GREMLIN Database
PHPDC - PHP domain-containing protein YciV
UniProt: P77766 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG14257
Length: 293 (267)
Sequences: 2487 (1858)
Seq/√Len: 113.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
16_T42_I4.9351.00
26_E53_P4.5361.00
188_H222_D4.2641.00
194_A222_D3.7681.00
188_H194_A3.2831.00
129_G151_C3.1191.00
23_L256_F3.0971.00
58_I67_L3.0411.00
187_I192_G2.8231.00
99_F186_V2.5121.00
155_S159_D2.4761.00
14_S28_L2.3991.00
232_S235_E2.3201.00
71_V100_L2.2271.00
113_L116_E2.1651.00
133_L150_E2.1111.00
43_T70_G2.0821.00
121_A171_G2.0781.00
14_S40_L2.0581.00
37_V40_L1.9961.00
30_H57_E1.9831.00
156_S159_D1.9691.00
57_E60_R1.9581.00
195_V251_S1.9551.00
33_V61_S1.9541.00
129_G147_F1.9241.00
123_I164_Y1.8761.00
240_A250_A1.8461.00
179_T182_Q1.8191.00
226_V250_A1.8071.00
95_L189_H1.8031.00
90_D93_H1.7991.00
101_A105_E1.7611.00
71_V86_G1.7391.00
48_T97_C1.7331.00
154_A159_D1.7191.00
35_M264_E1.7091.00
33_V65_L1.7071.00
94_P98_E1.6751.00
112_Q127_L1.6371.00
154_A160_V1.6201.00
195_V223_A1.6101.00
146_R157_M1.6061.00
29_V40_L1.5941.00
51_I69_P1.5721.00
31_R264_E1.5381.00
182_Q185_D1.5351.00
24_T27_A1.5281.00
58_I65_L1.4981.00
210_K245_Q1.4981.00
23_L31_R1.4851.00
158_A162_K1.4781.00
51_I67_L1.4711.00
115_A127_L1.4561.00
147_F151_C1.4441.00
231_Q239_L1.4201.00
200_G235_E1.4131.00
187_I194_A1.3911.00
217_A246_H1.3911.00
48_T89_I1.3641.00
217_A247_H1.3591.00
113_L117_R1.3561.00
260_C263_I1.3501.00
200_G231_Q1.3381.00
112_Q116_E1.3381.00
130_A134_A1.3351.00
114_I144_F1.3301.00
241_A245_Q1.3251.00
129_G150_E1.3221.00
52_A92_T1.3141.00
84_I187_I1.3101.00
166_A169_K1.3071.00
87_L251_S1.2840.99
216_F221_G1.2780.99
14_S32_A1.2770.99
119_E124_P1.2670.99
30_H34_E1.2630.99
32_A40_L1.2480.99
86_G187_I1.2470.99
55_R69_P1.2390.99
31_R34_E1.2390.99
85_V251_S1.2330.99
181_E215_H1.2310.99
40_L67_L1.2200.99
73_I183_A1.2180.99
105_E109_Q1.2160.99
55_R91_I1.2160.99
111_A144_F1.2140.99
27_A30_H1.2140.99
227_A240_A1.2060.99
9_I38_G1.2050.99
22_C258_Q1.2040.99
39_T66_N1.2020.99
111_A139_V1.1990.99
181_E185_D1.1860.99
227_A236_R1.1780.99
110_R161_F1.1780.99
115_A144_F1.1720.99
214_A246_H1.1720.99
243_A250_A1.1710.99
185_D189_H1.1650.99
55_R67_L1.1610.99
126_A129_G1.1600.99
75_T183_A1.1540.99
52_A91_I1.1500.99
56_E59_S1.1500.99
31_R35_M1.1440.99
228_Q252_Q1.1430.99
42_I50_A1.1430.99
178_C183_A1.1420.99
228_Q231_Q1.1380.99
54_A67_L1.1310.99
184_I219_H1.1300.99
129_G132_R1.1250.99
213_V224_M1.1210.99
115_A119_E1.1130.98
33_V62_G1.1060.98
107_R143_H1.1020.98
30_H61_S1.1010.98
116_E120_K1.1000.98
46_D107_R1.1000.98
110_R141_R1.0960.98
226_V239_L1.0950.98
226_V240_A1.0920.98
181_E219_H1.0860.98
46_D74_S1.0840.98
193_K222_D1.0780.98
180_I216_F1.0760.98
133_L147_F1.0680.98
25_P29_V1.0670.98
84_I180_I1.0620.98
26_E30_H1.0590.98
154_A165_L1.0510.98
108_N131_Q1.0490.98
