GREMLIN Database
YFCI - Uncharacterized protein YfcI
UniProt: P77768 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG14112
Length: 296 (268)
Sequences: 1477 (1231)
Seq/√Len: 75.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
266_I270_M4.8651.00
260_H264_L3.8101.00
256_M260_H3.7291.00
251_R257_Q3.6771.00
246_I250_L3.5421.00
259_K263_A3.4711.00
255_A259_K3.4181.00
269_E273_R3.1601.00
255_A261_E2.9751.00
270_M274_G2.8961.00
262_E266_I2.8461.00
267_A270_M2.7411.00
84_Q94_R2.6581.00
267_A284_T2.6331.00
266_I269_E2.5991.00
257_Q261_E2.5611.00
276_D279_L2.5571.00
261_E265_R2.5141.00
46_K67_S2.4741.00
273_R282_M2.4621.00
247_A250_L2.3881.00
256_M264_L2.3501.00
270_M275_L2.3331.00
268_Q272_D2.2181.00
259_K265_R2.1911.00
263_A269_E2.1241.00
265_R269_E2.0931.00
254_G258_G2.0811.00
263_A267_A2.0701.00
270_M273_R2.0501.00
267_A271_L2.0331.00
84_Q91_M1.9511.00
264_L268_Q1.9001.00
242_K246_I1.8831.00
270_M283_V1.8781.00
266_I284_T1.8421.00
91_M94_R1.8401.00
258_G262_E1.8331.00
259_K267_A1.7851.00
245_T248_D1.7741.00
264_L272_D1.7711.00
259_K262_E1.7231.00
266_I274_G1.7071.00
267_A275_L1.7061.00
246_I249_R1.6951.00
260_H268_Q1.6861.00
280_V284_T1.6761.00
255_A263_A1.6591.00
266_I275_L1.6581.00
253_E257_Q1.6521.00
277_R280_V1.6361.00
93_F107_L1.6331.00
267_A280_V1.6000.99
263_A271_L1.5850.99
247_A251_R1.5830.99
245_T250_L1.5570.99
244_M250_L1.5520.99
241_E244_M1.5500.99
163_P166_E1.5480.99
274_G284_T1.5470.99
281_M284_T1.5390.99
265_R273_R1.5380.99
252_E260_H1.5340.99
275_L279_L1.5160.99
239_E243_L1.5050.99
270_M284_T1.5040.99
272_D276_D1.5020.99
242_K250_L1.4920.99
267_A274_G1.4910.99
96_M100_I1.4760.99
262_E265_R1.4700.99
275_L283_V1.4680.99
273_R283_V1.4460.99
240_K243_L1.4200.99
238_Q242_K1.4190.99
261_E269_E1.3730.98
257_Q265_R1.3530.98
271_L275_L1.3380.98
270_M278_E1.3020.98
262_E270_M1.2930.98
273_R279_L1.2920.98
238_Q241_E1.2800.97
274_G282_M1.2680.97
263_A266_I1.2600.97
158_D161_V1.2570.97
270_M276_D1.2510.97
269_E282_M1.2440.97
266_I271_L1.2420.97
251_R255_A1.2320.97
266_I273_R1.2220.97
164_D178_L1.2020.96
277_R281_M1.1780.96
252_E256_M1.1730.96
248_D252_E1.1710.96
113_E141_A1.1650.96
271_L274_G1.1510.95
243_L246_I1.1500.95
250_L254_G1.1250.95
268_Q274_G1.1220.95
80_V119_P1.1210.95
248_D251_R1.1170.94
101_A104_Q1.1140.94
239_E246_I1.1140.94
67_S74_V1.1030.94
278_E282_M1.1000.94
99_S119_P1.0990.94
90_L139_E1.0820.93
25_R29_D1.0800.93
44_T69_K1.0690.93
275_L281_M1.0680.93
279_L282_M1.0630.93
103_M117_V1.0630.93
52_F65_L1.0590.93
276_D283_V1.0540.93
268_Q276_D1.0440.92
135_C153_A1.0390.92
212_L216_V1.0240.91
274_G280_V1.0180.91
62_S65_L1.0160.91
253_E261_E1.0030.91
244_M249_R0.9980.90
226_R230_G0.9860.90
274_G279_L0.9780.89
238_Q243_L0.9690.89
274_G277_R0.9690.89
276_D281_M0.9630.89
69_K74_V0.9530.88
97_R104_Q0.9500.88
267_A273_R0.9450.88
244_M248_D0.9400.87
269_E275_L0.9390.87
133_S138_D0.9370.87
95_M119_P0.9360.87
260_H263_A0.9340.87
