GREMLIN Database
LSRC - Autoinducer 2 import system permease protein LsrC
UniProt: P77672 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13807
Length: 342 (283)
Sequences: 30893 (19733)
Seq/√Len: 1173.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
96_L216_C4.0261.00
100_L212_S3.7061.00
100_L216_C3.0901.00
77_L98_L2.9191.00
104_F212_S2.8311.00
193_L207_R2.8241.00
81_L94_A2.6471.00
55_T265_A2.5861.00
48_I166_T2.5391.00
112_W204_E2.5081.00
186_F210_A2.4671.00
202_R205_A2.4631.00
99_G219_A2.4291.00
103_G215_G2.3811.00
205_A209_V2.2631.00
106_N124_T2.2351.00
174_A178_A2.1721.00
104_F208_I2.1521.00
176_L182_F2.1431.00
175_W179_K2.1431.00
243_K276_D2.1281.00
182_F209_V2.1071.00
185_S206_I2.1001.00
96_L220_L2.0211.00
87_S90_V2.0101.00
172_F176_L1.9971.00
108_V112_W1.9941.00
50_L244_A1.9681.00
99_G215_G1.9591.00
78_L95_T1.9421.00
171_A175_W1.9241.00
72_G132_M1.9001.00
89_P93_V1.8671.00
189_T206_I1.8401.00
44_A273_T1.7951.00
92_C223_I1.7741.00
78_L223_I1.7471.00
57_V214_N1.7451.00
24_P278_V1.7251.00
51_A265_A1.7191.00
188_A196_A1.6871.00
126_G129_R1.6821.00
107_G208_I1.6671.00
56_L173_M1.6341.00
44_A270_W1.6001.00
181_A185_S1.5631.00
59_L187_Y1.5631.00
102_A128_Y1.5431.00
48_I269_A1.5311.00
157_L160_S1.5301.00
82_L91_A1.5281.00
243_K293_A1.5221.00
182_F186_F1.4991.00
193_L197_R1.4981.00
96_L223_I1.4951.00
73_M102_A1.4701.00
80_M135_W1.4581.00
194_Q197_R1.4511.00
69_S129_R1.4471.00
50_L71_T1.4411.00
81_L84_A1.4331.00
71_T225_F1.4331.00
170_V266_V1.4301.00
251_G264_G1.4251.00
60_T210_A1.4151.00
185_S196_A1.4011.00
124_T128_Y1.3851.00
185_S201_V1.3721.00
81_L86_Y1.3721.00
209_V212_S1.3591.00
112_W208_I1.3561.00
150_Q153_A1.3471.00
53_G217_M1.3411.00
201_V206_I1.3371.00
56_L210_A1.3371.00
251_G268_G1.3301.00
49_L221_A1.3291.00
49_L224_V1.3161.00
80_M83_N1.3161.00
36_T277_S1.3051.00
86_Y94_A1.2971.00
196_A201_V1.2901.00
90_V93_V1.2861.00
62_N117_A1.2841.00
108_V208_I1.2781.00
86_Y90_V1.2691.00
261_A264_G1.2621.00
91_A95_T1.2581.00
111_A204_E1.2571.00
52_M173_M1.2471.00
208_I212_S1.2451.00
95_T99_G1.2421.00
62_N211_F1.2401.00
48_I266_V1.2361.00
54_A244_A1.2181.00
67_V218_A1.2161.00
62_N207_R1.2101.00
97_L100_L1.2031.00
77_L81_L1.1981.00
189_T203_T1.1971.00
93_V97_L1.1961.00
153_A156_L1.1931.00
152_S155_L1.1881.00
54_A248_C1.1851.00
189_T196_A1.1761.00
80_M136_T1.1721.00
277_S280_V1.1701.00
212_S216_C1.1651.00
51_A247_A1.1651.00
40_V273_T1.1621.00
59_L260_G1.1551.00
171_A174_A1.1391.00
40_V274_Q1.1391.00
197_R204_E1.1251.00
78_L227_S1.1191.00
164_W168_I1.1161.00
178_A187_Y1.1121.00
215_G219_A1.1111.00
209_V213_L1.1101.00
51_A248_C1.1001.00
95_T223_I1.0991.00
174_A179_K1.0881.00
44_A269_A1.0871.00
169_L217_M1.0861.00
69_S128_Y1.0781.00
111_A121_T1.0691.00
100_L219_A1.0681.00
76_V234_N1.0531.00
101_L104_F1.0471.00
109_L120_A1.0421.00
53_G67_V1.0381.00
70_I102_A1.0371.00
276_D293_A1.0311.00
144_L147_E1.0301.00
186_F206_I1.0231.00
76_V132_M1.0191.00
157_L164_W1.0061.00
272_L293_A1.0041.00
240_L243_K1.0001.00
247_A268_G0.9961.00
161_A164_W0.9921.00
