GREMLIN Database
YBCK - Uncharacterized protein YbcK
UniProt: P77698 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13627
Length: 508 (442)
Sequences: 4824 (4232)
Seq/√Len: 201.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
199_L220_H4.7091.00
45_Y69_A4.4281.00
273_S276_L4.3901.00
179_S190_D3.8721.00
62_A65_E3.5671.00
203_L216_Y3.4441.00
216_Y220_H3.2061.00
274_D278_Y3.1611.00
205_M276_L3.1411.00
199_L203_L2.8761.00
43_I65_E2.7191.00
6_A28_I2.7051.00
380_K414_E2.6991.00
190_D193_R2.6051.00
308_K460_K2.5681.00
381_I415_L2.4851.00
30_E34_V2.4561.00
205_M280_V2.4321.00
25_R29_A2.3971.00
308_K315_T2.3841.00
8_M25_R2.3761.00
373_A421_S2.3661.00
179_S188_V2.3271.00
374_N422_L2.3131.00
203_L208_R2.2721.00
310_E464_N2.2671.00
70_I75_I2.2541.00
377_L418_A2.2381.00
69_A74_Y2.2311.00
25_R44_T2.2121.00
202_K276_L2.2071.00
249_I265_A2.1891.00
244_K249_I2.1151.00
208_R216_Y2.0291.00
277_F281_Q2.0261.00
249_I274_D2.0111.00
314_N333_M1.9731.00
377_L422_L1.9641.00
346_R350_D1.9311.00
199_L216_Y1.9251.00
238_E242_A1.9211.00
381_I418_A1.9031.00
144_E151_R1.8981.00
131_L146_E1.8911.00
242_A285_L1.8811.00
32_L39_Y1.8511.00
247_I274_D1.8501.00
194_V198_E1.8091.00
384_L411_L1.8081.00
29_A44_T1.8071.00
95_G102_K1.7931.00
384_L415_L1.7721.00
202_K206_E1.7681.00
385_Q415_L1.7591.00
71_E103_L1.7541.00
4_A37_D1.7411.00
47_D62_A1.7391.00
201_F280_V1.7391.00
306_V455_Y1.7251.00
311_A340_D1.7211.00
378_E426_K1.7121.00
189_P271_V1.7101.00
181_D188_V1.7001.00
378_E422_L1.6921.00
26_R30_E1.6791.00
242_A284_R1.6671.00
451_R455_Y1.6641.00
193_R225_F1.6591.00
144_E148_K1.6221.00
113_T116_D1.6201.00
387_K397_V1.6111.00
83_V111_V1.6001.00
5_I75_I1.5801.00
211_N215_K1.5651.00
214_A237_I1.5461.00
396_S407_K1.5461.00
204_R241_L1.5331.00
415_L419_S1.5241.00
409_R413_K1.5131.00
12_S15_Q1.5051.00
201_F272_I1.5041.00
200_I213_I1.4981.00
159_K168_T1.4971.00
270_R274_D1.4961.00
400_E403_A1.4941.00
66_F81_L1.4911.00
32_L82_L1.4891.00
203_L206_E1.4781.00
446_G449_L1.4761.00
417_R421_S1.4741.00
216_Y219_D1.4651.00
31_W35_N1.4611.00
385_Q419_S1.4521.00
404_I408_I1.4501.00
205_M279_A1.4381.00
40_L43_I1.4361.00
278_Y282_E1.4341.00
127_E130_S1.4301.00
303_L350_D1.4261.00
380_K383_E1.4141.00
244_K247_I1.4141.00
135_I139_Q1.4111.00
176_R196_T1.4071.00
356_E359_F1.3971.00
191_P198_E1.3931.00
194_V271_V1.3931.00
25_R46_E1.3811.00
209_S212_A1.3771.00
201_F246_L1.3751.00
142_N146_E1.3721.00
63_F66_F1.3711.00
244_K251_V1.3681.00
265_A274_D1.3661.00
374_N378_E1.3641.00
29_A33_K1.3631.00
373_A376_T1.3621.00
419_S423_K1.3621.00
407_K410_L1.3561.00
210_L238_E1.3521.00
393_V407_K1.3461.00
65_E69_A1.3361.00
410_L414_E1.3341.00
203_L220_H1.3281.00
147_I151_R1.3271.00
189_P194_V1.3271.00
5_I66_F1.3241.00
157_K161_Q1.3101.00
218_N232_W1.3041.00
