GREMLIN Database
ARNB - UDP-4-amino-4-deoxy-L-arabinose--oxoglutarate aminotransferase
UniProt: P77690 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG14089
Length: 379 (351)
Sequences: 10893 (8237)
Seq/√Len: 439.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
268_Q293_F3.7391.00
41_A247_L3.1311.00
115_E146_R2.9891.00
270_A370_I2.8461.00
22_E34_K2.6631.00
141_R145_E2.6461.00
136_D139_A2.6141.00
347_W351_R2.5801.00
296_R351_R2.5631.00
17_L21_K2.4921.00
266_Q366_A2.4711.00
141_R151_V2.4601.00
138_D164_K2.4461.00
45_L254_E2.4261.00
162_Y167_H2.3791.00
316_R372_A2.3141.00
266_Q367_D2.2791.00
113_A116_S2.2221.00
312_A376_L2.1381.00
134_P168_I2.1341.00
50_H197_E2.1301.00
114_I140_I2.1271.00
49_Q195_D2.0931.00
112_E139_A2.0591.00
259_R262_E2.0531.00
41_A251_V2.0521.00
37_A41_A2.0401.00
162_Y287_V1.9991.00
316_R375_Q1.9751.00
17_L25_E1.9701.00
103_D106_T1.9681.00
362_T365_D1.9381.00
14_V18_A1.9371.00
110_T113_A1.9111.00
68_L150_A1.9051.00
100_V117_A1.8881.00
15_E251_V1.8871.00
368_H372_A1.8841.00
150_A173_T1.8781.00
113_A117_A1.8631.00
311_E315_E1.8511.00
192_I203_L1.8451.00
329_T346_E1.8351.00
42_F191_L1.8331.00
49_Q197_E1.8231.00
186_C246_A1.8091.00
239_T242_N1.7721.00
178_F191_L1.7721.00
75_E122_T1.7711.00
34_K247_L1.7711.00
142_A146_R1.7651.00
60_G175_I1.7521.00
197_E201_R1.7511.00
125_I144_G1.7461.00
270_A367_D1.7421.00
194_T200_A1.7391.00
176_F193_V1.7081.00
309_L376_L1.6711.00
266_Q363_T1.6661.00
21_K25_E1.6641.00
266_Q270_A1.6621.00
312_A315_E1.6471.00
202_Q231_T1.6311.00
55_S59_A1.6301.00
43_C51_A1.6171.00
40_Q44_Q1.6121.00
366_A370_I1.6101.00
144_G151_V1.6051.00
312_A316_R1.6031.00
82_T327_A1.5861.00
52_I200_A1.5691.00
75_E119_T1.5561.00
70_I95_A1.5541.00
313_L320_T1.5381.00
158_A168_I1.5371.00
74_D123_K1.5341.00
75_E96_T1.5261.00
273_A374_Q1.5061.00
45_L167_H1.4981.00
104_R344_N1.4961.00
118_I143_I1.4911.00
37_A247_L1.4801.00
173_T196_N1.4691.00
200_A204_R1.4661.00
51_A191_L1.4591.00
261_R287_V1.4561.00
75_E121_R1.4321.00
42_F159_V1.4301.00
196_N199_L1.4181.00
129_H137_I1.3951.00
78_T90_I1.3901.00
145_E173_T1.3831.00
166_R170_A1.3771.00
139_A142_A1.3691.00
309_L353_C1.3671.00
270_A374_Q1.3641.00
265_Q269_Q1.3521.00
310_M320_T1.3501.00
107_L348_N1.3501.00
138_D163_Y1.3381.00
119_T122_T1.3361.00
164_K285_P1.3281.00
16_E248_T1.3281.00
278_P296_R1.3261.00
80_S345_T1.3221.00
259_R263_I1.3161.00
34_K37_A1.3131.00
100_V113_A1.2961.00
258_T262_E1.2901.00
259_R363_T1.2801.00
271_L373_L1.2791.00
71_G74_D1.2751.00
104_R347_W1.2721.00
141_R171_K1.2691.00
64_T152_I1.2661.00
38_L246_A1.2631.00
102_V348_N1.2581.00
274_L374_Q1.2521.00
46_T193_V1.2491.00
140_I151_V1.2441.00
318_I372_A1.2421.00
248_T251_V1.2341.00
77_I100_V1.2211.00
105_D281_L1.2201.00
212_G230_L1.2181.00
62_H236_Y1.2131.00
309_L373_L1.2101.00
