GREMLIN Database
OMPN - Outer membrane protein N
UniProt: P77747 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13375
Length: 377 (326)
Sequences: 5579 (3998)
Seq/√Len: 221.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
35_Y60_G3.9881.00
63_G75_G3.6201.00
299_F326_K3.4301.00
72_T103_K3.4151.00
74_Y101_G3.2251.00
76_Q99_F3.1621.00
293_L332_A3.1181.00
64_E72_T3.1131.00
252_I287_Y2.8241.00
156_N168_F2.7781.00
346_Y367_D2.7231.00
216_A241_W2.5961.00
258_Y279_Q2.5201.00
121_D153_T2.4931.00
40_G83_A2.4831.00
38_V83_A2.4441.00
154_Y157_T2.4381.00
62_K76_Q2.3511.00
74_Y109_S2.3381.00
294_R335_Y2.3381.00
301_M326_K2.3361.00
118_V171_Q2.3251.00
260_E279_Q2.2501.00
336_F342_T2.2251.00
220_S239_D2.2171.00
333_T341_S2.1921.00
168_F204_T2.1911.00
74_Y111_D2.1841.00
214_A245_L2.1711.00
170_V202_L2.1681.00
293_L334_Y2.1671.00
289_F295_P2.1281.00
341_S374_V2.1101.00
16_A20_H2.0421.00
34_L61_F2.0181.00
97_L116_Y1.9851.00
35_Y78_E1.9781.00
151_V171_Q1.9781.00
71_L102_L1.9511.00
118_V169_A1.9431.00
103_K109_S1.9341.00
216_A243_A1.9231.00
114_R149_N1.9201.00
71_L106_D1.9001.00
162_L167_N1.8961.00
167_N205_T1.8831.00
156_N163_V1.8481.00
249_A254_L1.8401.00
35_Y76_Q1.8201.00
84_N176_N1.7601.00
37_K58_R1.7601.00
340_M375_Y1.7491.00
350_L365_T1.7311.00
110_F152_A1.6841.00
39_D343_Y1.6751.00
79_Y93_S1.6591.00
157_T163_V1.6531.00
342_T373_L1.6331.00
218_Y241_W1.6241.00
74_Y103_K1.6101.00
112_Y152_A1.6051.00
220_S237_K1.5851.00
286_Q294_R1.5671.00
35_Y62_K1.5671.00
155_R169_A1.5651.00
295_P332_A1.5631.00
80_N96_R1.5631.00
92_Q149_N1.5471.00
251_N287_Y1.5351.00
341_S376_Q1.5141.00
339_N375_Y1.5101.00
67_I73_G1.5071.00
245_L256_T1.5041.00
58_R78_E1.5011.00
58_R96_R1.4821.00
212_F247_Y1.4821.00
66_Q70_Q1.4451.00
255_A284_T1.4421.00
89_S95_T1.4371.00
246_K255_A1.4351.00
111_D155_R1.4141.00
111_D153_T1.3981.00
34_L59_L1.3941.00
126_T213_S1.3791.00
348_I365_T1.3691.00
78_E96_R1.3641.00
214_A243_A1.3631.00
59_L79_Y1.3541.00
107_Y154_Y1.3481.00
108_G154_Y1.3441.00
111_D115_N1.3411.00
254_L285_A1.3321.00
72_T105_A1.3311.00
208_L211_G1.3061.00
115_N151_V1.2921.00
97_L115_N1.2901.00
257_M282_E1.2881.00
290_D293_L1.2821.00
252_I285_A1.2701.00
173_Q199_G1.2681.00
74_Y99_F1.2531.00
82_Q87_E1.2501.00
148_A199_G1.2491.00
55_S374_V1.2451.00
285_A297_V1.2431.00
65_T337_N1.2431.00
252_I256_T1.2401.00
152_A174_G1.2361.00
246_K253_Y1.2361.00
71_L107_Y1.2311.00
348_I367_D1.2291.00
288_Q294_R1.2261.00
260_E277_K1.2251.00
66_Q72_T1.2211.00
156_N165_G1.2211.00
248_D251_N1.2201.00
299_F328_A1.2201.00
211_G247_Y1.2021.00
76_Q97_L1.2021.00
