PRPR - ECOLI - GREMLIN Contacts

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PRPR - Propionate catabolism operon regulatory protein

UniProt:	P77743	Sequences: MAHPPRLNDDKPVIWTVSVTRLFELFRDISLEFDHLANITPIQLGFEKAVTYIRKKLANERCDAIIAAGSNGAYLKSRLSVPVILIKPSGYDVLQALAKAGKLTSSIGVVTYQETIPALVAFQKTFNLRLDQRSYITEEDARGQINELKANGTEAVVGAGLITDLAEEAGMTGIFIYSAATVRQAFSDALDMTRMSLRHNTHDATRNALRTRYVLGDMLGQSPQMEQVRQTILLYARSSAAVLIEGETGTGKELAAQAIHREYFARHDARQGKKSHPFVAVNCGAIAESLLEAELFGYEEGAFTGSRRGGRAGLFEIAHGGTLFLDEIGEMPLPLQTRLLRVLEEKEVTRVGGHQPVPVDVRVISATHCNLEEDMQQGRFRRDLFYRLSILRLQLPPLRERVADILPLAESFLKVSLAALSAPFSAALRQGLQASETVLLHYDWPGNIRELRNMMERLALFLSVEPTPDLTPQFMQLLLPELARESAKTPAPRLLTPQQALEKFNGDKTAAANYLGISRTTFWRRLKS	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG13600
Length:	528 (427)
Sequences:	11919 (9065)
Seq/√Len:	438.7

ECOLI - PRPR HYFR FHLA YGEV DHAR NTRC RTCR GLRR ATOC ZRAR NORR TYRR
BACSU - YQIR ACOR ROCR

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
374_D	379_R	4.001	1.00
504_F	514_Y	3.933	1.00
247_E	399_R	3.596	1.00
299_E	310_G	3.318	1.00
314_L	349_T	3.127	1.00
373_E	377_Q	3.121	1.00
288_E	334_P	2.930	1.00
415_V	452_R	2.879	1.00
347_E	356_P	2.867	1.00
284_G	337_T	2.771	1.00
110_V	126_F	2.734	1.00
494_L	498_Q	2.716	1.00
316_E	350_R	2.669	1.00
348_V	359_V	2.659	1.00
347_E	358_P	2.636	1.00
234_L	463_S	2.582	1.00
504_F	511_A	2.577	1.00
369_C	374_D	2.556	1.00
232_I	255_A	2.506	1.00
510_A	513_N	2.448	1.00
315_F	342_V	2.381	1.00
320_G	360_D	2.376	1.00
324_F	366_A	2.338	1.00
349_T	356_P	2.336	1.00
299_E	353_G	2.294	1.00
137_T	140_D	2.293	1.00
496_T	500_A	2.241	1.00
406_L	436_E	2.203	1.00
503_K	514_Y	2.171	1.00
370_N	373_E	2.163	1.00
444_W	454_M	2.146	1.00
493_R	525_R	2.076	1.00
114_E	117_P	2.076	1.00
442_Y	445_P	2.074	1.00
373_E	376_Q	2.027	1.00
374_D	377_Q	2.011	1.00
406_L	440_L	2.008	1.00
315_F	323_L	1.992	1.00
255_A	395_L	1.991	1.00
409_A	431_G	1.981	1.00
431_G	455_M	1.969	1.00
221_Q	407_P	1.920	1.00
409_A	455_M	1.903	1.00
330_E	369_C	1.901	1.00
222_S	403_A	1.890	1.00
220_G	225_M	1.882	1.00
273_K	360_D	1.882	1.00
245_E	394_Q	1.793	1.00
240_A	456_E	1.786	1.00
402_V	443_D	1.786	1.00
344_E	452_R	1.784	1.00
253_E	341_R	1.779	1.00
435_S	439_L	1.751	1.00
500_A	504_F	1.750	1.00
94_L	113_Q	1.732	1.00
402_V	405_I	1.708	1.00
430_Q	466_P	1.701	1.00
432_L	435_S	1.693	1.00
353_G	357_V	1.683	1.00
