GREMLIN Database
THII - tRNA sulfurtransferase
UniProt: P77718 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13273
Length: 482 (379)
Sequences: 1421 (963)
Seq/√Len: 49.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
182_S194_S5.7841.00
306_N361_E5.3171.00
373_D377_E4.5511.00
246_P374_K4.2841.00
229_N332_G3.5741.00
85_T115_G3.2741.00
274_K373_D3.2641.00
85_T159_L3.1021.00
128_V152_L2.9191.00
111_V125_E2.9041.00
124_V154_V2.8131.00
224_A239_F2.7971.00
108_C143_L2.7631.00
374_K378_E2.7511.00
83_P89_D2.7221.00
180_V285_V2.6181.00
109_V132_L2.5581.00
111_V124_V2.5181.00
91_F131_G2.3991.00
183_L284_L2.3801.00
43_V52_V2.3761.00
301_L317_I2.3431.00
89_D92_E2.3371.00
229_N336_F2.2711.00
196_M327_L2.2161.00
7_L77_L2.2071.00
106_T140_R2.2001.00
181_L281_V2.1661.00
328_A333_T2.1601.00
300_N355_A2.1421.00
98_Y150_V2.1351.00
336_F339_T2.1201.00
90_I159_L2.1131.00
36_H66_A2.0321.00
7_L75_H2.0291.00
94_A128_V2.0261.00
224_A382_V2.0081.00
255_I263_I2.0071.00
278_R377_E1.9760.99
250_E254_K1.9700.99
273_S308_S1.9680.99
274_K277_E1.9620.99
180_V283_A1.9610.99
86_D89_D1.9430.99
270_R364_E1.9260.99
131_G135_H1.9140.99
180_V202_C1.9120.99
299_T354_K1.9090.99
221_R225_H1.9080.99
326_N330_Q1.8950.99
318_S323_H1.8870.99
327_L330_Q1.8860.99
242_I379_A1.8780.99
87_M124_V1.8710.99
238_R383_D1.8690.99
69_R232_G1.8620.99
110_R149_T1.8280.99
326_N329_R1.8220.99
220_V224_A1.8200.99
259_Q363_E1.8060.99
362_A365_E1.7740.99
363_E366_K1.7460.99
119_F127_Y1.7340.99
181_L207_C1.7230.99
273_S309_D1.7150.98
68_T76_I1.7150.98
282_Q299_T1.6920.98
283_A313_L1.6890.98
111_V154_V1.6880.98
256_D363_E1.6840.98
37_Y66_A1.6650.98
124_V128_V1.6640.98
369_F372_L1.6560.98
90_I128_V1.6420.98
95_L135_H1.6140.98
82_V93_K1.6100.98
81_D158_R1.5970.98
207_C275_V1.5970.98
95_L131_G1.5930.98
179_D205_H1.5850.97
150_V161_L1.5850.97
89_D93_K1.5820.97
273_S310_T1.5790.97
184_I227_L1.5760.97
376_V379_A1.5590.97
271_A372_L1.5410.97
25_I176_T1.5360.97
266_R364_E1.5320.97
23_I48_D1.5320.97
42_A53_R1.5250.97
49_N153_E1.5230.97
322_E326_N1.5210.97
303_L360_I1.5120.97
181_L275_V1.4900.96
207_C272_A1.4890.96
306_N357_K1.4880.96
303_L357_K1.4860.96
41_L52_V1.4750.96
154_V159_L1.4570.96
267_M367_F1.4530.96
276_A310_T1.4500.96
6_K73_I1.4400.96
110_R125_E1.4310.95
172_F177_Q1.4160.95
267_M369_F1.4030.95
26_L29_N1.3970.95
127_Y130_G1.3900.95
238_R381_N1.3790.94
9_P74_H1.3780.94
