GREMLIN Database
YLBH - Putative uncharacterized protein YlbH
UniProt: P77759 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG14327
Length: 236 (194)
Sequences: 460 (423)
Seq/√Len: 30.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
51_Y56_Y4.8961.00
18_D22_N4.3911.00
41_Q52_N3.4551.00
15_G18_D2.9541.00
69_P94_L2.9351.00
41_Q53_R2.7011.00
42_Q52_N2.4360.99
39_P52_N2.3970.99
52_N64_Y2.3550.99
6_D10_N2.3450.99
13_W52_N2.3160.99
46_E56_Y2.2870.99
41_Q64_Y2.2540.99
52_N72_L2.2510.99
41_Q72_L2.2470.99
37_R50_Y2.1650.98
52_N74_G2.1220.98
15_G52_N2.0660.98
49_L65_I2.0390.97
13_W41_Q2.0110.97
34_Q64_Y1.9410.97
37_R42_Q1.9140.96
18_D38_L1.9090.96
70_I74_G1.8630.96
15_G24_L1.8620.96
39_P64_Y1.8530.96
52_N83_L1.8500.95
36_Y42_Q1.8350.95
15_G39_P1.8340.95
53_R92_L1.8340.95
13_W72_L1.8310.95
81_Y85_P1.8230.95
41_Q46_E1.8170.95
39_P72_L1.8020.95
41_Q50_Y1.7800.94
34_Q43_Y1.7440.94
39_P50_Y1.7370.94
15_G34_Q1.7100.93
136_F143_R1.6920.93
7_A10_N1.6890.93
19_E34_Q1.6780.92
39_P42_Q1.6540.92
9_G58_D1.6100.91
62_G69_P1.5800.90
13_W42_Q1.5190.88
67_Q79_Y1.4660.86
38_L78_L1.4600.86
13_W39_P1.4570.86
58_D81_Y1.4320.85
34_Q84_N1.4230.84
41_Q92_L1.4050.84
53_R64_Y1.4010.83
17_Y64_Y1.3900.83
46_E51_Y1.3320.80
38_L81_Y1.3120.79
54_N71_G1.2890.78
15_G50_Y1.2870.78
42_Q50_Y1.2640.77
41_Q51_Y1.2590.76
15_G38_L1.2590.76
37_R52_N1.2480.76
63_R77_S1.2430.75
18_D43_Y1.2120.73
36_Y52_N1.1980.73
13_W67_Q1.1840.72
36_Y39_P1.1520.69
5_M11_I1.1440.69
23_Q29_P1.1400.69
12_A15_G1.1320.68
20_W53_R1.1260.68
36_Y41_Q1.1200.67
19_E42_Q1.1160.67
38_L85_P1.1130.67
72_L94_L1.1110.67
15_G41_Q1.1090.66
19_E43_Y1.1010.66
64_Y82_P1.0800.64
68_D93_G1.0780.64
41_Q74_G1.0770.64
17_Y24_L1.0720.64
41_Q94_L1.0630.63
36_Y50_Y1.0600.63
39_P43_Y1.0590.63
41_Q56_Y1.0550.63
44_D56_Y1.0470.62
44_D51_Y1.0460.62
5_M17_Y1.0450.62
36_Y51_Y1.0410.61
101_L105_K1.0400.61
141_F156_A1.0390.61
36_Y54_N1.0370.61
22_N52_N1.0360.61
43_Y50_Y1.0340.61
69_P92_L1.0240.60
41_Q70_I1.0190.60
13_W74_G1.0030.59
9_G48_G1.0000.58
64_Y72_L0.9940.58
99_V106_D0.9870.57
67_Q78_L0.9750.56
41_Q69_P0.9740.56
43_Y51_Y0.9620.55
13_W53_R0.9600.55
13_W34_Q0.9520.55
104_R108_L0.9360.53
52_N67_Q0.9330.53
20_W25_N0.9290.53
99_V103_R0.9280.53
155_S167_D0.9240.52
64_Y77_S0.9200.52
16_E36_Y0.9170.52
39_P71_G0.9140.52
20_W29_P0.9130.51
19_E24_L0.9120.51
50_Y83_L0.9110.51
54_N94_L0.9070.51
54_N92_L0.9030.51
193_K196_A0.9030.51
18_D52_N0.8980.50
13_W50_Y0.8860.49
164_E180_V0.8730.48
12_A58_D0.8630.47
17_Y86_V0.8610.47
40_G53_R0.8600.47
128_N131_G0.8570.47
16_E25_N0.8570.47
7_A14_S0.8560.47
62_G79_Y0.8500.46
14_S18_D0.8470.46
57_Y62_G0.8450.46
104_R107_Q0.8440.46
48_G59_P0.8430.46
34_Q50_Y0.8390.46
35_P39_P0.8380.45
42_Q53_R0.8340.45
37_R78_L0.8320.45
15_G64_Y0.8310.45
143_R173_F0.8280.45
36_Y66_T0.8250.44
67_Q70_I0.8210.44
116_I123_D0.8180.44
18_D64_Y0.8150.44
42_Q72_L0.8080.43
35_P42_Q0.8070.43
4_L34_Q0.8060.43
34_Q52_N0.8000.43
8_D47_S0.8000.43
10_N49_L0.7970.42
72_L75_G0.7930.42
140_A159_L0.7930.42
37_R51_Y0.7900.42
18_D23_Q0.7830.41
4_L58_D0.7810.41
5_M63_R0.7690.40
