OMPN - ECOLI - GREMLIN Contacts

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OMPN - Outer membrane protein N

UniProt:	P77747	Sequences: MKSKVLALLIPALLAAGAAHAAEVYNKDGNKLDLYGKVDGLHYFSDNSAKDGDQSYARLGFKGETQINDQLTGYGQWEYNIQANNTESSKNQSWTRLAFAGLKFADYGSFDYGRNYGVMYDIEGWTDMLPEFGGDSYTNADNFMTGRANGVATYRNTDFFGLVNGLNFAVQYQGNNEGASNGQEGTNNGRDVRHENGDGWGLSTTYDLGMGFSAGAAYTSSDRTNDQVNHTAAGGDKADAWTAGLKYDANNIYLATMYSETRNMTPFGDSDYAVANKTQNFEVTAQYQFDFGLRPAVSFLMSKGRDLHAAGGADNPAGVDDKDLVKYADIGATYYFNKNMSTYVDYKINLLDEDDSFYAANGISTDDIVALGLVYQF	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG13375
Length:	377 (326)
Sequences:	5579 (3998)
Seq/√Len:	221.4

ECOLI - OMPN YEDS PHOE OMPC NMPC OMPF

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
35_Y	60_G	3.988	1.00
63_G	75_G	3.620	1.00
299_F	326_K	3.430	1.00
72_T	103_K	3.415	1.00
74_Y	101_G	3.225	1.00
76_Q	99_F	3.162	1.00
293_L	332_A	3.118	1.00
64_E	72_T	3.113	1.00
252_I	287_Y	2.824	1.00
156_N	168_F	2.778	1.00
346_Y	367_D	2.723	1.00
216_A	241_W	2.596	1.00
258_Y	279_Q	2.520	1.00
121_D	153_T	2.493	1.00
40_G	83_A	2.483	1.00
38_V	83_A	2.444	1.00
154_Y	157_T	2.438	1.00
62_K	76_Q	2.351	1.00
74_Y	109_S	2.338	1.00
294_R	335_Y	2.338	1.00
301_M	326_K	2.336	1.00
118_V	171_Q	2.325	1.00
260_E	279_Q	2.250	1.00
336_F	342_T	2.225	1.00
220_S	239_D	2.217	1.00
333_T	341_S	2.192	1.00
168_F	204_T	2.191	1.00
74_Y	111_D	2.184	1.00
214_A	245_L	2.171	1.00
170_V	202_L	2.168	1.00
293_L	334_Y	2.167	1.00
289_F	295_P	2.128	1.00
341_S	374_V	2.110	1.00
16_A	20_H	2.042	1.00
34_L	61_F	2.018	1.00
97_L	116_Y	1.985	1.00
35_Y	78_E	1.978	1.00
151_V	171_Q	1.978	1.00
71_L	102_L	1.951	1.00
118_V	169_A	1.943	1.00
103_K	109_S	1.934	1.00
216_A	243_A	1.923	1.00
114_R	149_N	1.920	1.00
71_L	106_D	1.900	1.00
162_L	167_N	1.896	1.00
167_N	205_T	1.883	1.00
156_N	163_V	1.848	1.00
249_A	254_L	1.840	1.00
35_Y	76_Q	1.820	1.00
84_N	176_N	1.760	1.00
37_K	58_R	1.760	1.00
340_M	375_Y	1.749	1.00
350_L	365_T	1.731	1.00
110_F	152_A	1.684	1.00
39_D	343_Y	1.675	1.00
79_Y	93_S	1.659	1.00
157_T	163_V	1.653	1.00
342_T	373_L	1.633	1.00
218_Y	241_W	1.624	1.00
74_Y	103_K	1.610	1.00
112_Y	152_A	1.605	1.00
220_S	237_K	1.585	1.00
286_Q	294_R	1.567	1.00
35_Y	62_K	1.567	1.00
155_R	169_A	1.565	1.00
295_P	332_A	1.563	1.00
80_N	96_R	1.563	1.00
92_Q	149_N	1.547	1.00
251_N	287_Y	1.535	1.00
341_S	376_Q	1.514	1.00
339_N	375_Y	1.510	1.00
67_I	73_G	1.507	1.00
245_L	256_T	1.504	1.00
58_R	78_E	1.501	1.00
58_R	96_R	1.482	1.00
212_F	247_Y	1.482	1.00