241_A382_V1.3670.94
259_Q360_I1.3590.94
250_E253_E1.3410.93
214_A249_G1.3370.93
225_H339_T1.3300.93
205_H240_V1.3290.93
197_L285_V1.3290.93
220_V380_N1.3070.93
251_I263_I1.3020.92
334_E338_R1.2990.92
267_M270_R1.2780.92
262_V300_N1.2780.92
92_E96_V1.2720.91
142_K145_N1.2670.91
67_L73_I1.2640.91
357_K360_I1.2580.91
109_V150_V1.2530.91
188_F334_E1.2520.91
278_R379_A1.2500.91
30_I70_I1.2480.91
6_K52_V1.2400.90
183_L286_T1.2330.90
68_T166_Y1.2300.90
225_H228_W1.2270.90
267_M372_L1.2170.90
30_I43_V1.2160.90
93_K96_V1.2090.89
277_E310_T1.2040.89
242_I375_V1.1950.89
101_Q164_G1.1840.88
272_A284_L1.1790.88
112_K153_E1.1720.88
283_A298_L1.1680.88
313_L317_I1.1670.87
243_N378_E1.1590.87
337_A340_M1.1540.87
206_Y237_V1.1530.87
91_F127_Y1.1500.87
172_F200_R1.1490.87
95_L136_I1.1470.87
290_L317_I1.1470.87
319_Y327_L1.1460.87
243_N246_P1.1460.87
220_V382_V1.1420.86
98_Y132_L1.1390.86
4_I76_I1.1390.86
327_L332_G1.1340.86
24_K28_G1.1340.86
27_T45_R1.1290.86
78_E164_G1.1230.85
205_H238_R1.1130.85
357_K361_E1.0920.84
86_D91_F1.0900.84
246_P249_G1.0880.84
194_S204_V1.0830.83
194_S206_Y1.0800.83
25_I28_G1.0780.83
358_S361_E1.0680.82
97_Q161_L1.0630.82
120_S123_D1.0620.82
275_V379_A1.0380.81
126_R130_G1.0380.81
195_Y233_S1.0370.80
88_H92_E1.0370.80
167_E326_N1.0340.80
24_K45_R1.0300.80
109_V128_V1.0280.80
64_R76_I1.0220.79
5_I79_V1.0210.79
342_E346_V1.0140.79
304_I313_L1.0090.79
244_F264_L1.0090.79
94_A132_L1.0070.78
105_K148_V1.0050.78
183_L272_A1.0040.78
273_S276_A1.0020.78
75_H165_R1.0000.78
64_R166_Y0.9990.78
181_L205_H0.9950.78
270_R307_V0.9940.78
261_G264_L0.9790.76
94_A109_V0.9770.76
227_L237_V0.9740.76
274_K278_R0.9720.76
87_M119_F0.9610.75
322_E329_R0.9590.75
269_V308_S0.9560.75
90_I154_V0.9520.74
259_Q352_T0.9510.74
132_L150_V0.9510.74
229_N232_G0.9490.74
245_E341_P0.9490.74
3_F79_V0.9440.74
91_F95_L0.9430.74
274_K370_S0.9420.74
7_L49_N0.9410.74
23_I45_R0.9380.73
298_L313_L0.9360.73
83_P86_D0.9260.72
240_V379_A0.9260.72
129_G147_D0.9260.72
275_V279_Y0.9230.72
66_A70_I0.9200.72
77_L162_I0.9180.72
197_L318_S0.9170.72
98_Y148_V0.9160.72
286_T316_L0.9120.71
105_K147_D0.9090.71
88_H91_F0.9050.71
6_K50_I0.9020.70
248_V346_V0.8990.70
78_E166_Y0.8950.70
230_R234_S0.8930.70
274_K376_V0.8900.69
65_D68_T0.8880.69
236_R383_D0.8810.69
45_R48_D0.8770.68
39_E57_E0.8760.68
262_V304_I0.8740.68
199_R323_H0.8730.68
99_R103_E0.8690.67