297_V309_L1.2071.00
41_A44_Q1.2041.00
107_L296_R1.2021.00
18_A22_E1.1921.00
19_A248_T1.1871.00
15_E252_K1.1871.00
15_E18_A1.1841.00
62_H92_L1.1831.00
80_S328_H1.1751.00
133_A283_A1.1731.00
63_I203_L1.1711.00
18_A21_K1.1701.00
114_I143_I1.1661.00
367_D371_T1.1661.00
129_H172_G1.1661.00
127_P151_V1.1631.00
68_L152_I1.1611.00
109_V114_I1.1581.00
310_M353_C1.1581.00
266_Q370_I1.1531.00
205_M231_T1.1411.00
63_I206_L1.1391.00
294_I352_I1.1251.00
344_N347_W1.1241.00
262_E363_T1.1221.00
328_H346_E1.1141.00
36_Q40_Q1.1101.00
19_A251_V1.0951.00
279_L293_F1.0951.00
228_E331_K1.0931.00
115_E147_Y1.0931.00
115_E139_A1.0921.00
71_G95_A1.0911.00
308_A312_A1.0841.00
62_H66_M1.0841.00
263_I366_A1.0811.00
62_H234_Y1.0781.00
50_H200_A1.0771.00
328_H342_L1.0711.00
278_P298_D1.0661.00
16_E245_I1.0641.00
33_P37_A1.0631.00
31_T207_K1.0541.00
54_V63_I1.0491.00
159_V253_L1.0471.00
66_M93_L1.0451.00
111_P143_I1.0441.00
183_N291_H1.0391.00
103_D110_T1.0391.00
13_G252_K1.0371.00
263_I357_L1.0331.00
13_G16_E1.0321.00
53_A238_L1.0311.00
77_I114_I1.0281.00
299_E308_A1.0221.00
41_A250_L1.0071.00
19_A34_K1.0021.00
252_K255_H1.0021.00
72_K94_G0.9991.00
57_A60_G0.9951.00
50_H194_T0.9931.00
144_G149_I0.9921.00
124_A150_A0.9841.00
137_I171_K0.9821.00
88_N209_H0.9781.00
65_L126_I0.9771.00
141_R173_T0.9751.00
13_G17_L0.9741.00
100_V109_V0.9711.00
238_L243_A0.9681.00
64_T175_I0.9671.00
115_E119_T0.9641.00
107_L280_S0.9631.00
263_I361_M0.9621.00
65_L90_I0.9581.00
19_A22_E0.9541.00
298_D351_R0.9521.00
80_S342_L0.9501.00
305_S308_A0.9501.00
91_S333_Y0.9501.00
363_T366_A0.9501.00
87_L327_A0.9491.00
372_A375_Q0.9471.00
371_T375_Q0.9461.00
194_T199_L0.9431.00
264_A290_W0.9421.00
261_R282_P0.9411.00
186_C189_G0.9401.00
276_F298_D0.9391.00
112_E115_E0.9361.00
67_A203_L0.9361.00
55_S236_Y0.9351.00
115_E143_I0.9331.00
268_Q279_L0.9321.00
69_K202_Q0.9251.00
230_L331_K0.9231.00
87_L99_M0.9231.00
308_A376_L0.9221.00
124_A152_I0.9181.00
294_I354_S0.9181.00
42_F176_F0.9181.00
363_T367_D0.9131.00
48_N195_D0.9101.00
258_T261_R0.9051.00
155_A168_I0.9001.00
340_L346_E0.9001.00
364_A367_D0.8981.00
133_A286_H0.8951.00
316_R368_H0.8911.00
143_I147_Y0.8891.00
79_P90_I0.8861.00
70_I76_V0.8851.00
59_A236_Y0.8841.00
48_N170_A0.8831.00
361_M369_V0.8821.00
307_D311_E0.8811.00
75_E98_V0.8731.00
52_I204_R0.8711.00
51_A193_V0.8651.00
129_H153_E0.8651.00
312_A372_A0.8611.00
161_T289_A0.8571.00
267_Y369_V0.8571.00
311_E314_K0.8541.00
310_M314_K0.8531.00
127_P140_I0.8491.00
259_R360_D0.8481.00
35_N243_A0.8461.00
308_A311_E0.8451.00
33_P36_Q0.8371.00
40_Q43_C0.8361.00
78_T87_L0.8351.00
347_W350_E0.8341.00
70_I124_A0.8321.00
135_A140_I0.8311.00
43_C46_T0.8291.00
90_I97_P0.8291.00
255_H258_T0.8281.00
265_Q268_Q0.8281.00
142_A145_E0.8271.00
167_H170_A0.8271.00
37_A40_Q0.8221.00
