GREMLIN Database
PRPR - Propionate catabolism operon regulatory protein
UniProt: P77743 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13600
Length: 528 (427)
Sequences: 11919 (9065)
Seq/√Len: 438.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
374_D379_R4.0011.00
504_F514_Y3.9331.00
247_E399_R3.5961.00
299_E310_G3.3181.00
314_L349_T3.1271.00
373_E377_Q3.1211.00
288_E334_P2.9301.00
415_V452_R2.8791.00
347_E356_P2.8671.00
284_G337_T2.7711.00
110_V126_F2.7341.00
494_L498_Q2.7161.00
316_E350_R2.6691.00
348_V359_V2.6591.00
347_E358_P2.6361.00
234_L463_S2.5821.00
504_F511_A2.5771.00
369_C374_D2.5561.00
232_I255_A2.5061.00
510_A513_N2.4481.00
315_F342_V2.3811.00
320_G360_D2.3761.00
324_F366_A2.3381.00
349_T356_P2.3361.00
299_E353_G2.2941.00
137_T140_D2.2931.00
496_T500_A2.2411.00
406_L436_E2.2031.00
503_K514_Y2.1711.00
370_N373_E2.1631.00
444_W454_M2.1461.00
493_R525_R2.0761.00
114_E117_P2.0761.00
442_Y445_P2.0741.00
373_E376_Q2.0271.00
374_D377_Q2.0111.00
406_L440_L2.0081.00
315_F323_L1.9921.00
255_A395_L1.9911.00
409_A431_G1.9811.00
431_G455_M1.9691.00
221_Q407_P1.9201.00
409_A455_M1.9031.00
330_E369_C1.9011.00
222_S403_A1.8901.00
220_G225_M1.8821.00
273_K360_D1.8821.00
245_E394_Q1.7931.00
240_A456_E1.7861.00
402_V443_D1.7861.00
344_E452_R1.7841.00
253_E341_R1.7791.00
435_S439_L1.7511.00
500_A504_F1.7501.00
94_L113_Q1.7321.00
402_V405_I1.7081.00
430_Q466_P1.7011.00
432_L435_S1.6931.00
353_G357_V1.6831.00
402_V406_L1.6731.00
276_H320_G1.6711.00
292_E338_R1.6641.00
343_L363_V1.6631.00
233_L262_E1.6611.00
411_S415_V1.6511.00
113_Q117_P1.6341.00
185_A192_M1.6241.00
520_T524_R1.6131.00
410_E436_E1.6111.00
424_F430_Q1.5991.00
143_G172_T1.5751.00
202_H206_R1.5721.00
500_A511_A1.5571.00
250_T395_L1.5441.00
435_S467_T1.5431.00
245_E392_R1.5341.00
288_E332_P1.5331.00
412_F452_R1.5211.00
316_E357_V1.4951.00
312_A316_E1.4841.00
144_Q147_E1.4771.00
319_H359_V1.4761.00
319_H360_D1.4761.00
498_Q502_E1.4751.00
220_G229_R1.4641.00
371_L380_F1.4541.00
442_Y450_E1.4511.00
300_E308_R1.4451.00
509_T519_R1.4341.00
436_E440_L1.4311.00
329_G367_T1.4271.00
298_Y303_F1.4221.00
239_S273_K1.4211.00
394_Q400_E1.4211.00
434_A467_T1.4151.00
342_V348_V1.4101.00
520_T523_W1.4101.00
501_L511_A1.4091.00
239_S419_A1.4031.00
194_R198_R1.4021.00
300_E307_R1.3961.00
489_T492_P1.3961.00
438_V467_T1.3941.00
230_Q233_L1.3871.00
488_K492_P1.3861.00
94_L111_T1.3841.00
408_L412_F1.3841.00
299_E350_R1.3741.00
416_S459_A1.3741.00
518_S521_T1.3671.00
365_S388_L1.3661.00
123_Q148_L1.3651.00
240_A420_L1.3621.00
224_Q400_E1.3611.00
110_V121_A1.3591.00
201_T205_T1.3581.00
437_T441_H1.3541.00
499_Q503_K1.3541.00
202_H205_T1.3531.00
419_A456_E1.3471.00
225_M229_R1.3421.00
119_L144_Q1.3371.00
228_V393_L1.3351.00
