ARNB - ECOLI - GREMLIN Contacts

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ARNB - UDP-4-amino-4-deoxy-L-arabinose--oxoglutarate aminotransferase

UniProt:	P77690	Sequences: MSEFLPFSRPAMGVEELAAVKEVLESGWITTGPKNQALEQAFCQLTGNQHAIAVSSATAGMHITLMALKIGKGDEVITPSLTWVSTLNMISLLGATPVMVDVDRDTLMVTPEAIESAITPRTKAIIPVHYAGAPADIDAIRAIGERYGIAVIEDAAHAVGTYYKGRHIGAKGTAIFSFHAIKNITCAEGGLIVTDNENLARQLRMLKFHGLGVDAYDRQTWGRAPQAEVLTPGYKYNLTDINAAIALTQLVKLEHLNTRRREIAQQYQQALAALPFQPLSLPAWPHVHAWHLFIIRVDEQRCGISRDALMEALKERGIGTGLHFRAAHTQKYYRERFPTLSLPNTEWNSERICSLPLFPDMTTADADHVITALQQLAGQ	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG14089
Length:	379 (351)
Sequences:	10893 (8237)
Seq/√Len:	439.7

ECOLI - ARNB RFFA
BACSU - SPSC NTDA EPSN

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
268_Q	293_F	3.739	1.00
41_A	247_L	3.131	1.00
115_E	146_R	2.989	1.00
270_A	370_I	2.846	1.00
22_E	34_K	2.663	1.00
141_R	145_E	2.646	1.00
136_D	139_A	2.614	1.00
347_W	351_R	2.580	1.00
296_R	351_R	2.563	1.00
17_L	21_K	2.492	1.00
266_Q	366_A	2.471	1.00
141_R	151_V	2.460	1.00
138_D	164_K	2.446	1.00
45_L	254_E	2.426	1.00
162_Y	167_H	2.379	1.00
316_R	372_A	2.314	1.00
266_Q	367_D	2.279	1.00
113_A	116_S	2.222	1.00
312_A	376_L	2.138	1.00
134_P	168_I	2.134	1.00
50_H	197_E	2.130	1.00
114_I	140_I	2.127	1.00
49_Q	195_D	2.093	1.00
112_E	139_A	2.059	1.00
259_R	262_E	2.053	1.00
41_A	251_V	2.052	1.00
37_A	41_A	2.040	1.00
162_Y	287_V	1.999	1.00
316_R	375_Q	1.975	1.00
17_L	25_E	1.970	1.00
103_D	106_T	1.968	1.00
362_T	365_D	1.938	1.00
14_V	18_A	1.937	1.00
110_T	113_A	1.911	1.00
68_L	150_A	1.905	1.00
100_V	117_A	1.888	1.00
15_E	251_V	1.887	1.00
368_H	372_A	1.884	1.00
150_A	173_T	1.878	1.00
113_A	117_A	1.863	1.00
311_E	315_E	1.851	1.00
192_I	203_L	1.845	1.00
329_T	346_E	1.835	1.00
42_F	191_L	1.833	1.00
49_Q	197_E	1.823	1.00
186_C	246_A	1.809	1.00
239_T	242_N	1.772	1.00
178_F	191_L	1.772	1.00
75_E	122_T	1.771	1.00
34_K	247_L	1.771	1.00
142_A	146_R	1.765	1.00
60_G	175_I	1.752	1.00
197_E	201_R	1.751	1.00
125_I	144_G	1.746	1.00
270_A	367_D	1.742	1.00
194_T	200_A	1.739	1.00
176_F	193_V	1.708	1.00
309_L	376_L	1.671	1.00
266_Q	363_T	1.666	1.00
21_K	25_E	1.664	1.00
266_Q	270_A	1.662	1.00
312_A	315_E	1.647	1.00
