GREMLIN Database
OPPF - Oligopeptide transport ATP-binding protein OppF
UniProt: P77737 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10678
Length: 334 (269)
Sequences: 51015 (31774)
Seq/√Len: 1937.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
51_E234_R4.3891.00
102_D184_K3.6651.00
22_E46_R3.4811.00
25_D42_G3.4751.00
24_K80_H3.2401.00
38_K41_D3.0131.00
80_H87_E2.9021.00
53_L236_L2.8761.00
234_R246_L2.8231.00
248_T251_E2.7811.00
48_Y51_E2.7351.00
54_G232_S2.6821.00
150_K214_M2.6371.00
236_L243_A2.5451.00
84_L184_K2.5361.00
22_E82_A2.5071.00
41_D242_H2.4071.00
157_L160_R2.3521.00
23_I26_G2.2591.00
229_K250_D2.1931.00
24_K82_A2.1771.00
67_A221_I2.1451.00
49_E184_K2.1031.00
118_M122_E2.1011.00
147_M180_I2.0981.00
143_R146_A2.0801.00
29_W38_K2.0631.00
247_G252_V2.0551.00
87_E90_G2.0501.00
136_S139_E2.0021.00
143_R182_E1.9911.00
236_L246_L1.9271.00
72_G96_W1.8571.00
145_K158_I1.8421.00
67_A187_I1.8201.00
222_A228_V1.7591.00
54_G228_V1.7241.00
247_G251_E1.7221.00
19_V22_E1.7161.00
19_V48_Y1.7061.00
146_A150_K1.6641.00
23_I45_L1.6551.00
160_R164_E1.6281.00
84_L102_D1.6021.00
125_A140_V1.5961.00
121_G158_I1.5791.00
121_G159_N1.5661.00
96_W100_R1.5621.00
208_Q230_H1.5551.00
30_F65_T1.5451.00
125_A144_V1.5421.00
25_D44_T1.5401.00
145_K155_P1.5271.00
251_E255_N1.5101.00
210_L216_L1.5011.00
129_R140_V1.4971.00
182_E214_M1.4801.00
157_L165_F1.4791.00
121_G125_A1.4741.00
141_R145_K1.4711.00
29_W36_T1.4441.00
26_G76_A1.4311.00
188_C218_L1.4051.00
119_T122_E1.3991.00
47_L53_L1.3901.00
18_K49_E1.3841.00
45_L236_L1.3691.00
45_L66_F1.3571.00
204_V227_V1.3571.00
52_T211_Q1.3401.00
106_I188_C1.3181.00
124_I148_M1.3111.00
51_E233_D1.3091.00
53_L234_R1.3001.00
111_L170_C1.2951.00
23_I70_I1.2811.00
71_I105_M1.2671.00
165_F173_I1.2601.00
72_G75_K1.2581.00
122_E125_A1.2581.00
19_V46_R1.2461.00
182_E216_L1.2411.00
24_K46_R1.2391.00
141_R158_I1.2371.00
31_W34_P1.2301.00
52_T232_S1.2291.00
142_E146_A1.2131.00
52_T218_L1.2101.00
149_L155_P1.2051.00
262_R266_S1.2001.00
43_V66_F1.1981.00
69_A76_A1.1971.00
148_M158_I1.1961.00
49_E84_L1.1961.00
119_T159_N1.1931.00
145_K149_L1.1861.00
55_V219_I1.1821.00
32_Q35_K1.1721.00
24_K44_T1.1711.00
121_G141_R1.1681.00
207_L218_L1.1521.00
138_Q142_E1.1501.00
250_D254_H1.1471.00
139_E142_E1.1461.00
86_K91_M1.1451.00
82_A87_E1.1451.00
208_Q211_Q1.1391.00
154_L157_L1.1201.00
123_I177_R1.1161.00
117_R163_H1.1161.00
259_P262_R1.1111.00
91_M96_W1.1031.00
124_I180_I1.1011.00
156_N160_R1.0931.00
146_A149_L1.0921.00
104_Q183_P1.0891.00
25_D78_D1.0851.00
53_L246_L1.0821.00
66_F238_M1.0781.00
195_L203_V1.0771.00
235_V249_Y1.0721.00
48_Y234_R1.0681.00
186_I216_L1.0581.00
261_T265_M1.0551.00
132_H135_M1.0511.00
140_V144_V1.0421.00
118_M126_E1.0371.00
251_E254_H1.0311.00
152_G209_Q1.0311.00
125_A129_R1.0211.00
29_W41_D1.0151.00
47_L185_L1.0131.00
249_Y260_Y1.0121.00
55_V236_L1.0051.00
128_L180_I1.0031.00