214_A218_N1.3011.00
374_N426_K1.2981.00
233_G236_V1.2981.00
200_I217_L1.2971.00
28_I82_L1.2881.00
97_A138_A1.2881.00
68_D72_H1.2801.00
70_I81_L1.2781.00
200_I240_L1.2721.00
283_I287_P1.2671.00
241_L280_V1.2581.00
301_N318_V1.2551.00
181_D184_R1.2501.00
132_I143_E1.2411.00
101_L134_A1.2411.00
6_A39_Y1.2371.00
247_I277_F1.2281.00
382_I385_Q1.2231.00
149_S153_K1.2221.00
384_L418_A1.2201.00
83_V113_T1.2171.00
389_N410_L1.2051.00
421_S424_T1.1971.00
351_Y355_N1.1971.00
145_S148_K1.1941.00
70_I109_I1.1931.00
215_K219_D1.1901.00
97_A101_L1.1871.00
272_I280_V1.1791.00
250_C267_Y1.1781.00
87_D141_A1.1681.00
128_P150_S1.1671.00
8_M21_L1.1631.00
422_L426_K1.1631.00
329_Y346_R1.1611.00
45_Y66_F1.1581.00
204_R284_R1.1551.00
319_H330_V1.1551.00
196_T222_V1.1521.00
377_L421_S1.1491.00
414_E417_R1.1421.00
384_L414_E1.1411.00
381_I422_L1.1411.00
195_K198_E1.1391.00
374_N425_L1.1371.00
145_S149_S1.1361.00
208_R212_A1.1341.00
364_I370_K1.1221.00
87_D151_R1.1191.00
307_M349_V1.1171.00
389_N406_E1.1151.00
200_I237_I1.1141.00
345_K348_L1.1131.00
8_M44_T1.1101.00
132_I140_R1.1091.00
6_A44_T1.1061.00
214_A234_P1.1061.00
381_I419_S1.1051.00
388_I415_L1.1051.00
395_L401_V1.1041.00
462_I473_Y1.0981.00
5_I45_Y1.0961.00
85_S151_R1.0941.00
10_F15_Q1.0911.00
224_N227_G1.0871.00
334_R339_C1.0841.00
255_R258_G1.0811.00
71_E107_H1.0791.00
204_R283_I1.0791.00
132_I139_Q1.0751.00
375_E378_E1.0741.00
416_R419_S1.0711.00
30_E33_K1.0621.00
276_L280_V1.0621.00
249_I266_G1.0611.00
181_D186_A1.0581.00
169_I187_F1.0551.00
158_K166_S1.0521.00
86_L141_A1.0491.00
86_L134_A1.0491.00
7_Y47_D1.0471.00
68_D71_E1.0421.00
241_L281_Q1.0411.00
197_I201_F1.0391.00
50_L57_H1.0361.00
388_I408_I1.0361.00
413_K417_R1.0351.00
390_N395_L1.0321.00
310_E462_I1.0281.00
67_L100_R1.0271.00
116_D137_I1.0251.00
95_G99_E1.0211.00
416_R420_V1.0141.00
201_F277_F1.0131.00
395_L404_I1.0131.00
192_D195_K1.0131.00
283_I286_A1.0131.00
462_I471_D1.0121.00
203_L213_I1.0111.00
276_L279_A1.0101.00
179_S191_P1.0091.00
84_E154_L1.0091.00
86_L113_T1.0001.00
178_L246_L1.0001.00
56_K145_S0.9961.00
421_S425_L0.9941.00
418_A422_L0.9901.00
247_I278_Y0.9891.00
460_K473_Y0.9881.00
223_K231_A0.9831.00
148_K155_S0.9791.00
4_A80_T0.9781.00
105_L131_L0.9751.00
52_A90_S0.9731.00
196_T200_I0.9721.00
210_L214_A0.9710.99
205_M283_I0.9690.99
98_I135_I0.9690.99
92_E142_N0.9680.99
144_E147_I0.9640.99
100_R104_I0.9580.99
326_H345_K0.9570.99
407_K411_L0.9550.99
327_G346_R0.9540.99
63_F100_R0.9530.99
27_L84_E0.9500.99
50_L61_G0.9500.99
464_N471_D0.9470.99
316_M341_R0.9470.99
198_E276_L0.9420.99
384_L387_K0.9410.99
158_K161_Q0.9400.99
89_L100_R0.9390.99
46_E62_A0.9390.99
204_R213_I0.9370.99
392_I396_S0.9350.99
199_L202_K0.9350.99
223_K232_W0.9340.99
328_Y345_K0.9340.99
197_I271_V0.9320.99
