GREMLIN Database
RHMR - Uncharacterized HTH-type transcriptional regulator RhmR
UniProt: P77732 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG14086
Length: 260 (243)
Sequences: 12759 (9376)
Seq/√Len: 601.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
10_L13_A3.2141.00
96_T237_K3.0531.00
11_T52_Q2.7921.00
104_G140_I2.7911.00
89_R241_C2.7881.00
182_R186_Q2.5511.00
18_N68_R2.5501.00
87_R115_L2.3941.00
142_K179_E2.3731.00
14_I54_F2.3711.00
154_Q177_H2.3361.00
110_S132_S2.2201.00
142_K194_E2.1931.00
99_L225_Q2.1541.00
89_R244_D2.0961.00
20_I55_L2.0941.00
15_D52_Q2.0391.00
148_Q152_V2.0121.00
91_T117_V1.9721.00
147_W207_F1.9241.00
106_I135_L1.9011.00
191_D201_C1.8951.00
204_A238_A1.8871.00
192_N200_R1.8331.00
89_R248_L1.8091.00
92_Q244_D1.7881.00
230_Y233_Y1.7781.00
16_I31_I1.7741.00
200_R223_R1.7681.00
204_A242_A1.7651.00
56_S64_C1.7601.00
18_N52_Q1.7191.00
235_A239_I1.7101.00
92_Q96_T1.6781.00
86_A245_I1.6761.00
46_L55_L1.6741.00
19_L35_L1.6621.00
172_H175_Q1.6611.00
173_P177_H1.6481.00
94_M101_C1.6461.00
19_L26_C1.6341.00
19_L31_I1.6331.00
204_A239_I1.6221.00
193_G223_R1.6061.00
19_L34_T1.6011.00
219_V234_L1.5721.00
26_C34_T1.5661.00
46_L63_F1.5511.00
221_G226_I1.5481.00
27_S30_T1.5361.00
166_T169_T1.5281.00
179_E182_R1.5241.00
188_W235_A1.5121.00
31_I42_A1.5081.00
193_G198_D1.5041.00
153_Q177_H1.4991.00
89_R92_Q1.4981.00
118_E124_S1.4791.00
97_T237_K1.4681.00
25_P64_C1.4601.00
37_I42_A1.4541.00
25_P62_N1.4511.00
149_P152_V1.4421.00
237_K240_A1.4381.00
183_I189_S1.4351.00
111_A144_L1.4151.00
207_F246_S1.4101.00
68_R71_E1.4021.00
154_Q173_P1.3891.00
50_R57_L1.3721.00
111_A135_L1.3651.00
50_R55_L1.3551.00
83_R115_L1.3531.00
93_L237_K1.3511.00
14_I52_Q1.3481.00
18_N54_F1.3471.00
94_M117_V1.3431.00
20_I26_C1.3371.00
20_I25_P1.3231.00
109_G159_G1.3211.00
86_A103_L1.3211.00
23_I26_C1.2941.00
90_L103_L1.2911.00
242_A246_S1.2891.00
58_D64_C1.2831.00
180_L183_I1.2491.00
93_L241_C1.2471.00
38_P41_T1.2401.00
240_A244_D1.2391.00
87_R91_T1.2291.00
43_Y47_N1.2291.00
31_I46_L1.2211.00
32_I42_A1.2121.00
23_I34_T1.2001.00
137_R169_T1.1971.00
150_A177_H1.1921.00
158_E173_P1.1921.00
170_I179_E1.1851.00
207_F213_L1.1731.00
147_W205_P1.1731.00
146_A183_I1.1631.00
150_A154_Q1.1481.00
137_R165_A1.1421.00
153_Q184_R1.1331.00
28_A43_Y1.1251.00
104_G111_A1.1241.00
29_A33_D1.1241.00
97_T234_L1.1161.00
106_I148_Q1.1041.00
204_A235_A1.1011.00
7_V48_E1.1001.00
239_I243_R1.0981.00
106_I109_G1.0931.00
168_T193_G1.0891.00
90_L101_C1.0881.00
147_W213_L1.0831.00
27_S62_N1.0751.00
107_D132_S1.0741.00
150_A153_Q1.0741.00
105_I215_A1.0721.00
103_L215_A1.0651.00
