GREMLIN Database
FADM - Long-chain acyl-CoA thioesterase FadM
UniProt: P77712 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13251
Length: 132 (124)
Sequences: 6497 (4709)
Seq/√Len: 422.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
55_N59_N3.2911.00
77_Q87_S2.6301.00
62_R97_Q2.4121.00
27_L102_A2.3711.00
64_A99_V2.2691.00
57_N103_L2.2481.00
110_D113_T2.2391.00
61_R101_D2.1911.00
64_A70_L2.1311.00
22_R25_E1.9801.00
24_L56_I1.9661.00
73_T89_V1.9451.00
78_Q85_I1.9031.00
27_L100_A1.8921.00
73_T91_T1.8661.00
24_L58_I1.8161.00
4_Q69_L1.8081.00
92_L95_E1.7951.00
75_Q87_S1.7541.00
68_D92_L1.7251.00
50_A111_L1.7211.00
91_T98_V1.6881.00
89_V98_V1.6391.00
121_G125_E1.6371.00
4_Q71_T1.6161.00
18_V26_F1.5671.00
6_K69_L1.5501.00
59_N101_D1.5491.00
58_I100_A1.5331.00
27_L90_I1.5311.00
85_I103_L1.5261.00
72_I90_I1.4961.00
88_Q104_I1.4691.00
120_E123_L1.4571.00
63_P114_Q1.4491.00
82_K116_A1.4461.00
92_L97_Q1.4361.00
33_D37_N1.4161.00
87_S103_L1.4101.00
89_V101_D1.3821.00
30_A74_S1.3801.00
80_N83_S1.3621.00
77_Q103_L1.3581.00
124_R128_E1.3051.00
6_K36_E1.3051.00
6_K33_D1.2911.00
92_L99_V1.2581.00
30_A72_I1.2511.00
10_Y25_E1.2441.00
43_W46_A1.2411.00
83_S105_T1.2311.00
54_V59_N1.2101.00
21_A25_E1.1821.00
56_I104_I1.1791.00
8_R11_H1.1731.00
28_E31_R1.1631.00
109_I114_Q1.1611.00
36_E67_S1.1421.00
81_G118_A1.1211.00
40_S43_W1.1041.00
91_T96_G1.0891.00
52_V109_I1.0861.00
11_H25_E1.0781.00
7_V18_V1.0761.00
110_D117_L1.0731.00
55_N105_T1.0501.00
75_Q89_V1.0411.00
77_Q85_I1.0261.00
85_I105_T1.0211.00
20_N56_I1.0101.00
61_R98_V0.9811.00
54_V105_T0.9651.00
82_K107_V0.9561.00
5_I72_I0.9521.00
125_E128_E0.9421.00
98_V101_D0.9321.00
48_N112_K0.8931.00
26_F70_L0.8911.00
122_E125_E0.8851.00
121_G124_R0.8681.00
7_V26_F0.8661.00
74_S88_Q0.8521.00
49_I108_C0.8491.00
36_E40_S0.8441.00
27_L58_I0.8421.00
70_L99_V0.8291.00
8_R29_E0.8231.00
55_N103_L0.8221.00
11_H26_F0.8161.00
20_N60_Y0.8131.00
43_W47_H0.8111.00
87_S101_D0.8111.00
25_E28_E0.8001.00
76_L86_L0.7981.00
42_Q46_A0.7981.00
69_L94_P0.7931.00
71_T96_G0.7921.00
18_V64_A0.7821.00
8_R25_E0.7811.00
82_K118_A0.7681.00
19_N28_E0.7661.00
15_Y52_V0.7661.00
71_T94_P0.7641.00
34_G74_S0.7611.00
54_V61_R0.7461.00
9_G12_L0.7451.00
6_K67_S0.7411.00
47_H122_E0.7381.00
79_L124_R0.7371.00
71_T91_T0.7341.00
72_I88_Q0.7271.00
12_L16_Q0.7231.00
15_Y19_N0.7171.00
74_S86_L0.7161.00
9_G14_V0.7111.00
33_D36_E0.7111.00
56_I102_A0.7101.00
31_R53_V0.7041.00
20_N24_L0.6941.00
5_I29_E0.6921.00
54_V107_V0.6701.00
5_I8_R0.6681.00
122_E126_K0.6630.99
119_L124_R0.6600.99
88_Q106_F0.6590.99
20_N31_R0.6570.99
31_R88_Q0.6560.99
65_V114_Q0.6520.99
5_I26_F0.6500.99
15_Y20_N0.6430.99
42_Q67_S0.6420.99
34_G76_L0.6390.99
17_H63_P0.6320.99
17_H52_V0.6280.99
27_L88_Q0.6260.99
121_G128_E0.6220.99
12_L66_L0.6180.99
17_H114_Q0.6180.99
58_I102_A0.6170.99
9_G66_L0.6160.99
22_R26_F0.6160.99
15_Y50_A0.6090.99
31_R106_F0.6040.99
29_E33_D0.5990.99
84_G119_L0.5970.99
19_N22_R0.5940.99
54_V83_S0.5810.99
59_N103_L0.5780.99
23_Y64_A0.5750.99
111_L114_Q0.5680.98
10_Y19_N0.5670.98
88_Q102_A0.5660.98
31_R86_L0.5630.98
108_C117_L0.5610.98
81_G124_R0.5550.98
10_Y29_E0.5520.98
79_L127_L0.5510.98
12_L22_R0.5510.98
42_Q45_T0.5490.98
53_V106_F0.5450.98
23_Y100_A0.5390.98
118_A121_G0.5390.98
56_I60_Y0.5380.98
5_I11_H0.5360.98
92_L96_G0.5350.98
68_D99_V0.5320.98
49_I117_L0.5310.98
124_R127_L0.5290.98
7_V70_L0.5280.97
90_I100_A0.5270.97
80_N116_A0.5240.97
86_L106_F0.5240.97
68_D94_P0.5230.97
10_Y21_A0.5220.97
80_N124_R0.5210.97
64_A100_A0.5200.97
117_L123_L0.5180.97
30_A88_Q0.5150.97
54_V82_K0.5130.97
79_L84_G0.5120.97
53_V104_I0.5090.97
83_S124_R0.5080.97
11_H22_R0.5060.97
34_G38_S0.5050.97
62_R92_L0.5040.97
83_S107_V0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2essA 2 0.9621 100 0.244 Contact Map
1njkA 4 1 100 0.252 Contact Map
2ownA 3 0.9924 100 0.256 Contact Map
2hljA 2 0.9773 99.9 0.268 Contact Map
2o5uA 4 0.9924 99.9 0.273 Contact Map
2xemA 4 1 99.9 0.282 Contact Map
3ck1A 4 0.9924 99.9 0.282 Contact Map
3qy3A 4 0.9545 99.9 0.283 Contact Map
2nujA 3 0.9848 99.9 0.284 Contact Map
2w3xA 4 1 99.9 0.289 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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