186_I218_L1.0001.00
266_S282_Q0.9951.00
99_V103_I0.9901.00
136_S140_V0.9901.00
137_R140_V0.9891.00
220_F231_I0.9751.00
69_A74_V0.9711.00
31_W36_T0.9701.00
104_Q178_A0.9681.00
48_Y217_S0.9641.00
71_I187_I0.9621.00
211_Q218_L0.9611.00
70_I219_I0.9591.00
270_I273_P0.9571.00
31_W35_K0.9531.00
103_I185_L0.9421.00
40_V69_A0.9391.00
55_V66_F0.9281.00
49_E215_G0.9261.00
135_M140_V0.9251.00
23_I81_V0.9191.00
68_R73_L0.9181.00
200_Q224_D0.9181.00
125_A141_R0.9171.00
61_C238_M0.9141.00
121_G144_V0.9141.00
137_R141_R0.9061.00
139_E143_R0.9001.00
19_V49_E0.8941.00
68_R74_V0.8931.00
190_E223_H0.8881.00
114_L170_C0.8791.00
147_M150_K0.8691.00
208_Q231_I0.8681.00
20_H84_L0.8661.00
52_T208_Q0.8641.00
118_M123_I0.8631.00
147_M176_A0.8611.00
200_Q227_V0.8591.00
220_F232_S0.8521.00
290_S293_N0.8511.00
119_T161_Y0.8421.00
150_K209_Q0.8401.00
252_V261_T0.8351.00
120_I173_I0.8331.00
141_R159_N0.8321.00
29_W42_G0.8271.00
29_W77_T0.8251.00
256_P261_T0.8221.00
234_R244_V0.8211.00
26_G69_A0.8211.00
47_L217_S0.8201.00
149_L154_L0.8191.00
69_A77_T0.8191.00
259_P263_A0.8191.00
188_C207_L0.8171.00
83_W102_D0.8161.00
291_P294_P0.8131.00
133_P136_S0.8031.00
143_R147_M0.8021.00
40_V43_V0.8021.00
20_H83_W0.8001.00
106_I175_I0.7981.00
211_Q233_D0.7941.00
42_G242_H0.7931.00
30_F74_V0.7931.00
21_F70_I0.7931.00
47_L219_I0.7881.00
31_W38_K0.7871.00
56_V237_V0.7861.00
69_A81_V0.7861.00
140_V145_K0.7851.00
127_P177_R0.7841.00
32_Q36_T0.7831.00
249_Y253_Y0.7781.00
133_P143_R0.7761.00
135_M139_E0.7761.00
43_V243_A0.7761.00
86_K102_D0.7751.00
33_P36_T0.7741.00
87_E91_M0.7731.00
128_L134_K0.7721.00
56_V228_V0.7701.00
20_H48_Y0.7671.00
232_S235_V0.7641.00
243_A246_L0.7611.00
115_N118_M0.7601.00
227_V231_I0.7581.00
144_V158_I0.7581.00
101_S133_P0.7561.00
144_V147_M0.7551.00
20_H46_R0.7521.00
29_W78_D0.7501.00
253_Y256_P0.7501.00
39_A65_T0.7481.00
187_I219_I0.7431.00
30_F34_P0.7421.00
30_F39_A0.7411.00
127_P181_L0.7381.00
167_G172_R0.7361.00
206_L209_Q0.7341.00
152_G202_Q0.7331.00
293_N296_S0.7321.00
237_V256_P0.7301.00
232_S249_Y0.7281.00
120_I165_F0.7261.00
204_V230_H0.7251.00
281_I284_L0.7241.00
74_V77_T0.7231.00
287_E290_S0.7221.00
153_L157_L0.7211.00
286_G290_S0.7191.00
88_L99_V0.7191.00
53_L219_I0.7181.00
151_V176_A0.7181.00
245_E255_N0.7181.00
205_N209_Q0.7141.00
32_Q77_T0.7091.00
19_V84_L0.7091.00
21_F83_W0.7071.00
192_V227_V0.7061.00
239_Y244_V0.7041.00
289_P295_P0.7041.00
91_M99_V0.7021.00
291_P295_P0.7011.00
52_T231_I0.7001.00
162_P173_I0.7001.00
161_Y164_E0.6981.00
119_T123_I0.6981.00
201_A205_N0.6941.00
239_Y242_H0.6931.00
239_Y263_A0.6921.00
18_K48_Y0.6911.00
290_S294_P0.6871.00
258_H261_T0.6821.00
83_W99_V0.6781.00
237_V252_V0.6741.00
185_L219_I0.6731.00
129_R137_R0.6701.00
98_A101_S0.6691.00
288_L291_P0.6671.00
52_T233_D0.6671.00
20_H49_E0.6651.00
80_H90_G0.6651.00
106_I178_A0.6621.00
141_R144_V0.6581.00
165_F169_Q0.6581.00
20_H185_L0.6531.00