11_T48_E1.0621.00
103_L206_V1.0581.00
69_L76_A1.0561.00
11_T51_R1.0521.00
138_S141_G1.0421.00
140_I216_A1.0411.00
136_Y169_T1.0411.00
150_A181_A1.0331.00
91_T95_D1.0321.00
157_I173_P1.0301.00
244_D248_L1.0291.00
232_D236_G1.0241.00
97_T219_V1.0161.00
217_I245_I1.0131.00
236_G240_A1.0051.00
30_T33_D0.9991.00
208_N212_E0.9921.00
28_A32_I0.9921.00
96_T240_A0.9821.00
8_P12_R0.9811.00
92_Q241_C0.9791.00
54_F72_L0.9771.00
154_Q158_E0.9671.00
164_Q171_T0.9641.00
183_I186_Q0.9611.00
104_G113_Y0.9611.00
139_G201_C0.9601.00
29_A39_K0.9591.00
243_R247_R0.9581.00
227_N230_Y0.9391.00
205_P213_L0.9361.00
82_L215_A0.9351.00
112_Y132_S0.9131.00
16_I35_L0.9111.00
25_P58_D0.9111.00
143_C147_W0.9101.00
152_V155_S0.9091.00
87_R117_V0.9011.00
202_V235_A0.9011.00
165_A169_T0.8981.00
143_C213_L0.8861.00
167_P197_A0.8851.00
20_I24_G0.8851.00
85_L248_L0.8851.00
178_E182_R0.8841.00
30_T34_T0.8811.00
178_E181_A0.8801.00
145_L176_L0.8781.00
90_L115_L0.8731.00
22_R34_T0.8661.00
181_A185_R0.8661.00
155_S159_G0.8621.00
90_L217_I0.8601.00
175_Q179_E0.8601.00
153_Q180_L0.8591.00
17_L69_L0.8551.00
102_H220_V0.8531.00
165_A195_D0.8441.00
40_S43_Y0.8441.00
238_A242_A0.8431.00
186_Q235_A0.8421.00
101_C219_V0.8401.00
99_L121_A0.8401.00
16_I45_L0.8361.00
152_V156_I0.8341.00
193_G197_A0.8301.00
20_I23_I0.8271.00
143_C183_I0.8271.00
208_N214_T0.8261.00
83_R87_R0.8261.00
139_G203_A0.8251.00
177_H181_A0.8211.00
203_A218_S0.8181.00
50_R63_F0.8141.00
140_I218_S0.8141.00
175_Q178_E0.8111.00
12_R41_T0.8051.00
222_T225_Q0.7971.00
192_N223_R0.7941.00
179_E183_I0.7891.00
89_R245_I0.7851.00
146_A180_L0.7811.00
107_D112_Y0.7781.00
37_I41_T0.7741.00
241_C244_D0.7731.00
182_R185_R0.7721.00
179_E186_Q0.7711.00
170_I175_Q0.7681.00
106_I152_V0.7641.00
231_R235_A0.7581.00
144_L216_A0.7561.00
35_L42_A0.7541.00
17_L54_F0.7541.00
9_A13_A0.7541.00
233_Y237_K0.7511.00
231_R236_G0.7471.00
190_Y231_R0.7461.00
201_C220_V0.7421.00
102_H116_K0.7411.00
201_C218_S0.7391.00
69_L73_S0.7381.00
47_N50_R0.7341.00
32_I35_L0.7341.00
28_A46_L0.7291.00
102_H127_S0.7271.00
69_L72_L0.7221.00
57_L61_E0.7211.00
170_I176_L0.7211.00
28_A42_A0.7191.00
137_R195_D0.7181.00
90_L117_V0.7171.00
156_I160_L0.7171.00
65_L69_L0.7161.00
82_L86_A0.7161.00
28_A39_K0.7151.00
148_Q153_Q0.7141.00
153_Q156_I0.7101.00
47_N51_R0.7031.00
56_S66_W0.7001.00
153_Q181_A0.6971.00
236_G239_I0.6961.00
26_C31_I0.6941.00
202_V231_R0.6851.00
150_A184_R0.6851.00
109_G156_I0.6811.00
121_A225_Q0.6791.00
142_K183_I0.6791.00
10_L45_L0.6741.00
81_D84_E0.6711.00
207_F214_T0.6701.00
28_A63_F0.6681.00
192_N231_R0.6631.00
92_Q95_D0.6591.00
181_A184_R0.6591.00
106_I144_L0.6591.00
