GREMLIN Database
QUEC - 7-cyano-7-deazaguanine synthase
UniProt: P77756 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13252
Length: 231 (209)
Sequences: 2276 (1309)
Seq/√Len: 90.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
171_L177_K3.2771.00
118_A157_E3.2521.00
32_T43_I3.0221.00
34_D40_R2.9491.00
34_D62_D2.9041.00
167_E170_A2.7741.00
3_R27_E2.6791.00
208_N212_H2.6771.00
141_A145_A2.6551.00
52_K184_E2.5331.00
136_D140_K2.5331.00
32_T58_H2.5191.00
73_S93_N2.4941.00
16_T182_R2.3961.00
20_Q171_L2.3791.00
123_V139_V2.3471.00
124_C168_T2.3031.00
41_A186_L2.2991.00
108_A146_V2.2911.00
172_A182_R2.2781.00
173_D215_A2.0881.00
207_A211_N2.0301.00
83_D190_N2.0161.00
30_C55_A1.9551.00
59_K110_Y1.9301.00
83_D199_H1.9171.00
5_V116_A1.9161.00
192_F195_D1.9111.00
110_Y114_V1.8991.00
164_D167_E1.8731.00
19_V53_L1.7711.00
140_K144_H1.7281.00
15_T49_L1.7261.00
48_E184_E1.7221.00
29_H110_Y1.6921.00
47_R51_L1.6371.00
33_F103_F1.6321.00
47_R60_V1.6131.00
196_G207_A1.5711.00
29_H114_V1.5631.00
12_Q169_W1.5001.00
102_L109_I1.4991.00
101_I138_F1.4961.00
166_A212_H1.4611.00
30_C50_A1.4210.99
63_V106_L1.4170.99
143_N155_R1.4130.99
200_C203_C1.3730.99
17_C120_I1.3720.99
139_V158_T1.3680.99
145_A149_G1.3640.99
8_F30_C1.3230.99
41_A191_G1.3200.99
210_L218_P1.3200.99
64_T67_N1.3120.99
59_K68_E1.3030.99
197_C203_C1.2930.99
108_A145_A1.2920.99
24_Q120_I1.2890.99
163_I171_L1.2860.99
23_Q171_L1.2840.99
57_A114_V1.2790.99
23_Q177_K1.2730.99
29_H57_A1.2620.99
18_L28_V1.2580.98
142_L145_A1.2540.98
197_C200_C1.2490.98
208_N211_N1.2480.98
108_A142_L1.2480.98
98_G101_I1.2480.98
20_Q24_Q1.2470.98
147_S153_D1.2410.98
50_A55_A1.2380.98
24_Q157_E1.2310.98
186_L191_G1.2260.98
79_I93_N1.2250.98
173_D213_Y1.2210.98
188_C203_C1.2200.98
118_A155_R1.2150.98
188_C197_C1.2120.98
64_T68_E1.2050.98
188_C200_C1.1970.98
31_V110_Y1.1880.98
101_I149_G1.1840.98
142_L156_F1.1780.98
18_L53_L1.1540.97
158_T161_M1.1500.97
136_D162_W1.1480.97
22_L28_V1.1440.97
20_Q23_Q1.1270.97
3_R116_A1.1230.97
18_L30_C1.1210.97
44_D47_R1.1180.97
85_E204_N1.1090.97
67_N77_D1.1080.97
8_F15_T1.1020.96
143_N147_S1.1010.96
19_V180_L1.0930.96
97_P112_Y1.0850.96
112_Y150_M1.0830.96
26_D120_I1.0730.96
82_P93_N1.0590.96
50_A54_G1.0470.95
20_Q120_I1.0460.95
39_H191_G1.0320.95
98_G109_I1.0220.95
59_K114_V0.9920.94
44_D48_E0.9870.94
70_A76_R0.9820.93
41_A45_V0.9790.93
15_T180_L0.9760.93
131_Y134_C0.9700.93
16_T172_A0.9690.93
94_T131_Y0.9640.93
137_E140_K0.9640.93
210_L214_L0.9600.93
48_E51_L0.9540.92
3_R115_K0.9440.92
6_V28_V0.9420.92
121_T139_V0.9370.92
210_L217_K0.9360.92
59_K69_L0.9320.92
45_V49_L0.9200.91
170_A212_H0.9190.91
46_A58_H0.9130.91
104_L142_L0.9090.90
128_F135_R0.9090.90
199_H204_N0.9060.90
164_D212_H0.9020.90
29_H59_K0.8990.90
101_I145_A0.8920.90
180_L185_T0.8910.90
186_L209_G0.8910.90
172_A210_L0.8900.90
104_L121_T0.8780.89
8_F50_A0.8700.88
169_W213_Y0.8690.88
33_F106_L0.8640.88
141_A144_H0.8630.88
73_S79_I0.8550.88
117_E152_K0.8520.87
97_P152_K0.8490.87
125_E136_D0.8450.87
102_L106_L0.8430.87
46_A50_A0.8400.87
86_P204_N0.8390.87
49_L52_K0.8340.86
185_T206_R0.8340.86
170_A177_K0.8340.86
101_I105_T0.8320.86
83_D191_G0.8270.86
15_T185_T0.8220.85
101_I108_A0.8210.85
48_E52_K0.8210.85
40_R44_D0.8200.85
17_C21_A0.8160.85
120_I157_E0.8150.85
142_L146_V0.8130.85
132_P168_T0.8010.84
127_D134_C0.7980.84
31_V61_L0.7910.83
72_S75_T0.7910.83
71_V76_R0.7900.83
166_A170_A0.7880.83