66_Q	70_Q	1.445	1.00
255_A	284_T	1.442	1.00
89_S	95_T	1.437	1.00
246_K	255_A	1.435	1.00
111_D	155_R	1.414	1.00
111_D	153_T	1.398	1.00
34_L	59_L	1.394	1.00
126_T	213_S	1.379	1.00
348_I	365_T	1.369	1.00
78_E	96_R	1.364	1.00
214_A	243_A	1.363	1.00
59_L	79_Y	1.354	1.00
107_Y	154_Y	1.348	1.00
108_G	154_Y	1.344	1.00
111_D	115_N	1.341	1.00
254_L	285_A	1.332	1.00
72_T	105_A	1.331	1.00
208_L	211_G	1.306	1.00
115_N	151_V	1.292	1.00
97_L	115_N	1.290	1.00
257_M	282_E	1.288	1.00
290_D	293_L	1.282	1.00
252_I	285_A	1.270	1.00
173_Q	199_G	1.268	1.00
74_Y	99_F	1.253	1.00
82_Q	87_E	1.250	1.00
148_A	199_G	1.249	1.00
55_S	374_V	1.245	1.00
285_A	297_V	1.243	1.00
65_T	337_N	1.243	1.00
252_I	256_T	1.240	1.00
152_A	174_G	1.236	1.00
246_K	253_Y	1.236	1.00
71_L	107_Y	1.231	1.00
348_I	367_D	1.229	1.00
288_Q	294_R	1.226	1.00
260_E	277_K	1.225	1.00
66_Q	72_T	1.221	1.00
156_N	165_G	1.221	1.00
248_D	251_N	1.220	1.00
299_F	328_A	1.220	1.00
211_G	247_Y	1.202	1.00
76_Q	97_L	1.202	1.00
207_D	213_S	1.198	1.00
241_W	260_E	1.197	1.00
107_Y	110_F	1.197	1.00
292_G	335_Y	1.189	1.00
289_F	293_L	1.184	1.00
172_Y	200_W	1.178	1.00
256_T	281_F	1.175	1.00
298_S	329_D	1.169	1.00
92_Q	95_T	1.168	1.00
73_G	100_A	1.164	1.00
151_V	173_Q	1.161	1.00
41_L	53_D	1.155	1.00
43_Y	370_A	1.152	1.00
212_F	245_L	1.145	1.00
99_F	111_D	1.137	1.00
218_Y	239_D	1.136	1.00
96_R	147_R	1.134	1.00
301_M	324_L	1.125	1.00
296_A	331_G	1.121	1.00
37_K	376_Q	1.119	1.00
213_S	246_K	1.116	1.00
119_M	217_A	1.112	1.00
122_I	215_G	1.110	1.00
171_Q	201_G	1.108	1.00
64_E	74_Y	1.105	1.00
303_K	324_L	1.096	1.00
344_V	371_L	1.095	1.00
343_Y	372_G	1.093	1.00
248_D	253_Y	1.093	1.00
297_V	328_A	1.092	1.00
38_V	81_I	1.089	1.00
90_K	95_T	1.078	1.00
17_G	20_H	1.074	1.00
109_S	153_T	1.073	1.00
71_L	105_A	1.071	1.00
10_I	13_L	1.060	1.00
70_Q	105_A	1.052	1.00
4_K	8_L	1.050	1.00
41_L	370_A	1.048	1.00
256_T	283_V	1.046	1.00
153_T	171_Q	1.043	1.00
170_V	200_W	1.036	1.00
331_G	345_D	1.035	1.00
328_A	348_I	1.030	1.00
32_L	75_G	1.029	1.00
166_L	204_T	1.027	1.00
344_V	369_V	1.026	1.00
242_T	259_S	1.025	1.00
280_N	302_S	1.021	1.00
351_L	363_I	1.021	1.00
73_G	102_L	1.019	1.00
77_W	94_W	1.017	1.00
296_A	333_T	1.010	1.00
148_A	151_V	1.006	1.00
65_T	339_N	1.002	1.00
64_E	103_K	1.001	1.00
279_Q	305_R	1.000	1.00
46_D	367_D	0.997	1.00
166_L	208_L	0.992	1.00
58_R	147_R	0.987	1.00
77_W	98_A	0.983	1.00
325_V	351_L	0.982	1.00
157_T	162_L	0.977	1.00
128_M	286_Q	0.971	1.00
325_V	349_N	0.970	1.00