354_I358_L0.9310.99
364_I367_V0.9300.99
403_A412_D0.9290.99
302_L454_A0.9280.99
156_W159_K0.9270.99
81_L104_I0.9260.99
390_N398_A0.9230.99
373_A425_L0.9170.99
63_F96_E0.9170.99
155_S159_K0.9150.99
458_F461_I0.9150.99
101_L105_L0.9120.99
401_V405_A0.9090.99
307_M329_Y0.9080.99
387_K396_S0.9080.99
213_I237_I0.9010.99
80_T112_I0.9000.99
303_L346_R0.9000.99
282_E286_A0.8960.99
131_L142_N0.8950.99
5_I69_A0.8930.99
316_M463_I0.8920.99
397_V401_V0.8900.99
217_L232_W0.8880.99
388_I412_D0.8870.99
388_I411_L0.8860.99
309_C312_C0.8840.99
63_F89_L0.8830.99
210_L237_I0.8820.99
32_L37_D0.8810.99
118_T130_S0.8790.99
196_T199_L0.8780.99
405_A409_R0.8760.99
10_F20_S0.8750.99
8_M46_E0.8730.99
382_I386_M0.8730.99
218_N231_A0.8720.99
279_A282_E0.8710.99
383_E387_K0.8700.99
277_F280_V0.8700.99
306_V454_A0.8690.99
435_D438_A0.8670.99
251_V254_Y0.8670.99
383_E397_V0.8640.99
187_F245_A0.8590.99
148_K152_V0.8590.99
197_I246_L0.8570.99
381_I384_L0.8570.99
67_L103_L0.8550.99
412_D416_R0.8510.99
207_R213_I0.8500.99
178_L189_P0.8500.99
459_E473_Y0.8490.99
197_I240_L0.8480.99
151_R154_L0.8480.99
360_N363_K0.8480.99
110_D119_V0.8470.99
31_W82_L0.8440.99
380_K384_L0.8440.99
149_S152_V0.8410.99
37_D82_L0.8410.99
210_L284_R0.8400.99
222_V232_W0.8390.99
247_I270_R0.8390.99
70_I104_I0.8360.98
201_F205_M0.8360.98
384_L388_I0.8340.98
394_A399_P0.8330.98
378_E382_I0.8330.98
255_R259_K0.8310.98
103_L107_H0.8310.98
204_R287_P0.8310.98
83_V89_L0.8300.98
4_A32_L0.8290.98
301_N304_R0.8270.98
90_S97_A0.8250.98
312_C331_C0.8220.98
202_K205_M0.8220.98
28_I114_L0.8220.98
313_G462_I0.8210.98
420_V424_T0.8190.98
69_A75_I0.8180.98
136_L139_Q0.8160.98
15_Q18_G0.8140.98
301_N329_Y0.8120.98
152_V156_W0.8100.98
243_N246_L0.8090.98
195_K202_K0.8050.98
196_T217_L0.8020.98
246_L272_I0.7950.98
86_L116_D0.7930.98
247_I273_S0.7930.98
168_T185_T0.7930.98
97_A134_A0.7920.98
390_N394_A0.7900.98
391_L396_S0.7840.98
67_L71_E0.7830.98
347_D351_Y0.7830.98
57_H64_S0.7810.98
58_A90_S0.7800.98
418_A421_S0.7790.98
176_R193_R0.7790.98
309_C331_C0.7780.98
454_A458_F0.7780.98
134_A138_A0.7780.98
176_R232_W0.7770.98
37_D80_T0.7770.98
420_V423_K0.7760.98
189_P269_P0.7740.98
43_I74_Y0.7740.98
80_T110_D0.7740.98
97_A105_L0.7710.97
423_K426_K0.7710.97
318_V327_G0.7710.97
133_K137_I0.7710.97
311_A465_T0.7670.97
51_S57_H0.7670.97
212_A215_K0.7670.97
45_Y74_Y0.7650.97
85_S147_I0.7650.97
223_K227_G0.7630.97
191_P195_K0.7620.97
19_D22_N0.7600.97
246_L280_V0.7600.97
328_Y343_S0.7590.97
85_S116_D0.7580.97
70_I107_H0.7580.97
59_Q64_S0.7570.97
376_T380_K0.7540.97
388_I392_I0.7530.97
377_L381_I0.7520.97
303_L307_M0.7520.97
388_I403_A0.7510.97
182_D188_V0.7490.97
129_Y132_I0.7480.97
302_L350_D0.7480.97
160_R252_P0.7480.97
303_L353_I0.7470.97
92_E102_K0.7460.97
276_L283_I0.7450.97
