GREMLIN Database
TFAD - Putative tail fiber assembly protein homolog from lambdoid prophage DLP12
UniProt: P77699 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13640
Length: 247 (188)
Sequences: 206 (134)
Seq/√Len: 9.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
202_D224_R6.3011.00
185_T189_L3.7380.98
175_K179_I3.4030.96
203_A225_V2.4880.83
200_L209_A2.3900.80
163_N166_A2.3450.79
205_D221_K2.2970.77
209_A225_V2.2720.76
209_A213_E2.2380.75
205_D224_R2.1930.74
203_A229_R2.1510.72
146_L150_V2.1480.72
129_V150_V2.1480.72
66_S94_I2.1080.70
202_D209_A2.0300.67
200_L203_A2.0290.67
203_A209_A2.0130.67
221_K224_R2.0130.67
83_S88_G2.0120.67
200_L204_V2.0040.66
54_L110_V1.9590.65
98_Q111_F1.9300.63
204_V229_R1.9260.63
71_E119_H1.8600.60
135_G157_G1.8310.59
200_L225_V1.8100.58
226_L229_R1.8080.58
128_T137_A1.7460.55
202_D221_K1.7130.54
221_K229_R1.7040.53
202_D205_D1.6640.52
148_E172_E1.6570.51
209_A221_K1.6080.49
77_S104_P1.6080.49
200_L229_R1.5880.48
81_G87_L1.5860.48
208_I225_V1.5740.47
60_I94_I1.5710.47
203_A221_K1.5560.47
206_L220_W1.5500.46
62_N88_G1.5320.46
89_V99_R1.5210.45
83_S90_Y1.4920.44
200_L221_K1.4920.44
79_R90_Y1.4700.43
94_I115_E1.4670.43
200_L224_R1.4440.42
209_A229_R1.4380.41
203_A218_E1.4350.41
208_I224_R1.3990.40
182_A238_I1.3980.40
183_E186_K1.3910.39
213_E225_V1.3670.38
210_T216_L1.3650.38
157_G160_Q1.3290.37
221_K225_V1.3180.36
190_M213_E1.3080.36
68_Y110_V1.2930.35
200_L213_E1.2920.35
202_D229_R1.2920.35
218_E222_K1.2810.35
204_V209_A1.2690.34
122_E145_P1.2580.34
83_S89_V1.2240.32
76_K95_E1.1940.31
186_K202_D1.1930.31
124_H127_K1.1590.30
207_E220_W1.1590.30
65_G84_K1.1580.30
121_V143_L1.1490.29
202_D225_V1.1470.29
200_L228_N1.1280.29
200_L220_W1.1060.28
213_E216_L1.0870.27
67_D90_Y1.0850.27
190_M202_D1.0710.27
222_K225_V1.0670.26
98_Q134_S1.0670.26
55_P164_G1.0660.26
75_V140_I1.0560.26
63_A70_R1.0330.25
90_Y93_F1.0290.25
127_K146_L1.0220.25
64_M143_L1.0190.25
181_E186_K1.0190.25
201_Q205_D1.0180.25
88_G91_A1.0180.25
67_D83_S1.0160.25
225_V229_R1.0160.25
208_I221_K1.0120.25
108_V140_I1.0050.24
200_L226_L0.9990.24
205_D216_L0.9970.24
71_E111_F0.9910.24
211_E232_T0.9860.24
202_D228_N0.9820.24
107_F115_E0.9790.24
58_R230_V0.9780.23
76_K120_L0.9710.23
202_D210_T0.9530.23
88_G106_G0.9480.23
75_V222_K0.9440.22
211_E220_W0.9350.22
204_V227_L0.9300.22
215_S239_E0.9270.22
92_Y214_T0.9230.22
208_I218_E0.9210.22
203_A224_R0.9160.22
205_D208_I0.9150.21
104_P120_L0.9120.21
186_K201_Q0.9110.21
200_L216_L0.9110.21
210_T214_T0.9100.21
216_L234_T0.9070.21
213_E228_N0.9010.21
202_D213_E0.9000.21
62_N90_Y0.8950.21
200_L207_E0.8940.21
60_I103_I0.8870.21
129_V146_L0.8870.21
204_V226_L0.8850.21
147_P150_V0.8710.20
81_G90_Y0.8700.20
204_V224_R0.8660.20
220_W230_V0.8610.20
98_Q103_I0.8580.20
204_V225_V0.8520.20
89_V103_I0.8500.20
189_L199_P0.8490.20
60_I66_S0.8440.19
143_L146_L0.8360.19
65_G94_I0.8360.19
67_D147_P0.8350.19
205_D218_E0.8270.19
112_N180_R0.8270.19
200_L206_L0.8240.19
232_T239_E0.8200.19
99_R105_A0.8150.19
216_L228_N0.8140.19
78_A103_I0.8110.18
194_S200_L0.8050.18
202_D208_I0.8000.18
224_R229_R0.7850.18
69_I145_P0.7840.18
171_A174_E0.7830.18
56_F232_T0.7830.18