402_V	406_L	1.673	1.00
276_H	320_G	1.671	1.00
292_E	338_R	1.664	1.00
343_L	363_V	1.663	1.00
233_L	262_E	1.661	1.00
411_S	415_V	1.651	1.00
113_Q	117_P	1.634	1.00
185_A	192_M	1.624	1.00
520_T	524_R	1.613	1.00
410_E	436_E	1.611	1.00
424_F	430_Q	1.599	1.00
143_G	172_T	1.575	1.00
202_H	206_R	1.572	1.00
500_A	511_A	1.557	1.00
250_T	395_L	1.544	1.00
435_S	467_T	1.543	1.00
245_E	392_R	1.534	1.00
288_E	332_P	1.533	1.00
412_F	452_R	1.521	1.00
316_E	357_V	1.495	1.00
312_A	316_E	1.484	1.00
144_Q	147_E	1.477	1.00
319_H	359_V	1.476	1.00
319_H	360_D	1.476	1.00
498_Q	502_E	1.475	1.00
220_G	229_R	1.464	1.00
371_L	380_F	1.454	1.00
442_Y	450_E	1.451	1.00
300_E	308_R	1.445	1.00
509_T	519_R	1.434	1.00
436_E	440_L	1.431	1.00
329_G	367_T	1.427	1.00
298_Y	303_F	1.422	1.00
239_S	273_K	1.421	1.00
394_Q	400_E	1.421	1.00
434_A	467_T	1.415	1.00
342_V	348_V	1.410	1.00
520_T	523_W	1.410	1.00
501_L	511_A	1.409	1.00
239_S	419_A	1.403	1.00
194_R	198_R	1.402	1.00
300_E	307_R	1.396	1.00
489_T	492_P	1.396	1.00
438_V	467_T	1.394	1.00
230_Q	233_L	1.387	1.00
488_K	492_P	1.386	1.00
94_L	111_T	1.384	1.00
408_L	412_F	1.384	1.00
299_E	350_R	1.374	1.00
416_S	459_A	1.374	1.00
518_S	521_T	1.367	1.00
365_S	388_L	1.366	1.00
123_Q	148_L	1.365	1.00
240_A	420_L	1.362	1.00
224_Q	400_E	1.361	1.00
110_V	121_A	1.359	1.00
201_T	205_T	1.358	1.00
437_T	441_H	1.354	1.00
499_Q	503_K	1.354	1.00
202_H	205_T	1.353	1.00
419_A	456_E	1.347	1.00
225_M	229_R	1.342	1.00
119_L	144_Q	1.337	1.00
228_V	393_L	1.335	1.00
228_V	255_A	1.335	1.00
185_A	190_L	1.334	1.00
291_L	335_L	1.330	1.00
311_R	354_H	1.322	1.00
348_V	358_P	1.314	1.00
413_L	459_A	1.312	1.00
87_K	118_A	1.306	1.00
372_E	376_Q	1.304	1.00
235_Y	391_L	1.304	1.00
510_A	514_Y	1.298	1.00
149_K	152_G	1.296	1.00
492_P	496_T	1.292	1.00
508_K	523_W	1.289	1.00
245_E	372_E	1.279	1.00
350_R	353_G	1.278	1.00
175_F	193_T	1.271	1.00
417_L	423_P	1.266	1.00
219_L	411_S	1.263	1.00
509_T	513_N	1.256	1.00
413_L	431_G	1.240	1.00
462_L	469_D	1.238	1.00
201_T	206_R	1.237	1.00
376_Q	382_R	1.236	1.00
98_A	102_K	1.236	1.00
431_G	436_E	1.234	1.00
319_H	361_V	1.227	1.00
406_L	409_A	1.224	1.00
507_D	510_A	1.217	1.00
131_D	141_A	1.211	1.00
500_A	515_L	1.210	1.00
199_H	203_D	1.210	1.00
412_F	416_S	1.209	1.00
115_T	135_Y	1.207	1.00
329_G	371_L	1.206	1.00
471_T	474_F	1.204	1.00
500_A	514_Y	1.200	1.00
