GREMLIN Database
ABDH - Gamma-aminobutyraldehyde dehydrogenase
UniProt: P77674 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13766
Length: 474 (452)
Sequences: 36482 (21911)
Seq/√Len: 1030.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
290_K390_D4.9611.00
234_S238_S3.5651.00
290_K388_P3.1481.00
262_E299_K3.0701.00
293_Y388_P2.9071.00
20_P32_E2.8611.00
351_E361_A2.8001.00
49_D216_K2.7791.00
257_D289_Q2.7251.00
369_L372_D2.6451.00
337_E373_A2.6061.00
266_E303_A2.6061.00
183_K186_E2.5861.00
325_L329_E2.5831.00
336_E340_A2.4881.00
297_V386_V2.4721.00
257_D291_G2.4591.00
77_N80_V2.4111.00
412_T418_A2.3831.00
20_P29_V2.3801.00
75_E109_R2.3311.00
189_K194_A2.2421.00
335_V360_Y2.1981.00
49_D218_R2.1771.00
37_S40_Q2.1661.00
78_G102_P2.1641.00
332_G336_E2.1341.00
73_V190_D2.1271.00
79_Q97_F2.1221.00
70_L188_A2.1091.00
403_Q449_L2.0851.00
337_E341_T2.0501.00
392_E417_R2.0291.00
176_I324_S2.0091.00
345_K367_G2.0061.00
213_G235_H1.9921.00
137_D468_R1.9891.00
332_G352_K1.9841.00
209_D213_G1.9681.00
253_V268_V1.9371.00
136_R462_E1.9351.00
80_V183_K1.9331.00
420_R424_R1.9291.00
332_G360_Y1.9271.00
301_G305_A1.9221.00
295_T299_K1.9201.00
322_L331_V1.8411.00
230_E449_L1.8341.00
339_K346_V1.8341.00
347_I366_A1.8251.00
231_H234_S1.8241.00
258_D417_R1.8121.00
73_V191_I1.7871.00
77_N190_D1.7861.00
46_R216_K1.7811.00
42_D210_P1.7771.00
73_V76_E1.7761.00
287_Y398_W1.7731.00
66_C192_F1.7591.00
375_V387_T1.7471.00
29_V32_E1.7221.00
426_Q448_K1.7081.00
42_D46_R1.6931.00
136_R465_T1.6901.00
203_R206_T1.6831.00
84_L183_K1.6401.00
289_Q389_F1.6341.00
345_K366_A1.6281.00
370_Q398_W1.6271.00
394_Q397_N1.6181.00
68_L109_R1.6171.00
301_G347_I1.6111.00
185_A199_I1.6081.00
75_E105_V1.6031.00
93_L97_F1.6001.00
304_V364_L1.5971.00
365_L374_I1.5941.00
73_V187_L1.5901.00
392_E420_R1.5881.00
390_D394_Q1.5871.00
273_Y304_V1.5721.00
293_Y297_V1.5611.00
108_F160_A1.5571.00
287_Y395_V1.5531.00
59_T62_V1.5521.00
298_E302_A1.5491.00
299_K302_A1.5451.00
325_L358_Y1.5431.00
268_V296_L1.5401.00
333_K373_A1.5321.00
69_K72_D1.5281.00
72_D76_E1.5151.00
52_F56_G1.5081.00
18_K32_E1.5081.00
373_A377_K1.5071.00
265_V299_K1.5051.00
168_C196_V1.5031.00
261_I299_K1.4771.00
57_Q424_R1.4661.00
256_F417_R1.4581.00
186_E190_D1.4581.00
78_G97_F1.4541.00
62_V65_E1.4531.00
294_D388_P1.4431.00
28_D356_N1.4411.00
286_I384_V1.4401.00
42_D214_H1.4391.00