53_R94_L0.7690.40
38_L52_N0.7680.40
34_Q66_T0.7640.40
40_G51_Y0.7540.39
64_Y94_L0.7500.39
103_R106_D0.7470.38
70_I94_L0.7470.38
37_R47_S0.7450.38
118_S131_G0.7410.38
36_Y67_Q0.7410.38
52_N71_G0.7400.38
118_S121_Y0.7390.38
52_N78_L0.7370.38
13_W35_P0.7320.37
23_Q26_E0.7320.37
70_I78_L0.7250.37
137_H147_L0.7250.37
15_G22_N0.7220.37
43_Y52_N0.7190.36
127_L132_T0.7140.36
26_E29_P0.7130.36
71_G78_L0.7010.35
36_Y86_V0.7010.35
80_A83_L0.6980.35
23_Q63_R0.6970.35
191_N194_D0.6950.35
55_R68_D0.6950.35
67_Q88_G0.6900.34
52_N92_L0.6900.34
53_R56_Y0.6880.34
5_M85_P0.6840.34
18_D24_L0.6820.34
28_N31_H0.6750.33
4_L36_Y0.6710.33
39_P83_L0.6670.33
134_Q139_M0.6660.33
19_E22_N0.6640.32
41_Q83_L0.6640.32
36_Y56_Y0.6610.32
13_W64_Y0.6610.32
43_Y56_Y0.6540.32
34_Q38_L0.6510.31
16_E45_K0.6500.31
160_G164_E0.6480.31
143_R174_G0.6470.31
40_G81_Y0.6470.31
69_P78_L0.6460.31
53_R62_G0.6450.31
22_N54_N0.6430.31
13_W94_L0.6420.31
5_M84_N0.6420.31
35_P46_E0.6410.31
52_N70_I0.6410.31
49_L71_G0.6380.31
20_W56_Y0.6340.30
13_W82_P0.6330.30
15_G37_R0.6260.30
26_E45_K0.6250.30
33_H65_I0.6230.30
18_D81_Y0.6210.29
53_R58_D0.6190.29
12_A40_G0.6180.29
20_W39_P0.6170.29
46_E50_Y0.6130.29
58_D61_Q0.6130.29
34_Q58_D0.6110.29
177_G187_M0.6040.28
42_Q64_Y0.6030.28
55_R90_D0.5960.28
55_R93_G0.5950.28
194_D198_N0.5930.28
5_M64_Y0.5930.28
47_S80_A0.5830.27
36_Y72_L0.5810.27
39_P67_Q0.5800.27
15_G19_E0.5790.27
53_R63_R0.5790.27
81_Y91_P0.5740.26
14_S58_D0.5740.26
44_D50_Y0.5720.26
73_E94_L0.5710.26
50_Y82_P0.5710.26
15_G66_T0.5700.26
64_Y70_I0.5690.26
15_G83_L0.5670.26
71_G75_G0.5670.26
20_W82_P0.5660.26
24_L42_Q0.5650.26
54_N67_Q0.5650.26
88_G92_L0.5630.26
37_R75_G0.5630.26
35_P53_R0.5630.26
17_Y23_Q0.5610.26
22_N43_Y0.5600.26
53_R88_G0.5600.26
83_L88_G0.5590.25
37_R49_L0.5590.25
11_I26_E0.5570.25
42_Q76_W0.5500.25
103_R107_Q0.5470.25
18_D41_Q0.5440.25
171_N195_L0.5440.25
41_Q77_S0.5440.25
17_Y39_P0.5430.25
16_E60_L0.5420.24
74_G94_L0.5380.24
17_Y34_Q0.5380.24
50_Y56_Y0.5360.24
39_P88_G0.5310.24
34_Q41_Q0.5260.24
162_E166_R0.5260.24
36_Y61_Q0.5250.23
72_L76_W0.5240.23
21_G90_D0.5240.23
39_P70_I0.5220.23
13_W83_L0.5210.23
36_Y53_R0.5210.23
191_N195_L0.5200.23
95_S102_I0.5190.23
39_P81_Y0.5190.23
7_A65_I0.5190.23
170_L191_N0.5180.23
179_K184_H0.5160.23
49_L69_P0.5130.23
124_M135_F0.5130.23
56_Y61_Q0.5120.23
30_H33_H0.5110.23
23_Q35_P0.5100.23
37_R43_Y0.5080.23
5_M67_Q0.5070.22
121_Y125_K0.5050.22
19_E25_N0.5040.22
34_Q37_R0.5030.22
33_H81_Y0.5020.22
150_A164_E0.5000.22
24_L39_P0.5000.22
120_T124_M0.5000.22
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4iglB 1 0.3941 100 0.355 Contact Map
4o9xA 1 0.3941 100 0.362 Contact Map
2mxwA 1 0.3602 50.7 0.931 Contact Map
3wknE 1 0.161 45.6 0.933 Contact Map
4iglA 1 0.3771 11.7 0.95 Contact Map
2y3cA 1 0.3136 9.6 0.952 Contact Map
4hrvA 2 0.1653 6.8 0.955 Contact Map
4cgkA 3 0.2712 5.5 0.957 Contact Map
4pk1A 1 0.3729 4.9 0.958 Contact Map
1yu0A 3 0.2966 4.3 0.959 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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