220_V241_A0.8660.67
87_M127_Y0.8640.67
247_V375_V0.8600.67
202_C298_L0.8600.67
88_H131_G0.8590.67
169_I195_Y0.8580.66
246_P375_V0.8560.66
238_R279_Y0.8560.66
274_K372_L0.8560.66
290_L313_L0.8550.66
340_M345_G0.8530.66
264_L271_A0.8470.65
370_S373_D0.8440.65
12_T48_D0.8430.65
94_A161_L0.8410.65
71_P169_I0.8400.65
102_L147_D0.8400.65
115_G156_D0.8360.64
352_T355_A0.8360.64
257_D349_K0.8340.64
248_V345_G0.8330.64
8_F12_T0.8280.64
181_L272_A0.8280.64
196_M318_S0.8260.63
270_R372_L0.8260.63
198_M234_S0.8260.63
302_R306_N0.8190.63
51_E160_L0.8180.63
108_C144_T0.8160.63
204_V237_V0.8150.62
7_L162_I0.8150.62
17_S345_G0.8110.62
225_H336_F0.8100.62
99_R136_I0.8080.62
244_F263_I0.8060.62
182_S206_Y0.8060.62
236_R385_R0.8050.61
219_G340_M0.8040.61
248_V343_Y0.8030.61
276_A281_V0.8010.61
180_V298_L0.7980.61
44_V53_R0.7950.61
309_D312_I0.7930.60
361_E365_E0.7870.60
265_K348_S0.7840.59
106_T133_N0.7840.59
263_I270_R0.7820.59
104_G148_V0.7800.59
15_S177_Q0.7790.59
229_N335_D0.7790.59
81_D160_L0.7770.59
205_H279_Y0.7730.58
205_H281_V0.7720.58
356_V359_K0.7690.58
11_I50_I0.7660.58
95_L99_R0.7650.58
303_L355_A0.7650.58
37_Y112_K0.7650.58
240_V381_N0.7650.58
319_Y323_H0.7640.57
239_F382_V0.7620.57
195_Y327_L0.7590.57
288_E347_I0.7580.57
216_H351_P0.7530.56
30_I50_I0.7520.56
272_A376_V0.7490.56
91_F135_H0.7490.56
224_A241_A0.7480.56
11_I286_T0.7480.56
215_A222_Q0.7480.56
5_I153_E0.7460.56
219_G341_P0.7460.56
264_L300_N0.7450.56
132_L139_A0.7440.55
197_L202_C0.7370.55
186_G222_Q0.7360.55
202_C290_L0.7330.54
286_T317_I0.7320.54
271_A376_V0.7290.54
208_F219_G0.7280.54
122_I125_E0.7260.54
67_L76_I0.7220.53
7_L155_E0.7210.53
266_R270_R0.7210.53
99_R135_H0.7190.53
17_S265_K0.7180.53
303_L306_N0.7160.53
305_D312_I0.7160.53
29_N174_I0.7160.53
27_T31_R0.7150.53
54_A63_I0.7130.52
208_F346_V0.7130.52
372_L376_V0.7120.52
25_I353_V0.7110.52
134_Q137_E0.7070.52
175_G200_R0.7020.51
41_L63_I0.7020.51
162_I165_R0.7010.51
208_F344_C0.7000.51
260_M264_L0.6990.51
181_L194_S0.6970.51
8_F49_N0.6960.51
134_Q325_I0.6950.50
17_S343_Y0.6920.50
198_M267_M0.6910.50
12_T23_I0.6860.50
127_Y131_G0.6850.49
198_M304_I0.6830.49
108_C146_P0.6830.49
30_I67_L0.6810.49
288_E346_V0.6810.49
340_M343_Y0.6790.49
277_E309_D0.6760.49
62_A65_D0.6760.49
155_E288_E0.6740.48
305_D314_R0.6730.48
216_H341_P0.6720.48
71_P331_I0.6680.48
37_Y55_K0.6630.47
95_L132_L0.6630.47
42_A150_V0.6620.47