425_S	465_E	1.195	1.00
417_L	425_S	1.194	1.00
229_R	232_I	1.191	1.00
497_P	522_F	1.183	1.00
298_Y	310_G	1.178	1.00
232_I	393_L	1.174	1.00
227_Q	230_Q	1.171	1.00
405_I	409_A	1.170	1.00
225_M	228_V	1.169	1.00
237_R	272_G	1.167	1.00
215_L	258_A	1.163	1.00
507_D	519_R	1.159	1.00
257_Q	280_A	1.157	1.00
144_Q	148_L	1.153	1.00
284_G	330_E	1.150	1.00
278_F	321_G	1.147	1.00
508_K	519_R	1.146	1.00
330_E	368_H	1.145	1.00
228_V	232_I	1.141	1.00
414_K	418_A	1.140	1.00
217_D	261_R	1.139	1.00
232_I	259_I	1.138	1.00
188_D	192_M	1.136	1.00
88_P	94_L	1.134	1.00
416_S	455_M	1.132	1.00
203_D	206_R	1.130	1.00
201_T	204_A	1.127	1.00
291_L	295_L	1.127	1.00
240_A	390_I	1.123	1.00
240_A	460_L	1.122	1.00
112_Y	121_A	1.122	1.00
294_E	311_R	1.120	1.00
417_L	424_F	1.114	1.00
402_V	440_L	1.111	1.00
247_E	397_P	1.110	1.00
232_I	258_A	1.107	1.00
346_K	358_P	1.105	1.00
495_L	499_Q	1.105	1.00
518_S	524_R	1.098	1.00
115_T	119_L	1.098	1.00
242_V	259_I	1.095	1.00
129_R	145_I	1.089	1.00
243_L	365_S	1.076	1.00
168_E	172_T	1.073	1.00
316_E	348_V	1.070	1.00
280_A	341_R	1.069	1.00
223_P	227_Q	1.066	1.00
410_E	414_K	1.061	1.00
425_S	430_Q	1.060	1.00
122_F	145_I	1.059	1.00
121_A	124_K	1.058	1.00
412_F	455_M	1.057	1.00
228_V	395_L	1.056	1.00
231_T	461_F	1.054	1.00
224_Q	227_Q	1.051	1.00
218_M	254_L	1.051	1.00
403_A	440_L	1.049	1.00
239_S	272_G	1.047	1.00
293_A	298_Y	1.041	1.00
218_M	225_M	1.040	1.00
495_L	498_Q	1.040	1.00
253_E	280_A	1.033	1.00
190_L	193_T	1.032	1.00
244_I	255_A	1.027	1.00
258_A	262_E	1.022	1.00
390_I	453_N	1.019	1.00
432_L	466_P	1.019	1.00
471_T	475_M	1.013	1.00
372_E	473_Q	1.012	1.00
457_R	461_F	1.012	1.00
218_M	229_R	1.011	1.00
519_R	523_W	1.008	1.00
350_R	357_V	1.006	1.00
199_H	202_H	1.001	1.00
298_Y	302_A	0.996	1.00
195_M	198_R	0.994	1.00
521_T	525_R	0.994	1.00
323_L	363_V	0.993	1.00
131_D	156_V	0.991	1.00
185_A	188_D	0.990	1.00
98_A	111_T	0.988	1.00
241_A	346_K	0.983	1.00
497_P	525_R	0.982	1.00
317_I	354_H	0.980	1.00
431_G	435_S	0.975	1.00
417_L	459_A	0.972	1.00
504_F	510_A	0.972	1.00
128_L	190_L	0.970	1.00
467_T	471_T	0.970	1.00
257_Q	261_R	0.967	1.00
218_M	255_A	0.963	1.00
499_Q	502_E	0.962	1.00
488_K	496_T	0.961	1.00
115_T	141_A	0.958	1.00
202_H	209_L	0.958	1.00
142_R	154_E	0.958	1.00
501_L	526_L	0.957	1.00
221_Q	226_E	0.956	1.00
204_A	208_A	0.955	1.00
315_F	361_V	0.955	1.00
496_T	515_L	0.955	1.00