83_E87_R1.4381.00
287_Y389_F1.4361.00
267_G411_W1.4321.00
336_E339_K1.4321.00
58_T62_V1.4321.00
303_A306_T1.4241.00
68_L116_R1.4231.00
27_G356_N1.4231.00
268_V286_I1.4161.00
293_Y366_A1.4131.00
108_F156_A1.4081.00
346_V365_L1.4061.00
114_A117_C1.4041.00
135_R423_A1.4021.00
22_Y29_V1.3981.00
394_Q398_W1.3971.00
288_A296_L1.3901.00
71_A109_R1.3891.00
295_T298_E1.3861.00
79_Q83_E1.3811.00
408_S427_Y1.3801.00
308_K316_S1.3701.00
77_N183_K1.3701.00
17_E35_E1.3521.00
257_D417_R1.3501.00
144_S169_V1.3441.00
233_I452_Y1.3391.00
40_Q43_A1.3381.00
83_E313_D1.3371.00
331_V381_G1.3351.00
219_M244_H1.3261.00
334_A379_V1.3211.00
393_E424_R1.3171.00
328_L332_G1.3091.00
72_D109_R1.3071.00
294_D298_E1.2921.00
155_A171_L1.2921.00
389_F398_W1.2911.00
341_T373_A1.2891.00
256_F389_F1.2861.00
23_N26_T1.2861.00
86_S96_A1.2761.00
328_L360_Y1.2761.00
329_E333_K1.2701.00
297_V301_G1.2701.00
325_L328_L1.2691.00
254_I395_V1.2551.00
302_A305_A1.2491.00
256_F421_V1.2481.00
185_A197_I1.2371.00
52_F168_C1.2361.00
328_L352_K1.2361.00
391_N394_Q1.2331.00
292_I295_T1.2231.00
289_Q391_N1.2201.00
209_D235_H1.2141.00
333_K337_E1.2121.00
371_D376_Q1.2121.00
299_K303_A1.2111.00
71_A75_E1.2101.00
305_A348_T1.2091.00
396_V421_V1.2021.00
308_K318_E1.2011.00
46_R50_A1.2011.00
459_Y462_E1.1971.00
289_Q292_I1.1891.00
458_L462_E1.1861.00
133_M419_H1.1741.00
302_A306_T1.1701.00
58_T66_C1.1661.00
136_R467_V1.1621.00
195_G198_N1.1611.00
83_E93_L1.1561.00
45_V217_V1.1511.00
188_A197_I1.1411.00
422_S470_V1.1411.00
370_Q401_D1.1401.00
175_E203_R1.1391.00
86_S312_P1.1391.00
297_V366_A1.1391.00
45_V216_K1.1381.00
300_L384_V1.1381.00
45_V214_H1.1381.00
408_S430_T1.1381.00
182_L201_F1.1361.00
38_A210_P1.1351.00
296_L300_L1.1261.00
209_D231_H1.1261.00
139_L219_M1.1231.00
418_A432_V1.1211.00
81_F183_K1.1181.00
231_H235_H1.1181.00
41_V207_V1.1161.00
69_K73_V1.1011.00
310_G317_T1.0991.00
338_A365_L1.0971.00
47_A198_N1.0971.00
175_E205_K1.0961.00
445_G454_K1.0961.00
341_T372_D1.0931.00
121_L458_L1.0901.00
253_V283_A1.0871.00
19_Q35_E1.0831.00
35_E206_T1.0831.00
233_I243_T1.0821.00
68_L113_G1.0821.00
227_A231_H1.0811.00
376_Q403_Q1.0801.00
228_T231_H1.0801.00
393_E420_R1.0771.00
393_E397_N1.0691.00
454_K466_V1.0681.00
70_L187_L1.0631.00
459_Y467_V1.0601.00
31_L179_L1.0581.00
343_H365_L1.0581.00
23_N311_A1.0501.00
305_A361_A1.0501.00
25_A312_P1.0461.00