47_L66_W0.9340.87
263_A274_G0.9320.87
243_L250_L0.9270.87
14_F83_H0.9160.86
65_L102_A0.9130.86
11_D15_K0.9110.86
106_H115_P0.9110.86
242_K245_T0.9090.86
270_M280_V0.9070.86
269_E274_G0.9040.85
132_Y154_F0.9010.85
261_E272_D0.9000.85
237_P243_L0.9000.85
28_I79_V0.9000.85
65_L76_Y0.8990.85
93_F100_I0.8920.85
279_L283_V0.8880.84
263_A268_Q0.8870.84
15_K51_S0.8870.84
29_D37_R0.8850.84
135_C151_S0.8850.84
238_Q246_I0.8850.84
70_T73_G0.8780.84
85_S124_H0.8780.84
266_I272_D0.8750.83
87_P132_Y0.8750.83
239_E242_K0.8710.83
272_D275_L0.8670.83
60_Y101_A0.8660.83
164_D181_K0.8660.83
99_S103_M0.8560.82
99_S117_V0.8520.82
274_G278_E0.8500.82
256_M259_K0.8500.82
277_R284_T0.8450.81
269_E284_T0.8430.81
41_D44_T0.8430.81
25_R40_C0.8420.81
264_L267_A0.8420.81
27_F136_W0.8330.80
240_K246_I0.8330.80
252_E255_A0.8320.80
75_G105_N0.8290.80
274_G283_V0.8280.80
177_E180_Q0.8240.80
267_A272_D0.8240.80
248_D260_H0.8220.79
280_V283_V0.8150.79
118_L155_P0.8110.79
80_V99_S0.8100.78
253_E256_M0.8090.78
262_E267_A0.8080.78
18_L81_I0.8080.78
209_L216_V0.8070.78
239_E244_M0.8070.78
230_G233_A0.8070.78
266_I276_D0.8050.78
268_Q284_T0.8030.78
259_K264_L0.7940.77
232_I235_R0.7900.77
270_M277_R0.7840.76
264_L274_G0.7830.76
275_L284_T0.7790.76
249_R253_E0.7780.76
264_L270_M0.7770.76
130_Y133_S0.7750.75
99_S152_S0.7730.75
251_R254_G0.7680.75
278_E281_M0.7660.74
60_Y97_R0.7660.74
137_L151_S0.7630.74
263_A275_L0.7530.73
149_I153_A0.7520.73
273_R278_E0.7490.73
184_R187_D0.7470.73
236_A239_E0.7440.72
275_L282_M0.7400.72
24_A66_W0.7360.71
103_M136_W0.7340.71
269_E280_V0.7310.71
270_M279_L0.7310.71
28_I120_M0.7300.71
237_P245_T0.7300.71
82_E98_Y0.7300.71
80_V95_M0.7220.70
237_P240_K0.7210.70
268_Q273_R0.7210.70
96_M150_Y0.7210.70
10_H14_F0.7190.70
27_F31_H0.7180.70
231_E235_R0.7170.70
266_I283_V0.7170.70
18_L30_I0.7140.69
39_L141_A0.7130.69
241_E246_I0.7120.69
256_M268_Q0.7120.69
130_Y148_K0.7110.69
262_E274_G0.7100.69
232_I238_Q0.7060.68
18_L24_A0.7010.68
271_L278_E0.7000.68
254_G262_E0.6990.68
52_F102_A0.6960.67
125_G130_Y0.6930.67
236_A244_M0.6920.67
241_E245_T0.6890.66
255_A260_H0.6880.66
270_M281_M0.6850.66
135_C138_D0.6850.66
245_T249_R0.6800.65
210_K214_N0.6790.65
244_M247_A0.6770.65
26_D30_I0.6770.65
178_L181_K0.6770.65
240_K244_M0.6720.65
266_I278_E0.6720.65
212_L223_Q0.6720.65
125_G158_D0.6720.65
227_A231_E0.6680.64
48_E51_S0.6670.64
166_E169_Q0.6670.64
268_Q275_L0.6630.63
250_L253_E0.6620.63
273_R277_R0.6620.63
164_D182_H0.6590.63
267_A281_M0.6580.63
275_L278_E0.6580.63
277_R282_M0.6570.63
147_R153_A0.6560.63
12_A59_Q0.6550.63
134_L137_L0.6550.63
230_G234_E0.6490.62
213_F223_Q0.6490.62
243_L249_R0.6480.62
13_V84_Q0.6450.61
121_L130_Y0.6410.61
86_K94_R0.6400.61
239_E245_T0.6390.61
227_A230_G0.6380.61
229_I233_A0.6380.61
203_N206_D0.6380.61
260_H265_R0.6340.60
136_W152_S0.6330.60
263_A273_R0.6320.60
269_E272_D0.6310.60
121_L156_L0.6310.60
122_F125_G0.6300.60