207_D213_S1.1981.00
241_W260_E1.1971.00
107_Y110_F1.1971.00
292_G335_Y1.1891.00
289_F293_L1.1841.00
172_Y200_W1.1781.00
256_T281_F1.1751.00
298_S329_D1.1691.00
92_Q95_T1.1681.00
73_G100_A1.1641.00
151_V173_Q1.1611.00
41_L53_D1.1551.00
43_Y370_A1.1521.00
212_F245_L1.1451.00
99_F111_D1.1371.00
218_Y239_D1.1361.00
96_R147_R1.1341.00
301_M324_L1.1251.00
296_A331_G1.1211.00
37_K376_Q1.1191.00
213_S246_K1.1161.00
119_M217_A1.1121.00
122_I215_G1.1101.00
171_Q201_G1.1081.00
64_E74_Y1.1051.00
303_K324_L1.0961.00
344_V371_L1.0951.00
343_Y372_G1.0931.00
248_D253_Y1.0931.00
297_V328_A1.0921.00
38_V81_I1.0891.00
90_K95_T1.0781.00
17_G20_H1.0741.00
109_S153_T1.0731.00
71_L105_A1.0711.00
10_I13_L1.0601.00
70_Q105_A1.0521.00
4_K8_L1.0501.00
41_L370_A1.0481.00
256_T283_V1.0461.00
153_T171_Q1.0431.00
170_V200_W1.0361.00
331_G345_D1.0351.00
328_A348_I1.0301.00
32_L75_G1.0291.00
166_L204_T1.0271.00
344_V369_V1.0261.00
242_T259_S1.0251.00
280_N302_S1.0211.00
351_L363_I1.0211.00
73_G102_L1.0191.00
77_W94_W1.0171.00
296_A333_T1.0101.00
148_A151_V1.0061.00
65_T339_N1.0021.00
64_E103_K1.0011.00
279_Q305_R1.0001.00
46_D367_D0.9971.00
166_L208_L0.9921.00
58_R147_R0.9871.00
77_W98_A0.9831.00
325_V351_L0.9821.00
157_T162_L0.9771.00
128_M286_Q0.9711.00
325_V349_N0.9701.00
340_M373_L0.9651.00
89_S92_Q0.9591.00
169_A203_S0.9581.00
129_L331_G0.9571.00
40_G84_N0.9531.00
248_D287_Y0.9461.00
57_A81_I0.9421.00
31_K64_E0.9411.00
119_M240_A0.9401.00
37_K374_V0.9361.00
203_S217_A0.9361.00
167_N207_D0.9351.00
177_E180_S0.9291.00
248_D288_Q0.9261.00
289_F332_A0.9230.99
297_V330_I0.9210.99
324_L352_D0.9190.99
117_G148_A0.9180.99
284_T298_S0.9160.99
115_N153_T0.9150.99
119_M242_T0.9090.99
11_P14_L0.9030.99
54_Q341_S0.9020.99
60_G78_E0.9010.99
129_L296_A0.8960.99
11_P16_A0.8940.99
251_N288_Q0.8920.99
6_L10_I0.8880.99
170_V204_T0.8810.99
335_Y341_S0.8760.99
253_Y286_Q0.8750.99
118_V217_A0.8740.99
68_N337_N0.8710.99
329_D347_K0.8690.99
86_T94_W0.8680.99
80_N95_T0.8670.99
253_Y288_Q0.8630.99
346_Y369_V0.8570.99
336_F340_M0.8570.99
128_M284_T0.8480.99
173_Q176_N0.8480.99
118_V203_S0.8480.99
55_S341_S0.8460.99
10_I14_L0.8460.99
176_N179_A0.8450.99
153_T169_A0.8420.99
103_K106_D0.8420.99
122_I155_R0.8390.99
3_S6_L0.8380.99
39_D52_G0.8360.99
282_E300_L0.8360.99
5_V8_L0.8330.99
279_Q303_K0.8320.99
33_D62_K0.8300.99
121_D155_R0.8260.99
7_A10_I0.8240.99
118_V201_G0.8210.99
30_N65_T0.8210.99
65_T340_M0.8180.99
47_N366_D0.8140.99
9_L12_A0.8080.99
82_Q85_N0.8060.99
215_G244_G0.8040.99
238_A261_T0.7950.98
278_T302_S0.7930.98
14_L18_A0.7920.98
55_S376_Q0.7880.98