202_Q	231_T	1.631	1.00
55_S	59_A	1.630	1.00
43_C	51_A	1.617	1.00
40_Q	44_Q	1.612	1.00
366_A	370_I	1.610	1.00
144_G	151_V	1.605	1.00
312_A	316_R	1.603	1.00
82_T	327_A	1.586	1.00
52_I	200_A	1.569	1.00
75_E	119_T	1.556	1.00
70_I	95_A	1.554	1.00
313_L	320_T	1.538	1.00
158_A	168_I	1.537	1.00
74_D	123_K	1.534	1.00
75_E	96_T	1.526	1.00
273_A	374_Q	1.506	1.00
45_L	167_H	1.498	1.00
104_R	344_N	1.496	1.00
118_I	143_I	1.491	1.00
37_A	247_L	1.480	1.00
173_T	196_N	1.469	1.00
200_A	204_R	1.466	1.00
51_A	191_L	1.459	1.00
261_R	287_V	1.456	1.00
75_E	121_R	1.432	1.00
42_F	159_V	1.430	1.00
196_N	199_L	1.418	1.00
129_H	137_I	1.395	1.00
78_T	90_I	1.390	1.00
145_E	173_T	1.383	1.00
166_R	170_A	1.377	1.00
139_A	142_A	1.369	1.00
309_L	353_C	1.367	1.00
270_A	374_Q	1.364	1.00
265_Q	269_Q	1.352	1.00
310_M	320_T	1.350	1.00
107_L	348_N	1.350	1.00
138_D	163_Y	1.338	1.00
119_T	122_T	1.336	1.00
164_K	285_P	1.328	1.00
16_E	248_T	1.328	1.00
278_P	296_R	1.326	1.00
80_S	345_T	1.322	1.00
259_R	263_I	1.316	1.00
34_K	37_A	1.313	1.00
100_V	113_A	1.296	1.00
258_T	262_E	1.290	1.00
259_R	363_T	1.280	1.00
271_L	373_L	1.279	1.00
71_G	74_D	1.275	1.00
104_R	347_W	1.272	1.00
141_R	171_K	1.269	1.00
64_T	152_I	1.266	1.00
38_L	246_A	1.263	1.00
102_V	348_N	1.258	1.00
274_L	374_Q	1.252	1.00
46_T	193_V	1.249	1.00
140_I	151_V	1.244	1.00
318_I	372_A	1.242	1.00
248_T	251_V	1.234	1.00
77_I	100_V	1.221	1.00
105_D	281_L	1.220	1.00
212_G	230_L	1.218	1.00
62_H	236_Y	1.213	1.00
309_L	373_L	1.210	1.00
297_V	309_L	1.207	1.00
41_A	44_Q	1.204	1.00
107_L	296_R	1.202	1.00
18_A	22_E	1.192	1.00
19_A	248_T	1.187	1.00
15_E	252_K	1.187	1.00
15_E	18_A	1.184	1.00
62_H	92_L	1.183	1.00
80_S	328_H	1.175	1.00
133_A	283_A	1.173	1.00
63_I	203_L	1.171	1.00
18_A	21_K	1.170	1.00
114_I	143_I	1.166	1.00
367_D	371_T	1.166	1.00
129_H	172_G	1.166	1.00
127_P	151_V	1.163	1.00
68_L	152_I	1.161	1.00
109_V	114_I	1.158	1.00
310_M	353_C	1.158	1.00
266_Q	370_I	1.153	1.00
205_M	231_T	1.141	1.00
63_I	206_L	1.139	1.00
294_I	352_I	1.125	1.00
344_N	347_W	1.124	1.00
262_E	363_T	1.122	1.00
328_H	346_E	1.114	1.00
36_Q	40_Q	1.110	1.00
19_A	251_V	1.095	1.00
279_L	293_F	1.095	1.00
228_E	331_K	1.093	1.00
115_E	147_Y	1.093	1.00
115_E	139_A	1.092	1.00