144_S221_S1.0461.00
210_P214_H1.0421.00
254_I421_V1.0421.00
159_L197_I1.0401.00
70_L108_F1.0391.00
353_R361_A1.0331.00
297_V347_I1.0321.00
159_L169_V1.0311.00
35_E203_R1.0261.00
328_L358_Y1.0241.00
396_V424_R1.0221.00
70_L192_F1.0201.00
376_Q401_D1.0191.00
230_E240_I1.0151.00
254_I399_A1.0131.00
337_E340_A1.0131.00
143_A217_V1.0121.00
389_F395_V1.0101.00
260_D413_K1.0041.00
301_G348_T1.0031.00
64_A116_R1.0001.00
27_G358_Y0.9951.00
392_E421_V0.9941.00
104_I156_A0.9941.00
150_Y279_D0.9931.00
51_A168_C0.9931.00
141_V168_C0.9931.00
213_G238_S0.9891.00
414_D417_R0.9851.00
260_D263_A0.9851.00
311_A314_D0.9811.00
307_L319_L0.9771.00
250_K284_C0.9761.00
349_G361_A0.9751.00
263_A267_G0.9731.00
175_E204_G0.9721.00
186_E189_K0.9711.00
121_L459_Y0.9661.00
77_N186_E0.9651.00
447_Q466_V0.9631.00
81_F187_L0.9621.00
269_R303_A0.9581.00
115_A164_A0.9491.00
135_R470_V0.9481.00
68_L112_A0.9451.00
80_V83_E0.9441.00
182_L199_I0.9411.00
82_A97_F0.9401.00
409_S435_H0.9401.00
38_A42_D0.9371.00
397_N401_D0.9371.00
271_F283_A0.9361.00
139_L242_R0.9351.00
262_E295_T0.9351.00
143_A211_L0.9351.00
76_E190_D0.9331.00
73_V77_N0.9321.00
368_A372_D0.9301.00
233_I237_A0.9291.00
38_A206_T0.9261.00
77_N187_L0.9251.00
132_S442_M0.9241.00
87_R313_D0.9211.00
333_K336_E0.9171.00
142_V219_M0.9171.00
334_A337_E0.9171.00
349_G363_T0.9161.00
331_V383_V0.9141.00
23_N87_R0.9131.00
104_I152_L0.9131.00
65_E69_K0.9101.00
53_A397_N0.9091.00
218_R426_Q0.9081.00
252_P408_S0.9041.00
272_G284_C0.9001.00
49_D53_A0.8991.00
64_A68_L0.8981.00
89_C177_T0.8971.00
253_V411_W0.8961.00
137_D423_A0.8901.00
176_I326_A0.8851.00
137_D447_Q0.8841.00
261_I265_V0.8841.00
56_G426_Q0.8841.00
43_A47_A0.8821.00
230_E234_S0.8811.00
91_K100_E0.8801.00
22_Y358_Y0.8781.00
141_V217_V0.8761.00
60_P64_A0.8761.00
294_D297_V0.8751.00
53_A57_Q0.8741.00
41_V143_A0.8741.00
233_I236_T0.8711.00
419_H423_A0.8711.00
339_K365_L0.8711.00
57_Q423_A0.8681.00
53_A426_Q0.8671.00
185_A189_K0.8661.00
23_N28_D0.8661.00
331_V379_V0.8611.00
256_F412_T0.8561.00
293_Y386_V0.8561.00
343_H372_D0.8561.00
256_F392_E0.8541.00
25_A359_Y0.8541.00
71_A112_A0.8531.00
442_M469_H0.8521.00
387_T398_W0.8461.00
182_L186_E0.8461.00
408_S425_L0.8451.00
225_S228_T0.8431.00
265_V300_L0.8431.00
265_V303_A0.8411.00
334_A373_A0.8401.00
329_E332_G0.8401.00
220_V236_T0.8391.00
165_A465_T0.8391.00
242_R466_V0.8341.00
