GREMLIN Database
FOCB - Probable formate transporter 2
UniProt: P77733 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG14220
Length: 282 (247)
Sequences: 2162 (1452)
Seq/√Len: 92.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
164_V263_I7.0681.00
164_V259_L4.6901.00
38_A119_G3.8401.00
188_C192_V3.8111.00
163_S257_V3.7881.00
99_K106_W3.5641.00
259_L263_I3.1401.00
23_A26_K3.0841.00
39_M126_C3.0831.00
35_F119_G3.0071.00
117_A258_M2.9321.00
160_F256_P2.7851.00
46_A127_F2.7591.00
51_F200_L2.4681.00
23_A98_A2.3481.00
216_I249_F2.3371.00
89_F93_V2.2531.00
35_F115_L2.1941.00
172_L268_L2.1831.00
99_K109_W2.1391.00
129_L133_F2.0811.00
75_T195_I2.0551.00
186_S189_D1.8991.00
109_W113_A1.8891.00
28_A108_T1.8381.00
113_A262_I1.8201.00
92_S112_N1.8001.00
84_C273_Y1.7961.00
31_K115_L1.7521.00
159_T162_E1.7501.00
220_I249_F1.7281.00
79_I191_I1.7251.00
99_K104_I1.7251.00
184_G189_D1.6881.00
110_L114_L1.6791.00
89_F262_I1.6651.00
34_V115_L1.6481.00
43_V172_L1.6411.00
128_S221_A1.6381.00
117_A209_C1.6201.00
220_I246_V1.5791.00
150_H153_E1.5701.00
39_M122_A1.5631.00
35_F39_M1.5511.00
250_I255_L1.5341.00
80_L176_L1.5231.00
93_V113_A1.5041.00
168_I263_I1.5031.00
129_L221_A1.4951.00
121_L213_L1.4871.00
11_L14_R1.4681.00
52_Y70_G1.4651.00
51_F199_T1.4601.00
245_T248_H1.4511.00
84_C179_W1.4380.99
130_L165_S1.4280.99
98_A104_I1.4190.99
158_H166_L1.4190.99
161_T165_S1.4080.99
209_C258_M1.4060.99
183_C187_L1.3800.99
68_L199_T1.3550.99
114_L118_C1.3380.99
35_F122_A1.3340.99
47_I172_L1.3330.99
16_A278_L1.3330.99
21_R103_V1.3280.99
37_M276_I1.3040.99
107_R111_I1.2960.99
262_I266_A1.2860.99
15_K183_C1.2700.99
268_L272_C1.2700.99
184_G187_L1.2600.99
130_L169_M1.2580.99
153_E157_H1.2500.99
125_A221_A1.2450.98
258_M262_I1.2320.98
106_W110_L1.2290.98
71_G203_A1.2290.98
51_F203_A1.2080.98
72_L195_I1.1920.98
76_L200_L1.1910.98
83_V187_L1.1910.98
167_G256_P1.1850.98
162_E166_L1.1830.98
24_A103_V1.1830.98
105_S108_T1.1820.98
255_L259_L1.1810.98
118_C122_A1.1690.98
56_I147_A1.1620.98
180_M193_A1.1620.98
121_L125_A1.1450.97
212_N253_N1.1410.97
40_S272_C1.1250.97
50_T204_S1.1220.97
154_G157_H1.1220.97
43_V46_A1.1180.97
216_I220_I1.1140.97
160_F259_L1.1140.97
49_F215_V1.1090.97
86_T273_Y1.0960.97
135_G162_E1.0950.97
53_L151_C1.0930.97
97_M270_S1.0850.96
128_S218_F1.0850.96
267_V271_M1.0780.96
72_L199_T1.0760.96
117_A254_L1.0680.96
153_E243_A1.0640.96
147_A150_H1.0600.96
55_V69_V1.0590.96
172_L269_V1.0480.96
210_I213_L1.0450.96
167_G258_M1.0420.95
47_I127_F1.0410.95
170_C210_I1.0380.95
269_V273_Y1.0350.95
34_V111_I1.0340.95
146_V150_H1.0330.95
158_H163_S1.0230.95
56_I70_G1.0070.95
218_F222_I1.0050.94
19_A182_Y1.0020.94