228_V255_A1.3351.00
185_A190_L1.3341.00
291_L335_L1.3301.00
311_R354_H1.3221.00
348_V358_P1.3141.00
413_L459_A1.3121.00
87_K118_A1.3061.00
372_E376_Q1.3041.00
235_Y391_L1.3041.00
510_A514_Y1.2981.00
149_K152_G1.2961.00
492_P496_T1.2921.00
508_K523_W1.2891.00
245_E372_E1.2791.00
350_R353_G1.2781.00
175_F193_T1.2711.00
417_L423_P1.2661.00
219_L411_S1.2631.00
509_T513_N1.2561.00
413_L431_G1.2401.00
462_L469_D1.2381.00
201_T206_R1.2371.00
376_Q382_R1.2361.00
98_A102_K1.2361.00
431_G436_E1.2341.00
319_H361_V1.2271.00
406_L409_A1.2241.00
507_D510_A1.2171.00
131_D141_A1.2111.00
500_A515_L1.2101.00
199_H203_D1.2101.00
412_F416_S1.2091.00
115_T135_Y1.2071.00
329_G371_L1.2061.00
471_T474_F1.2041.00
500_A514_Y1.2001.00
425_S465_E1.1951.00
417_L425_S1.1941.00
229_R232_I1.1911.00
497_P522_F1.1831.00
298_Y310_G1.1781.00
232_I393_L1.1741.00
227_Q230_Q1.1711.00
405_I409_A1.1701.00
225_M228_V1.1691.00
237_R272_G1.1671.00
215_L258_A1.1631.00
507_D519_R1.1591.00
257_Q280_A1.1571.00
144_Q148_L1.1531.00
284_G330_E1.1501.00
278_F321_G1.1471.00
508_K519_R1.1461.00
330_E368_H1.1451.00
228_V232_I1.1411.00
414_K418_A1.1401.00
217_D261_R1.1391.00
232_I259_I1.1381.00
188_D192_M1.1361.00
88_P94_L1.1341.00
416_S455_M1.1321.00
203_D206_R1.1301.00
201_T204_A1.1271.00
291_L295_L1.1271.00
240_A390_I1.1231.00
240_A460_L1.1221.00
112_Y121_A1.1221.00
294_E311_R1.1201.00
417_L424_F1.1141.00
402_V440_L1.1111.00
247_E397_P1.1101.00
232_I258_A1.1071.00
346_K358_P1.1051.00
495_L499_Q1.1051.00
518_S524_R1.0981.00
115_T119_L1.0981.00
242_V259_I1.0951.00
129_R145_I1.0891.00
243_L365_S1.0761.00
168_E172_T1.0731.00
316_E348_V1.0701.00
280_A341_R1.0691.00
223_P227_Q1.0661.00
410_E414_K1.0611.00
425_S430_Q1.0601.00
122_F145_I1.0591.00
121_A124_K1.0581.00
412_F455_M1.0571.00
228_V395_L1.0561.00
231_T461_F1.0541.00
224_Q227_Q1.0511.00
218_M254_L1.0511.00
403_A440_L1.0491.00
239_S272_G1.0471.00
293_A298_Y1.0411.00
218_M225_M1.0401.00
495_L498_Q1.0401.00
253_E280_A1.0331.00
190_L193_T1.0321.00
244_I255_A1.0271.00
258_A262_E1.0221.00
390_I453_N1.0191.00
432_L466_P1.0191.00
471_T475_M1.0131.00
372_E473_Q1.0121.00
457_R461_F1.0121.00
218_M229_R1.0111.00
519_R523_W1.0081.00
350_R357_V1.0061.00
199_H202_H1.0011.00
298_Y302_A0.9961.00
195_M198_R0.9941.00
521_T525_R0.9941.00
323_L363_V0.9931.00
131_D156_V0.9911.00
185_A188_D0.9901.00
98_A111_T0.9881.00
241_A346_K0.9831.00
497_P525_R0.9821.00
317_I354_H0.9801.00
431_G435_S0.9751.00
417_L459_A0.9721.00
504_F510_A0.9721.00
128_L190_L0.9701.00
467_T471_T0.9701.00
257_Q261_R0.9671.00
218_M255_A0.9631.00
499_Q502_E0.9621.00
488_K496_T0.9611.00
115_T141_A0.9581.00
202_H209_L0.9581.00
142_R154_E0.9581.00
501_L526_L0.9571.00
221_Q226_E0.9561.00
204_A208_A0.9551.00