74_I104_I0.8331.00
161_P460_G0.8261.00
370_Q387_T0.8241.00
39_E43_A0.8241.00
158_K455_D0.8211.00
64_A112_A0.8201.00
51_A196_V0.8171.00
48_A198_N0.8141.00
171_L181_A0.8091.00
36_A40_Q0.8091.00
139_L466_V0.8081.00
162_A169_V0.8061.00
233_I240_I0.8061.00
43_A46_R0.8061.00
19_Q203_R0.8061.00
47_A195_G0.8041.00
395_V398_W0.8031.00
298_E301_G0.8021.00
53_A56_G0.8021.00
173_P201_F0.7961.00
410_V421_V0.7961.00
55_W196_V0.7941.00
265_V296_L0.7931.00
68_L72_D0.7931.00
39_E42_D0.7921.00
415_V418_A0.7921.00
396_V400_N0.7911.00
66_C191_I0.7891.00
229_G247_L0.7871.00
264_V268_V0.7861.00
94_H318_E0.7821.00
255_V296_L0.7811.00
326_A329_E0.7811.00
220_V232_I0.7781.00
139_L167_N0.7771.00
156_A184_L0.7751.00
61_K116_R0.7741.00
89_C323_S0.7731.00
427_Y430_T0.7721.00
75_E78_G0.7721.00
230_E238_S0.7701.00
30_L87_R0.7691.00
366_A388_P0.7691.00
205_K209_D0.7681.00
155_A159_L0.7661.00
335_V383_V0.7661.00
87_R179_L0.7641.00
309_S353_R0.7641.00
389_F394_Q0.7641.00
261_I292_I0.7591.00
86_S93_L0.7561.00
202_G207_V0.7551.00
331_V360_Y0.7541.00
226_I449_L0.7531.00
229_G245_M0.7531.00
50_A53_A0.7521.00
144_S158_K0.7501.00
289_Q392_E0.7451.00
69_K191_I0.7451.00
251_A284_C0.7451.00
307_L318_E0.7441.00
222_L228_T0.7441.00
300_L364_L0.7421.00
212_T232_I0.7421.00
206_T209_D0.7411.00
293_Y367_G0.7401.00
252_P399_A0.7401.00
350_G363_T0.7391.00
207_V210_P0.7391.00
152_L180_T0.7391.00
36_A44_A0.7381.00
334_A377_K0.7361.00
67_L164_A0.7351.00
262_E303_A0.7341.00
82_A93_L0.7331.00
236_T243_T0.7321.00
50_A54_E0.7321.00
93_L313_D0.7301.00
339_K351_E0.7291.00
132_S469_H0.7271.00
413_K416_G0.7251.00
155_A181_A0.7251.00
208_G212_T0.7221.00
48_A168_C0.7161.00
75_E102_P0.7161.00
79_Q93_L0.7141.00
82_A86_S0.7121.00
97_F315_E0.7091.00
55_W66_C0.7051.00
54_E58_T0.7051.00
22_Y27_G0.7031.00
139_L218_R0.7021.00
212_T235_H0.7021.00
143_A220_V0.7001.00
176_I323_S0.7001.00
80_V186_E0.6971.00
146_A155_A0.6951.00
314_D317_T0.6951.00
264_V296_L0.6941.00
265_V269_R0.6941.00
330_R333_K0.6931.00
171_L197_I0.6911.00
288_A292_I0.6901.00
324_S327_H0.6901.00
42_D216_K0.6891.00
17_E206_T0.6861.00
235_H238_S0.6851.00
301_G304_V0.6851.00
234_S237_A0.6821.00
72_D75_E0.6801.00
18_K34_A0.6781.00
27_G325_L0.6771.00
49_D52_F0.6761.00
304_V348_T0.6751.00
192_F197_I0.6731.00
256_F289_Q0.6711.00
415_V419_H0.6681.00
84_L179_L0.6681.00
60_P115_A0.6681.00
155_A184_L0.6671.00
