GREMLIN Database
YAJO - Uncharacterized oxidoreductase YajO
UniProt: P77735 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13611
Length: 324 (267)
Sequences: 32139 (19946)
Seq/√Len: 1220.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
46_R293_D3.2011.00
110_D150_K3.0301.00
37_E72_R2.9651.00
261_L307_Q2.8341.00
75_R117_G2.8161.00
109_I145_V2.5441.00
304_K307_Q2.5161.00
106_L144_D2.4271.00
41_R76_D2.4121.00
106_L148_A2.3941.00
46_R50_G2.3741.00
260_E310_E2.2221.00
143_N147_K2.0711.00
275_S308_I2.0481.00
41_R72_R2.0411.00
260_E307_Q2.0301.00
255_T259_E2.0201.00
120_Y152_R1.9781.00
111_D115_R1.9711.00
144_D148_A1.9701.00
200_L204_E1.9361.00
305_P309_A1.9101.00
79_R82_D1.8941.00
289_E293_D1.8921.00
201_C208_V1.8871.00
256_G310_E1.8811.00
17_C54_F1.8691.00
125_Q181_S1.8101.00
102_R144_D1.8071.00
65_S68_E1.8021.00
46_R289_E1.8011.00
50_G293_D1.7701.00
85_V118_M1.7601.00
87_T121_V1.7531.00
276_K312_E1.7461.00
165_A169_E1.7371.00
263_A301_I1.7191.00
144_D147_K1.7191.00
68_E115_R1.6991.00
271_A301_I1.6951.00
253_R256_G1.6591.00
102_R106_L1.6521.00
47_A52_I1.6491.00
50_G296_L1.6371.00
264_T294_E1.6331.00
165_A200_L1.6201.00
87_T112_S1.6101.00
41_R45_K1.6071.00
297_N300_D1.6051.00
41_R73_A1.6021.00
89_V124_L1.5991.00
109_I124_L1.5901.00
207_A281_A1.5891.00
89_V105_I1.5861.00
309_A313_T1.5821.00
36_P39_S1.5711.00
106_L110_D1.5671.00
86_A125_Q1.5621.00
141_A144_D1.5551.00
143_N177_A1.5531.00
45_K76_D1.5381.00
46_R49_E1.5341.00
20_C55_F1.5161.00
59_N108_S1.4971.00
11_L153_Y1.4931.00
125_Q209_I1.4711.00
196_E199_P1.4431.00
107_R111_D1.4431.00
121_V151_A1.4361.00
44_I73_A1.4211.00
263_A267_Q1.4191.00
48_L83_V1.4131.00
39_S42_P1.4051.00
110_D114_R1.4021.00
202_Y277_P1.3921.00
160_H163_Q1.3901.00
168_L204_E1.3861.00
199_P203_Q1.3831.00
146_V177_A1.3711.00
37_E41_R1.3681.00
293_D297_N1.3331.00
11_L84_V1.3221.00
45_K49_E1.3201.00
184_D208_V1.3171.00
102_R140_E1.3171.00
168_L200_L1.3031.00
271_A275_S1.2991.00
106_L141_A1.2971.00
145_V151_A1.2951.00
310_E313_T1.2821.00
263_A268_V1.2821.00
151_A154_I1.2811.00
153_Y180_V1.2761.00
111_D114_R1.2731.00
42_P46_R1.2611.00
253_R310_E1.2611.00
102_R141_A1.2531.00
286_T291_Q1.2451.00
136_E170_L1.2281.00
161_A200_L1.2221.00
55_F70_V1.2211.00
116_L121_V1.2181.00
257_V268_V1.2161.00
84_V123_I1.2131.00
264_T267_Q1.2111.00
256_G260_E1.2081.00
80_R120_Y1.2061.00
67_E112_S1.2011.00
109_I121_V1.1961.00
286_T292_L1.1881.00
80_R118_M1.1851.00
72_R117_G1.1831.00
71_G117_G1.1831.00
165_A203_Q1.1761.00
68_E72_R1.1661.00
198_L202_Y1.1631.00
123_I181_S1.1611.00
290_E293_D1.1511.00
188_L311_L1.1431.00
45_K77_F1.1421.00
129_W163_Q1.1391.00
104_Q107_R1.1361.00
137_E140_E1.1351.00
143_N146_V1.1121.00
38_E42_P1.1111.00
110_D148_A1.1081.00
9_T153_Y1.1071.00
103_A107_R1.1061.00
54_F209_I1.1051.00
186_Y276_K1.0931.00
273_L282_P1.0921.00
146_V180_V1.0901.00
43_I292_L1.0871.00
255_T265_R1.0831.00