47_I173_M0.9960.94
101_R274_R0.9900.94
77_G202_V0.9870.94
221_A246_V0.9860.94
30_S33_S0.9860.94
81_L86_T0.9820.94
171_N201_F0.9660.93
21_R25_H0.9600.93
79_I196_L0.9540.93
65_L69_V0.9490.93
37_M87_S0.9440.92
82_A194_M0.9390.92
155_K171_N0.9390.92
100_S274_R0.9310.92
148_V218_F0.9270.92
53_L148_V0.9240.92
23_A96_V0.9240.92
27_I104_I0.9210.91
81_L167_G0.9200.91
22_I26_K0.9140.91
100_S271_M0.9120.91
209_C254_L0.9080.91
40_S44_F0.9080.91
44_F86_T0.9010.91
248_H252_A0.9000.90
112_N116_V0.8930.90
160_F164_V0.8920.90
24_A28_A0.8900.90
166_L207_E0.8890.90
138_M162_E0.8880.90
223_R243_A0.8830.90
174_V201_F0.8810.90
127_F172_L0.8800.89
156_M248_H0.8760.89
58_D71_G0.8690.89
31_K35_F0.8660.89
152_A216_I0.8600.88
155_K212_N0.8590.88
252_A256_P0.8580.88
32_V275_A0.8550.88
125_A128_S0.8370.87
136_L166_L0.8320.87
59_A65_L0.8310.87
152_A219_A0.8300.87
21_R24_A0.8290.86
256_P259_L0.8280.86
156_M220_I0.8260.86
53_L214_F0.8260.86
84_C180_M0.8250.86
55_V73_C0.8250.86
160_F252_A0.8230.86
125_A217_P0.8220.86
95_T98_A0.8200.86
72_L79_I0.8150.86
18_I182_Y0.8100.85
82_A178_L0.8090.85
106_W109_W0.8080.85
34_V116_V0.8030.85
140_E146_V0.7990.84
57_A147_A0.7980.84
155_K211_A0.7970.84
14_R17_A0.7970.84
89_F210_I0.7960.84
44_F273_Y0.7890.84
223_R242_P0.7860.83
108_T111_I0.7840.83
155_K201_F0.7830.83
84_C176_L0.7790.83
46_A214_F0.7750.83
87_S92_S0.7700.82
117_A121_L0.7690.82
180_M197_P0.7670.82
201_F212_N0.7660.82
267_V272_C0.7660.82
75_T79_I0.7650.82
87_S116_V0.7650.82
20_E23_A0.7610.81
179_W273_Y0.7590.81
31_K114_L0.7560.81
265_G270_S0.7520.81
172_L176_L0.7480.80
44_F80_L0.7430.80
83_V183_C0.7420.80
80_L173_M0.7420.80
36_L272_C0.7400.80
37_M179_W0.7360.79
116_V179_W0.7360.79
38_A116_V0.7330.79
57_A143_M0.7290.79
173_M194_M0.7270.78
126_C129_L0.7260.78
135_G166_L0.7250.78
163_S167_G0.7240.78
128_S217_P0.7230.78
170_C257_V0.7220.78
17_A21_R0.7200.78
117_A210_I0.7200.78
140_E143_M0.7200.78
89_F258_M0.7170.77
177_A201_F0.7120.77
20_E101_R0.7050.76
50_T137_V0.7020.76
217_P221_A0.7000.76
164_V167_G0.6910.75
146_V149_L0.6900.75
99_K110_L0.6830.74
53_L215_V0.6820.74
94_M191_I0.6780.73
250_I256_P0.6780.73
171_N198_I0.6760.73
90_T170_C0.6750.73
89_F117_A0.6720.73
139_S143_M0.6690.72
93_V265_G0.6640.72
179_W269_V0.6630.72
79_I194_M0.6630.72
201_F211_A0.6600.71
153_E244_L0.6580.71
52_Y56_I0.6510.70
131_I169_M0.6500.70
156_M219_A0.6500.70
12_S15_K0.6470.70
18_I22_I0.6460.70
102_G106_W0.6430.69
151_C215_V0.6430.69
207_E212_N0.6400.69
148_V219_A0.6380.69
160_F163_S0.6370.69
266_A270_S0.6350.68
99_K102_G0.6340.68
171_N212_N0.6310.68
179_W277_Y0.6300.68
209_C257_V0.6290.68
114_L255_L0.6290.68
214_F217_P0.6290.68
36_L276_I0.6280.68