340_M	373_L	0.965	1.00
89_S	92_Q	0.959	1.00
169_A	203_S	0.958	1.00
129_L	331_G	0.957	1.00
40_G	84_N	0.953	1.00
248_D	287_Y	0.946	1.00
57_A	81_I	0.942	1.00
31_K	64_E	0.941	1.00
119_M	240_A	0.940	1.00
37_K	374_V	0.936	1.00
203_S	217_A	0.936	1.00
167_N	207_D	0.935	1.00
177_E	180_S	0.929	1.00
248_D	288_Q	0.926	1.00
289_F	332_A	0.923	0.99
297_V	330_I	0.921	0.99
324_L	352_D	0.919	0.99
117_G	148_A	0.918	0.99
284_T	298_S	0.916	0.99
115_N	153_T	0.915	0.99
119_M	242_T	0.909	0.99
11_P	14_L	0.903	0.99
54_Q	341_S	0.902	0.99
60_G	78_E	0.901	0.99
129_L	296_A	0.896	0.99
11_P	16_A	0.894	0.99
251_N	288_Q	0.892	0.99
6_L	10_I	0.888	0.99
170_V	204_T	0.881	0.99
335_Y	341_S	0.876	0.99
253_Y	286_Q	0.875	0.99
118_V	217_A	0.874	0.99
68_N	337_N	0.871	0.99
329_D	347_K	0.869	0.99
86_T	94_W	0.868	0.99
80_N	95_T	0.867	0.99
253_Y	288_Q	0.863	0.99
346_Y	369_V	0.857	0.99
336_F	340_M	0.857	0.99
128_M	284_T	0.848	0.99
173_Q	176_N	0.848	0.99
118_V	203_S	0.848	0.99
55_S	341_S	0.846	0.99
10_I	14_L	0.846	0.99
176_N	179_A	0.845	0.99
153_T	169_A	0.842	0.99
103_K	106_D	0.842	0.99
122_I	155_R	0.839	0.99
3_S	6_L	0.838	0.99
39_D	52_G	0.836	0.99
282_E	300_L	0.836	0.99
5_V	8_L	0.833	0.99
279_Q	303_K	0.832	0.99
33_D	62_K	0.830	0.99
121_D	155_R	0.826	0.99
7_A	10_I	0.824	0.99
118_V	201_G	0.821	0.99
30_N	65_T	0.821	0.99
65_T	340_M	0.818	0.99
47_N	366_D	0.814	0.99
9_L	12_A	0.808	0.99
82_Q	85_N	0.806	0.99
215_G	244_G	0.804	0.99
238_A	261_T	0.795	0.98
278_T	302_S	0.793	0.98
14_L	18_A	0.792	0.98
55_S	376_Q	0.788	0.98
128_M	298_S	0.788	0.98
281_F	303_K	0.786	0.98
8_L	11_P	0.786	0.98
116_Y	120_Y	0.786	0.98
132_F	135_D	0.784	0.98
351_L	355_D	0.776	0.98
41_L	55_S	0.776	0.98
178_G	194_H	0.775	0.98
126_T	244_G	0.768	0.98
150_G	176_N	0.766	0.98
99_F	115_N	0.761	0.98
333_T	374_V	0.760	0.98
280_N	300_L	0.758	0.98
292_G	332_A	0.757	0.98
255_A	286_Q	0.755	0.98
16_A	19_A	0.753	0.98
241_W	279_Q	0.753	0.98
201_G	219_T	0.752	0.98
155_R	167_N	0.751	0.98
262_R	277_K	0.751	0.98
294_R	333_T	0.749	0.98
4_K	7_A	0.748	0.98
65_T	68_N	0.745	0.98
128_M	282_E	0.743	0.98
114_R	147_R	0.742	0.98
148_A	171_Q	0.742	0.98
330_I	346_Y	0.741	0.98
286_Q	296_A	0.737	0.98
371_L	375_Y	0.735	0.97
109_S	155_R	0.733	0.97
59_L	93_S	0.731	0.97
129_L	298_S	0.727	0.97
122_I	203_S	0.724	0.97
138_T	141_D	0.722	0.97
125_W	205_T	0.710	0.97
350_L	364_S	0.709	0.97
60_G	96_R	0.708	0.97
324_L	350_L	0.706	0.97
70_Q	106_D	0.702	0.97
249_A	252_I	0.700	0.97
9_L	13_L	0.693	0.96
162_L	207_D	0.693	0.96
