GREMLIN Database
YCJP - Inner membrane ABC transporter permease protein YcjP
UniProt: P77716 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13913
Length: 280 (253)
Sequences: 68277 (44577)
Seq/√Len: 2802.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
185_Q189_R3.9321.00
75_R79_V3.1481.00
177_M186_I3.0561.00
162_K166_D2.9921.00
73_Y232_G2.6541.00
72_D75_R2.5981.00
35_S59_Y2.5961.00
101_R173_E2.5151.00
182_N185_Q2.5141.00
83_V146_I2.5031.00
87_V150_V2.4841.00
164_Y198_G2.4791.00
176_A186_I2.4661.00
227_F235_A2.4161.00
60_V64_N2.3961.00
173_E191_T2.3721.00
71_V75_R2.3471.00
183_R186_I2.2821.00
85_S203_F2.2761.00
57_E60_V2.2731.00
184_L188_F2.1801.00
161_L199_L2.1781.00
243_I246_R2.1291.00
57_E61_D2.1261.00
104_F107_R2.0951.00
181_L185_Q2.0231.00
185_Q188_F2.0141.00
157_A202_V1.9571.00
93_I187_I1.9411.00
79_V142_E1.9311.00
100_S166_D1.8901.00
172_I194_L1.8801.00
165_F195_A1.8641.00
111_N162_K1.8471.00
176_A181_L1.8471.00
29_F33_M1.8291.00
33_M37_K1.8281.00
89_V203_F1.8131.00
93_I195_A1.8091.00
72_D76_N1.7281.00
177_M183_R1.6991.00
173_E186_I1.6751.00
84_S210_A1.6691.00
224_A227_F1.6601.00
81_S207_F1.6551.00
92_G157_A1.6371.00
79_V83_V1.6311.00
95_G158_V1.6091.00
93_I161_L1.6001.00
142_E226_N1.5951.00
173_E177_M1.5811.00
61_D246_R1.5591.00
14_Y18_A1.5241.00
99_L158_V1.5211.00
170_D173_E1.5171.00
232_G236_L1.4941.00
61_D64_N1.4811.00
66_M69_P1.4781.00
26_F30_V1.4241.00
157_A206_C1.4191.00
56_L60_V1.4171.00
103_R107_R1.3991.00
106_G109_T1.3951.00
100_S162_K1.3911.00
214_Y218_S1.3861.00
32_L252_L1.3731.00
90_F94_L1.3521.00
80_V228_T1.3481.00
192_V199_L1.3471.00
30_V34_T1.3391.00
69_P72_D1.3351.00
165_F191_T1.3261.00
96_A161_L1.3261.00
201_S205_Y1.3181.00
88_A206_C1.3151.00
263_A267_R1.3121.00
55_T58_H1.2921.00
161_L202_V1.2861.00
214_Y234_N1.2731.00
170_D174_E1.2681.00
101_R170_D1.2621.00
216_F220_F1.2461.00
93_I199_L1.2381.00
227_F232_G1.2381.00
171_E174_E1.2151.00
148_T220_F1.1951.00
236_L243_I1.1881.00
176_A190_I1.1861.00
109_T112_A1.1811.00
133_I144_A1.1801.00
97_Y165_F1.1781.00
41_E53_Q1.1781.00
168_I194_L1.1771.00
86_V90_F1.1751.00
221_L226_N1.1671.00
89_V199_L1.1661.00
77_S229_L1.1611.00
61_D65_P1.1451.00
196_M200_I1.1441.00
236_L241_D1.1411.00
76_N79_V1.1351.00
83_V86_V1.1331.00
235_A239_T1.1261.00
18_A22_I1.1151.00
223_S226_N1.0871.00
182_N186_I1.0821.00
9_S13_F1.0801.00
31_M252_L1.0721.00
154_L158_V1.0701.00
38_G41_E1.0691.00
109_T113_S1.0671.00
267_R270_K1.0591.00
87_V146_I1.0571.00
145_L217_A1.0541.00
11_I15_C1.0531.00
161_L198_G1.0401.00
141_T226_N1.0381.00
131_K135_A1.0361.00
213_D216_F1.0321.00
30_V33_M1.0281.00
173_E183_R1.0271.00
146_I150_V1.0231.00
100_S165_F1.0151.00
228_T231_V1.0151.00
83_V87_V1.0101.00
59_Y252_L1.0081.00