74_D95_A0.8221.00
342_L345_T0.8181.00
39_E53_A0.8111.00
323_H354_S0.8111.00
46_T167_H0.8071.00
261_R265_Q0.8051.00
309_L313_L0.8041.00
268_Q282_P0.8031.00
137_I141_R0.8011.00
262_E265_Q0.7971.00
54_V192_I0.7921.00
255_H259_R0.7911.00
166_R171_K0.7891.00
257_N289_A0.7871.00
266_Q269_Q0.7851.00
34_K240_D0.7851.00
168_I174_A0.7821.00
127_P135_A0.7801.00
20_V241_I0.7771.00
45_L160_G0.7761.00
13_G25_E0.7751.00
368_H371_T0.7751.00
90_I95_A0.7741.00
111_P135_A0.7731.00
299_E305_S0.7721.00
171_K174_A0.7711.00
268_Q290_W0.7711.00
63_I207_K0.7701.00
306_R322_L0.7691.00
264_A293_F0.7681.00
83_W227_A0.7661.00
160_G257_N0.7651.00
23_V244_A0.7631.00
77_I117_A0.7601.00
103_D111_P0.7571.00
14_V25_E0.7541.00
20_V24_L0.7541.00
71_G123_K0.7531.00
254_E258_T0.7531.00
263_I267_Y0.7501.00
76_V90_I0.7501.00
138_D142_A0.7461.00
271_L374_Q0.7451.00
365_D368_H0.7441.00
20_V245_I0.7421.00
326_A345_T0.7411.00
89_M93_L0.7411.00
262_E266_Q0.7401.00
86_T89_M0.7391.00
88_N333_Y0.7381.00
270_A273_A0.7371.00
14_V17_L0.7371.00
92_L234_Y0.7371.00
205_M230_L0.7361.00
64_T192_I0.7361.00
52_I203_L0.7361.00
344_N348_N0.7341.00
198_N201_R0.7311.00
66_M92_L0.7301.00
339_T350_E0.7291.00
65_L152_I0.7261.00
91_S97_P0.7261.00
42_F250_L0.7211.00
170_A195_D0.7201.00
370_I374_Q0.7201.00
65_L70_I0.7201.00
183_N257_N0.7191.00
367_D370_I0.7191.00
70_I123_K0.7181.00
201_R212_G0.7181.00
270_A371_T0.7171.00
269_Q272_A0.7171.00
187_A241_I0.7121.00
35_N238_L0.7121.00
144_G147_Y0.7101.00
46_T170_A0.7091.00
103_D136_D0.7091.00
57_A175_I0.7051.00
118_I149_I0.7041.00
22_E26_S0.7031.00
35_N53_A0.7021.00
133_A282_P0.7011.00
81_L323_H0.6971.00
62_H93_L0.6961.00
153_E174_A0.6961.00
162_Y165_G0.6941.00
42_F51_A0.6941.00
46_T51_A0.6921.00
358_F361_M0.6881.00
79_P128_V0.6881.00
153_E172_G0.6841.00
130_Y157_H0.6791.00
141_R172_G0.6771.00
283_A286_H0.6751.00
16_E252_K0.6741.00
125_I149_I0.6731.00
189_G238_L0.6721.00
346_E350_E0.6701.00
163_Y286_H0.6701.00
167_H254_E0.6701.00
76_V124_A0.6701.00
209_H237_N0.6651.00
111_P140_I0.6641.00
282_P288_H0.6641.00
326_A349_S0.6631.00
329_T340_L0.6621.00
15_E248_T0.6581.00
11_A360_D0.6581.00
114_I125_I0.6581.00
338_P341_S0.6561.00
91_S332_Y0.6551.00
268_Q281_L0.6541.00
127_P137_I0.6531.00
90_I126_I0.6520.99
213_V228_E0.6490.99
341_S346_E0.6420.99
326_A329_T0.6420.99
309_L312_A0.6410.99
15_E19_A0.6400.99
54_V60_G0.6370.99
64_T68_L0.6360.99
336_R340_L0.6350.99
163_Y171_K0.6350.99
137_I151_V0.6320.99
139_A163_Y0.6300.99
12_M16_E0.6280.99
77_I122_T0.6260.99
19_A244_A0.6260.99
80_S99_M0.6260.99
263_I266_Q0.6260.99
254_E287_V0.6250.99
202_Q206_L0.6240.99
314_K320_T0.6240.99
161_T168_I0.6230.99
257_N261_R0.6210.99
331_K334_R0.6210.99
48_N193_V0.6200.99
264_A268_Q0.6190.99
277_Q295_I0.6190.99
11_A252_K0.6180.99
60_G192_I0.6180.99