128_M298_S0.7880.98
281_F303_K0.7860.98
8_L11_P0.7860.98
116_Y120_Y0.7860.98
132_F135_D0.7840.98
351_L355_D0.7760.98
41_L55_S0.7760.98
178_G194_H0.7750.98
126_T244_G0.7680.98
150_G176_N0.7660.98
99_F115_N0.7610.98
333_T374_V0.7600.98
280_N300_L0.7580.98
292_G332_A0.7570.98
255_A286_Q0.7550.98
16_A19_A0.7530.98
241_W279_Q0.7530.98
201_G219_T0.7520.98
155_R167_N0.7510.98
262_R277_K0.7510.98
294_R333_T0.7490.98
4_K7_A0.7480.98
65_T68_N0.7450.98
128_M282_E0.7430.98
114_R147_R0.7420.98
148_A171_Q0.7420.98
330_I346_Y0.7410.98
286_Q296_A0.7370.98
371_L375_Y0.7350.97
109_S155_R0.7330.97
59_L93_S0.7310.97
129_L298_S0.7270.97
122_I203_S0.7240.97
138_T141_D0.7220.97
125_W205_T0.7100.97
350_L364_S0.7090.97
60_G96_R0.7080.97
324_L350_L0.7060.97
70_Q106_D0.7020.97
249_A252_I0.7000.97
9_L13_L0.6930.96
162_L207_D0.6930.96
157_T165_G0.6920.96
261_T278_T0.6920.96
168_F202_L0.6910.96
80_N94_W0.6900.96
58_R80_N0.6890.96
7_A14_L0.6880.96
332_A344_V0.6870.96
282_E298_S0.6850.96
291_F334_Y0.6830.96
129_L135_D0.6830.96
66_Q69_D0.6810.96
127_D132_F0.6790.96
156_N170_V0.6790.96
105_A154_Y0.6790.96
200_W204_T0.6780.96
345_D370_A0.6730.96
179_A194_H0.6720.96
226_D231_T0.6630.95
65_T375_Y0.6620.95
84_N150_G0.6600.95
156_N164_N0.6600.95
195_E222_D0.6590.95
175_N180_S0.6590.95
172_Y198_D0.6580.95
372_G377_F0.6560.95
123_E242_T0.6520.95
126_T255_A0.6520.95
45_S368_I0.6490.95
355_D363_I0.6480.95
117_G201_G0.6470.95
30_N66_Q0.6460.95
209_G247_Y0.6450.95
116_Y147_R0.6440.95
5_V9_L0.6440.95
119_M201_G0.6430.95
105_A110_F0.6420.95
277_K303_K0.6380.94
5_V17_G0.6380.94
211_G249_A0.6380.94
6_L9_L0.6360.94
148_A173_Q0.6350.94
65_T73_G0.6340.94
112_Y115_N0.6330.94
258_Y281_F0.6320.94
90_K93_S0.6300.94
43_Y368_I0.6300.94
80_N147_R0.6300.94
156_N162_L0.6300.94
243_A258_Y0.6280.94
107_Y157_T0.6260.94
241_W258_Y0.6240.94
12_A20_H0.6220.94
157_T167_N0.6200.93
238_A263_N0.6190.93
59_L81_I0.6170.93
204_T216_A0.6170.93
165_G206_Y0.6150.93
6_L13_L0.6140.93
329_D345_D0.6130.93
7_A11_P0.6120.93
6_L14_L0.6090.93
46_D363_I0.6060.93
4_K14_L0.6050.93
288_Q292_G0.6040.93
8_L12_A0.6040.93
328_A365_T0.6000.92
108_G157_T0.5990.92
4_K9_L0.5990.92
29_G33_D0.5990.92
231_T234_G0.5990.92
211_G248_D0.5990.92
79_Y94_W0.5980.92
35_Y96_R0.5970.92
53_D370_A0.5940.92
277_K305_R0.5930.92
199_G221_S0.5900.92
300_L327_Y0.5890.92
178_G195_E0.5890.92
117_G219_T0.5860.91
204_T209_G0.5860.91
337_N340_M0.5850.91
222_D237_K0.5850.91
85_N94_W0.5830.91
67_I340_M0.5830.91
14_L17_G0.5830.91
131_E135_D0.5810.91
51_D83_A0.5750.91
251_N289_F0.5740.91
91_N95_T0.5720.90
29_G66_Q0.5690.90
3_S7_A0.5670.90