71_G	95_A	1.091	1.00
308_A	312_A	1.084	1.00
62_H	66_M	1.084	1.00
263_I	366_A	1.081	1.00
62_H	234_Y	1.078	1.00
50_H	200_A	1.077	1.00
328_H	342_L	1.071	1.00
278_P	298_D	1.066	1.00
16_E	245_I	1.064	1.00
33_P	37_A	1.063	1.00
31_T	207_K	1.054	1.00
54_V	63_I	1.049	1.00
159_V	253_L	1.047	1.00
66_M	93_L	1.045	1.00
111_P	143_I	1.044	1.00
183_N	291_H	1.039	1.00
103_D	110_T	1.039	1.00
13_G	252_K	1.037	1.00
263_I	357_L	1.033	1.00
13_G	16_E	1.032	1.00
53_A	238_L	1.031	1.00
77_I	114_I	1.028	1.00
299_E	308_A	1.022	1.00
41_A	250_L	1.007	1.00
19_A	34_K	1.002	1.00
252_K	255_H	1.002	1.00
72_K	94_G	0.999	1.00
57_A	60_G	0.995	1.00
50_H	194_T	0.993	1.00
144_G	149_I	0.992	1.00
124_A	150_A	0.984	1.00
137_I	171_K	0.982	1.00
88_N	209_H	0.978	1.00
65_L	126_I	0.977	1.00
141_R	173_T	0.975	1.00
13_G	17_L	0.974	1.00
100_V	109_V	0.971	1.00
238_L	243_A	0.968	1.00
64_T	175_I	0.967	1.00
115_E	119_T	0.964	1.00
107_L	280_S	0.963	1.00
263_I	361_M	0.962	1.00
65_L	90_I	0.958	1.00
19_A	22_E	0.954	1.00
298_D	351_R	0.952	1.00
80_S	342_L	0.950	1.00
305_S	308_A	0.950	1.00
91_S	333_Y	0.950	1.00
363_T	366_A	0.950	1.00
87_L	327_A	0.949	1.00
372_A	375_Q	0.947	1.00
371_T	375_Q	0.946	1.00
194_T	199_L	0.943	1.00
264_A	290_W	0.942	1.00
261_R	282_P	0.941	1.00
186_C	189_G	0.940	1.00
276_F	298_D	0.939	1.00
112_E	115_E	0.936	1.00
67_A	203_L	0.936	1.00
55_S	236_Y	0.935	1.00
115_E	143_I	0.933	1.00
268_Q	279_L	0.932	1.00
69_K	202_Q	0.925	1.00
230_L	331_K	0.923	1.00
87_L	99_M	0.923	1.00
308_A	376_L	0.922	1.00
124_A	152_I	0.918	1.00
294_I	354_S	0.918	1.00
42_F	176_F	0.918	1.00
363_T	367_D	0.913	1.00
48_N	195_D	0.910	1.00
258_T	261_R	0.905	1.00
155_A	168_I	0.900	1.00
340_L	346_E	0.900	1.00
364_A	367_D	0.898	1.00
133_A	286_H	0.895	1.00
316_R	368_H	0.891	1.00
143_I	147_Y	0.889	1.00
79_P	90_I	0.886	1.00
70_I	76_V	0.885	1.00
59_A	236_Y	0.884	1.00
48_N	170_A	0.883	1.00
361_M	369_V	0.882	1.00
307_D	311_E	0.881	1.00
75_E	98_V	0.873	1.00
52_I	204_R	0.871	1.00
51_A	193_V	0.865	1.00
129_H	153_E	0.865	1.00
312_A	372_A	0.861	1.00
161_T	289_A	0.857	1.00
267_Y	369_V	0.857	1.00
311_E	314_K	0.854	1.00
310_M	314_K	0.853	1.00
127_P	140_I	0.849	1.00
259_R	360_D	0.848	1.00
35_N	243_A	0.846	1.00
308_A	311_E	0.845	1.00
33_P	36_Q	0.837	1.00
