215_E0.5481.00
23_L206_N0.5471.00
59_G102_S0.5471.00
171_G175_G0.5441.00
180_P188_P0.5381.00
197_A224_S0.5381.00
139_K150_R0.5331.00
53_D57_L0.5331.00
243_R246_I0.5311.00
93_Q150_R0.5301.00
242_H245_A0.5291.00
47_L53_D0.5281.00
110_I211_L0.5271.00
284_R290_E0.5271.00
15_H169_P0.5261.00
43_P52_A0.5261.00
92_T111_S0.5261.00
69_E88_R0.5251.00
174_L177_M0.5231.00
96_V100_N0.5221.00
121_L124_V0.5221.00
247_L253_A0.5211.00
81_K85_C0.5201.00
132_P146_E0.5201.00
204_M222_M0.5181.00
159_C220_F0.5181.00
50_G53_D0.5161.00
216_L220_F0.5151.00
9_T29_V0.5141.00
56_N60_V0.5131.00
175_G179_P0.5091.00
18_P202_D0.5071.00
220_F276_L0.5061.00
197_A227_P0.5051.00
148_A160_L0.5041.00
117_Y162_R0.5041.00
172_G176_K0.5031.00
57_L95_L0.5011.00
28_T56_N0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1rkxA 3 0.9428 100 0.219 Contact Map
1sb8A 2 0.9663 100 0.225 Contact Map
1rpnA 4 0.9596 100 0.227 Contact Map
3rufA 2 0.9529 100 0.228 Contact Map
3m2pA 2 0.9327 100 0.231 Contact Map
1orrA 3 0.9562 100 0.238 Contact Map
3slgA 4 0.9562 100 0.239 Contact Map
3oh8A 1 0.8754 100 0.239 Contact Map
2c20A 2 0.9562 100 0.24 Contact Map
2z1mA 4 0.9832 100 0.24 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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