315_F361_V0.9551.00
496_T515_L0.9551.00
121_A126_F0.9531.00
322_T364_I0.9521.00
226_E230_Q0.9491.00
205_T209_L0.9481.00
517_I521_T0.9461.00
129_R152_G0.9461.00
458_L462_L0.9421.00
437_T440_L0.9391.00
315_F359_V0.9361.00
300_E310_G0.9331.00
140_D143_G0.9281.00
314_L317_I0.9241.00
389_S392_R0.9201.00
312_A354_H0.9181.00
282_N330_E0.9171.00
220_G407_P0.9151.00
244_I364_I0.9151.00
173_G177_Y0.9091.00
508_K520_T0.9031.00
488_K491_A0.9021.00
114_E135_Y0.9001.00
279_V318_A0.8991.00
244_I256_A0.8981.00
235_Y242_V0.8981.00
241_A365_S0.8971.00
215_L232_I0.8971.00
312_A317_I0.8941.00
491_A495_L0.8901.00
323_L342_V0.8901.00
422_A459_A0.8891.00
134_S160_G0.8861.00
405_I439_L0.8831.00
523_W527_K0.8821.00
186_F189_A0.8811.00
201_T208_A0.8811.00
517_I522_F0.8781.00
287_A351_V0.8731.00
279_V317_I0.8721.00
168_E171_M0.8711.00
454_M458_L0.8711.00
433_Q437_T0.8691.00
508_K522_F0.8671.00
508_K515_L0.8671.00
226_E229_R0.8601.00
117_P120_V0.8571.00
508_K526_L0.8551.00
389_S457_R0.8541.00
433_Q436_E0.8501.00
372_E392_R0.8481.00
331_M335_L0.8471.00
506_G526_L0.8451.00
131_D135_Y0.8451.00
219_L407_P0.8441.00
141_A145_I0.8411.00
120_V123_Q0.8411.00
369_C379_R0.8391.00
223_P226_E0.8371.00
521_T524_R0.8371.00
501_L508_K0.8351.00
410_E430_Q0.8341.00
108_G116_I0.8311.00
105_S187_S0.8311.00
112_Y118_A0.8301.00
88_P98_A0.8291.00
317_I353_G0.8281.00
116_I120_V0.8271.00
302_A351_V0.8231.00
497_P515_L0.8221.00
139_E169_A0.8211.00
229_R255_A0.8201.00
489_T496_T0.8191.00
363_V388_L0.8181.00
163_T167_E0.8171.00
129_R132_Q0.8161.00
417_L422_A0.8121.00
511_A514_Y0.8121.00
238_S460_L0.8091.00
234_L422_A0.8081.00
111_T115_T0.8071.00
409_A436_E0.8061.00
315_F348_V0.8061.00
247_E250_T0.8041.00
230_Q463_S0.8021.00
229_R233_L0.8021.00
165_L177_Y0.8001.00
501_L506_G0.7991.00
94_L98_A0.7981.00
303_F306_S0.7921.00
452_R456_E0.7881.00
420_L459_A0.7851.00
312_A350_R0.7821.00
130_L190_L0.7811.00
232_I262_E0.7801.00
282_N331_M0.7771.00
164_D168_E0.7761.00
329_G368_H0.7751.00
199_H206_R0.7751.00
341_R345_E0.7741.00
523_W526_L0.7731.00
406_L410_E0.7731.00
240_A391_L0.7731.00
91_Y95_Q0.7731.00
244_I395_L0.7701.00
298_Y307_R0.7671.00
185_A189_A0.7671.00
420_L460_L0.7661.00
518_S523_W0.7651.00
502_E506_G0.7651.00
413_L417_L0.7651.00
298_Y351_V0.7651.00
142_R156_V0.7651.00
298_Y311_R0.7641.00
522_F526_L0.7601.00
281_V323_L0.7591.00
375_M385_F0.7591.00
236_A262_E0.7581.00
131_D154_E0.7571.00
402_V407_P0.7551.00
416_S452_R0.7551.00
189_A192_M0.7531.00
287_A290_L0.7491.00
201_T209_L0.7471.00
95_Q98_A0.7461.00
416_S456_E0.7461.00
185_A193_T0.7441.00
133_R165_L0.7391.00
328_I388_L0.7391.00
291_L331_M0.7381.00
256_A278_F0.7321.00
234_L461_F0.7301.00
220_G255_A0.7291.00
348_V357_V0.7291.00
438_V474_F0.7271.00
273_K276_H0.7251.00