40_Q	43_C	0.836	1.00
78_T	87_L	0.835	1.00
347_W	350_E	0.834	1.00
70_I	124_A	0.832	1.00
135_A	140_I	0.831	1.00
43_C	46_T	0.829	1.00
90_I	97_P	0.829	1.00
255_H	258_T	0.828	1.00
265_Q	268_Q	0.828	1.00
142_A	145_E	0.827	1.00
167_H	170_A	0.827	1.00
37_A	40_Q	0.822	1.00
74_D	95_A	0.822	1.00
342_L	345_T	0.818	1.00
39_E	53_A	0.811	1.00
323_H	354_S	0.811	1.00
46_T	167_H	0.807	1.00
261_R	265_Q	0.805	1.00
309_L	313_L	0.804	1.00
268_Q	282_P	0.803	1.00
137_I	141_R	0.801	1.00
262_E	265_Q	0.797	1.00
54_V	192_I	0.792	1.00
255_H	259_R	0.791	1.00
166_R	171_K	0.789	1.00
257_N	289_A	0.787	1.00
266_Q	269_Q	0.785	1.00
34_K	240_D	0.785	1.00
168_I	174_A	0.782	1.00
127_P	135_A	0.780	1.00
20_V	241_I	0.777	1.00
45_L	160_G	0.776	1.00
13_G	25_E	0.775	1.00
368_H	371_T	0.775	1.00
90_I	95_A	0.774	1.00
111_P	135_A	0.773	1.00
299_E	305_S	0.772	1.00
171_K	174_A	0.771	1.00
268_Q	290_W	0.771	1.00
63_I	207_K	0.770	1.00
306_R	322_L	0.769	1.00
264_A	293_F	0.768	1.00
83_W	227_A	0.766	1.00
160_G	257_N	0.765	1.00
23_V	244_A	0.763	1.00
77_I	117_A	0.760	1.00
103_D	111_P	0.757	1.00
14_V	25_E	0.754	1.00
20_V	24_L	0.754	1.00
71_G	123_K	0.753	1.00
254_E	258_T	0.753	1.00
263_I	267_Y	0.750	1.00
76_V	90_I	0.750	1.00
138_D	142_A	0.746	1.00
271_L	374_Q	0.745	1.00
365_D	368_H	0.744	1.00
20_V	245_I	0.742	1.00
326_A	345_T	0.741	1.00
89_M	93_L	0.741	1.00
262_E	266_Q	0.740	1.00
86_T	89_M	0.739	1.00
88_N	333_Y	0.738	1.00
270_A	273_A	0.737	1.00
14_V	17_L	0.737	1.00
92_L	234_Y	0.737	1.00
205_M	230_L	0.736	1.00
64_T	192_I	0.736	1.00
52_I	203_L	0.736	1.00
344_N	348_N	0.734	1.00
198_N	201_R	0.731	1.00
66_M	92_L	0.730	1.00
339_T	350_E	0.729	1.00
65_L	152_I	0.726	1.00
91_S	97_P	0.726	1.00
42_F	250_L	0.721	1.00
170_A	195_D	0.720	1.00
370_I	374_Q	0.720	1.00
65_L	70_I	0.720	1.00
183_N	257_N	0.719	1.00
367_D	370_I	0.719	1.00
70_I	123_K	0.718	1.00
201_R	212_G	0.718	1.00
270_A	371_T	0.717	1.00
269_Q	272_A	0.717	1.00
187_A	241_I	0.712	1.00
35_N	238_L	0.712	1.00
144_G	147_Y	0.710	1.00
46_T	170_A	0.709	1.00
103_D	136_D	0.709	1.00
57_A	175_I	0.705	1.00
118_I	149_I	0.704	1.00
22_E	26_S	0.703	1.00
35_N	53_A	0.702	1.00
133_A	282_P	0.701	1.00
81_L	323_H	0.697	1.00
62_H	93_L	0.696	1.00
153_E	174_A	0.696	1.00