130_G134_Q0.6620.47
34_L38_D0.6600.47
362_A366_K0.6570.47
50_I198_M0.6570.47
213_G343_Y0.6560.46
94_A160_L0.6560.46
250_E368_D0.6550.46
252_L260_M0.6540.46
265_K345_G0.6530.46
10_E19_R0.6530.46
90_I160_L0.6520.46
208_F283_A0.6490.46
82_V161_L0.6490.46
114_R155_E0.6470.46
248_V347_I0.6470.46
207_C242_I0.6470.46
285_V318_S0.6460.45
210_N220_V0.6440.45
269_V312_I0.6440.45
288_E314_R0.6420.45
180_V197_L0.6410.45
203_R238_R0.6410.45
300_N352_T0.6390.45
96_V99_R0.6370.45
97_Q136_I0.6370.45
91_F128_V0.6350.44
8_F212_G0.6330.44
213_G348_S0.6330.44
242_I275_V0.6320.44
98_Y128_V0.6310.44
324_I351_P0.6280.44
104_G139_A0.6250.43
214_A219_G0.6250.43
188_F338_R0.6250.43
279_Y379_A0.6240.43
373_D376_V0.6230.43
265_K304_I0.6220.43
10_E26_L0.6220.43
94_A150_V0.6220.43
114_R153_E0.6210.43
269_V286_T0.6210.43
179_D279_Y0.6200.43
5_I223_V0.6200.43
103_E132_L0.6200.43
196_M199_R0.6200.43
288_E304_I0.6180.43
222_Q226_Y0.6120.42
34_L63_I0.6120.42
43_V50_I0.6120.42
188_F192_V0.6110.42
43_V153_E0.6110.42
262_V360_I0.6100.42
307_V361_E0.6100.42
374_K377_E0.6090.42
55_K58_N0.6080.42
70_I332_G0.6070.42
176_T349_K0.6060.41
288_E307_V0.6060.41
179_D203_R0.6040.41
48_D162_I0.6020.41
26_L200_R0.6020.41
9_P348_S0.6010.41
323_H326_N0.5970.41
174_I177_Q0.5950.40
307_V364_E0.5930.40
231_F234_S0.5930.40
269_V288_E0.5920.40
66_A280_G0.5900.40
31_R61_L0.5890.40
115_G119_F0.5880.40
191_G222_Q0.5880.40
24_K31_R0.5870.40
179_D238_R0.5870.40
221_R224_A0.5860.40
17_S337_A0.5850.39
88_H284_L0.5850.39
97_Q101_Q0.5820.39
261_G304_I0.5820.39
34_L52_V0.5810.39
286_T301_L0.5800.39
359_K363_E0.5790.39
157_D160_L0.5770.39
12_T45_R0.5770.39
22_F222_Q0.5770.39
301_L313_L0.5760.39
285_V298_L0.5760.39
123_D126_R0.5760.39
123_D229_N0.5750.38
207_C376_V0.5750.38
275_V381_N0.5740.38
119_F149_T0.5730.38
83_P236_R0.5710.38
79_V165_R0.5700.38
217_E220_V0.5700.38
343_Y346_V0.5690.38
226_Y345_G0.5690.38
254_K272_A0.5670.38
147_D176_T0.5670.38
33_V236_R0.5660.38
16_Q19_R0.5660.38
12_T19_R0.5660.38
124_V290_L0.5650.37
341_P345_G0.5650.37
219_G245_E0.5640.37
13_I281_V0.5620.37
215_A219_G0.5620.37
284_L310_T0.5620.37
151_H165_R0.5610.37
228_W384_I0.5610.37
195_Y331_I0.5600.37
216_H219_G0.5590.37
262_V301_L0.5570.37
17_S347_I0.5570.37
65_D69_R0.5560.37
191_G337_A0.5560.37
245_E264_L0.5560.37
142_K146_P0.5560.37
243_N375_V0.5550.37
214_A245_E0.5520.36
137_E370_S0.5520.36
17_S248_V0.5510.36