121_A	126_F	0.953	1.00
322_T	364_I	0.952	1.00
226_E	230_Q	0.949	1.00
205_T	209_L	0.948	1.00
517_I	521_T	0.946	1.00
129_R	152_G	0.946	1.00
458_L	462_L	0.942	1.00
437_T	440_L	0.939	1.00
315_F	359_V	0.936	1.00
300_E	310_G	0.933	1.00
140_D	143_G	0.928	1.00
314_L	317_I	0.924	1.00
389_S	392_R	0.920	1.00
312_A	354_H	0.918	1.00
282_N	330_E	0.917	1.00
220_G	407_P	0.915	1.00
244_I	364_I	0.915	1.00
173_G	177_Y	0.909	1.00
508_K	520_T	0.903	1.00
488_K	491_A	0.902	1.00
114_E	135_Y	0.900	1.00
279_V	318_A	0.899	1.00
244_I	256_A	0.898	1.00
235_Y	242_V	0.898	1.00
241_A	365_S	0.897	1.00
215_L	232_I	0.897	1.00
312_A	317_I	0.894	1.00
491_A	495_L	0.890	1.00
323_L	342_V	0.890	1.00
422_A	459_A	0.889	1.00
134_S	160_G	0.886	1.00
405_I	439_L	0.883	1.00
523_W	527_K	0.882	1.00
186_F	189_A	0.881	1.00
201_T	208_A	0.881	1.00
517_I	522_F	0.878	1.00
287_A	351_V	0.873	1.00
279_V	317_I	0.872	1.00
168_E	171_M	0.871	1.00
454_M	458_L	0.871	1.00
433_Q	437_T	0.869	1.00
508_K	522_F	0.867	1.00
508_K	515_L	0.867	1.00
226_E	229_R	0.860	1.00
117_P	120_V	0.857	1.00
508_K	526_L	0.855	1.00
389_S	457_R	0.854	1.00
433_Q	436_E	0.850	1.00
372_E	392_R	0.848	1.00
331_M	335_L	0.847	1.00
506_G	526_L	0.845	1.00
131_D	135_Y	0.845	1.00
219_L	407_P	0.844	1.00
141_A	145_I	0.841	1.00
120_V	123_Q	0.841	1.00
369_C	379_R	0.839	1.00
223_P	226_E	0.837	1.00
521_T	524_R	0.837	1.00
501_L	508_K	0.835	1.00
410_E	430_Q	0.834	1.00
108_G	116_I	0.831	1.00
105_S	187_S	0.831	1.00
112_Y	118_A	0.830	1.00
88_P	98_A	0.829	1.00
317_I	353_G	0.828	1.00
116_I	120_V	0.827	1.00
302_A	351_V	0.823	1.00
497_P	515_L	0.822	1.00
139_E	169_A	0.821	1.00
229_R	255_A	0.820	1.00
489_T	496_T	0.819	1.00
363_V	388_L	0.818	1.00
163_T	167_E	0.817	1.00
129_R	132_Q	0.816	1.00
417_L	422_A	0.812	1.00
511_A	514_Y	0.812	1.00
238_S	460_L	0.809	1.00
234_L	422_A	0.808	1.00
111_T	115_T	0.807	1.00
409_A	436_E	0.806	1.00
315_F	348_V	0.806	1.00
247_E	250_T	0.804	1.00
230_Q	463_S	0.802	1.00
229_R	233_L	0.802	1.00
165_L	177_Y	0.800	1.00
501_L	506_G	0.799	1.00
94_L	98_A	0.798	1.00
303_F	306_S	0.792	1.00
452_R	456_E	0.788	1.00
420_L	459_A	0.785	1.00
312_A	350_R	0.782	1.00
130_L	190_L	0.781	1.00
232_I	262_E	0.780	1.00
282_N	331_M	0.777	1.00
164_D	168_E	0.776	1.00
329_G	368_H	0.775	1.00
199_H	206_R	0.775	1.00
341_R	345_E	0.774	1.00
523_W	526_L	0.773	1.00
406_L	410_E	0.773	1.00