25_Y118_A0.7880.83
130_G205_L0.7840.83
144_H148_L0.7790.82
187_T202_A0.7770.82
52_K183_N0.7760.82
76_R79_I0.7730.82
32_T39_H0.7700.82
204_N208_N0.7680.81
4_A120_I0.7680.81
92_P130_G0.7650.81
145_A154_I0.7600.81
43_I58_H0.7590.81
61_L106_L0.7550.80
45_V48_E0.7540.80
205_L209_G0.7540.80
17_C160_L0.7510.80
144_H147_S0.7480.80
131_Y189_Y0.7450.79
31_V107_A0.7400.79
117_E157_E0.7390.79
139_V161_M0.7370.79
98_G150_M0.7300.78
138_F142_L0.7280.78
160_L171_L0.7200.77
33_F63_V0.7170.77
65_L106_L0.7110.76
145_A148_L0.7090.76
140_K143_N0.7070.76
207_A216_D0.7040.75
27_E57_A0.7000.75
82_P94_T0.6960.75
81_V190_N0.6940.74
190_N199_H0.6880.74
134_C189_Y0.6860.73
170_A213_Y0.6850.73
144_H155_R0.6850.73
4_A26_D0.6840.73
146_V156_F0.6820.73
104_L139_V0.6800.73
75_T79_I0.6780.73
21_A120_I0.6760.72
121_T158_T0.6710.72
173_D182_R0.6690.72
54_G57_A0.6660.71
32_T46_A0.6660.71
15_T19_V0.6650.71
73_S94_T0.6640.71
41_A192_F0.6640.71
214_L217_K0.6630.71
6_V21_A0.6560.70
17_C20_Q0.6550.70
117_E154_I0.6500.69
127_D135_R0.6480.69
8_F18_L0.6460.69
94_T134_C0.6440.69
34_D43_I0.6410.68
30_C58_H0.6400.68
81_V93_N0.6400.68
141_A148_L0.6380.68
6_V18_L0.6370.68
26_D118_A0.6320.67
98_G149_G0.6310.67
127_D131_Y0.6270.67
41_A44_D0.6250.66
47_R58_H0.6240.66
169_W210_L0.6230.66
163_I167_E0.6220.66
186_L190_N0.6190.66
115_K118_A0.6190.66
119_V156_F0.6180.66
170_A173_D0.6160.65
182_R210_L0.6150.65
91_I128_F0.6090.64
123_V158_T0.6060.64
38_R81_V0.6040.64
138_F148_L0.6010.63
25_Y157_E0.5990.63
119_V154_I0.5990.63
207_A215_A0.5980.63
19_V52_K0.5970.63
95_F130_G0.5930.62
41_A193_K0.5910.62
69_L109_I0.5890.62
43_I60_V0.5890.62
22_L55_A0.5880.62
117_E155_R0.5870.62
166_A209_G0.5870.62
39_H134_C0.5800.61
6_V17_C0.5780.60
39_H127_D0.5780.60
17_C26_D0.5770.60
16_T178_L0.5740.60
5_V110_Y0.5730.60
160_L209_G0.5720.60
96_V189_Y0.5680.59
169_W182_R0.5680.59
71_V113_Q0.5680.59
62_D67_N0.5670.59
143_N153_D0.5670.59
23_Q170_A0.5670.59
48_E216_D0.5650.59
104_L156_F0.5620.58
189_Y202_A0.5610.58
39_H94_T0.5610.58
9_S14_S0.5600.58
70_A79_I0.5580.58
61_L65_L0.5550.57
169_W181_V0.5530.57
87_E90_G0.5500.57
65_L68_E0.5490.57
43_I47_R0.5480.56
179_D183_N0.5470.56
17_C122_G0.5450.56
7_V33_F0.5440.56
33_F60_V0.5430.56
24_Q171_L0.5420.56
85_E88_A0.5420.56
183_N214_L0.5420.56
49_L180_L0.5410.55
89_D215_A0.5410.55
94_T189_Y0.5400.55
18_L55_A0.5380.55
91_I130_G0.5370.55
35_Y99_R0.5370.55
146_V149_G0.5320.54
187_T197_C0.5320.54
86_P89_D0.5310.54
16_T180_L0.5290.54
185_T210_L0.5250.53
186_L192_F0.5250.53
91_I95_F0.5250.53
104_L123_V0.5230.53
97_P133_D0.5230.53
11_G14_S0.5230.53
52_K181_V0.5210.53
45_V186_L0.5200.53
178_L217_K0.5200.53
91_I201_A0.5190.52
201_A205_L0.5180.52
144_H153_D0.5180.52
108_A138_F0.5130.52
16_T64_T0.5070.51
137_E148_L0.5070.51
94_T130_G0.5060.51
138_F145_A0.5030.50
160_L163_I0.5010.50
96_V134_C0.5010.50
74_L96_V0.5010.50
122_G202_A0.5010.50
39_H131_Y0.5000.50
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2pg3A 2 0.9394 100 0.41 Contact Map
3bl5A 3 0.8312 100 0.546 Contact Map
1vl2A 4 0.9004 99.9 0.697 Contact Map
4xfjA 4 0.8961 99.9 0.707 Contact Map
1k92A 4 0.9177 99.9 0.711 Contact Map
3k32A 2 0.8268 99.9 0.72 Contact Map
3rjzA 2 0.7316 99.9 0.723 Contact Map
4nzpA 4 0.8571 99.9 0.724 Contact Map
1korA 4 0.8701 99.9 0.727 Contact Map
3uowA 2 0.8139 99.9 0.73 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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