157_T	165_G	0.692	0.96
261_T	278_T	0.692	0.96
168_F	202_L	0.691	0.96
80_N	94_W	0.690	0.96
58_R	80_N	0.689	0.96
7_A	14_L	0.688	0.96
332_A	344_V	0.687	0.96
282_E	298_S	0.685	0.96
291_F	334_Y	0.683	0.96
129_L	135_D	0.683	0.96
66_Q	69_D	0.681	0.96
127_D	132_F	0.679	0.96
156_N	170_V	0.679	0.96
105_A	154_Y	0.679	0.96
200_W	204_T	0.678	0.96
345_D	370_A	0.673	0.96
179_A	194_H	0.672	0.96
226_D	231_T	0.663	0.95
65_T	375_Y	0.662	0.95
84_N	150_G	0.660	0.95
156_N	164_N	0.660	0.95
195_E	222_D	0.659	0.95
175_N	180_S	0.659	0.95
172_Y	198_D	0.658	0.95
372_G	377_F	0.656	0.95
123_E	242_T	0.652	0.95
126_T	255_A	0.652	0.95
45_S	368_I	0.649	0.95
355_D	363_I	0.648	0.95
117_G	201_G	0.647	0.95
30_N	66_Q	0.646	0.95
209_G	247_Y	0.645	0.95
116_Y	147_R	0.644	0.95
5_V	9_L	0.644	0.95
119_M	201_G	0.643	0.95
105_A	110_F	0.642	0.95
277_K	303_K	0.638	0.94
5_V	17_G	0.638	0.94
211_G	249_A	0.638	0.94
6_L	9_L	0.636	0.94
148_A	173_Q	0.635	0.94
65_T	73_G	0.634	0.94
112_Y	115_N	0.633	0.94
258_Y	281_F	0.632	0.94
90_K	93_S	0.630	0.94
43_Y	368_I	0.630	0.94
80_N	147_R	0.630	0.94
156_N	162_L	0.630	0.94
243_A	258_Y	0.628	0.94
107_Y	157_T	0.626	0.94
241_W	258_Y	0.624	0.94
12_A	20_H	0.622	0.94
157_T	167_N	0.620	0.93
238_A	263_N	0.619	0.93
59_L	81_I	0.617	0.93
204_T	216_A	0.617	0.93
165_G	206_Y	0.615	0.93
6_L	13_L	0.614	0.93
329_D	345_D	0.613	0.93
7_A	11_P	0.612	0.93
6_L	14_L	0.609	0.93
46_D	363_I	0.606	0.93
4_K	14_L	0.605	0.93
288_Q	292_G	0.604	0.93
8_L	12_A	0.604	0.93
328_A	365_T	0.600	0.92
108_G	157_T	0.599	0.92
4_K	9_L	0.599	0.92
29_G	33_D	0.599	0.92
231_T	234_G	0.599	0.92
211_G	248_D	0.599	0.92
79_Y	94_W	0.598	0.92
35_Y	96_R	0.597	0.92
53_D	370_A	0.594	0.92
277_K	305_R	0.593	0.92
199_G	221_S	0.590	0.92
300_L	327_Y	0.589	0.92
178_G	195_E	0.589	0.92
117_G	219_T	0.586	0.91
204_T	209_G	0.586	0.91
337_N	340_M	0.585	0.91
222_D	237_K	0.585	0.91
85_N	94_W	0.583	0.91
67_I	340_M	0.583	0.91
14_L	17_G	0.583	0.91
131_E	135_D	0.581	0.91
51_D	83_A	0.575	0.91
251_N	289_F	0.574	0.91
91_N	95_T	0.572	0.90
29_G	66_Q	0.569	0.90
3_S	7_A	0.567	0.90
333_T	376_Q	0.566	0.90
180_S	194_H	0.566	0.90
244_G	257_M	0.566	0.90
304_G	323_D	0.563	0.90
100_A	337_N	0.563	0.90
41_L	343_Y	0.562	0.90
43_Y	347_K	0.562	0.90
163_V	167_N	0.562	0.90
288_Q	335_Y	0.561	0.90
205_T	215_G	0.561	0.90
133_G	136_S	0.561	0.90
327_Y	349_N	0.560	0.89
67_I	70_Q	0.557	0.89
289_F	292_G	0.556	0.89
198_D	222_D	0.555	0.89
101_G	111_D	0.555	0.89
6_L	12_A	0.555	0.89
44_F	367_D	0.554	0.89
122_I	169_A	0.554	0.89