84_S88_A1.0051.00
160_M202_V0.9961.00
94_L98_A0.9911.00
194_L197_S0.9891.00
11_I14_Y0.9881.00
65_P69_P0.9871.00
63_F71_V0.9851.00
232_G235_A0.9851.00
10_R14_Y0.9811.00
84_S149_M0.9791.00
97_Y187_I0.9781.00
143_M147_I0.9781.00
78_L82_V0.9771.00
97_Y183_R0.9691.00
181_L186_I0.9691.00
186_I189_R0.9531.00
142_E146_I0.9461.00
217_A228_T0.9411.00
129_L220_F0.9401.00
86_V203_F0.9391.00
39_A43_I0.9351.00
213_D217_A0.9311.00
227_F231_V0.9261.00
107_R166_D0.9231.00
13_F17_L0.9211.00
232_G250_A0.9201.00
79_V143_M0.9181.00
138_I143_M0.9121.00
84_S146_I0.9111.00
35_S39_A0.9051.00
96_A100_S0.9001.00
264_L268_F0.8981.00
237_F247_M0.8981.00
218_S231_V0.8961.00
82_V86_V0.8881.00
164_Y195_A0.8851.00
34_T248_M0.8841.00
34_T37_K0.8831.00
129_L148_T0.8801.00
76_N142_E0.8801.00
79_V82_V0.8791.00
108_M111_N0.8791.00
74_F229_L0.8771.00
80_V142_E0.8721.00
21_L25_L0.8701.00
258_V262_Y0.8691.00
88_A92_G0.8621.00
37_K41_E0.8601.00
149_M210_A0.8561.00
195_A198_G0.8561.00
161_L195_A0.8511.00
141_T144_A0.8461.00
186_I191_T0.8451.00
92_G158_V0.8441.00
115_Y159_F0.8431.00
234_N238_S0.8351.00
36_F54_W0.8341.00
74_F78_L0.8341.00
105_K108_M0.8311.00
62_I253_V0.8281.00
99_L111_N0.8241.00
87_V90_F0.8231.00
187_I192_V0.8221.00
148_T216_F0.8201.00
188_F192_V0.8201.00
157_A161_L0.8191.00
196_M199_L0.8171.00
130_F134_T0.8161.00
126_V215_L0.8111.00
75_R78_L0.8071.00
69_P224_A0.8051.00
206_C210_A0.8041.00
80_V149_M0.8021.00
63_F66_M0.8011.00
122_G152_Q0.8001.00
96_A158_V0.8001.00
40_K43_I0.7991.00
98_A104_F0.7991.00
70_F250_A0.7941.00
236_L250_A0.7911.00
181_L189_R0.7891.00
58_H245_G0.7781.00
183_R187_I0.7781.00
260_I264_L0.7781.00
265_S268_F0.7751.00
236_L246_R0.7671.00
31_M248_M0.7671.00
140_D223_S0.7541.00
34_T38_G0.7501.00
73_Y76_N0.7491.00
96_A165_F0.7441.00
95_G154_L0.7441.00
172_I190_I0.7381.00
83_V150_V0.7381.00
248_M252_L0.7361.00
58_H61_D0.7351.00
88_A157_A0.7351.00
196_M268_F0.7311.00
254_T258_V0.7261.00
143_M146_I0.7221.00
37_K51_P0.7201.00
38_G53_Q0.7201.00
88_A210_A0.7181.00
61_D243_I0.7161.00
85_S207_F0.7121.00
168_I195_A0.7111.00
54_W57_E0.7091.00
136_L139_Y0.7091.00
89_V161_L0.7071.00
134_T139_Y0.7071.00
229_L254_T0.7071.00
20_F24_T0.7051.00
187_I191_T0.7041.00
12_G15_C0.7011.00
122_G215_L0.6991.00
26_F29_F0.6971.00
81_S85_S0.6971.00
199_L202_V0.6971.00
175_A179_D0.6951.00
36_F55_T0.6951.00
125_L151_T0.6931.00
99_L162_K0.6921.00
60_V63_F0.6901.00
92_G161_L0.6881.00
153_T206_C0.6881.00
126_V219_I0.6861.00
175_A178_M0.6851.00
15_C18_A0.6841.00
246_R250_A0.6811.00
264_L267_R0.6761.00
71_V74_F0.6761.00
170_D177_M0.6741.00
73_Y229_L0.6741.00
115_Y118_Y0.6731.00
233_L250_A0.6731.00
231_V235_A0.6721.00
161_L165_F0.6711.00
55_T59_Y0.6701.00
213_D228_T0.6681.00
66_M72_D0.6651.00
88_A153_T0.6621.00
