GREMLIN Database
ABGR - HTH-type transcriptional regulator AbgR
UniProt: P77744 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13353
Length: 302 (284)
Sequences: 79640 (58040)
Seq/√Len: 3444.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
74_L78_E3.6041.00
19_Q28_M3.3891.00
164_E294_R2.6701.00
100_G145_L2.4811.00
71_H85_D2.4571.00
15_E28_M2.3181.00
235_V242_S2.2771.00
165_K168_E2.2251.00
179_H193_Y2.2201.00
168_E271_A2.2191.00
96_Q127_R2.2061.00
165_K271_A2.1581.00
170_Q246_E2.1551.00
96_Q125_K2.0811.00
24_G27_R2.0771.00
49_A64_A2.0751.00
12_A39_S2.0551.00
168_E269_K2.0271.00
186_S189_Q2.0261.00
116_R292_Q2.0141.00
18_R73_S1.9931.00
14_V73_S1.9871.00
71_H78_E1.9771.00
236_A257_G1.9751.00
98_N127_R1.9641.00
14_V69_Y1.9461.00
14_V18_R1.9431.00
15_E18_R1.9181.00
15_E19_Q1.9121.00
196_T240_F1.9021.00
172_A246_E1.9021.00
232_I252_P1.9001.00
12_A36_L1.8771.00
17_A61_L1.8651.00
175_C261_L1.8551.00
75_I79_L1.8491.00
69_Y73_S1.8211.00
236_A252_P1.7591.00
22_I40_I1.7351.00
53_F60_T1.7241.00
172_A260_M1.7201.00
194_S222_G1.7141.00
68_F82_A1.6981.00
136_M148_T1.6941.00
163_F273_Y1.6821.00
67_S85_D1.6821.00
139_E144_E1.6491.00
17_A69_Y1.6291.00
19_Q24_G1.5901.00
184_A189_Q1.5601.00
18_R28_M1.5571.00
14_V72_A1.5551.00
117_F289_L1.5491.00
162_T278_R1.5381.00
13_F69_Y1.5281.00
138_N142_Q1.5241.00
12_A31_M1.5131.00
9_Q39_S1.5051.00
9_Q46_G1.4911.00
71_H74_L1.4811.00
164_E276_Q1.4801.00
92_Q123_Q1.4791.00
117_F124_V1.4741.00
21_S24_G1.4591.00
23_R33_Q1.4501.00
6_K9_Q1.4421.00
50_Q53_F1.4411.00
32_S35_A1.4381.00
15_E29_L1.4291.00
63_D66_E1.4211.00
9_Q42_E1.4211.00
205_Y209_S1.4101.00
290_I294_R1.4041.00
150_N275_I1.4031.00
71_H81_A1.3941.00
162_T276_Q1.3851.00
276_Q290_I1.3831.00
107_R229_S1.3811.00
14_V76_L1.3781.00
75_I82_A1.3561.00
282_Q286_T1.3561.00
94_A123_Q1.3441.00
177_P257_G1.3411.00
55_R60_T1.3311.00
98_N129_M1.3271.00
288_S291_T1.3211.00
7_I79_L1.3191.00
140_L148_T1.3181.00
139_E145_L1.3051.00
169_K247_E1.3031.00
141_R160_E1.3001.00
116_R120_Q1.2991.00
274_L290_I1.2971.00
78_E81_A1.2971.00
120_Q292_Q1.2841.00
68_F83_Q1.2821.00
147_F274_L1.2751.00
231_C242_S1.2721.00
147_F286_T1.2681.00
193_Y241_L1.2601.00
70_Q74_L1.2521.00
175_C241_L1.2471.00
118_H222_G1.2461.00
46_G83_Q1.2281.00
71_H82_A1.2161.00
233_S236_A1.2101.00
246_E260_M1.2061.00
246_E250_C1.2061.00
177_P259_V1.2011.00
67_S70_Q1.1941.00
118_H194_S1.1931.00
165_K273_Y1.1911.00
115_S119_Q1.1871.00
13_F52_F1.1811.00
252_P257_G1.1751.00
31_M35_A1.1591.00
66_E70_Q1.1581.00
41_Q45_E1.1541.00
131_G135_S1.1501.00
38_K42_E1.1441.00
163_F275_I1.1411.00
115_S237_K1.1381.00
13_F17_A1.1301.00
127_R224_V1.1251.00
180_P193_Y1.1241.00
38_K41_Q1.1071.00
116_R119_Q1.1041.00
194_S220_Q1.1031.00
250_C254_H1.0921.00
121_H288_S1.0911.00
212_L217_Q1.0901.00
106_S130_E1.0891.00
13_F51_L1.0881.00
131_G139_E1.0871.00
10_I72_A1.0771.00
74_L81_A1.0731.00
67_S71_H1.0701.00
22_I59_V1.0701.00
196_T231_C1.0641.00
185_R259_V1.0631.00
291_T294_R1.0621.00
277_R280_S1.0621.00
37_S41_Q1.0601.00