54_F86_A1.0781.00
101_S104_Q1.0761.00
142_L154_I1.0731.00
165_A204_E1.0711.00
189_I251_A1.0691.00
185_H190_Y1.0661.00
254_L265_R1.0601.00
126_I142_L1.0521.00
252_E256_G1.0451.00
191_R315_Y1.0391.00
20_C70_V1.0311.00
53_N84_V1.0311.00
45_K73_A1.0231.00
267_Q297_N1.0221.00
256_G259_E1.0221.00
136_E166_Q1.0141.00
166_Q170_L1.0091.00
252_E255_T1.0001.00
42_P289_E0.9921.00
161_A165_A0.9911.00
8_K180_V0.9911.00
145_V150_K0.9911.00
92_R99_G0.9861.00
14_S53_N0.9781.00
156_A179_F0.9611.00
74_L83_V0.9611.00
274_L298_A0.9581.00
292_L296_L0.9571.00
140_E144_D0.9541.00
15_R274_L0.9531.00
188_L269_A0.9521.00
181_S209_I0.9511.00
72_R76_D0.9501.00
199_P202_Y0.9461.00
14_S52_I0.9371.00
102_R137_E0.9371.00
100_L126_I0.9361.00
267_Q294_E0.9321.00
122_D152_R0.9301.00
195_R199_P0.9281.00
9_T180_V0.9281.00
209_I281_A0.9281.00
68_E114_R0.9141.00
145_V148_A0.9071.00
294_E297_N0.9021.00
59_N104_Q0.9001.00
270_L298_A0.8971.00
44_I55_F0.8951.00
106_L109_I0.8941.00
156_A164_F0.8931.00
290_E294_E0.8891.00
107_R110_D0.8861.00
260_E304_K0.8841.00
67_E115_R0.8831.00
141_A145_V0.8821.00
202_Y279_I0.8741.00
15_R299_V0.8741.00
154_I179_F0.8711.00
182_M201_C0.8711.00
42_P45_K0.8691.00
257_V261_L0.8691.00
86_A209_I0.8651.00
309_A312_E0.8601.00
275_S302_T0.8601.00
276_K308_I0.8591.00
224_G255_T0.8581.00
306_E310_E0.8521.00
261_L304_K0.8451.00
158_S211_W0.8441.00
306_E309_A0.8421.00
143_N154_I0.8421.00
140_E143_N0.8411.00
288_R291_Q0.8341.00
166_Q169_E0.8321.00
48_L79_R0.8261.00
86_A123_I0.8261.00
200_L203_Q0.8251.00
99_G104_Q0.8241.00
106_L145_V0.8241.00
9_T146_V0.8231.00
194_E199_P0.8211.00
198_L208_V0.8201.00
164_F206_V0.8151.00
20_C66_S0.8141.00
18_L47_A0.8031.00
37_E65_S0.7971.00
113_L150_K0.7941.00
191_R312_E0.7841.00
213_P284_I0.7811.00
128_R158_S0.7791.00
275_S305_P0.7691.00
161_A197_M0.7671.00
269_A273_L0.7651.00
57_T70_V0.7601.00
17_C284_I0.7581.00
168_L178_Q0.7561.00
46_R292_L0.7561.00
224_G252_E0.7541.00
245_E249_Q0.7541.00
18_L23_F0.7531.00
186_Y198_L0.7521.00
59_N99_G0.7481.00
139_L167_A0.7441.00
113_L118_M0.7431.00
87_T124_L0.7341.00
76_D79_R0.7321.00
50_G297_N0.7271.00
59_N115_R0.7271.00
59_N111_D0.7161.00
210_P213_P0.7131.00
139_L179_F0.7131.00
197_M201_C0.7081.00
303_L308_I0.7081.00
263_A300_D0.7071.00
210_P282_P0.7071.00
272_W312_E0.7061.00
156_A182_M0.7061.00
109_I150_K0.7041.00
40_S69_I0.7011.00
81_E120_Y0.7001.00
207_A280_A0.6961.00
263_A297_N0.6961.00
271_A298_A0.6951.00
52_I296_L0.6941.00
191_R194_E0.6901.00
100_L138_T0.6891.00
139_L154_I0.6891.00
253_R314_P0.6891.00
105_I145_V0.6871.00
11_L152_R0.6861.00
16_L274_L0.6851.00
261_L268_V0.6851.00
287_S291_Q0.6831.00
201_C206_V0.6821.00
249_Q252_E0.6811.00
108_S111_D0.6801.00
43_I289_E0.6731.00
45_K79_R0.6731.00
254_L311_L0.6711.00
48_L55_F0.6701.00
135_I170_L0.6701.00
44_I48_L0.6691.00
156_A159_M0.6691.00
257_V307_Q0.6671.00
266_A294_E0.6651.00
23_F43_I0.6651.00