162_Y	165_G	0.694	1.00
42_F	51_A	0.694	1.00
46_T	51_A	0.692	1.00
358_F	361_M	0.688	1.00
79_P	128_V	0.688	1.00
153_E	172_G	0.684	1.00
130_Y	157_H	0.679	1.00
141_R	172_G	0.677	1.00
283_A	286_H	0.675	1.00
16_E	252_K	0.674	1.00
125_I	149_I	0.673	1.00
189_G	238_L	0.672	1.00
346_E	350_E	0.670	1.00
163_Y	286_H	0.670	1.00
167_H	254_E	0.670	1.00
76_V	124_A	0.670	1.00
209_H	237_N	0.665	1.00
111_P	140_I	0.664	1.00
282_P	288_H	0.664	1.00
326_A	349_S	0.663	1.00
329_T	340_L	0.662	1.00
15_E	248_T	0.658	1.00
11_A	360_D	0.658	1.00
114_I	125_I	0.658	1.00
338_P	341_S	0.656	1.00
91_S	332_Y	0.655	1.00
268_Q	281_L	0.654	1.00
127_P	137_I	0.653	1.00
90_I	126_I	0.652	0.99
213_V	228_E	0.649	0.99
341_S	346_E	0.642	0.99
326_A	329_T	0.642	0.99
309_L	312_A	0.641	0.99
15_E	19_A	0.640	0.99
54_V	60_G	0.637	0.99
64_T	68_L	0.636	0.99
336_R	340_L	0.635	0.99
163_Y	171_K	0.635	0.99
137_I	151_V	0.632	0.99
139_A	163_Y	0.630	0.99
12_M	16_E	0.628	0.99
77_I	122_T	0.626	0.99
19_A	244_A	0.626	0.99
80_S	99_M	0.626	0.99
263_I	266_Q	0.626	0.99
254_E	287_V	0.625	0.99
202_Q	206_L	0.624	0.99
314_K	320_T	0.624	0.99
161_T	168_I	0.623	0.99
257_N	261_R	0.621	0.99
331_K	334_R	0.621	0.99
48_N	193_V	0.620	0.99
264_A	268_Q	0.619	0.99
277_Q	295_I	0.619	0.99
11_A	252_K	0.618	0.99
60_G	192_I	0.618	0.99
129_H	168_I	0.618	0.99
129_H	135_A	0.616	0.99
9_R	360_D	0.615	0.99
282_P	286_H	0.615	0.99
56_S	235_K	0.614	0.99
252_K	256_L	0.614	0.99
89_M	126_I	0.613	0.99
23_V	26_S	0.613	0.99
82_T	86_T	0.612	0.99
296_R	347_W	0.609	0.99
101_D	344_N	0.609	0.99
102_V	345_T	0.607	0.99
66_M	206_L	0.606	0.99
56_S	59_A	0.605	0.99
174_A	193_V	0.605	0.99
261_R	290_W	0.605	0.99
65_L	93_L	0.603	0.99
86_T	128_V	0.601	0.99
155_A	174_A	0.599	0.99
17_L	24_L	0.596	0.99
170_A	174_A	0.596	0.99
23_V	34_K	0.595	0.99
83_W	211_L	0.595	0.99
71_G	93_L	0.594	0.99
68_L	199_L	0.594	0.99
76_V	126_I	0.594	0.99
264_A	357_L	0.594	0.99
296_R	352_I	0.592	0.99
232_P	332_Y	0.591	0.99
156_A	182_K	0.591	0.99
282_P	290_W	0.590	0.99
22_E	37_A	0.590	0.99
134_P	161_T	0.589	0.99
118_I	122_T	0.589	0.99
267_Y	366_A	0.588	0.99
86_T	126_I	0.588	0.99
69_K	95_A	0.587	0.99
295_I	353_C	0.585	0.99
131_A	323_H	0.584	0.99
173_T	195_D	0.583	0.99
343_P	346_E	0.583	0.99
66_M	234_Y	0.583	0.99