174_F260_M1.0601.00
112_A237_K1.0581.00
15_E25_A1.0561.00
97_I289_L1.0561.00
75_I78_E1.0551.00
117_F292_Q1.0541.00
225_C231_C1.0471.00
8_H11_R1.0431.00
16_V25_A1.0421.00
260_M263_V1.0421.00
287_A291_T1.0401.00
164_E290_I1.0381.00
39_S42_E1.0241.00
176_R238_S1.0221.00
141_R158_D1.0211.00
233_S237_K1.0161.00
113_V293_F1.0141.00
232_I236_A1.0141.00
11_R80_R1.0131.00
83_Q87_R1.0081.00
206_K209_S1.0071.00
61_L65_G0.9981.00
170_Q269_K0.9861.00
187_I265_E0.9831.00
175_C179_H0.9801.00
80_R83_Q0.9681.00
179_H182_I0.9671.00
17_A52_F0.9661.00
131_G136_M0.9651.00
174_F249_G0.9641.00
77_E81_A0.9641.00
31_M36_L0.9621.00
68_F72_A0.9541.00
129_M139_E0.9521.00
80_R84_E0.9511.00
13_F61_L0.9501.00
197_M221_V0.9491.00
173_I241_L0.9491.00
117_F121_H0.9491.00
16_V22_I0.9481.00
12_A29_L0.9461.00
292_Q295_R0.9411.00
42_E45_E0.9241.00
25_A36_L0.9191.00
139_E142_Q0.9181.00
225_C234_L0.9121.00
120_Q295_R0.9091.00
113_V292_Q0.9081.00
13_F43_L0.9041.00
24_G28_M0.8961.00
283_T286_T0.8931.00
100_G136_M0.8931.00
179_H183_G0.8911.00
52_F59_V0.8811.00
49_A86_I0.8781.00
125_K220_Q0.8691.00
74_L77_E0.8661.00
249_G252_P0.8651.00
103_A227_T0.8641.00
17_A65_G0.8621.00
20_G60_T0.8611.00
70_Q73_S0.8591.00
145_L148_T0.8571.00
100_G150_N0.8531.00
206_K210_E0.8501.00
8_H39_S0.8491.00
162_T165_K0.8471.00
137_I141_R0.8471.00
23_R27_R0.8461.00
180_P185_R0.8451.00
124_V285_L0.8451.00
194_S221_V0.8401.00
189_Q192_D0.8381.00
211_L215_Q0.8361.00
175_C180_P0.8291.00
55_R58_G0.8231.00
29_L36_L0.8221.00
179_H194_S0.8211.00
160_E278_R0.8191.00
181_A193_Y0.8171.00
291_T295_R0.8171.00
7_I76_L0.8151.00
99_I147_F0.8141.00
129_M145_L0.8131.00
161_F275_I0.8131.00
253_L256_Q0.8101.00
183_G194_S0.8071.00
174_F242_S0.8061.00
95_G285_L0.8021.00
282_Q287_A0.8001.00
79_L83_Q0.7991.00
20_G66_E0.7971.00
64_A86_I0.7961.00
13_F68_F0.7931.00
100_G148_T0.7921.00
115_S239_D0.7901.00
195_W219_P0.7891.00
208_L212_L0.7831.00
17_A20_G0.7801.00
186_S264_S0.7791.00
33_Q37_S0.7791.00
18_R69_Y0.7781.00
78_E82_A0.7741.00
81_A85_D0.7711.00
188_K191_L0.7711.00
135_S138_N0.7711.00
118_H239_D0.7691.00
67_S89_R0.7691.00
176_R239_D0.7681.00
19_Q25_A0.7631.00
64_A67_S0.7621.00
284_P288_S0.7611.00
79_L82_A0.7601.00
41_Q50_Q0.7571.00
178_G182_I0.7551.00
95_G124_V0.7531.00
252_P255_G0.7511.00
16_V52_F0.7511.00
20_G58_G0.7501.00
9_Q12_A0.7471.00
170_Q262_P0.7371.00
16_V40_I0.7331.00
64_A89_R0.7331.00
87_R90_Q0.7321.00
234_L239_D0.7311.00
174_F244_L0.7261.00
120_Q288_S0.7241.00
82_A86_I0.7231.00
11_R15_E0.7231.00
236_A255_G0.7211.00
117_F288_S0.7211.00
147_F289_L0.7211.00
141_R161_F0.7191.00
101_M106_S0.7181.00
208_L211_L0.7151.00
53_F62_T0.7131.00
182_I259_V0.7131.00
211_L214_D0.7131.00
73_S77_E0.7131.00
191_L217_Q0.7111.00
93_L121_H0.7111.00
175_C181_A0.7091.00
72_A75_I0.7091.00
16_V36_L0.7091.00
210_E214_D0.7081.00
22_I36_L0.7061.00
207_Q211_L0.7041.00
186_S265_E0.6971.00
175_C259_V0.6971.00
245_P248_M0.6971.00
61_L66_E0.6961.00
280_S283_T0.6931.00
227_T230_A0.6901.00
98_N145_L0.6891.00
53_F58_G0.6891.00