138_T141_A0.6621.00
38_E41_R0.6581.00
48_L77_F0.6551.00
254_L269_A0.6541.00
53_N82_D0.6531.00
273_L280_A0.6531.00
105_I138_T0.6521.00
291_Q294_E0.6511.00
101_S138_T0.6501.00
198_L276_K0.6501.00
161_A196_E0.6491.00
21_M212_S0.6451.00
186_Y273_L0.6441.00
268_V303_L0.6441.00
268_V301_I0.6401.00
259_E262_G0.6381.00
112_S124_L0.6371.00
146_V153_Y0.6341.00
213_P273_L0.6341.00
39_S289_E0.6331.00
13_V281_A0.6261.00
263_A271_A0.6251.00
60_S90_F0.6241.00
130_D133_T0.6201.00
142_L146_V0.6161.00
73_A77_F0.6151.00
50_G292_L0.6141.00
165_A168_L0.6121.00
257_V310_E0.6101.00
79_R83_V0.6101.00
146_V151_A0.6091.00
186_Y208_V0.6091.00
248_A252_E0.6071.00
105_I141_A0.6071.00
89_V100_L0.6071.00
258_S265_R0.6021.00
125_Q155_G0.6021.00
17_C281_A0.6001.00
303_L307_Q0.5981.00
135_I138_T0.5961.00
109_I113_L0.5941.00
113_L121_V0.5941.00
251_A255_T0.5921.00
43_I286_T0.5881.00
258_S268_V0.5871.00
268_V307_Q0.5861.00
191_R195_R0.5801.00
106_L150_K0.5751.00
22_T216_R0.5731.00
121_V124_L0.5701.00
188_L272_W0.5691.00
13_V54_F0.5681.00
25_E69_I0.5661.00
56_D183_Q0.5651.00
186_Y191_R0.5631.00
8_K205_G0.5581.00
8_K178_Q0.5571.00
113_L120_Y0.5561.00
23_F40_S0.5561.00
124_L151_A0.5551.00
186_Y280_A0.5551.00
17_C283_I0.5551.00
48_L53_N0.5541.00
274_L282_P0.5531.00
48_L82_D0.5521.00
49_E289_E0.5511.00
307_Q310_E0.5501.00
168_L206_V0.5481.00
65_S69_I0.5471.00
163_Q166_Q0.5451.00
257_V314_P0.5441.00
268_V311_L0.5421.00
188_L315_Y0.5411.00
156_A167_A0.5401.00
271_A302_T0.5381.00
44_I70_V0.5371.00
89_V108_S0.5371.00
167_A179_F0.5361.00
258_S261_L0.5341.00
48_L73_A0.5341.00
276_K280_A0.5321.00
289_E292_L0.5311.00
212_S216_R0.5311.00
189_I218_R0.5311.00
261_L301_I0.5281.00
136_E140_E0.5281.00
64_G115_R0.5271.00
67_E87_T0.5271.00
126_I138_T0.5251.00
55_F74_L0.5241.00
249_Q253_R0.5241.00
113_L119_D0.5241.00
7_G13_V0.5221.00
37_E69_I0.5221.00
257_V260_E0.5211.00
210_P279_I0.5211.00
267_Q301_I0.5211.00
135_I163_Q0.5201.00
54_F84_V0.5201.00
59_N90_F0.5171.00
91_H100_L0.5171.00
57_T66_S0.5161.00
18_L43_I0.5161.00
271_A299_V0.5151.00
218_R247_D0.5141.00
254_L258_S0.5131.00
129_W159_M0.5131.00
146_V178_Q0.5121.00
109_I141_A0.5111.00
80_R122_D0.5101.00
154_I177_A0.5101.00
102_R105_I0.5091.00
91_H128_R0.5061.00
218_R251_A0.5041.00
70_V73_A0.5031.00
147_K177_A0.5011.00
7_G207_A0.5011.00
124_L142_L0.5011.00
308_I312_E0.5001.00
135_I166_Q0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1pyfA 1 0.9475 100 0.101 Contact Map
1pz1A 1 0.9691 100 0.102 Contact Map
4xk2A 5 0.9198 100 0.104 Contact Map
3eauA 3 0.966 100 0.105 Contact Map
3lutA 3 0.963 100 0.105 Contact Map
3v0sA 1 0.8272 100 0.107 Contact Map
1lqaA 2 0.9722 100 0.108 Contact Map
3n2tA 1 0.9599 100 0.114 Contact Map
3erpA 6 0.9043 100 0.121 Contact Map
3n6qA 5 0.9105 100 0.126 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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