487_A491_A0.7251.00
215_L229_R0.7231.00
286_I295_L0.7221.00
192_M195_M0.7201.00
115_T137_T0.7191.00
112_Y117_P0.7181.00
319_H357_V0.7161.00
315_F363_V0.7161.00
487_A495_L0.7121.00
206_R209_L0.7111.00
120_V124_K0.7071.00
203_D207_N0.7051.00
143_G147_E0.7041.00
405_I440_L0.7031.00
512_A522_F0.7001.00
202_H207_N0.6991.00
310_G355_Q0.6971.00
519_R524_R0.6961.00
215_L262_E0.6951.00
416_S420_L0.6951.00
293_A303_F0.6951.00
490_P494_L0.6941.00
372_E382_R0.6941.00
220_G226_E0.6931.00
107_I191_D0.6921.00
167_E171_M0.6911.00
522_F525_R0.6891.00
372_E385_F0.6891.00
320_G361_V0.6871.00
310_G350_R0.6871.00
200_N204_A0.6851.00
439_L444_W0.6851.00
384_L388_L0.6841.00
450_E473_Q0.6821.00
185_A194_R0.6821.00
311_R314_L0.6801.00
511_A522_F0.6801.00
225_M255_A0.6771.00
402_V441_H0.6741.00
131_D145_I0.6741.00
372_E375_M0.6731.00
442_Y474_F0.6721.00
524_R527_K0.6711.00
497_P511_A0.6701.00
188_D193_T0.6691.00
457_R460_L0.6691.00
98_A101_G0.6661.00
493_R497_P0.6661.00
329_G369_C0.6661.00
223_P403_A0.6651.00
385_F389_S0.6651.00
188_D191_D0.6601.00
155_A189_A0.6591.00
205_T208_A0.6571.00
415_V419_A0.6551.00
435_S458_L0.6551.00
416_S419_A0.6510.99
422_A425_S0.6500.99
239_S360_D0.6480.99
281_V314_L0.6480.99
295_L335_L0.6470.99
409_A458_L0.6460.99
191_D195_M0.6440.99
497_P526_L0.6380.99
178_S182_V0.6380.99
224_Q403_A0.6380.99
145_I154_E0.6380.99
515_L525_R0.6310.99
215_L233_L0.6310.99
248_T330_E0.6290.99
307_R310_G0.6280.99
158_G161_L0.6280.99
311_R317_I0.6270.99
312_A348_V0.6270.99
319_H358_P0.6260.99
88_P93_V0.6260.99
163_T166_A0.6250.99
490_P493_R0.6230.99
228_V231_T0.6220.99
486_S500_A0.6210.99
237_R271_Q0.6210.99
90_G94_L0.6200.99
220_G404_D0.6200.99
117_P121_A0.6180.99
432_L467_T0.6160.99
143_G168_E0.6160.99
211_T261_R0.6160.99
281_V295_L0.6150.99
253_E345_E0.6140.99
238_S420_L0.6130.99
407_P410_E0.6130.99
329_G380_F0.6120.99
331_M339_L0.6120.99
398_L451_L0.6110.99
88_P102_K0.6110.99
424_F459_A0.6090.99
239_S420_L0.6070.99
319_H348_V0.6070.99
221_Q403_A0.6050.99
409_A413_L0.6040.99
273_K361_V0.6040.99
236_A271_Q0.6030.99
302_A306_S0.6030.99
290_L351_V0.6020.99
390_I456_E0.6000.99
290_L304_T0.5980.99
298_Y306_S0.5980.99
187_S191_D0.5960.99
397_P400_E0.5950.99
171_M176_I0.5940.99
217_D258_A0.5940.99
146_N153_T0.5940.99
286_I291_L0.5940.99
190_L194_R0.5930.99
519_R522_F0.5920.99
407_P411_S0.5920.99
304_T366_A0.5920.99
157_V160_G0.5900.99
506_G511_A0.5900.99
254_L258_A0.5890.99
423_P465_E0.5890.99
96_A100_A0.5870.99
231_T391_L0.5870.99
438_V441_H0.5870.99
230_Q234_L0.5860.99
419_A452_R0.5860.99
184_Q188_D0.5850.99
438_V442_Y0.5840.99
186_F192_M0.5840.99
346_K361_V0.5830.99
425_S459_A0.5830.99
346_K360_D0.5820.99
508_K518_S0.5800.99
97_L101_G0.5790.99
99_K102_K0.5770.99