240_A	391_L	0.773	1.00
91_Y	95_Q	0.773	1.00
244_I	395_L	0.770	1.00
298_Y	307_R	0.767	1.00
185_A	189_A	0.767	1.00
420_L	460_L	0.766	1.00
518_S	523_W	0.765	1.00
502_E	506_G	0.765	1.00
413_L	417_L	0.765	1.00
298_Y	351_V	0.765	1.00
142_R	156_V	0.765	1.00
298_Y	311_R	0.764	1.00
522_F	526_L	0.760	1.00
281_V	323_L	0.759	1.00
375_M	385_F	0.759	1.00
236_A	262_E	0.758	1.00
131_D	154_E	0.757	1.00
402_V	407_P	0.755	1.00
416_S	452_R	0.755	1.00
189_A	192_M	0.753	1.00
287_A	290_L	0.749	1.00
201_T	209_L	0.747	1.00
95_Q	98_A	0.746	1.00
416_S	456_E	0.746	1.00
185_A	193_T	0.744	1.00
133_R	165_L	0.739	1.00
328_I	388_L	0.739	1.00
291_L	331_M	0.738	1.00
256_A	278_F	0.732	1.00
234_L	461_F	0.730	1.00
220_G	255_A	0.729	1.00
348_V	357_V	0.729	1.00
438_V	474_F	0.727	1.00
273_K	276_H	0.725	1.00
487_A	491_A	0.725	1.00
215_L	229_R	0.723	1.00
286_I	295_L	0.722	1.00
192_M	195_M	0.720	1.00
115_T	137_T	0.719	1.00
112_Y	117_P	0.718	1.00
319_H	357_V	0.716	1.00
315_F	363_V	0.716	1.00
487_A	495_L	0.712	1.00
206_R	209_L	0.711	1.00
120_V	124_K	0.707	1.00
203_D	207_N	0.705	1.00
143_G	147_E	0.704	1.00
405_I	440_L	0.703	1.00
512_A	522_F	0.700	1.00
202_H	207_N	0.699	1.00
310_G	355_Q	0.697	1.00
519_R	524_R	0.696	1.00
215_L	262_E	0.695	1.00
416_S	420_L	0.695	1.00
293_A	303_F	0.695	1.00
490_P	494_L	0.694	1.00
372_E	382_R	0.694	1.00
220_G	226_E	0.693	1.00
107_I	191_D	0.692	1.00
167_E	171_M	0.691	1.00
522_F	525_R	0.689	1.00
372_E	385_F	0.689	1.00
320_G	361_V	0.687	1.00
310_G	350_R	0.687	1.00
200_N	204_A	0.685	1.00
439_L	444_W	0.685	1.00
384_L	388_L	0.684	1.00
450_E	473_Q	0.682	1.00
185_A	194_R	0.682	1.00
311_R	314_L	0.680	1.00
511_A	522_F	0.680	1.00
225_M	255_A	0.677	1.00
402_V	441_H	0.674	1.00
131_D	145_I	0.674	1.00
372_E	375_M	0.673	1.00
442_Y	474_F	0.672	1.00
524_R	527_K	0.671	1.00
497_P	511_A	0.670	1.00
188_D	193_T	0.669	1.00
457_R	460_L	0.669	1.00
98_A	101_G	0.666	1.00
493_R	497_P	0.666	1.00
329_G	369_C	0.666	1.00
223_P	403_A	0.665	1.00
385_F	389_S	0.665	1.00
188_D	191_D	0.660	1.00
155_A	189_A	0.659	1.00
205_T	208_A	0.657	1.00
415_V	419_A	0.655	1.00
435_S	458_L	0.655	1.00
416_S	419_A	0.651	0.99
422_A	425_S	0.650	0.99
239_S	360_D	0.648	0.99
281_V	314_L	0.648	0.99
295_L	335_L	0.647	0.99
409_A	458_L	0.646	0.99
191_D	195_M	0.644	0.99
497_P	526_L	0.638	0.99
178_S	182_V	0.638	0.99
224_Q	403_A	0.638	0.99
145_I	154_E	0.638	0.99