141_R161_F1.0470.98
14_S265_L1.0320.97
148_L154_A1.0300.97
196_L213_V1.0270.97
24_T28_L1.0230.97
41_A70_G1.0150.97
200_G239_L1.0150.97
57_E61_S1.0140.97
237_T241_A1.0140.97
82_I202_Y1.0080.97
55_R59_S1.0080.97
125_G130_A1.0030.97
99_F182_Q0.9990.97
99_F102_Q0.9970.97
10_Y39_T0.9940.97
215_H218_E0.9930.97
73_I100_L0.9820.97
17_T24_T0.9670.96
39_T68_I0.9660.96
128_E131_Q0.9600.96
123_I148_L0.9560.96
10_Y275_V0.9540.96
25_P57_E0.9490.96
224_M239_L0.9440.96
268_K272_P0.9430.96
95_L98_E0.9350.95
125_G128_E0.9340.95
121_A170_T0.9330.95
106_R176_Q0.9250.95
223_A249_W0.9220.95
86_G89_I0.9220.95
123_I153_K0.9110.95
29_V54_A0.9110.95
99_F178_C0.9100.95
118_L171_G0.9050.95
148_L153_K0.9000.94
167_R172_Y0.8980.94
226_V243_A0.8980.94
233_P237_T0.8960.94
117_R171_G0.8930.94
141_R145_A0.8920.94
23_L27_A0.8920.94
117_R120_K0.8880.94
244_R274_G0.8880.94
58_I62_G0.8880.94
264_E267_R0.8860.94
125_G147_F0.8820.94
141_R165_L0.8790.94
31_R256_F0.8790.94
68_I88_N0.8790.94
226_V236_R0.8780.94
75_T81_E0.8770.94
107_R110_R0.8760.94
193_K249_W0.8740.93
142_G145_A0.8740.93
215_H219_H0.8730.93
51_I91_I0.8700.93
93_H190_S0.8630.93
115_A125_G0.8600.93
29_V57_E0.8580.93
238_Q242_L0.8510.93
51_I55_R0.8470.92
85_V223_A0.8460.92
55_R58_I0.8450.92
26_E57_E0.8440.92
110_R114_I0.8400.92
87_L195_V0.8390.92
33_V60_R0.8390.92
52_A56_E0.8380.92
201_R230_Q0.8300.92
84_I194_A0.8280.91
18_A53_P0.8270.91
56_E60_R0.8260.91
69_P91_I0.8230.91
149_V156_S0.8230.91
159_D163_K0.8210.91
115_A130_A0.8170.91
127_L131_Q0.8150.91
229_C263_I0.8100.91
69_P89_I0.8080.90
75_T84_I0.8030.90
238_Q241_A0.8020.90
71_V89_I0.7980.90
110_R145_A0.7970.90
111_A127_L0.7950.90
30_H33_V0.7950.90
214_A218_E0.7920.90
270_W275_V0.7920.90
109_Q112_Q0.7880.89
108_N112_Q0.7880.89
42_I67_L0.7880.89
270_W274_G0.7840.89
41_A51_I0.7830.89
272_P275_V0.7640.88
78_E215_H0.7610.88
110_R140_T0.7600.88
45_H257_H0.7580.87
149_V157_M0.7580.87
109_Q113_L0.7570.87
127_L130_A0.7540.87
75_T180_I0.7540.87
196_L221_G0.7510.87
54_A58_I0.7510.87
271_L275_V0.7450.87
161_F165_L0.7450.87
146_R150_E0.7370.86
132_R150_E0.7350.86
231_Q236_R0.7350.86
114_I141_R0.7290.85
52_A55_R0.7260.85
29_V58_I0.7260.85
96_M100_L0.7250.85
110_R143_H0.7240.85
75_T103_Q0.7220.85
263_I268_K0.7160.84
110_R142_G0.7140.84
145_A161_F0.7110.84
18_A49_A0.7110.84
29_V36_R0.7000.83
262_W267_R0.6990.83
86_G183_A0.6990.83
184_I188_H0.6960.83
228_Q236_R0.6950.83
95_L190_S0.6910.82
249_W274_G0.6890.82
118_L123_I0.6880.82
50_A57_E0.6860.82
218_E246_H0.6860.82
28_L265_L0.6850.82
46_D110_R0.6850.82
124_P151_C0.6840.81
37_V65_L0.6790.81
114_I165_L0.6790.81
214_A245_Q0.6790.81
193_K278_V0.6740.81
244_R250_A0.6730.80
102_Q106_R0.6710.80
186_V190_S0.6700.80
90_D97_C0.6700.80
205_S239_L0.6700.80
29_V67_L0.6670.80
149_V154_A0.6660.80
117_R121_A0.6650.80
83_H198_H0.6620.79
144_F171_G0.6610.79
38_G66_N0.6610.79
271_L274_G0.6600.79