276_A319_L0.6641.00
304_V307_L0.6641.00
74_I105_V0.6641.00
360_Y363_T0.6621.00
309_S319_L0.6611.00
167_N465_T0.6611.00
327_H330_R0.6601.00
342_G372_D0.6601.00
258_D412_T0.6601.00
242_R463_D0.6601.00
55_W163_L0.6591.00
143_A208_G0.6581.00
287_Y375_V0.6571.00
56_G424_R0.6561.00
462_E467_V0.6561.00
255_V264_V0.6551.00
462_E465_T0.6541.00
286_I296_L0.6541.00
23_N313_D0.6541.00
341_T371_D0.6541.00
85_E88_N0.6541.00
135_R468_R0.6531.00
188_A192_F0.6531.00
212_T220_V0.6531.00
62_V66_C0.6531.00
54_E57_Q0.6511.00
370_Q375_V0.6501.00
422_S432_V0.6491.00
426_Q447_Q0.6491.00
269_R300_L0.6491.00
78_G82_A0.6481.00
261_I295_T0.6481.00
418_A422_S0.6471.00
269_R307_L0.6451.00
398_W401_D0.6431.00
268_V300_L0.6431.00
41_V210_P0.6431.00
287_Y370_Q0.6421.00
131_T419_H0.6401.00
263_A266_E0.6401.00
204_G208_G0.6391.00
41_V45_V0.6381.00
325_L352_K0.6361.00
244_H463_D0.6331.00
53_A424_R0.6311.00
311_A317_T0.6291.00
263_A413_K0.6291.00
326_A330_R0.6281.00
56_G138_P0.6271.00
74_I108_F0.6271.00
47_A194_A0.6251.00
91_K150_Y0.6241.00
158_K221_S0.6231.00
328_L353_R0.6221.00
118_L465_T0.6221.00
71_A105_V0.6221.00
38_A213_G0.6191.00
338_A379_V0.6191.00
51_A54_E0.6181.00
392_E396_V0.6171.00
233_I245_M0.6161.00
175_E330_R0.6151.00
91_K95_S0.6141.00
368_A374_I0.6131.00
34_A201_F0.6121.00
21_V31_L0.6101.00
368_A375_V0.6091.00
83_E86_S0.6091.00
258_D414_D0.6081.00
391_N397_N0.6071.00
101_I105_V0.6061.00
335_V365_L0.6061.00
258_D413_K0.6061.00
85_E180_T0.6051.00
56_G137_D0.6041.00
412_T417_R0.6031.00
44_A200_L0.6021.00
183_K187_L0.6021.00
416_G419_H0.6011.00
21_V88_N0.6011.00
175_E231_H0.6011.00
118_L461_L0.6011.00
85_E96_A0.6001.00
300_L386_V0.5961.00
159_L171_L0.5961.00
85_E100_E0.5961.00
30_L179_L0.5951.00
262_E302_A0.5941.00
322_L327_H0.5931.00
202_G208_G0.5931.00
332_G339_K0.5911.00
271_F435_H0.5911.00
46_R49_D0.5911.00
81_F152_L0.5901.00
60_P164_A0.5891.00
38_A209_D0.5891.00
86_S313_D0.5891.00
346_V363_T0.5871.00
379_V383_V0.5871.00
110_F114_A0.5851.00
370_Q397_N0.5851.00
395_V399_A0.5841.00
410_V418_A0.5841.00
205_K231_H0.5831.00
350_G361_A0.5821.00
335_V363_T0.5821.00
396_V420_R0.5821.00
74_I184_L0.5811.00
170_V198_N0.5801.00
334_A338_A0.5801.00
261_I264_V0.5791.00
152_L184_L0.5791.00
253_V286_I0.5781.00
226_I230_E0.5781.00
82_A101_I0.5771.00
142_V167_N0.5771.00
33_I178_P0.5751.00
272_G384_V0.5751.00
261_I296_L0.5751.00
367_G388_P0.5751.00