515_L	525_R	0.631	0.99
215_L	233_L	0.631	0.99
248_T	330_E	0.629	0.99
307_R	310_G	0.628	0.99
158_G	161_L	0.628	0.99
311_R	317_I	0.627	0.99
312_A	348_V	0.627	0.99
319_H	358_P	0.626	0.99
88_P	93_V	0.626	0.99
163_T	166_A	0.625	0.99
490_P	493_R	0.623	0.99
228_V	231_T	0.622	0.99
486_S	500_A	0.621	0.99
237_R	271_Q	0.621	0.99
90_G	94_L	0.620	0.99
220_G	404_D	0.620	0.99
117_P	121_A	0.618	0.99
432_L	467_T	0.616	0.99
143_G	168_E	0.616	0.99
211_T	261_R	0.616	0.99
281_V	295_L	0.615	0.99
253_E	345_E	0.614	0.99
238_S	420_L	0.613	0.99
407_P	410_E	0.613	0.99
329_G	380_F	0.612	0.99
331_M	339_L	0.612	0.99
398_L	451_L	0.611	0.99
88_P	102_K	0.611	0.99
424_F	459_A	0.609	0.99
239_S	420_L	0.607	0.99
319_H	348_V	0.607	0.99
221_Q	403_A	0.605	0.99
409_A	413_L	0.604	0.99
273_K	361_V	0.604	0.99
236_A	271_Q	0.603	0.99
302_A	306_S	0.603	0.99
290_L	351_V	0.602	0.99
390_I	456_E	0.600	0.99
290_L	304_T	0.598	0.99
298_Y	306_S	0.598	0.99
187_S	191_D	0.596	0.99
397_P	400_E	0.595	0.99
171_M	176_I	0.594	0.99
217_D	258_A	0.594	0.99
146_N	153_T	0.594	0.99
286_I	291_L	0.594	0.99
190_L	194_R	0.593	0.99
519_R	522_F	0.592	0.99
407_P	411_S	0.592	0.99
304_T	366_A	0.592	0.99
157_V	160_G	0.590	0.99
506_G	511_A	0.590	0.99
254_L	258_A	0.589	0.99
423_P	465_E	0.589	0.99
96_A	100_A	0.587	0.99
231_T	391_L	0.587	0.99
438_V	441_H	0.587	0.99
230_Q	234_L	0.586	0.99
419_A	452_R	0.586	0.99
184_Q	188_D	0.585	0.99
438_V	442_Y	0.584	0.99
186_F	192_M	0.584	0.99
346_K	361_V	0.583	0.99
425_S	459_A	0.583	0.99
346_K	360_D	0.582	0.99
508_K	518_S	0.580	0.99
97_L	101_G	0.579	0.99
99_K	102_K	0.577	0.99
287_A	292_E	0.577	0.99
170_G	176_I	0.577	0.99
277_P	317_I	0.576	0.99
92_D	96_A	0.576	0.99
88_P	91_Y	0.574	0.99
231_T	234_L	0.571	0.99
342_V	345_E	0.571	0.99
112_Y	115_T	0.571	0.99
189_A	193_T	0.570	0.99
245_E	370_N	0.569	0.99
218_M	258_A	0.569	0.99
299_E	351_V	0.569	0.99
122_F	129_R	0.569	0.99
509_T	523_W	0.568	0.99
184_Q	187_S	0.567	0.99
253_E	344_E	0.566	0.99
282_N	285_A	0.566	0.99
346_K	359_V	0.565	0.99
122_F	126_F	0.564	0.99
353_G	356_P	0.564	0.99
518_S	525_R	0.564	0.99
190_L	195_M	0.564	0.99
227_Q	231_T	0.563	0.99
130_L	155_A	0.563	0.99
86_I	109_V	0.561	0.98
491_A	494_L	0.561	0.98
496_T	499_Q	0.561	0.98
167_E	170_G	0.560	0.98
508_K	517_I	0.560	0.98
286_I	314_L	0.559	0.98
189_A	194_R	0.559	0.98
458_L	470_L	0.559	0.98
403_A	406_L	0.559	0.98