129_H168_I0.6180.99
129_H135_A0.6160.99
9_R360_D0.6150.99
282_P286_H0.6150.99
56_S235_K0.6140.99
252_K256_L0.6140.99
89_M126_I0.6130.99
23_V26_S0.6130.99
82_T86_T0.6120.99
296_R347_W0.6090.99
101_D344_N0.6090.99
102_V345_T0.6070.99
66_M206_L0.6060.99
56_S59_A0.6050.99
174_A193_V0.6050.99
261_R290_W0.6050.99
65_L93_L0.6030.99
86_T128_V0.6010.99
155_A174_A0.5990.99
17_L24_L0.5960.99
170_A174_A0.5960.99
23_V34_K0.5950.99
83_W211_L0.5950.99
71_G93_L0.5940.99
68_L199_L0.5940.99
76_V126_I0.5940.99
264_A357_L0.5940.99
296_R352_I0.5920.99
232_P332_Y0.5910.99
156_A182_K0.5910.99
282_P290_W0.5900.99
22_E37_A0.5900.99
134_P161_T0.5890.99
118_I122_T0.5890.99
267_Y366_A0.5880.99
86_T126_I0.5880.99
69_K95_A0.5870.99
295_I353_C0.5850.99
131_A323_H0.5840.99
173_T195_D0.5830.99
343_P346_E0.5830.99
66_M234_Y0.5830.99
139_A143_I0.5810.99
187_A242_N0.5800.99
91_S232_P0.5790.99
81_L352_I0.5780.99
131_A294_I0.5770.99
105_D278_P0.5740.99
299_E351_R0.5740.99
57_A156_A0.5720.99
134_P286_H0.5700.99
292_L354_S0.5680.99
133_A288_H0.5660.99
158_A161_T0.5650.99
43_C50_H0.5630.99
76_V95_A0.5630.99
116_S120_P0.5610.98
43_C48_N0.5610.98
178_F246_A0.5610.98
48_N174_A0.5610.98
238_L242_N0.5610.98
31_T240_D0.5580.98
53_A191_L0.5570.98
179_H188_E0.5530.98
169_G176_F0.5520.98
160_G253_L0.5510.98
102_V344_N0.5510.98
134_P163_Y0.5500.98
312_A375_Q0.5490.98
153_E169_G0.5480.98
70_I74_D0.5470.98
19_A23_V0.5460.98
118_I147_Y0.5450.98
163_Y166_R0.5450.98
268_Q272_A0.5450.98
254_E257_N0.5440.98
201_R205_M0.5440.98
108_M134_P0.5400.98
205_M212_G0.5370.98
17_L20_V0.5350.98
270_A366_A0.5340.98
26_S33_P0.5340.98
138_D166_R0.5340.98
35_N240_D0.5330.98
296_R348_N0.5320.98
111_P136_D0.5320.98
87_L333_Y0.5320.98
123_K150_A0.5310.98
253_L257_N0.5300.98
62_H89_M0.5290.98
195_D199_L0.5290.98
204_R207_K0.5270.98
81_L130_Y0.5240.98
140_I143_I0.5220.98
295_I373_L0.5210.98
150_A196_N0.5210.98
211_L229_V0.5200.98
329_T350_E0.5190.98
52_I194_T0.5180.97
152_I175_I0.5160.97
129_H155_A0.5120.97
282_P287_V0.5110.97
84_V211_L0.5110.97
110_T139_A0.5100.97
78_T86_T0.5100.97
109_V127_P0.5080.97
50_H204_R0.5060.97
61_M89_M0.5060.97
16_E20_V0.5060.97
38_L42_F0.5040.97
241_I245_I0.5030.97
126_I152_I0.5030.97
75_E118_I0.5010.97
337_F341_S0.5010.97
295_I355_L0.5000.97
26_S34_K0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4zwvA 2 0.9551 100 0.42 Contact Map
2fnuA 2 0.971 100 0.46 Contact Map
1o69A 2 0.9261 100 0.46 Contact Map
3frkA 2 0.9446 100 0.466 Contact Map
4lc3A 2 0.9736 100 0.47 Contact Map
2c81A 2 0.9763 100 0.472 Contact Map
3bb8A 2 0.9842 100 0.476 Contact Map
3b8xA 2 0.9763 100 0.481 Contact Map
1mdoA 2 0.9631 100 0.482 Contact Map
3nytA 2 0.934 100 0.494 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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