GREMLIN Database
GTRA - Bactoprenol-linked glucose translocase homolog from prophage CPS-53
UniProt: P77682 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG14131
Length: 120 (116)
Sequences: 155 (115)
Seq/√Len: 10.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
56_F78_S5.4241.00
18_I48_F4.0860.99
70_Y106_C2.6820.89
32_T37_A2.6700.89
47_S78_S2.3830.83
47_S62_T2.0780.73
14_L21_V2.0260.71
48_F52_A1.9420.68
73_F110_Y1.9040.66
22_V44_V1.8930.66
69_L106_C1.8880.65
8_Y16_T1.8630.64
110_Y115_V1.8260.63
20_W95_T1.8030.62
52_A92_P1.7850.61
87_R117_R1.7600.60
35_A61_S1.6700.55
17_L27_I1.6670.55
54_A105_V1.6290.54
72_G77_L1.6270.53
77_L90_L1.6070.52
3_K6_A1.6030.52
20_W116_F1.5980.52
9_T13_V1.5500.50
5_F104_L1.5360.49
26_C69_L1.4560.45
16_T103_S1.4400.45
17_L114_I1.4380.44
17_L44_V1.4250.44
26_C41_G1.3140.39
11_I41_G1.2930.38
79_A109_V1.2900.38
7_K37_A1.2450.36
27_I37_A1.2310.35
63_T68_M1.2290.35
39_F106_C1.2230.35
50_F73_F1.2180.35
47_S50_F1.2070.34
112_K118_D1.2030.34
68_M98_T1.1950.34
37_A115_V1.1930.33
83_W106_C1.1610.32
8_Y103_S1.1590.32
27_I113_F1.1570.32
102_I106_C1.1550.32
85_A88_C1.1480.32
12_G16_T1.1420.31
72_G113_F1.1360.31
8_Y12_G1.1270.31
8_Y15_N1.1230.31
2_L6_A1.1180.30
18_I39_F1.1110.30
21_V69_L1.1100.30
47_S51_F1.0920.29
2_L85_A1.0390.27
46_V57_T1.0360.27
69_L76_T1.0330.27
36_L79_A1.0230.27
31_H78_S1.0230.27
31_H41_G1.0200.27
15_N103_S1.0190.27
90_L98_T1.0150.26
36_L101_A1.0020.26
43_V62_T0.9990.26
11_I52_A0.9970.26
59_K93_M0.9790.25
41_G62_T0.9530.24
6_A85_A0.9490.24
60_A78_S0.9490.24
72_G76_T0.9320.23
35_A65_M0.9110.23
55_K88_C0.8960.22
74_M117_R0.8940.22
32_T94_I0.8900.22
18_I50_F0.8810.22
55_K92_P0.8690.21
47_S56_F0.8660.21
63_T109_V0.8640.21
22_V28_Y0.8540.21
84_A106_C0.8480.21
24_G115_V0.8360.20
77_L98_T0.8360.20
17_L22_V0.8340.20
35_A78_S0.8290.20
79_A114_I0.8140.20
20_W99_F0.8080.20
75_G111_S0.8060.19
16_T100_S0.7950.19
4_L10_S0.7940.19
37_A88_C0.7900.19
108_F111_S0.7890.19
17_L105_V0.7860.19
102_I114_I0.7810.19
60_A106_C0.7780.19
2_L10_S0.7680.18
103_S111_S0.7670.18
46_V73_F0.7660.18
35_A70_Y0.7630.18
52_A94_I0.7600.18
33_N39_F0.7520.18
13_V109_V0.7500.18
26_C31_H0.7480.18
15_N19_H0.7400.18
25_V39_F0.7260.17
69_L101_A0.7200.17
11_I90_L0.7170.17
46_V110_Y0.7130.17
84_A118_D0.7120.17
63_T66_R0.7120.17
7_K46_V0.7090.17
63_T73_F0.7070.17
88_C112_K0.7010.17
52_A102_I0.7010.17
100_S103_S0.7000.16
6_A9_T0.6990.16
21_V41_G0.6930.16
28_Y32_T0.6910.16
20_W115_V0.6800.16
62_T72_G0.6790.16
10_S46_V0.6780.16
11_I111_S0.6770.16
28_Y77_L0.6720.16
34_Q95_T0.6710.16
54_A73_F0.6630.16
43_V80_T0.6610.16
9_T70_Y0.6550.15
27_I71_V0.6550.15
43_V71_V0.6440.15
81_V84_A0.6430.15
21_V117_R0.6370.15
106_C117_R0.6340.15
70_Y73_F0.6300.15
18_I105_V0.6230.15
63_T96_L0.6170.14
61_S64_T0.6150.14
58_F107_G0.6110.14
14_L35_A0.6110.14
7_K72_G0.6110.14
35_A52_A0.6070.14
13_V98_T0.6040.14
99_F105_V0.6030.14
88_C91_P0.6030.14
56_F89_A0.6020.14
81_V98_T0.5950.14
3_K91_P0.5940.14
46_V70_Y0.5910.14
93_M112_K0.5850.14
12_G42_F0.5770.14
12_G20_W0.5710.13
40_A62_T0.5670.13
91_P118_D0.5620.13
85_A92_P0.5580.13
15_N54_A0.5550.13
69_L72_G0.5540.13
56_F72_G0.5480.13
16_T19_H0.5430.13
81_V106_C0.5410.13
10_S73_F0.5400.13
2_L109_V0.5390.13
3_K43_V0.5380.13
40_A113_F0.5360.13
47_S77_L0.5350.13
99_F116_F0.5340.13
30_A35_A0.5340.13
11_I105_V0.5310.13
6_A71_V0.5270.12
43_V106_C0.5190.12
44_V89_A0.5160.12
92_P117_R0.5130.12
47_S115_V0.5120.12
32_T41_G0.5120.12
98_T113_F0.5050.12
40_A80_T0.5050.12
89_A114_I0.5000.12
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2zy9A 2 0.7 33.6 0.936 Contact Map
4q65A 1 0.825 12.5 0.948 Contact Map
4oh3A 2 0.875 11.7 0.948 Contact Map
2gfpA 2 0.7833 10.3 0.95 Contact Map
3wdoA 1 0.85 8 0.952 Contact Map
1p7bA 3 0.9833 7.4 0.953 Contact Map
4ikvA 1 0.9583 6.2 0.954 Contact Map
4lp8A 4 0.9833 4.7 0.957 Contact Map
4ldsA 2 0.75 4.7 0.957 Contact Map
3syaA 3 1 4.5 0.957 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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