93_L219_V0.6591.00
233_Y236_G0.6561.00
105_I114_I0.6531.00
217_I242_A0.6531.00
16_I42_A0.6521.00
241_C245_I0.6491.00
56_S67_T0.6481.00
153_Q157_I0.6481.00
243_R246_S0.6471.00
239_I242_A0.6461.00
94_M119_S0.6451.00
10_L14_I0.6451.00
73_S76_A0.6431.00
230_Y234_L0.6411.00
204_A246_S0.6411.00
144_L148_Q0.6331.00
240_A243_R0.6331.00
166_T170_I0.6321.00
54_F68_R0.6311.00
171_T175_Q0.6301.00
99_L221_G0.6281.00
30_T62_N0.6251.00
102_H201_C0.6231.00
85_L88_P0.6221.00
12_R37_I0.6221.00
145_L180_L0.6201.00
58_D62_N0.6181.00
57_L63_F0.6121.00
93_L101_C0.6101.00
217_I241_C0.6081.00
244_D247_R0.6081.00
136_Y162_W0.6051.00
93_L97_T0.6031.00
18_N71_E0.6021.00
88_P248_L0.5951.00
9_A45_L0.5931.00
91_T115_L0.5931.00
95_D120_S0.5901.00
193_G200_R0.5891.00
168_T197_A0.5881.00
116_K129_E0.5871.00
47_N57_L0.5861.00
128_H131_K0.5851.00
187_G207_F0.5851.00
7_V45_L0.5821.00
134_S137_R0.5811.00
118_E128_H0.5791.00
138_S201_C0.5781.00
144_L215_A0.5781.00
32_I39_K0.5741.00
145_L153_Q0.5721.00
21_A72_L0.5701.00
53_R68_R0.5691.00
192_N228_E0.5691.00
98_G120_S0.5671.00
15_D18_N0.5661.00
116_K127_S0.5651.00
99_L219_V0.5641.00
113_Y138_S0.5621.00
101_C117_V0.5611.00
86_A90_L0.5591.00
123_I224_L0.5581.00
174_Q177_H0.5571.00
188_W239_I0.5550.99
164_Q167_P0.5540.99
15_D19_L0.5540.99
237_K241_C0.5540.99
204_A217_I0.5520.99
10_L48_E0.5490.99
113_Y140_I0.5490.99
111_A140_I0.5480.99
176_L180_L0.5450.99
18_N72_L0.5420.99
143_C203_A0.5420.99
111_A133_L0.5410.99
206_V246_S0.5400.99
43_Y57_L0.5380.99
17_L72_L0.5380.99
113_Y127_S0.5380.99
27_S39_K0.5370.99
140_I201_C0.5360.99
143_C205_P0.5360.99
85_L245_I0.5360.99
19_L23_I0.5350.99
21_A65_L0.5350.99
111_A138_S0.5340.99
13_A45_L0.5340.99
234_L237_K0.5320.99
70_V77_L0.5290.99
135_L156_I0.5280.99
143_C189_S0.5250.99
104_G138_S0.5240.99
198_D223_R0.5190.99
206_V215_A0.5190.99
174_Q178_E0.5130.99
12_R45_L0.5120.99
142_K191_D0.5120.99
168_T192_N0.5120.99
7_V10_L0.5100.99
127_S131_K0.5100.99
113_Y116_K0.5090.99
100_L116_K0.5090.99
14_I48_E0.5080.99
74_G77_L0.5080.99
217_I238_A0.5070.99
207_F215_A0.5030.99
164_Q169_T0.5010.99
169_T172_H0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3mq0A 2 0.9538 100 0.095 Contact Map
2ia2A 4 0.9538 100 0.098 Contact Map
2g7uA 6 0.9615 100 0.101 Contact Map
1mkmA 4 0.9462 100 0.107 Contact Map
3r4kA 2 0.9731 100 0.11 Contact Map
2xrnA 3 0.9192 100 0.133 Contact Map
2o0yA 4 0.95 100 0.149 Contact Map
1ysqA 1 0.6769 100 0.402 Contact Map
1tf1A 1 0.7077 100 0.403 Contact Map
3obfA 1 0.6769 100 0.412 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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