281_F	285_A	0.552	0.89
342_T	372_G	0.551	0.89
32_L	65_T	0.551	0.89
257_M	284_T	0.551	0.89
127_D	142_N	0.550	0.89
302_S	325_V	0.550	0.89
208_L	212_F	0.549	0.89
3_S	8_L	0.548	0.88
57_A	83_A	0.548	0.88
44_F	348_I	0.547	0.88
171_Q	199_G	0.547	0.88
79_Y	98_A	0.547	0.88
264_M	275_A	0.546	0.88
32_L	63_G	0.545	0.88
29_G	32_L	0.545	0.88
306_D	323_D	0.542	0.88
330_I	344_V	0.541	0.88
6_L	11_P	0.540	0.88
263_N	266_P	0.538	0.88
281_F	301_M	0.537	0.87
166_L	206_Y	0.536	0.87
326_K	352_D	0.535	0.87
56_Y	130_P	0.534	0.87
154_Y	168_F	0.534	0.87
209_G	212_F	0.534	0.87
40_G	43_Y	0.533	0.87
123_E	257_M	0.533	0.87
263_N	278_T	0.533	0.87
119_M	219_T	0.533	0.87
177_E	196_N	0.533	0.87
348_I	369_V	0.531	0.87
93_S	98_A	0.531	0.87
40_G	44_F	0.530	0.87
56_Y	116_Y	0.530	0.87
53_D	56_Y	0.529	0.87
44_F	369_V	0.528	0.87
10_I	106_D	0.528	0.87
154_Y	163_V	0.527	0.86
132_F	136_S	0.526	0.86
351_L	354_D	0.525	0.86
56_Y	80_N	0.524	0.86
213_S	248_D	0.524	0.86
106_D	110_F	0.524	0.86
43_Y	48_S	0.524	0.86
58_R	97_L	0.524	0.86
95_T	98_A	0.524	0.86
4_K	11_P	0.523	0.86
40_G	57_A	0.522	0.86
31_K	63_G	0.520	0.86
240_A	261_T	0.520	0.86
124_G	127_D	0.519	0.86
37_K	55_S	0.519	0.86
127_D	282_E	0.519	0.86
139_N	142_N	0.519	0.86
175_N	179_A	0.517	0.85
74_Y	153_T	0.516	0.85
43_Y	50_K	0.516	0.85
156_N	166_L	0.516	0.85
262_R	279_Q	0.514	0.85
40_G	370_A	0.513	0.85
75_G	94_W	0.513	0.85
337_N	375_Y	0.513	0.85
208_L	245_L	0.513	0.85
303_K	322_K	0.512	0.85
127_D	135_D	0.512	0.85
102_L	105_A	0.512	0.85
17_G	105_A	0.512	0.85
194_H	198_D	0.511	0.85
176_N	180_S	0.510	0.85
347_K	368_I	0.510	0.85
355_D	359_A	0.510	0.85
259_S	278_T	0.508	0.84
208_L	216_A	0.507	0.84
62_K	338_K	0.507	0.84
169_A	205_T	0.507	0.84
137_Y	140_A	0.505	0.84
291_F	295_P	0.505	0.84
52_G	57_A	0.505	0.84
208_L	214_A	0.504	0.84
134_G	327_Y	0.503	0.84
65_T	75_G	0.503	0.84
199_G	219_T	0.503	0.84
259_S	280_N	0.502	0.84
54_Q	333_T	0.502	0.84
13_L	18_A	0.501	0.84
306_D	352_D	0.500	0.84

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1phoA	3	0.8621	100	0.276	Contact Map
2j1nA	3	0.8966	100	0.278	Contact Map
3nsgA	3	0.8753	100	0.283	Contact Map
2zfgA	3	0.8621	100	0.294	Contact Map
2fgqX	3	0.809	100	0.304	Contact Map
3vy8X	3	0.8382	100	0.327	Contact Map
3wi5A	3	0.7905	100	0.367	Contact Map
2porA	3	0.7533	100	0.401	Contact Map
3prnA	3	0.7188	100	0.41	Contact Map
2o4vA	3	0.8727	99.4	0.787	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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