GREMLIN Database
ALLA - Ureidoglycolate lyase
UniProt: P77731 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13615
Length: 160 (152)
Sequences: 682 (475)
Seq/√Len: 38.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
6_L106_R6.8981.00
89_F110_T4.4611.00
58_R135_D4.1411.00
8_L19_V3.6381.00
53_L142_G3.4751.00
96_G100_P2.9141.00
73_R148_D2.6761.00
45_E120_R2.6171.00
18_D119_H2.5061.00
91_V110_T2.2090.99
100_P105_L2.1930.99
46_I52_T2.0690.99
54_I139_I2.0600.99
40_D51_C2.0520.99
82_I137_L1.9850.99
16_Y106_R1.9210.98
80_A117_N1.8770.98
125_H128_F1.8710.98
18_D117_N1.8580.98
96_G105_L1.8470.98
95_L121_N1.8350.98
42_A117_N1.7140.97
85_K135_D1.6990.96
92_V107_A1.6920.96
5_V90_V1.6860.96
59_A127_L1.6490.96
75_P146_N1.6250.95
71_L107_A1.5720.94
84_M137_L1.5610.94
98_D101_D1.4580.92
125_H129_A1.4340.91
95_L104_T1.4320.91
96_G121_N1.4000.90
34_L126_P1.3900.90
40_D54_I1.3720.89
68_I71_L1.3480.88
5_V109_I1.3390.88
27_F36_E1.3350.88
44_V52_T1.3310.88
10_Q21_E1.3270.87
45_E50_D1.3210.87
21_E114_Q1.3010.86
57_N138_T1.2940.86
66_L92_V1.2890.86
101_D104_T1.2770.85
32_N151_S1.2530.84
62_A66_L1.2400.84
95_L106_R1.2360.83
87_E131_Q1.2150.82
121_N148_D1.2050.82
70_E151_S1.1700.80
140_D146_N1.1180.77
102_L105_L1.1160.76
34_L62_A1.1100.76
30_I35_V1.1070.76
9_S19_V1.0930.75
71_L121_N1.0870.75
8_L114_Q1.0860.74
69_H132_R1.0780.74
92_V128_F1.0730.74
42_A80_A1.0490.72
77_G141_R1.0440.71
100_P126_P1.0430.71
48_E154_E1.0380.71
37_R77_G1.0350.71
88_V131_Q1.0310.71
44_V54_I1.0140.69
55_S75_P0.9720.66
49_Q144_S0.9690.66
37_R65_P0.9640.65
99_K103_S0.9520.64
39_H55_S0.9480.64
116_V138_T0.9440.64
76_L145_D0.9420.63
55_S99_K0.9320.63
62_A127_L0.9260.62
78_T117_N0.9120.61
13_F17_G0.9090.61
11_E21_E0.9080.61
28_F39_H0.9080.61
61_P133_V0.9060.60
71_L152_I0.9060.60
118_Y121_N0.9000.60
59_A62_A0.8960.60
68_I92_V0.8910.59
30_I141_R0.8900.59
118_Y122_V0.8840.58
40_D44_V0.8790.58
34_L71_L0.8770.58
57_N77_G0.8770.58
56_I109_I0.8740.58
84_M135_D0.8700.57
21_E111_N0.8640.57
22_T56_I0.8640.57
122_V138_T0.8530.56
105_L147_C0.8510.56
20_I103_S0.8490.55
25_R149_V0.8490.55
44_V139_I0.8470.55
74_H79_Q0.8410.55
30_I140_D0.8390.55
105_L152_I0.8370.54
11_E48_E0.8350.54
54_I137_L0.8300.54
80_A146_N0.8190.53
77_G127_L0.8160.52
101_D105_L0.8110.52
8_L110_T0.7900.50
20_I52_T0.7890.50
6_L12_A0.7860.50
3_L24_Q0.7850.50
32_N149_V0.7780.49
77_G140_D0.7770.49
19_V110_T0.7740.49
71_L94_A0.7660.48
54_I117_N0.7630.48
35_V59_A0.7620.48
3_L88_V0.7570.47
86_G112_G0.7540.47
5_V106_R0.7530.47
16_Y95_L0.7450.46