88_N193_K0.6570.79
85_V195_V0.6540.79
46_D143_H0.6540.79
96_M186_V0.6510.78
76_V177_W0.6470.78
234_N237_T0.6460.78
58_I61_S0.6450.78
214_A242_L0.6410.77
226_V231_Q0.6400.77
241_A244_R0.6390.77
15_H19_S0.6340.76
224_M242_L0.6310.76
141_R160_V0.6310.76
127_L139_V0.6280.76
198_H257_H0.6230.75
188_H193_K0.6230.75
235_E238_Q0.6230.75
49_A104_T0.6220.75
229_C268_K0.6180.75
116_E119_E0.6170.74
229_C260_C0.6150.74
133_L146_R0.6150.74
139_V144_F0.6120.74
154_A164_Y0.6050.73
110_R165_L0.6050.73
85_V228_Q0.6040.73
130_A147_F0.5990.72
45_H255_D0.5980.72
13_H19_S0.5980.72
185_D219_H0.5960.72
18_A25_P0.5950.72
236_R268_K0.5950.72
274_G277_G0.5940.72
213_V248_L0.5940.72
110_R160_V0.5930.72
156_S162_K0.5930.72
187_I190_S0.5880.71
89_I96_M0.5870.71
48_T51_I0.5850.70
119_E126_A0.5840.70
29_V65_L0.5830.70
9_I37_V0.5830.70
142_G161_F0.5820.70
130_A139_V0.5790.70
109_Q237_T0.5780.70
107_R141_R0.5770.69
163_K170_T0.5750.69
117_R173_V0.5740.69
272_P277_G0.5710.69
66_N88_N0.5710.69
118_L144_F0.5700.69
145_A160_V0.5690.68
62_G65_L0.5680.68
205_S208_W0.5680.68
92_T97_C0.5680.68
148_L165_L0.5670.68
247_H250_A0.5670.68
31_R265_L0.5660.68
122_Q263_I0.5650.68
232_S236_R0.5630.68
41_A68_I0.5600.67
186_V189_H0.5600.67
147_F153_K0.5590.67
184_I216_F0.5590.67
122_Q231_Q0.5590.67
126_A147_F0.5580.67
84_I196_L0.5560.67
78_E211_R0.5560.67
11_D14_S0.5510.66
121_A169_K0.5510.66
236_R240_A0.5500.66
130_A171_G0.5490.66
130_A133_L0.5450.65
41_A87_L0.5440.65
105_E108_N0.5440.65
71_V183_A0.5440.65
98_E102_Q0.5440.65
140_T161_F0.5410.65
42_I51_I0.5410.65
222_D249_W0.5400.64
129_G133_L0.5390.64
54_A62_G0.5390.64
97_C101_A0.5370.64
126_A130_A0.5360.64
69_P88_N0.5330.63
110_R173_V0.5330.63
84_I179_T0.5330.63
159_D162_K0.5310.63
74_S83_H0.5290.63
18_A47_T0.5260.62
15_H20_D0.5250.62
83_H197_A0.5250.62
223_A278_V0.5250.62
192_G195_V0.5240.62
61_S65_L0.5240.62
213_V242_L0.5230.62
32_A37_V0.5230.62
117_R174_P0.5220.62
16_T41_A0.5210.62
185_D188_H0.5190.61
20_D45_H0.5180.61
184_I220_H0.5170.61
140_T145_A0.5170.61
145_A165_L0.5150.61
80_H167_R0.5110.60
93_H189_H0.5090.60
178_C186_V0.5090.60
20_D257_H0.5080.60
98_E101_A0.5080.60
229_C267_R0.5070.60
148_L160_V0.5070.60
83_H118_L0.5060.59
29_V42_I0.5060.59
47_T50_A0.5060.59
108_N127_L0.5050.59
252_Q258_Q0.5020.59
20_D198_H0.5010.59
196_L207_K0.5000.59
22_C259_P0.5000.59
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2yb1A 1 0.9556 100 0.338 Contact Map
3o0fA 1 0.9659 100 0.344 Contact Map
3e38A 4 0.6997 100 0.646 Contact Map
2anuA 5 0.6519 100 0.662 Contact Map
1m65A 3 0.7133 100 0.669 Contact Map
4gc3A 1 0.7406 100 0.675 Contact Map
3qy7A 1 0.7167 100 0.686 Contact Map
2yxoA 3 0.7645 100 0.688 Contact Map
2wjeA 1 0.7304 100 0.692 Contact Map
2w9mA 1 0.7304 99.9 0.719 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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