18_K84_L0.6531.00
133_P140_V0.6511.00
285_E288_L0.6491.00
205_N208_Q0.6461.00
92_K98_A0.6451.00
157_L169_Q0.6441.00
114_L173_I0.6441.00
71_I103_I0.6441.00
42_G78_D0.6431.00
286_G291_P0.6411.00
225_L253_Y0.6401.00
292_I295_P0.6391.00
80_H89_L0.6361.00
280_T283_L0.6351.00
185_L217_S0.6331.00
262_R265_M0.6311.00
245_E257_L0.6311.00
147_M179_L0.6301.00
124_I144_V0.6301.00
68_R105_M0.6291.00
33_P38_K0.6281.00
73_L107_F0.6281.00
280_T284_L0.6281.00
291_P296_S0.6271.00
289_P293_N0.6271.00
114_L123_I0.6261.00
70_I81_V0.6261.00
286_G289_P0.6251.00
112_A170_C0.6251.00
83_W185_L0.6251.00
263_A266_S0.6241.00
263_A267_A0.6231.00
52_T220_F0.6211.00
98_A102_D0.6201.00
51_E246_L0.6201.00
245_E256_P0.6181.00
133_P137_R0.6161.00
278_N282_Q0.6161.00
255_N258_H0.6141.00
244_V258_H0.6131.00
148_M157_L0.6131.00
64_S68_R0.6111.00
92_K96_W0.6111.00
23_I66_F0.6051.00
288_L295_P0.6041.00
156_N159_N0.6031.00
205_N230_H0.6021.00
121_G124_I0.6011.00
287_E294_P0.5991.00
142_E149_L0.5961.00
179_L216_L0.5931.00
274_D278_N0.5921.00
83_W88_L0.5901.00
283_L287_E0.5851.00
133_P138_Q0.5831.00
251_E257_L0.5831.00
21_F185_L0.5821.00
40_V66_F0.5811.00
287_E291_P0.5801.00
222_A227_V0.5791.00
202_Q205_N0.5781.00
175_I203_V0.5771.00
279_K282_Q0.5771.00
59_S190_E0.5771.00
58_E61_C0.5761.00
50_G217_S0.5751.00
290_S295_P0.5721.00
288_L292_I0.5711.00
123_I162_P0.5681.00
82_A85_G0.5661.00
236_L244_V0.5651.00
228_V232_S0.5621.00
127_P130_T0.5621.00
75_K89_L0.5601.00
88_L103_I0.5591.00
142_E145_K0.5581.00
166_S169_Q0.5571.00
288_L294_P0.5571.00
192_V203_V0.5571.00
32_Q69_A0.5571.00
49_E217_S0.5561.00
32_Q37_L0.5551.00
282_Q285_E0.5541.00
136_S145_K0.5531.00
81_V89_L0.5491.00
260_Y263_A0.5481.00
211_Q214_M0.5481.00
153_L169_Q0.5471.00
86_K99_V0.5461.00
260_Y264_L0.5461.00
113_S174_G0.5421.00
125_A158_I0.5421.00
46_R246_L0.5421.00
143_R150_K0.5411.00
184_K216_L0.5361.00
284_L287_E0.5351.00
171_Q194_A0.5321.00
29_W32_Q0.5311.00
109_D112_A0.5301.00
88_L96_W0.5251.00
289_P294_P0.5251.00
284_L288_L0.5241.00
245_E252_V0.5221.00
31_W77_T0.5221.00
228_V235_V0.5211.00
139_E148_M0.5211.00
289_P292_I0.5181.00
123_I127_P0.5151.00
106_I171_Q0.5151.00
38_K42_G0.5141.00
238_M243_A0.5141.00
124_I127_P0.5121.00
279_K283_L0.5101.00
128_L181_L0.5071.00
125_A128_L0.5061.00
267_A270_I0.5061.00
76_A89_L0.5041.00
247_G253_Y0.5041.00
239_Y258_H0.5021.00
58_E239_Y0.5011.00
267_A271_P0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3tuiC 2 0.8892 100 0.237 Contact Map
4ry2A 2 0.7485 100 0.242 Contact Map
4fwiB 1 0.9072 100 0.247 Contact Map
4f4cA 1 0.7305 100 0.253 Contact Map
4mkiB 2 0.8443 100 0.264 Contact Map
3b5xA 2 0.7665 100 0.264 Contact Map
4q9hA 1 0.7695 100 0.266 Contact Map
1oxxK 1 0.9012 100 0.267 Contact Map
4huqA 1 0.8383 100 0.268 Contact Map
4ymuJ 2 0.7186 100 0.268 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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