69_H151_S0.7440.46
39_H80_A0.7420.46
80_A115_G0.7420.46
75_P118_Y0.7390.46
41_L44_V0.7360.45
32_N69_H0.7360.45
70_E152_I0.7330.45
19_V33_G0.7300.45
20_I90_V0.7270.44
151_S154_E0.7200.44
103_S109_I0.7170.44
61_P84_M0.7130.43
53_L137_L0.7080.43
64_L130_W0.7010.42
44_V82_I0.6990.42
18_D43_L0.6970.42
5_V70_E0.6950.42
79_Q124_H0.6940.42
74_H124_H0.6940.42
55_S146_N0.6790.40
91_V116_V0.6790.40
66_L89_F0.6780.40
37_R55_S0.6770.40
40_D53_L0.6760.40
67_T129_A0.6700.39
38_Y58_R0.6690.39
31_N57_N0.6690.39
64_L84_M0.6670.39
76_L153_P0.6660.39
35_V70_E0.6650.39
96_G99_K0.6630.39
89_F118_Y0.6620.39
121_N147_C0.6580.38
102_L149_V0.6570.38
9_S109_I0.6550.38
29_H36_E0.6510.38
35_V78_T0.6500.38
30_I78_T0.6500.38
89_F136_F0.6470.38
127_L134_T0.6410.37
19_V114_Q0.6390.37
70_E149_V0.6300.36
47_L52_T0.6270.36
18_D40_D0.6250.36
36_E60_Q0.6230.36
55_S142_G0.6210.35
75_P80_A0.6200.35
56_I137_L0.6200.35
98_D102_L0.6190.35
145_D148_D0.6170.35
26_D36_E0.6170.35
47_L120_R0.6130.35
39_H142_G0.6100.34
46_I68_I0.6090.34
55_S140_D0.6080.34
71_L101_D0.6020.34
35_V57_N0.6020.34
150_E153_P0.6010.34
90_V114_Q0.5950.33
55_S138_T0.5910.33
38_Y41_L0.5870.33
6_L154_E0.5870.33
10_Q69_H0.5850.32
48_E145_D0.5830.32
138_T141_R0.5820.32
141_R146_N0.5820.32
110_T114_Q0.5790.32
75_P90_V0.5780.32
4_Q155_Q0.5770.32
77_G143_G0.5750.32
30_I77_G0.5720.31
127_L140_D0.5720.31
6_L16_Y0.5700.31
60_Q150_E0.5620.31
37_R141_R0.5560.30
72_E79_Q0.5550.30
52_T142_G0.5550.30
73_R96_G0.5550.30
82_I115_G0.5520.30
29_H60_Q0.5500.30
51_C82_I0.5490.30
62_A128_F0.5440.29
14_S144_S0.5410.29
107_A128_F0.5390.29
23_Q38_Y0.5380.29
10_Q23_Q0.5370.29
22_T38_Y0.5340.29
134_T138_T0.5340.29
20_I26_D0.5340.29
39_H53_L0.5310.28
37_R134_T0.5280.28
71_L116_V0.5270.28
32_N116_V0.5260.28
126_P129_A0.5240.28
78_T141_R0.5170.27
67_T154_E0.5170.27
9_S12_A0.5160.27
140_D147_C0.5150.27
53_L84_M0.5130.27
31_N35_V0.5120.27
82_I139_I0.5060.27
62_A126_P0.5050.26
57_N62_A0.5020.26
16_Y75_P0.5010.26
10_Q24_Q0.5010.26
28_F147_C0.5010.26
138_T149_V0.5000.26
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1xsqA 2 0.9625 100 0.177 Contact Map
2bdrA 2 1 100 0.201 Contact Map
3d0jA 2 0.7812 84.8 0.926 Contact Map
2y0oA 2 0.875 22.4 0.953 Contact Map
2d5fA 5 0.875 20.3 0.953 Contact Map
3fz3A 5 0.925 17.9 0.955 Contact Map
1fxzA 3 0.85 17.9 0.955 Contact Map
5buvA 2 0.9 14.3 0.957 Contact Map
2fqpA 3 0.6062 13.7 0.957 Contact Map
3ejkA 2 0.8688 12 0.958 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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