160_F255_L0.6260.67
16_A179_W0.6220.67
247_S252_A0.6140.66
76_L80_L0.6130.66
77_G116_V0.6130.66
48_G77_G0.6130.66
94_M277_Y0.6120.66
136_L204_S0.6060.65
104_I108_T0.6050.65
173_M197_P0.6050.65
191_I196_L0.6030.64
58_D64_A0.6020.64
132_W221_A0.6020.64
14_R185_R0.6010.64
145_G149_L0.5980.64
52_Y202_V0.5980.64
246_V250_I0.5960.64
243_A248_H0.5940.63
134_S137_V0.5940.63
174_V198_I0.5930.63
242_P248_H0.5930.63
147_A151_C0.5900.63
223_R245_T0.5880.63
273_Y277_Y0.5870.62
20_E278_L0.5870.62
35_F167_G0.5860.62
175_C207_E0.5850.62
244_L248_H0.5820.62
153_E156_M0.5810.62
89_F209_C0.5750.61
60_P66_T0.5750.61
37_M86_T0.5750.61
194_M198_I0.5740.61
121_L246_V0.5740.61
121_L217_P0.5740.61
149_L219_A0.5730.61
22_I25_H0.5720.60
110_L263_I0.5710.60
94_M269_V0.5690.60
17_A24_A0.5670.60
48_G71_G0.5660.60
95_T116_V0.5650.59
134_S166_L0.5650.59
132_W222_I0.5650.59
73_C199_T0.5650.59
201_F207_E0.5630.59
28_A244_L0.5630.59
202_V211_A0.5610.59
34_V112_N0.5610.59
145_G219_A0.5610.59
31_K111_I0.5580.59
121_L250_I0.5580.59
27_I96_V0.5580.59
43_V268_L0.5570.58
11_L15_K0.5560.58
156_M216_I0.5550.58
243_A267_V0.5540.58
47_I95_T0.5540.58
254_L257_V0.5530.58
150_H154_G0.5530.58
89_F265_G0.5500.57
171_N211_A0.5490.57
201_F253_N0.5480.57
17_A20_E0.5460.57
189_D192_V0.5460.57
175_C213_L0.5430.57
41_A89_F0.5420.56
176_L269_V0.5420.56
41_A91_S0.5410.56
134_S165_S0.5400.56
82_A181_S0.5390.56
254_L258_M0.5370.56
163_S256_P0.5320.55
38_A41_A0.5300.55
19_A23_A0.5300.55
59_A64_A0.5300.55
124_I213_L0.5300.55
163_S252_A0.5290.55
118_C250_I0.5280.54
45_M49_F0.5260.54
12_S277_Y0.5240.54
84_C183_C0.5230.54
16_A97_M0.5230.54
17_A103_V0.5220.54
74_F201_F0.5220.54
71_G202_V0.5210.53
220_I223_R0.5210.53
49_F214_F0.5190.53
102_G105_S0.5180.53
38_A115_L0.5170.53
78_F94_M0.5160.53
29_R34_V0.5150.53
170_C201_F0.5140.53
252_A255_L0.5140.53
272_C275_A0.5130.52
15_K126_C0.5130.52
15_K179_W0.5120.52
27_I112_N0.5100.52
59_A66_T0.5100.52
11_L23_A0.5080.52
26_K171_N0.5070.52
176_L180_M0.5070.52
247_S250_I0.5050.51
220_I244_L0.5040.51
249_F254_L0.5040.51
76_L274_R0.5040.51
87_S112_N0.5030.51
39_M43_V0.5010.51
94_M266_A0.5010.51
36_L275_A0.5010.51
146_V245_T0.5000.51
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3kcuA 3 0.8901 100 0.076 Contact Map
3klyA 3 0.9078 100 0.088 Contact Map
3tdsE 3 0.9007 100 0.154 Contact Map
4fc4A 3 0.8723 100 0.178 Contact Map
3zojA 3 0.8546 84.9 0.941 Contact Map
3llqA 3 0.8227 83.3 0.941 Contact Map
2o9gA 3 0.8121 74.6 0.946 Contact Map
3cn5A 3 0.8156 69.2 0.948 Contact Map
3iyzA 3 0.7553 58.2 0.952 Contact Map
4nefA 4 0.7872 32.6 0.959 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0085 seconds.