287_A292_E0.5770.99
170_G176_I0.5770.99
277_P317_I0.5760.99
92_D96_A0.5760.99
88_P91_Y0.5740.99
231_T234_L0.5710.99
342_V345_E0.5710.99
112_Y115_T0.5710.99
189_A193_T0.5700.99
245_E370_N0.5690.99
218_M258_A0.5690.99
299_E351_V0.5690.99
122_F129_R0.5690.99
509_T523_W0.5680.99
184_Q187_S0.5670.99
253_E344_E0.5660.99
282_N285_A0.5660.99
346_K359_V0.5650.99
122_F126_F0.5640.99
353_G356_P0.5640.99
518_S525_R0.5640.99
190_L195_M0.5640.99
227_Q231_T0.5630.99
130_L155_A0.5630.99
86_I109_V0.5610.98
491_A494_L0.5610.98
496_T499_Q0.5610.98
167_E170_G0.5600.98
508_K517_I0.5600.98
286_I314_L0.5590.98
189_A194_R0.5590.98
458_L470_L0.5590.98
403_A406_L0.5590.98
486_S525_R0.5570.98
235_Y393_L0.5550.98
250_T254_L0.5540.98
316_E319_H0.5540.98
454_M470_L0.5540.98
91_Y94_L0.5540.98
96_A99_K0.5540.98
310_G357_V0.5530.98
515_L521_T0.5520.98
88_P95_Q0.5520.98
89_S132_Q0.5510.98
520_T527_K0.5490.98
342_V361_V0.5490.98
329_G366_A0.5450.98
119_L133_R0.5450.98
173_G176_I0.5450.98
128_L194_R0.5440.98
310_G353_G0.5430.98
191_D194_R0.5430.98
501_L504_F0.5430.98
123_Q144_Q0.5430.98
165_L168_E0.5420.98
507_D511_A0.5410.98
88_P135_Y0.5410.98
222_S225_M0.5400.98
213_Y217_D0.5360.98
304_T368_H0.5360.98
489_T525_R0.5360.98
329_G374_D0.5350.98
391_L461_F0.5340.98
507_D523_W0.5330.98
234_L469_D0.5300.98
220_G224_Q0.5290.98
502_E505_N0.5290.98
130_L157_V0.5280.98
220_G232_I0.5280.98
245_E368_H0.5270.98
411_S414_K0.5260.98
161_L166_A0.5250.98
283_C291_L0.5240.98
380_F384_L0.5240.98
333_L337_T0.5230.98
392_R457_R0.5220.98
204_A207_N0.5220.98
186_F193_T0.5220.98
370_N394_Q0.5200.98
258_A261_R0.5200.98
119_L141_A0.5200.98
489_T493_R0.5190.98
88_P101_G0.5190.98
241_A390_I0.5180.97
140_D144_Q0.5180.97
105_S191_D0.5160.97
508_K511_A0.5150.97
430_Q465_E0.5150.97
308_R311_R0.5140.97
124_K130_L0.5120.97
229_R258_A0.5120.97
348_V356_P0.5110.97
369_C378_G0.5110.97
129_R141_A0.5110.97
257_Q345_E0.5100.97
487_A492_P0.5090.97
459_A462_L0.5090.97
133_R156_V0.5090.97
280_A347_E0.5080.97
346_K419_A0.5070.97
271_Q274_K0.5070.97
486_S490_P0.5070.97
161_L179_A0.5050.97
486_S489_T0.5040.97
409_A439_L0.5030.97
204_A209_L0.5020.97
198_R202_H0.5020.97
319_H346_K0.5020.97
262_E271_Q0.5020.97
438_V470_L0.5000.97
128_L153_T0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4l4uA 2 0.7235 100 0.295 Contact Map
3dzdA 2 0.6894 100 0.444 Contact Map
1ojlA 3 0.5663 100 0.49 Contact Map
4fwgA 3 0.6913 100 0.646 Contact Map
4qhsA 3 0.4583 100 0.694 Contact Map
4qosA 1 0.4508 100 0.695 Contact Map
1r6bX 1 0.8674 100 0.715 Contact Map
1qvrA 3 0.8655 100 0.718 Contact Map
4ciuA 1 0.8485 100 0.727 Contact Map
4d2uA 3 0.8561 100 0.729 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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