411_L415_L0.7450.97
255_R261_I0.7450.97
399_P405_A0.7450.97
235_S239_K0.7430.97
95_G98_I0.7430.97
217_L237_I0.7430.97
178_L270_R0.7420.97
132_I135_I0.7420.97
98_I102_K0.7390.97
177_W246_L0.7390.97
242_A281_Q0.7370.97
408_I412_D0.7350.97
214_A232_W0.7330.97
385_Q389_N0.7290.96
23_R158_K0.7260.96
249_I267_Y0.7260.96
39_Y44_T0.7250.96
458_F472_I0.7240.96
6_A25_R0.7230.96
302_L329_Y0.7230.96
393_V401_V0.7220.96
174_C187_F0.7210.96
318_V346_R0.7210.96
303_L461_I0.7200.96
387_K411_L0.7190.96
224_N232_W0.7180.96
390_N393_V0.7180.96
282_E285_L0.7170.96
85_S137_I0.7150.96
210_L234_P0.7140.96
8_M28_I0.7120.96
75_I109_I0.7120.96
237_I240_L0.7110.96
45_Y65_E0.7100.96
135_I138_A0.7090.96
322_S325_L0.7090.96
403_A408_I0.7080.96
442_T450_C0.7070.96
174_C180_L0.7060.96
281_Q284_R0.7060.96
23_R27_L0.7050.96
182_D185_T0.7030.96
201_F276_L0.7000.96
392_I403_A0.7000.96
31_W37_D0.6980.95
21_L48_L0.6980.95
390_N396_S0.6930.95
58_A63_F0.6920.95
350_D354_I0.6890.95
152_V155_S0.6870.95
302_L447_R0.6870.95
84_E115_C0.6860.95
285_L288_F0.6840.95
318_V329_Y0.6820.95
195_K199_L0.6810.95
10_F18_G0.6790.95
26_R158_K0.6790.95
255_R260_G0.6750.95
23_R154_L0.6710.94
447_R450_C0.6710.94
39_Y43_I0.6680.94
380_K418_A0.6660.94
89_L111_V0.6660.94
308_K462_I0.6630.94
266_G269_P0.6630.94
194_V197_I0.6590.94
247_I251_V0.6580.94
198_E202_K0.6560.94
43_I69_A0.6520.93
98_I105_L0.6510.93
212_A216_Y0.6490.93
371_K429_G0.6480.93
133_K140_R0.6470.93
381_I385_Q0.6470.93
66_F69_A0.6460.93
307_M461_I0.6450.93
20_S24_Q0.6450.93
196_T232_W0.6400.93
32_L36_S0.6390.93
25_R28_I0.6390.93
130_S137_I0.6380.93
204_R210_L0.6370.93
258_G261_I0.6340.93
330_V335_R0.6330.92
179_S193_R0.6300.92
176_R197_I0.6300.92
380_K421_S0.6290.92
23_R84_E0.6280.92
161_Q166_S0.6270.92
5_I40_L0.6240.92
135_I140_R0.6240.92
275_D279_A0.6230.92
386_M390_N0.6200.92
272_I276_L0.6200.92
141_A151_R0.6160.91
159_K170_M0.6160.91
406_E410_L0.6160.91
393_V397_V0.6150.91
136_L140_R0.6150.91
132_I136_L0.6130.91
357_L457_T0.6130.91
190_D195_K0.6130.91
424_T428_K0.6130.91
365_Q368_E0.6110.91
419_S422_L0.6100.91
204_R209_S0.6100.91
97_A100_R0.6080.91
99_E104_I0.6080.91
157_K160_R0.6080.91
133_K139_Q0.6080.91
143_E146_E0.6070.91
200_I232_W0.6060.91
148_K151_R0.6050.91
266_G274_D0.6050.91
355_N359_F0.6020.90
307_M316_M0.6000.90
98_I101_L0.6000.90
180_L185_T0.6000.90
140_R147_I0.5990.90
391_L404_I0.5970.90
156_W160_R0.5970.90
110_D121_N0.5970.90
133_K136_L0.5940.90
4_A82_L0.5940.90
169_I175_P0.5930.90
279_A283_I0.5900.90
52_A91_R0.5900.90
447_R451_R0.5890.90
143_E147_I0.5890.90
95_G105_L0.5880.89
383_E386_M0.5850.89
64_S67_L0.5830.89
334_R342_P0.5810.89
317_I332_P0.5800.89
120_Y134_A0.5800.89
90_S96_E0.5790.89
218_N224_N0.5780.89
333_M338_R0.5780.89
13_P48_L0.5770.89
6_A29_A0.5770.89
445_N449_L0.5770.89