60_T66_E0.6881.00
66_E69_Y0.6881.00
35_A39_S0.6851.00
176_R179_H0.6821.00
64_A68_F0.6781.00
63_D67_S0.6721.00
288_S292_Q0.6701.00
143_G277_R0.6691.00
146_D286_T0.6661.00
205_Y224_V0.6641.00
209_S213_D0.6621.00
98_N146_D0.6601.00
199_T224_V0.6591.00
68_F86_I0.6541.00
198_P231_C0.6541.00
11_R14_V0.6521.00
174_F253_L0.6501.00
206_K211_L0.6481.00
44_E49_A0.6441.00
210_E213_D0.6431.00
116_R295_R0.6421.00
8_H42_E0.6411.00
178_G238_S0.6411.00
223_V234_L0.6411.00
77_E80_R0.6391.00
180_P184_A0.6371.00
81_A84_E0.6361.00
101_M110_M0.6361.00
125_K224_V0.6331.00
71_H75_I0.6311.00
44_E54_R0.6301.00
154_Q273_Y0.6301.00
249_G253_L0.6301.00
209_S212_L0.6301.00
27_R30_N0.6291.00
180_P183_G0.6291.00
192_D220_Q0.6271.00
107_R233_S0.6261.00
170_Q266_I0.6241.00
178_G181_A0.6201.00
72_A76_L0.6161.00
97_I285_L0.6161.00
253_L260_M0.6151.00
173_I190_L0.6121.00
130_E226_E0.6111.00
181_A184_A0.6101.00
40_I44_E0.6101.00
22_I58_G0.6061.00
177_P256_Q0.6041.00
284_P287_A0.6031.00
135_S139_E0.6021.00
149_I293_F0.6021.00
178_G259_V0.6011.00
25_A29_L0.6011.00
173_I243_K0.5991.00
147_F290_I0.5971.00
195_W241_L0.5971.00
16_V21_S0.5951.00
94_A125_K0.5931.00
154_Q158_D0.5911.00
199_T226_E0.5901.00
6_K46_G0.5861.00
151_T270_A0.5851.00
84_E88_Q0.5841.00
97_I147_F0.5821.00
169_K270_A0.5801.00
110_M113_V0.5801.00
11_R76_L0.5801.00
207_Q210_E0.5781.00
140_L275_I0.5771.00
188_K215_Q0.5771.00
67_S86_I0.5771.00
112_A115_S0.5761.00
167_L272_Y0.5751.00
47_L86_I0.5711.00
289_L293_F0.5701.00
212_L219_P0.5681.00
173_I195_W0.5671.00
47_L68_F0.5651.00
231_C235_V0.5621.00
52_F61_L0.5601.00
276_Q287_A0.5581.00
61_L69_Y0.5581.00
225_C230_A0.5571.00
112_A116_R0.5561.00
130_E227_T0.5551.00
13_F65_G0.5531.00
8_H12_A0.5511.00
49_A53_F0.5501.00
234_L240_F0.5491.00
35_A38_K0.5491.00
34_P38_K0.5481.00
204_Y208_L0.5471.00
121_H124_V0.5461.00
76_L80_R0.5431.00
162_T279_D0.5431.00
171_F243_K0.5421.00
154_Q271_A0.5401.00
105_I109_L0.5391.00
32_S38_K0.5391.00
179_H184_A0.5391.00
95_G123_Q0.5381.00
140_L161_F0.5371.00
136_M143_G0.5361.00
47_L50_Q0.5331.00
114_I126_V0.5301.00
244_L249_G0.5301.00
179_H241_L0.5281.00
204_Y207_Q0.5281.00
166_L274_L0.5271.00
200_P224_V0.5261.00
70_Q85_D0.5241.00
12_A40_I0.5221.00
175_C182_I0.5221.00
170_Q267_L0.5181.00
22_I33_Q0.5181.00
100_G129_M0.5181.00
263_V266_I0.5161.00
76_L79_L0.5151.00
31_M39_S0.5131.00
17_A66_E0.5121.00
107_R227_T0.5091.00
109_L113_V0.5051.00
138_N144_E0.5051.00
228_F245_P0.5021.00
88_Q93_L0.5011.00
84_E87_R0.5001.00
50_Q64_A0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3fxqA 3 0.9768 100 0.085 Contact Map
2esnA 3 0.9768 100 0.086 Contact Map
1uthA 2 0.745 100 0.092 Contact Map
3fzvA 4 0.9503 100 0.1 Contact Map
1ixcA 4 0.9603 100 0.107 Contact Map
1al3A 1 0.6954 100 0.113 Contact Map
4x6gA 4 0.9868 100 0.113 Contact Map
2h98A 2 0.6755 100 0.115 Contact Map
2h9bA 2 0.6755 100 0.118 Contact Map
3szpA 3 0.9536 100 0.128 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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