332_G335_V0.5741.00
288_A386_V0.5711.00
416_G420_R0.5711.00
288_A293_Y0.5701.00
36_A200_L0.5701.00
74_I152_L0.5691.00
253_V409_S0.5671.00
410_V432_V0.5661.00
219_M463_D0.5651.00
133_M470_V0.5641.00
352_K361_A0.5631.00
365_L368_A0.5611.00
141_V218_R0.5601.00
165_A461_L0.5591.00
44_A198_N0.5581.00
71_A108_F0.5581.00
65_E68_L0.5531.00
114_A458_L0.5521.00
392_E424_R0.5511.00
113_G116_R0.5511.00
279_D282_A0.5511.00
137_D426_Q0.5501.00
70_L73_V0.5491.00
17_E37_S0.5491.00
61_K65_E0.5481.00
341_T369_L0.5481.00
426_Q466_V0.5471.00
308_K314_D0.5471.00
286_I386_V0.5471.00
97_F102_P0.5451.00
49_D141_V0.5411.00
348_T364_L0.5411.00
101_I152_L0.5401.00
431_W434_T0.5401.00
47_A51_A0.5401.00
168_C198_N0.5401.00
396_V425_L0.5401.00
243_T452_Y0.5391.00
102_P105_V0.5381.00
111_F161_P0.5371.00
374_I379_V0.5361.00
184_L188_A0.5361.00
257_D389_F0.5361.00
251_A407_A0.5351.00
163_L192_F0.5351.00
322_L360_Y0.5351.00
163_L197_I0.5351.00
48_A170_V0.5341.00
209_D212_T0.5341.00
66_C70_L0.5341.00
157_W456_M0.5331.00
399_A425_L0.5331.00
189_K195_G0.5321.00
89_C275_N0.5301.00
301_G364_L0.5301.00
283_A409_S0.5301.00
227_A326_A0.5281.00
259_A264_V0.5241.00
142_V169_V0.5241.00
153_M157_W0.5241.00
421_V425_L0.5241.00
21_V178_P0.5231.00
290_K293_Y0.5231.00
78_G105_V0.5231.00
266_E270_T0.5221.00
103_A153_M0.5211.00
48_A141_V0.5201.00
212_T239_S0.5201.00
130_H434_T0.5181.00
221_S464_Y0.5141.00
33_I179_L0.5131.00
346_V350_G0.5131.00
430_T468_R0.5111.00
330_R334_A0.5111.00
265_V292_I0.5111.00
144_S159_L0.5091.00
44_A170_V0.5081.00
309_S318_E0.5081.00
347_I367_G0.5081.00
92_P317_T0.5071.00
300_L304_V0.5051.00
447_Q454_K0.5041.00
107_V456_M0.5041.00
327_H331_V0.5031.00
407_A431_W0.5021.00
81_F101_I0.5011.00
47_A50_A0.5011.00
175_E227_A0.5011.00
226_I403_Q0.5011.00
82_A96_A0.5011.00
74_I81_F0.5011.00
100_E150_Y0.5001.00
346_V349_G0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1wndA 4 1 100 0.008 Contact Map
4o5hA 4 0.9979 100 0.013 Contact Map
3ek1A 5 0.9916 100 0.015 Contact Map
4qf6A 4 0.9958 100 0.017 Contact Map
4pxlA 4 0.9958 100 0.017 Contact Map
4yweA 5 0.9873 100 0.017 Contact Map
1a4sA 4 0.9916 100 0.018 Contact Map
4qtoA 4 0.9958 100 0.021 Contact Map
4pz2A 4 0.9958 100 0.022 Contact Map
4f3xA 4 0.9958 100 0.022 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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