81_L91_A0.9891.00
50_L221_A0.9891.00
288_W291_F0.9881.00
173_M213_L0.9851.00
222_G226_A0.9841.00
68_G241_E0.9831.00
168_I172_F0.9821.00
25_G29_R0.9821.00
213_L217_M0.9801.00
206_I209_V0.9791.00
247_A269_A0.9781.00
58_M248_C0.9751.00
156_L160_S0.9711.00
170_V217_M0.9711.00
182_F206_I0.9711.00
108_V113_L0.9671.00
46_I221_A0.9651.00
45_Q163_G0.9641.00
197_R203_T0.9641.00
129_R133_L0.9641.00
38_T42_S0.9641.00
279_L292_I0.9641.00
154_P157_L0.9611.00
64_D67_V0.9561.00
263_I267_L0.9531.00
166_T170_V0.9531.00
21_F25_G0.9501.00
55_T248_C0.9491.00
97_L101_L0.9421.00
93_V96_L0.9411.00
60_T186_F0.9391.00
73_M77_L0.9391.00
55_T260_G0.9351.00
214_N218_A0.9341.00
155_L158_G0.9321.00
195_G199_L0.9281.00
25_G32_L0.9231.00
69_S125_L0.9211.00
79_G232_I0.9201.00
75_A226_A0.9181.00
96_L219_A0.9091.00
57_V64_D0.9071.00
125_L129_R0.9061.00
184_R187_Y0.9031.00
299_A303_F0.9031.00
114_K193_L0.8991.00
59_L178_A0.8931.00
54_A67_V0.8901.00
51_A269_A0.8891.00
149_K153_A0.8871.00
109_L113_L0.8861.00
142_E145_P0.8841.00
110_V120_A0.8791.00
267_L309_C0.8781.00
261_A265_A0.8701.00
205_A208_I0.8701.00
106_N120_A0.8691.00
68_G239_G0.8671.00
76_V136_T0.8661.00
167_I171_A0.8651.00
152_S156_L0.8631.00
74_C222_G0.8591.00
259_S263_I0.8581.00
48_I170_V0.8561.00
149_K152_S0.8561.00
90_V94_A0.8551.00
306_R310_A0.8531.00
70_I218_A0.8521.00
162_I224_V0.8511.00
71_T237_G0.8481.00
218_A222_G0.8481.00
78_L82_L0.8421.00
192_N195_G0.8421.00
28_D32_L0.8401.00
43_S47_L0.8381.00
21_F274_Q0.8371.00
278_V282_L0.8361.00
235_Q238_T0.8331.00
71_T240_L0.8311.00
143_G146_A0.8301.00
37_L278_V0.8281.00
189_T210_A0.8281.00
176_L179_K0.8271.00
203_T207_R0.8271.00
49_L166_T0.8251.00
20_L24_P0.8241.00
52_M265_A0.8231.00
177_L186_F0.8231.00
74_C99_G0.8211.00
35_Q38_T0.8211.00
172_F175_W0.8181.00
246_A297_L0.8181.00
74_C95_T0.8141.00
134_L288_W0.8131.00
239_G243_K0.8111.00
156_L159_V0.8101.00
161_A165_L0.8091.00
56_L213_L0.8051.00
96_L100_L0.8031.00
52_M169_L0.8031.00
105_F109_L0.8021.00
77_L80_M0.7991.00
204_E208_I0.7991.00
101_L105_F0.7981.00
75_A232_I0.7921.00
277_S281_L0.7891.00
204_E207_R0.7871.00
174_A263_I0.7851.00
50_L53_G0.7841.00
163_G167_I0.7821.00
189_T207_R0.7771.00
107_G112_W0.7761.00
216_C220_L0.7751.00
295_L299_A0.7731.00
56_L177_L0.7701.00
78_L91_A0.7651.00
75_A236_T0.7621.00
70_I99_G0.7621.00
216_C219_A0.7571.00
53_G218_A0.7551.00
193_L203_T0.7531.00
130_G133_L0.7511.00
131_I135_W0.7501.00
265_A269_A0.7501.00
71_T221_A0.7461.00
49_L169_L0.7451.00
73_M99_G0.7441.00
104_F108_V0.7441.00
143_G147_E0.7411.00
80_M84_A0.7401.00
150_Q154_P0.7401.00
129_R241_E0.7361.00
107_G111_A0.7341.00
50_L67_V0.7341.00
99_G103_G0.7311.00
117_A211_F0.7311.00
270_W274_Q0.7301.00
47_L243_K0.7301.00
65_V245_I0.7261.00
39_M43_S0.7251.00
44_A48_I0.7161.00
136_T139_K0.7131.00
225_F229_I0.7111.00
103_G212_S0.7071.00
70_I106_N0.7061.00
111_A208_I0.7051.00
141_I144_L0.7031.00
58_M245_I0.6981.00
269_A273_T0.6971.00
185_S202_R0.6971.00
92_C96_L0.6951.00
40_V277_S0.6931.00
305_G308_R0.6911.00
182_F213_L0.6901.00