333_T376_Q0.5660.90
180_S194_H0.5660.90
244_G257_M0.5660.90
304_G323_D0.5630.90
100_A337_N0.5630.90
41_L343_Y0.5620.90
43_Y347_K0.5620.90
163_V167_N0.5620.90
288_Q335_Y0.5610.90
205_T215_G0.5610.90
133_G136_S0.5610.90
327_Y349_N0.5600.89
67_I70_Q0.5570.89
289_F292_G0.5560.89
198_D222_D0.5550.89
101_G111_D0.5550.89
6_L12_A0.5550.89
44_F367_D0.5540.89
122_I169_A0.5540.89
281_F285_A0.5520.89
342_T372_G0.5510.89
32_L65_T0.5510.89
257_M284_T0.5510.89
127_D142_N0.5500.89
302_S325_V0.5500.89
208_L212_F0.5490.89
3_S8_L0.5480.88
57_A83_A0.5480.88
44_F348_I0.5470.88
171_Q199_G0.5470.88
79_Y98_A0.5470.88
264_M275_A0.5460.88
32_L63_G0.5450.88
29_G32_L0.5450.88
306_D323_D0.5420.88
330_I344_V0.5410.88
6_L11_P0.5400.88
263_N266_P0.5380.88
281_F301_M0.5370.87
166_L206_Y0.5360.87
326_K352_D0.5350.87
56_Y130_P0.5340.87
154_Y168_F0.5340.87
209_G212_F0.5340.87
40_G43_Y0.5330.87
123_E257_M0.5330.87
263_N278_T0.5330.87
119_M219_T0.5330.87
177_E196_N0.5330.87
348_I369_V0.5310.87
93_S98_A0.5310.87
40_G44_F0.5300.87
56_Y116_Y0.5300.87
53_D56_Y0.5290.87
44_F369_V0.5280.87
10_I106_D0.5280.87
154_Y163_V0.5270.86
132_F136_S0.5260.86
351_L354_D0.5250.86
56_Y80_N0.5240.86
213_S248_D0.5240.86
106_D110_F0.5240.86
43_Y48_S0.5240.86
58_R97_L0.5240.86
95_T98_A0.5240.86
4_K11_P0.5230.86
40_G57_A0.5220.86
31_K63_G0.5200.86
240_A261_T0.5200.86
124_G127_D0.5190.86
37_K55_S0.5190.86
127_D282_E0.5190.86
139_N142_N0.5190.86
175_N179_A0.5170.85
74_Y153_T0.5160.85
43_Y50_K0.5160.85
156_N166_L0.5160.85
262_R279_Q0.5140.85
40_G370_A0.5130.85
75_G94_W0.5130.85
337_N375_Y0.5130.85
208_L245_L0.5130.85
303_K322_K0.5120.85
127_D135_D0.5120.85
102_L105_A0.5120.85
17_G105_A0.5120.85
194_H198_D0.5110.85
176_N180_S0.5100.85
347_K368_I0.5100.85
355_D359_A0.5100.85
259_S278_T0.5080.84
208_L216_A0.5070.84
62_K338_K0.5070.84
169_A205_T0.5070.84
137_Y140_A0.5050.84
291_F295_P0.5050.84
52_G57_A0.5050.84
208_L214_A0.5040.84
134_G327_Y0.5030.84
65_T75_G0.5030.84
199_G219_T0.5030.84
259_S280_N0.5020.84
54_Q333_T0.5020.84
13_L18_A0.5010.84
306_D352_D0.5000.84
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1phoA 3 0.8621 100 0.276 Contact Map
2j1nA 3 0.8966 100 0.278 Contact Map
3nsgA 3 0.8753 100 0.283 Contact Map
2zfgA 3 0.8621 100 0.294 Contact Map
2fgqX 3 0.809 100 0.304 Contact Map
3vy8X 3 0.8382 100 0.327 Contact Map
3wi5A 3 0.7905 100 0.367 Contact Map
2porA 3 0.7533 100 0.401 Contact Map
3prnA 3 0.7188 100 0.41 Contact Map
2o4vA 3 0.8727 99.4 0.787 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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