GREMLIN Database
YKFI - Toxin YkfI
UniProt: P77692 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG14333
Length: 113 (106)
Sequences: 145 (61)
Seq/√Len: 5.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
7_I12_V4.2730.95
3_T16_L3.1640.81
58_T89_L2.9710.77
92_A104_L2.5430.64
42_P70_Y2.4910.62
42_P63_V2.4160.60
51_E78_K2.4070.60
96_R101_T2.1230.50
28_R46_E2.0420.47
2_K5_P1.9550.44
44_C50_K1.8130.39
3_T11_A1.7680.38
5_P15_C1.7280.36
75_I101_T1.7240.36
63_V82_W1.6690.34
92_A106_Q1.5820.32
2_K24_M1.5200.30
95_L101_T1.5160.30
2_K28_R1.5140.30
46_E71_E1.4760.28
5_P10_R1.4500.28
52_H65_F1.4480.28
4_L7_I1.3700.26
2_K13_K1.3270.24
75_I92_A1.3230.24
14_P19_V1.3190.24
2_K6_A1.3170.24
58_T94_I1.3120.24
73_V96_R1.2890.23
13_K20_A1.2850.23
79_G85_Q1.2800.23
4_L9_Q1.2790.23
13_K24_M1.2510.22
43_F59_L1.2460.22
82_W91_A1.2150.22
22_W43_F1.2150.22
3_T8_T1.2110.21
11_A17_S1.1900.21
3_T27_T1.1710.21
48_V57_I1.1370.20
43_F62_A1.1370.20
3_T10_R1.1330.20
61_D81_S1.1280.20
95_L98_R1.0970.19
17_S37_T1.0910.19
19_V61_D1.0850.19
10_R27_T1.0830.19
77_R85_Q1.0770.18
97_A100_A1.0720.18
6_A32_Q1.0490.18
15_C20_A1.0370.18
91_A101_T1.0340.18
47_A75_I1.0260.17
32_Q105_R1.0150.17
9_Q13_K1.0080.17
45_N60_A1.0060.17
55_A65_F1.0000.17
7_I13_K0.9810.17
46_E61_D0.9770.16
6_A9_Q0.9760.16
4_L12_V0.9760.16
19_V65_F0.9620.16
11_A44_C0.9490.16
21_V69_K0.9440.16
52_H67_V0.9430.16
95_L100_A0.9390.16
5_P12_V0.9290.16
11_A24_M0.9120.15
101_T104_L0.9040.15
4_L50_K0.9020.15
41_T74_R0.9020.15
98_R103_L0.8890.15
69_K105_R0.8830.15
55_A71_E0.8790.15
42_P53_I0.8790.15
10_R15_C0.8680.14
36_L74_R0.8640.14
36_L41_T0.8560.14
8_T28_R0.8530.14
84_E88_Y0.8520.14
7_I15_C0.8490.14
8_T16_L0.8410.14
67_V87_P0.8120.13
63_V66_L0.8100.13
57_I104_L0.8080.13
63_V70_Y0.8060.13
2_K8_T0.8030.13
39_N54_D0.8020.13
22_W59_L0.7990.13
28_R66_L0.7800.13
22_W52_H0.7790.13
55_A59_L0.7710.13
26_L74_R0.7580.13
70_Y82_W0.7540.13
3_T61_D0.7520.13
5_P31_E0.7500.13
26_L41_T0.7480.12
40_D74_R0.7350.12
10_R13_K0.7350.12
6_A15_C0.7340.12
2_K16_L0.7290.12
9_Q20_A0.7260.12
24_M32_Q0.7200.12
81_S90_R0.7150.12
7_I44_C0.7080.12
26_L36_L0.7060.12
59_L62_A0.6890.12
60_A91_A0.6840.12
66_L83_Q0.6830.12
69_K78_K0.6800.11
36_L40_D0.6790.11
32_Q69_K0.6730.11
91_A99_Q0.6620.11
77_R91_A0.6600.11
10_R20_A0.6600.11
12_V20_A0.6580.11
22_W62_A0.6570.11
46_E66_L0.6500.11
100_A103_L0.6500.11
79_G89_L0.6490.11
65_F84_E0.6480.11
20_A31_E0.6420.11
60_A104_L0.6420.11
86_S101_T0.6410.11
28_R48_V0.6380.11
10_R50_K0.6310.11
100_A104_L0.6260.11
32_Q44_C0.6240.11
98_R101_T0.6220.11
1_M5_P0.6180.11
69_K99_Q0.6140.11
6_A27_T0.5990.10
20_A69_K0.5880.10
33_H43_F0.5830.10
11_A48_V0.5820.10
100_A106_Q0.5810.10
6_A24_M0.5800.10
69_K104_L0.5700.10
18_P48_V0.5690.10
58_T87_P0.5580.10
39_N45_N0.5580.10
15_C27_T0.5560.10
88_Y100_A0.5550.10
7_I10_R0.5550.10
31_E60_A0.5540.10
43_F52_H0.5510.10
26_L40_D0.5480.10
78_K82_W0.5470.10
18_P94_I0.5420.10
8_T46_E0.5380.10
61_D96_R0.5280.09
8_T20_A0.5220.09
1_M32_Q0.5220.09
50_K103_L0.5210.09
66_L92_A0.5190.09
69_K106_Q0.5170.09
34_Y68_E0.5100.09
70_Y84_E0.5060.09
71_E75_I0.5000.09
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4wbdA 2 0.9381 42.9 0.943 Contact Map
3d3lA 1 0.6991 18.2 0.953 Contact Map
1vejA 1 0.5841 12.2 0.956 Contact Map
1at3A 3 0.7168 12.1 0.956 Contact Map
2knzA 1 0.4602 10.9 0.957 Contact Map
2jy5A 1 0.4513 10.4 0.958 Contact Map
1iedA 2 0.6814 10.1 0.958 Contact Map
1o6eA 4 0.6814 9.9 0.958 Contact Map
2pbkA 2 0.6814 9.7 0.958 Contact Map
1jqkA 3 0.8407 9.4 0.958 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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