204_T208_Q0.6280.59
54_D122_F0.6260.59
225_F249_R0.6240.59
257_Q269_E0.6210.58
33_P36_L0.6180.58
271_L280_V0.6170.58
236_A240_K0.6170.58
267_A277_R0.6160.58
271_L277_R0.6130.57
36_L118_L0.6100.57
249_R252_E0.6090.57
266_I280_V0.6060.57
24_A32_L0.6060.57
271_L281_M0.6050.56
238_Q245_T0.6040.56
113_E188_L0.6040.56
257_Q260_H0.6020.56
272_D282_M0.6000.56
95_M121_L0.6000.56
84_Q124_H0.5990.56
15_K80_V0.5980.56
273_R276_D0.5980.56
174_A178_L0.5980.56
269_E283_V0.5960.55
81_I92_A0.5940.55
35_P38_K0.5930.55
89_E132_Y0.5920.55
20_H23_T0.5920.55
81_I94_R0.5910.55
47_L105_N0.5880.54
213_F217_L0.5870.54
276_D284_T0.5860.54
109_A117_V0.5830.54
231_E234_E0.5800.53
236_A246_I0.5740.53
276_D282_M0.5740.53
100_I103_M0.5740.53
83_H215_Y0.5730.52
257_Q263_A0.5710.52
272_D283_V0.5710.52
148_K155_P0.5680.52
51_S58_R0.5680.52
236_A242_K0.5650.51
274_G281_M0.5640.51
270_M282_M0.5630.51
13_V140_F0.5620.51
85_S130_Y0.5620.51
266_I277_R0.5610.51
97_R100_I0.5610.51
172_K212_L0.5610.51
107_L114_L0.5600.51
248_D256_M0.5600.51
83_H123_Y0.5590.51
54_D57_L0.5580.51
124_H180_Q0.5550.50
206_D210_K0.5530.50
211_A215_Y0.5510.50
20_H211_A0.5490.49
267_A276_D0.5480.49
30_I173_M0.5470.49
36_L195_I0.5470.49
173_M177_E0.5450.49
119_P124_H0.5430.49
165_D194_Q0.5420.49
247_A253_E0.5410.48
251_R256_M0.5410.48
18_L83_H0.5400.48
209_L220_G0.5400.48
119_P152_S0.5400.48
60_Y94_R0.5390.48
238_Q244_M0.5380.48
273_R284_T0.5380.48
262_E278_E0.5380.48
118_L219_T0.5370.48
212_L222_A0.5370.48
138_D141_A0.5360.48
246_I253_E0.5360.48
239_E253_E0.5350.48
187_D190_G0.5350.48
36_L62_S0.5340.48
225_F235_R0.5330.47
51_S80_V0.5330.47
267_A282_M0.5310.47
227_A234_E0.5280.47
241_E248_D0.5280.47
65_L106_H0.5260.47
65_L101_A0.5240.46
239_E247_A0.5240.46
54_D61_Y0.5230.46
245_T251_R0.5220.46
15_K88_E0.5220.46
26_D29_D0.5210.46
268_Q280_V0.5200.46
225_F253_E0.5200.46
269_E279_L0.5190.46
89_E113_E0.5190.46
241_E247_A0.5180.46
93_F157_V0.5170.45
237_P241_E0.5160.45
65_L123_Y0.5160.45
17_F23_T0.5160.45
265_R268_Q0.5160.45
99_S150_Y0.5150.45
258_G266_I0.5130.45
18_L23_T0.5120.45
99_S136_W0.5120.45
243_L247_A0.5110.45
36_L124_H0.5100.45
50_N61_Y0.5100.45
44_T68_V0.5090.44
265_R271_L0.5090.44
129_P282_M0.5090.44
54_D65_L0.5090.44
263_A270_M0.5070.44
78_Y119_P0.5070.44
62_S80_V0.5050.44
65_L159_I0.5040.44
80_V124_H0.5030.44
10_H119_P0.5020.44
15_K23_T0.5020.44
236_A241_E0.5000.43
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4dyqA 5 0.1385 59.7 0.942 Contact Map
3e3vA 1 0.3142 55.7 0.944 Contact Map
1jkoC 1 0.1453 45.4 0.947 Contact Map
2lfwA 1 0.4426 40.9 0.949 Contact Map
3c1dA 2 0.3682 39.3 0.949 Contact Map
1tc3C 1 0.1453 32.4 0.951 Contact Map
2jpcA 1 0.1182 29.1 0.952 Contact Map
3mzyA 1 0.3446 26.6 0.953 Contact Map
2cobA 1 0.1723 24.6 0.954 Contact Map
2x48A 1 0.1723 24.4 0.954 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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