486_S	525_R	0.557	0.98
235_Y	393_L	0.555	0.98
250_T	254_L	0.554	0.98
316_E	319_H	0.554	0.98
454_M	470_L	0.554	0.98
91_Y	94_L	0.554	0.98
96_A	99_K	0.554	0.98
310_G	357_V	0.553	0.98
515_L	521_T	0.552	0.98
88_P	95_Q	0.552	0.98
89_S	132_Q	0.551	0.98
520_T	527_K	0.549	0.98
342_V	361_V	0.549	0.98
329_G	366_A	0.545	0.98
119_L	133_R	0.545	0.98
173_G	176_I	0.545	0.98
128_L	194_R	0.544	0.98
310_G	353_G	0.543	0.98
191_D	194_R	0.543	0.98
501_L	504_F	0.543	0.98
123_Q	144_Q	0.543	0.98
165_L	168_E	0.542	0.98
507_D	511_A	0.541	0.98
88_P	135_Y	0.541	0.98
222_S	225_M	0.540	0.98
213_Y	217_D	0.536	0.98
304_T	368_H	0.536	0.98
489_T	525_R	0.536	0.98
329_G	374_D	0.535	0.98
391_L	461_F	0.534	0.98
507_D	523_W	0.533	0.98
234_L	469_D	0.530	0.98
220_G	224_Q	0.529	0.98
502_E	505_N	0.529	0.98
130_L	157_V	0.528	0.98
220_G	232_I	0.528	0.98
245_E	368_H	0.527	0.98
411_S	414_K	0.526	0.98
161_L	166_A	0.525	0.98
283_C	291_L	0.524	0.98
380_F	384_L	0.524	0.98
333_L	337_T	0.523	0.98
392_R	457_R	0.522	0.98
204_A	207_N	0.522	0.98
186_F	193_T	0.522	0.98
370_N	394_Q	0.520	0.98
258_A	261_R	0.520	0.98
119_L	141_A	0.520	0.98
489_T	493_R	0.519	0.98
88_P	101_G	0.519	0.98
241_A	390_I	0.518	0.97
140_D	144_Q	0.518	0.97
105_S	191_D	0.516	0.97
508_K	511_A	0.515	0.97
430_Q	465_E	0.515	0.97
308_R	311_R	0.514	0.97
124_K	130_L	0.512	0.97
229_R	258_A	0.512	0.97
348_V	356_P	0.511	0.97
369_C	378_G	0.511	0.97
129_R	141_A	0.511	0.97
257_Q	345_E	0.510	0.97
487_A	492_P	0.509	0.97
459_A	462_L	0.509	0.97
133_R	156_V	0.509	0.97
280_A	347_E	0.508	0.97
346_K	419_A	0.507	0.97
271_Q	274_K	0.507	0.97
486_S	490_P	0.507	0.97
161_L	179_A	0.505	0.97
486_S	489_T	0.504	0.97
409_A	439_L	0.503	0.97
204_A	209_L	0.502	0.97
198_R	202_H	0.502	0.97
319_H	346_K	0.502	0.97
262_E	271_Q	0.502	0.97
438_V	470_L	0.500	0.97
128_L	153_T	0.500	0.97

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4l4uA	2	0.7235	100	0.295	Contact Map
3dzdA	2	0.6894	100	0.444	Contact Map
1ojlA	3	0.5663	100	0.49	Contact Map
4fwgA	3	0.6913	100	0.646	Contact Map
4qhsA	3	0.4583	100	0.694	Contact Map
4qosA	1	0.4508	100	0.695	Contact Map
1r6bX	1	0.8674	100	0.715	Contact Map
1qvrA	3	0.8655	100	0.718	Contact Map
4ciuA	1	0.8485	100	0.727	Contact Map
4d2uA	3	0.8561	100	0.729	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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