74_C98_L0.6881.00
55_T262_I0.6871.00
45_Q166_T0.6831.00
47_L247_A0.6711.00
150_Q155_L0.6701.00
70_I215_G0.6691.00
156_L164_W0.6681.00
300_V304_D0.6651.00
73_M128_Y0.6631.00
36_T281_L0.6621.00
110_V211_F0.6581.00
60_T189_T0.6581.00
276_D289_N0.6561.00
41_Y45_Q0.6551.00
34_V37_L0.6541.00
247_A265_A0.6521.00
70_I74_C0.6461.00
82_L227_S0.6451.00
219_A223_I0.6431.00
24_P28_D0.6411.00
74_C218_A0.6401.00
39_M277_S0.6401.00
42_S228_Q0.6401.00
127_L131_I0.6391.00
173_M177_L0.6381.00
125_L241_E0.6371.00
55_T59_L0.6361.00
170_V174_A0.6361.00
25_G28_D0.6351.00
110_V117_A0.6351.00
57_V211_F0.6321.00
62_N193_L0.6311.00
66_S106_N0.6301.00
53_G57_V0.6301.00
290_D293_A0.6291.00
42_S163_G0.6291.00
149_K155_L0.6271.00
287_W290_D0.6261.00
21_F24_P0.6241.00
213_L216_C0.6241.00
70_I103_G0.6241.00
169_L220_L0.6231.00
176_L209_V0.6201.00
81_L98_L0.6191.00
247_A272_L0.6181.00
72_G237_G0.6181.00
173_M217_M0.6121.00
70_I128_Y0.6111.00
225_F240_L0.6071.00
77_L94_A0.6051.00
57_V62_N0.6051.00
175_W178_A0.6031.00
212_S215_G0.6021.00
47_L269_A0.6001.00
56_L176_L0.5971.00
207_R210_A0.5941.00
46_I228_Q0.5941.00
129_R238_T0.5941.00
279_L284_I0.5931.00
100_L103_G0.5931.00
203_T206_I0.5911.00
246_A293_A0.5911.00
250_L300_V0.5861.00
243_K290_D0.5861.00
40_V44_A0.5841.00
78_L222_G0.5841.00
122_L126_G0.5811.00
81_L85_G0.5801.00
307_L310_A0.5781.00
60_T207_R0.5771.00
196_A203_T0.5761.00
22_V25_G0.5761.00
100_L215_G0.5741.00
114_K204_E0.5731.00
96_L99_G0.5711.00
251_G265_A0.5711.00
187_Y260_G0.5711.00
86_Y89_P0.5701.00
304_D308_R0.5671.00
121_T125_L0.5661.00
232_I236_T0.5651.00
168_I171_A0.5641.00
88_L227_S0.5631.00
176_L180_T0.5611.00
250_L268_G0.5591.00
77_L95_T0.5581.00
64_D214_N0.5571.00
247_A251_G0.5551.00
47_L240_L0.5541.00
52_M170_V0.5541.00
215_G218_A0.5521.00
258_G262_I0.5521.00
86_Y91_A0.5511.00
194_Q198_Q0.5501.00
29_R32_L0.5451.00
188_A195_G0.5441.00
155_L159_V0.5431.00
187_Y190_G0.5421.00
109_L115_I0.5411.00
41_Y44_A0.5391.00
122_L125_L0.5391.00
52_M174_A0.5341.00
248_C265_A0.5331.00
126_G130_G0.5321.00
22_V26_F0.5321.00
67_V214_N0.5311.00
61_R207_R0.5311.00
46_I225_F0.5311.00
36_T39_M0.5281.00
233_P236_T0.5261.00
174_A261_A0.5261.00
291_F295_L0.5241.00
73_M98_L0.5241.00
178_A181_A0.5201.00
165_L220_L0.5181.00
264_G268_G0.5181.00
165_L168_I0.5161.00
37_L41_Y0.5151.00
306_R309_C0.5141.00
43_S277_S0.5141.00
132_M136_T0.5131.00
128_Y132_M0.5121.00
77_L99_G0.5111.00
165_L169_L0.5101.00
26_F29_R0.5091.00
57_V210_A0.5091.00
238_T241_E0.5061.00
45_Q49_L0.5041.00
169_L173_M0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2qi9A 2 0.8216 97.4 0.881 Contact Map
4g1uA 2 0.7661 97 0.888 Contact Map
2nq2A 2 0.7953 96.9 0.889 Contact Map
4ldsA 2 0.6023 74.7 0.934 Contact Map
3wdoA 1 0.9123 74 0.934 Contact Map
4pypA 1 0.8099 52.9 0.943 Contact Map
2cfqA 1 0.6257 45.4 0.945 Contact Map
4zw9A 1 0.8509 44.7 0.945 Contact Map
2l16A 1 0.1228 30 0.95 Contact Map
1pw4A 1 0.6345 27.2 0.951 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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