31_M251_S0.6621.00
144_A148_T0.6621.00
153_T209_V0.6571.00
191_T194_L0.6571.00
259_V263_A0.6551.00
77_S230_P0.6551.00
17_L21_L0.6531.00
98_A102_L0.6521.00
99_L110_I0.6511.00
131_K134_T0.6501.00
85_S89_V0.6501.00
199_L203_F0.6451.00
12_G16_G0.6391.00
21_L24_T0.6361.00
22_I26_F0.6351.00
50_L53_Q0.6321.00
198_G202_V0.6311.00
56_L59_Y0.6311.00
80_V146_I0.6311.00
95_G114_F0.6281.00
80_V145_L0.6231.00
230_P254_T0.6221.00
41_E52_Q0.6211.00
111_N159_F0.6201.00
91_L150_V0.6191.00
123_I219_I0.6161.00
104_F110_I0.6131.00
91_L154_L0.6101.00
245_G248_M0.6091.00
248_M251_S0.6091.00
16_G20_F0.6091.00
76_N226_N0.6071.00
38_G52_Q0.6041.00
25_L29_F0.6011.00
145_L221_L0.6001.00
106_G110_I0.5991.00
88_A150_V0.5961.00
244_W247_M0.5951.00
244_W248_M0.5951.00
188_F191_T0.5941.00
62_I250_A0.5921.00
81_S210_A0.5911.00
129_L132_I0.5901.00
160_M198_G0.5891.00
215_L218_S0.5891.00
69_P232_G0.5841.00
209_V212_N0.5841.00
260_I263_A0.5821.00
112_A116_T0.5821.00
105_K109_T0.5801.00
145_L149_M0.5791.00
263_A266_E0.5771.00
203_F206_C0.5761.00
144_A220_F0.5751.00
186_I190_I0.5751.00
35_S249_A0.5721.00
10_R13_F0.5701.00
200_I203_F0.5691.00
53_Q57_E0.5671.00
102_L183_R0.5671.00
118_Y155_P0.5671.00
89_V93_I0.5661.00
210_A213_D0.5661.00
221_L227_F0.5641.00
34_T39_A0.5601.00
37_K53_Q0.5601.00
96_A162_K0.5591.00
81_S211_W0.5581.00
103_R108_M0.5581.00
231_V234_N0.5561.00
60_V65_P0.5551.00
59_Y249_A0.5551.00
118_Y156_T0.5541.00
108_M112_A0.5541.00
97_Y191_T0.5521.00
80_V84_S0.5521.00
122_G126_V0.5491.00
236_L239_T0.5481.00
77_S211_W0.5481.00
215_L219_I0.5471.00
62_I246_R0.5451.00
149_M152_Q0.5431.00
37_K52_Q0.5421.00
149_M213_D0.5411.00
14_Y17_L0.5411.00
262_Y266_E0.5391.00
27_P31_M0.5351.00
174_E177_M0.5351.00
133_I139_Y0.5341.00
137_G140_D0.5321.00
242_Y245_G0.5301.00
95_G98_A0.5291.00
246_R249_A0.5291.00
66_M71_V0.5271.00
103_R106_G0.5271.00
103_R170_D0.5241.00
182_N188_F0.5221.00
126_V130_F0.5211.00
111_N166_D0.5211.00
251_S254_T0.5201.00
168_I173_E0.5191.00
208_M212_N0.5191.00
149_M217_A0.5131.00
85_S210_A0.5121.00
224_A235_A0.5121.00
113_S117_V0.5111.00
39_A51_P0.5111.00
217_A231_V0.5071.00
111_N158_V0.5071.00
84_S150_V0.5051.00
53_Q56_L0.5041.00
257_P260_I0.5041.00
32_L36_F0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3rlfG 1 0.9607 100 0.257 Contact Map
4tquN 1 0.9464 100 0.265 Contact Map
2onkC 2 0.8643 100 0.299 Contact Map
4tquM 1 0.9107 100 0.325 Contact Map
3d31C 2 0.8464 100 0.327 Contact Map
3rlfF 1 0.9179 100 0.369 Contact Map
4ymuD 2 0.7607 99.9 0.483 Contact Map
3tuiA 2 0.7429 99.9 0.524 Contact Map
3mktA 1 0.55 9.1 0.949 Contact Map
3dh4A 3 0.7536 6.5 0.953 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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