86_D164_G0.5500.36
302_R361_E0.5490.36
222_Q343_Y0.5480.36
213_G222_Q0.5470.36
301_L308_S0.5450.36
15_S353_V0.5450.36
110_R143_L0.5450.36
82_V159_L0.5440.35
30_I35_K0.5440.35
111_V328_A0.5440.35
241_A381_N0.5430.35
213_G340_M0.5430.35
278_R376_V0.5420.35
57_E86_D0.5410.35
199_R202_C0.5410.35
325_I341_P0.5400.35
328_A334_E0.5400.35
27_T48_D0.5390.35
273_S284_L0.5380.35
128_V131_G0.5380.35
197_L317_I0.5370.35
261_G265_K0.5370.35
4_I67_L0.5370.35
98_Y109_V0.5360.35
96_V100_D0.5360.35
302_R310_T0.5350.35
226_Y230_R0.5350.35
133_N141_V0.5350.35
8_F11_I0.5350.35
70_I229_N0.5340.35
20_L24_K0.5340.35
226_Y343_Y0.5340.35
220_V239_F0.5330.34
248_V342_E0.5320.34
7_L153_E0.5320.34
215_A343_Y0.5320.34
195_Y259_Q0.5310.34
122_I126_R0.5310.34
226_Y340_M0.5310.34
211_L248_V0.5310.34
261_G269_V0.5300.34
313_L316_L0.5300.34
212_G347_I0.5290.34
110_R122_I0.5280.34
199_R273_S0.5280.34
265_K343_Y0.5280.34
181_L279_Y0.5270.34
10_E14_K0.5270.34
22_F215_A0.5250.34
177_Q301_L0.5240.34
133_N355_A0.5230.34
5_I160_L0.5230.34
123_D361_E0.5220.33
78_E154_V0.5210.33
106_T147_D0.5210.33
83_P312_I0.5190.33
15_S343_Y0.5190.33
13_I172_F0.5180.33
10_E200_R0.5180.33
133_N143_L0.5180.33
266_R307_V0.5170.33
257_D348_S0.5170.33
207_C284_L0.5160.33
37_Y62_A0.5160.33
23_I318_S0.5150.33
102_L138_S0.5140.33
202_C282_Q0.5140.33
194_S230_R0.5140.33
19_R47_W0.5140.33
17_S222_Q0.5130.33
27_T50_I0.5130.33
86_D134_Q0.5120.33
174_I203_R0.5110.32
285_V332_G0.5110.32
35_K103_E0.5100.32
277_E306_N0.5100.32
301_L311_L0.5090.32
226_Y336_F0.5090.32
263_I267_M0.5080.32
208_F267_M0.5080.32
17_S213_G0.5080.32
188_F229_N0.5080.32
210_N214_A0.5070.32
222_Q338_R0.5060.32
216_H324_I0.5060.32
223_V349_K0.5060.32
56_D59_Q0.5050.32
213_G219_G0.5050.32
16_Q350_S0.5040.32
212_G312_I0.5030.32
22_F116_K0.5020.32
12_T76_I0.5020.32
16_Q300_N0.5020.32
112_K125_E0.5010.32
218_I221_R0.5000.31
261_G300_N0.5000.31
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2c5sA 2 0.7656 100 0.511 Contact Map
4kr6A 2 0.778 100 0.519 Contact Map
1vbkA 2 0.6203 100 0.594 Contact Map
3uowA 2 0.7573 99.9 0.881 Contact Map
1gpmA 3 0.751 99.8 0.889 Contact Map
2dplA 2 0.5021 99.8 0.89 Contact Map
2ywbA 4 0.7178 99.8 0.893 Contact Map
3tqiA 3 0.7075 99.8 0.894 Contact Map
2dirA 1 0.1971 99.8 0.895 Contact Map
3q4gA 2 0.4917 99.7 0.904 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0122 seconds.