139_A	143_I	0.581	0.99
187_A	242_N	0.580	0.99
91_S	232_P	0.579	0.99
81_L	352_I	0.578	0.99
131_A	294_I	0.577	0.99
105_D	278_P	0.574	0.99
299_E	351_R	0.574	0.99
57_A	156_A	0.572	0.99
134_P	286_H	0.570	0.99
292_L	354_S	0.568	0.99
133_A	288_H	0.566	0.99
158_A	161_T	0.565	0.99
43_C	50_H	0.563	0.99
76_V	95_A	0.563	0.99
116_S	120_P	0.561	0.98
43_C	48_N	0.561	0.98
178_F	246_A	0.561	0.98
48_N	174_A	0.561	0.98
238_L	242_N	0.561	0.98
31_T	240_D	0.558	0.98
53_A	191_L	0.557	0.98
179_H	188_E	0.553	0.98
169_G	176_F	0.552	0.98
160_G	253_L	0.551	0.98
102_V	344_N	0.551	0.98
134_P	163_Y	0.550	0.98
312_A	375_Q	0.549	0.98
153_E	169_G	0.548	0.98
70_I	74_D	0.547	0.98
19_A	23_V	0.546	0.98
118_I	147_Y	0.545	0.98
163_Y	166_R	0.545	0.98
268_Q	272_A	0.545	0.98
254_E	257_N	0.544	0.98
201_R	205_M	0.544	0.98
108_M	134_P	0.540	0.98
205_M	212_G	0.537	0.98
17_L	20_V	0.535	0.98
270_A	366_A	0.534	0.98
26_S	33_P	0.534	0.98
138_D	166_R	0.534	0.98
35_N	240_D	0.533	0.98
296_R	348_N	0.532	0.98
111_P	136_D	0.532	0.98
87_L	333_Y	0.532	0.98
123_K	150_A	0.531	0.98
253_L	257_N	0.530	0.98
62_H	89_M	0.529	0.98
195_D	199_L	0.529	0.98
204_R	207_K	0.527	0.98
81_L	130_Y	0.524	0.98
140_I	143_I	0.522	0.98
295_I	373_L	0.521	0.98
150_A	196_N	0.521	0.98
211_L	229_V	0.520	0.98
329_T	350_E	0.519	0.98
52_I	194_T	0.518	0.97
152_I	175_I	0.516	0.97
129_H	155_A	0.512	0.97
282_P	287_V	0.511	0.97
84_V	211_L	0.511	0.97
110_T	139_A	0.510	0.97
78_T	86_T	0.510	0.97
109_V	127_P	0.508	0.97
50_H	204_R	0.506	0.97
61_M	89_M	0.506	0.97
16_E	20_V	0.506	0.97
38_L	42_F	0.504	0.97
241_I	245_I	0.503	0.97
126_I	152_I	0.503	0.97
75_E	118_I	0.501	0.97
337_F	341_S	0.501	0.97
295_I	355_L	0.500	0.97
26_S	34_K	0.500	0.97

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4zwvA	2	0.9551	100	0.42	Contact Map
2fnuA	2	0.971	100	0.46	Contact Map
1o69A	2	0.9261	100	0.46	Contact Map
3frkA	2	0.9446	100	0.466	Contact Map
4lc3A	2	0.9736	100	0.47	Contact Map
2c81A	2	0.9763	100	0.472	Contact Map
3bb8A	2	0.9842	100	0.476	Contact Map
3b8xA	2	0.9763	100	0.481	Contact Map
1mdoA	2	0.9631	100	0.482	Contact Map
3nytA	2	0.934	100	0.494	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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