197_I280_V0.5770.89
300_I304_R0.5760.88
278_Y281_Q0.5740.88
422_L429_G0.5740.88
119_V127_E0.5730.88
84_E151_R0.5720.88
386_M389_N0.5720.88
393_V396_S0.5720.88
353_I356_E0.5720.88
191_P194_V0.5720.88
394_A407_K0.5710.88
14_G17_S0.5700.88
240_L246_L0.5700.88
82_L112_I0.5690.88
302_L451_R0.5680.88
5_I81_L0.5670.88
69_A72_H0.5660.88
238_E284_R0.5650.88
129_Y143_E0.5650.88
104_I109_I0.5650.88
204_R280_V0.5650.88
96_E102_K0.5640.87
436_F439_I0.5640.87
446_G450_C0.5630.87
375_E379_L0.5630.87
264_I267_Y0.5600.87
453_L457_T0.5580.87
102_K106_N0.5570.87
32_L40_L0.5570.87
377_L380_K0.5560.87
245_A269_P0.5560.87
89_L104_I0.5560.87
100_R105_L0.5560.87
37_D79_T0.5550.87
210_L241_L0.5540.87
395_L408_I0.5540.87
99_E103_L0.5520.86
234_P238_E0.5500.86
73_G109_I0.5500.86
86_L138_A0.5490.86
413_K416_R0.5470.86
344_I349_V0.5470.86
211_N234_P0.5470.86
402_T412_D0.5440.86
96_E99_E0.5430.85
101_L138_A0.5430.85
363_K367_V0.5420.85
250_C264_I0.5420.85
247_I272_I0.5420.85
221_A224_N0.5410.85
127_E131_L0.5390.85
19_D155_S0.5390.85
381_I388_I0.5360.85
18_G48_L0.5360.85
207_R283_I0.5350.85
31_W34_V0.5350.85
244_K254_Y0.5350.85
199_L222_V0.5350.85
223_K228_K0.5340.84
47_D50_L0.5340.84
378_E381_I0.5340.84
321_V324_S0.5330.84
131_L135_I0.5330.84
52_A96_E0.5310.84
199_L217_L0.5300.84
410_L413_K0.5280.84
410_L417_R0.5270.84
27_L154_L0.5260.84
69_A73_G0.5260.84
245_A268_Y0.5260.84
417_R420_V0.5250.83
96_E105_L0.5250.83
4_A39_Y0.5250.83
224_N228_K0.5250.83
250_C268_Y0.5250.83
63_F67_L0.5230.83
428_K431_N0.5220.83
426_K430_V0.5220.83
228_K231_A0.5210.83
173_S226_S0.5210.83
205_M277_F0.5210.83
157_K253_S0.5210.83
10_F49_G0.5200.83
137_I140_R0.5200.83
365_Q369_N0.5180.83
332_P336_L0.5180.83
387_K393_V0.5180.83
189_P195_K0.5180.83
188_V191_P0.5180.83
112_I119_V0.5160.82
67_L99_E0.5150.82
385_Q388_I0.5140.82
20_S23_R0.5140.82
101_L104_I0.5130.82
209_S215_K0.5130.82
400_E412_D0.5130.82
329_Y350_D0.5120.82
374_N377_L0.5120.82
43_I62_A0.5110.82
10_F16_M0.5100.82
10_F23_R0.5070.81
51_S56_K0.5070.81
155_S158_K0.5060.81
189_P193_R0.5060.81
137_I147_I0.5060.81
35_N82_L0.5060.81
60_S177_W0.5050.81
85_S115_C0.5040.81
21_L46_E0.5030.81
31_W112_I0.5030.81
147_I154_L0.5020.81
441_L445_N0.5020.81
208_R213_I0.5010.81
216_Y221_A0.5000.80
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4bqqA 2 0.5512 100 0.41 Contact Map
4kisA 2 0.6122 100 0.516 Contact Map
2r0qC 3 0.374 100 0.646 Contact Map
1gdtA 2 0.3602 100 0.673 Contact Map
3guvA 2 0.2874 100 0.677 Contact Map
3g13A 2 0.3031 100 0.678 Contact Map
3uj3X 2 0.2441 100 0.696 Contact Map
3bvpA 4 0.2638 100 0.73 Contact Map
2gm5A 4 0.2441 100 0.745 Contact Map
3lhkA 2 0.2874 100 0.746 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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