231_D234_T0.7820.18
178_R228_N0.7820.18
187_N202_D0.7790.18
70_R79_R0.7770.18
67_D76_K0.7710.17
194_S202_D0.7690.17
212_E238_I0.7680.17
62_N83_S0.7670.17
142_E147_P0.7650.17
60_I159_F0.7640.17
203_A213_E0.7630.17
88_G93_F0.7600.17
58_R107_F0.7580.17
242_T245_V0.7510.17
202_D218_E0.7500.17
79_R101_T0.7490.17
67_D92_Y0.7460.17
218_E221_K0.7430.17
218_E225_V0.7420.17
129_V180_R0.7410.17
210_T213_E0.7310.16
131_D149_N0.7290.16
148_E212_E0.7280.16
203_A210_T0.7280.16
187_N204_V0.7260.16
225_V228_N0.7220.16
187_N203_A0.7210.16
64_M76_K0.7210.16
132_V193_A0.7180.16
201_Q221_K0.7180.16
200_L208_I0.7140.16
194_S203_A0.7070.16
63_A91_A0.7070.16
79_R95_E0.7070.16
66_S81_G0.7040.16
204_V221_K0.7040.16
219_A224_R0.7030.16
65_G88_G0.6970.16
211_E230_V0.6920.15
106_G189_L0.6910.15
207_E211_E0.6900.15
54_L65_G0.6890.15
218_E224_R0.6890.15
200_L210_T0.6870.15
200_L227_L0.6860.15
210_T224_R0.6860.15
140_I143_L0.6850.15
114_D147_P0.6830.15
58_R238_I0.6830.15
130_Y217_L0.6830.15
128_T139_F0.6820.15
77_S110_V0.6810.15
211_E214_T0.6780.15
65_G79_R0.6780.15
192_V243_N0.6740.15
205_D229_R0.6730.15
198_A205_D0.6730.15
77_S94_I0.6720.15
92_Y102_L0.6700.15
137_A149_N0.6680.15
210_T228_N0.6660.15
212_E215_S0.6550.15
209_A220_W0.6490.14
194_S205_D0.6490.14
65_G77_S0.6480.14
60_I80_V0.6470.14
91_A147_P0.6450.14
68_Y146_L0.6440.14
199_P224_R0.6370.14
142_E161_K0.6340.14
194_S224_R0.6320.14
137_A152_W0.6310.14
194_S220_W0.6290.14
186_K206_L0.6250.14
58_R163_N0.6250.14
104_P127_K0.6190.14
110_V120_L0.6110.14
202_D220_W0.6100.14
62_N77_S0.6090.14
209_A222_K0.6060.14
57_Q245_V0.6050.13
194_S197_I0.6030.13
84_K124_H0.6000.13
200_L214_T0.5990.13
213_E221_K0.5970.13
179_I237_D0.5900.13
109_A120_L0.5870.13
54_L77_S0.5870.13
190_M198_A0.5850.13
67_D89_V0.5790.13
208_I220_W0.5790.13
65_G76_K0.5780.13
61_M101_T0.5780.13
232_T245_V0.5770.13
158_E234_T0.5770.13
213_E218_E0.5760.13
224_R228_N0.5700.13
87_L129_V0.5690.13
175_K226_L0.5690.13
59_A81_G0.5680.13
77_S80_V0.5640.13
61_M67_D0.5640.13
94_I110_V0.5640.13
172_E176_L0.5620.13
82_Y157_G0.5610.13
58_R119_H0.5580.13
184_E187_N0.5560.12
56_F171_A0.5480.12
80_V120_L0.5460.12
190_M224_R0.5440.12
127_K185_T0.5430.12
146_L152_W0.5410.12
54_L104_P0.5410.12
113_S132_V0.5400.12
70_R88_G0.5390.12
182_A232_T0.5370.12
135_G158_E0.5340.12
203_A208_I0.5320.12
62_N80_V0.5290.12
202_D206_L0.5230.12
79_R139_F0.5220.12
203_A228_N0.5210.12
195_E211_E0.5200.12
66_S102_L0.5200.12
131_D141_S0.5170.12
94_I120_L0.5130.12
172_E212_E0.5130.12
82_Y119_H0.5120.12
63_A141_S0.5110.12
61_M70_R0.5100.12
60_I200_L0.5070.12
199_P202_D0.5070.12
210_T243_N0.5070.12
58_R83_S0.5040.11
190_M203_A0.5020.11
64_M108_V0.5000.11
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2kz6A 1 0.3927 99.7 0.841 Contact Map
3vfzA 2 0.1053 18.3 0.975 Contact Map
4mzvA 2 0.3117 14.8 0.976 Contact Map
2o8xA 7 0.085 13.3 0.976 Contact Map
2o6nA 3 0.1336 10.2 0.977 Contact Map
3r0rA 9 0.3198 9.5 0.978 Contact Map
4zcnA 3 0.3401 7.2 0.979 Contact Map
4egcB 1 0.3239 6.6 0.979 Contact Map
1mdaH 1 0.5061 6.2 0.98 Contact Map
1jsuC 1 0.2753 5.8 0.98 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0082 seconds.