GREMLIN Database
ALLB - Allantoinase
UniProt: P77671 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13619
Length: 453 (421)
Sequences: 8601 (6082)
Seq/√Len: 296.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
7_I46_A4.4471.00
426_I431_V3.8351.00
49_L423_T3.8321.00
232_K258_E3.5591.00
396_S417_T3.5411.00
12_V21_V3.3361.00
10_G51_V3.2661.00
424_K431_V3.2501.00
359_M362_K3.1921.00
42_E434_D3.1201.00
10_G46_A3.1181.00
26_K31_A3.1041.00
34_G37_L2.9211.00
32_A382_P2.7891.00
294_L298_K2.7171.00
356_S359_M2.7051.00
380_I388_F2.7021.00
8_K43_V2.6851.00
23_I51_V2.6451.00
377_K385_D2.6341.00
5_L426_I2.5201.00
81_A118_I2.4621.00
224_I248_G2.4331.00
367_N370_D2.4091.00
379_R384_K2.4031.00
401_N414_V2.4021.00
400_T403_D2.3471.00
25_V388_F2.2991.00
46_A390_F2.2881.00
49_L390_F2.2811.00
6_I24_A2.2681.00
119_D428_R2.2611.00
52_S391_I2.1731.00
256_R310_D2.1541.00
11_T20_V2.1391.00
51_V390_F2.1111.00
266_S270_Y2.0931.00
82_K433_Y2.0821.00
54_G86_T2.0751.00
351_Q419_G2.0451.00
294_L297_Q2.0371.00
261_D371_I2.0241.00
239_H263_T2.0211.00
399_L418_I1.9601.00
397_Y421_R1.9391.00
348_E352_K1.9361.00
58_A372_F1.9151.00
362_K367_N1.9001.00
82_K405_E1.8601.00
81_A432_I1.8321.00
370_D379_R1.8291.00
28_G385_D1.8291.00
396_S419_G1.8041.00
133_R136_E1.7941.00
87_T121_A1.7881.00
33_I382_P1.7801.00
50_V357_L1.7771.00
381_A384_K1.7641.00
175_K178_E1.7641.00
392_Q395_S1.7631.00
12_V23_I1.7561.00
228_L262_V1.7491.00
44_M426_I1.7191.00
9_N45_D1.7151.00
246_P295_E1.7081.00
228_L251_E1.7071.00
29_K376_Q1.7051.00
362_K366_T1.6901.00
24_A41_K1.6901.00
398_V417_T1.6801.00
395_S423_T1.6761.00
424_K434_D1.6711.00
49_L392_Q1.6671.00
62_I76_G1.6641.00
106_E110_D1.6501.00
225_R251_E1.6491.00
350_V360_F1.6391.00
327_N330_K1.6361.00
345_M360_F1.6281.00
52_S361_G1.6231.00
254_R258_E1.6191.00
395_S421_R1.6151.00
85_I341_C1.6151.00
21_V33_I1.6091.00
345_M364_M1.6041.00
107_L111_A1.6041.00
231_A238_L1.6031.00
18_A358_P1.5841.00
74_E78_R1.5821.00
22_D37_L1.5741.00
8_K22_D1.5561.00
431_V434_D1.5511.00
221_V247_E1.5491.00
274_D294_L1.5311.00
267_C270_Y1.5271.00
55_M342_M1.5271.00
170_F233_V1.5191.00
392_Q423_T1.4991.00
359_M363_L1.4751.00
29_K385_D1.4701.00
243_V252_V1.4591.00
361_G365_A1.4561.00
10_G390_F1.4561.00
253_T306_N1.4401.00
72_G407_R1.4291.00
5_L25_V1.4281.00
250_E254_R1.4121.00
69_H320_P1.4121.00
7_I390_F1.4051.00
311_C371_I1.4041.00
425_T433_Y1.3981.00
24_A32_A1.3981.00
273_L344_V1.3931.00
176_L181_Q1.3901.00
225_R229_Y1.3801.00
165_N168_Q1.3661.00
423_T435_I1.3621.00
400_T414_V1.3561.00
176_L183_V1.3411.00
271_F300_M1.3291.00
23_I380_I1.3281.00
252_V264_C1.3271.00
42_E431_V1.3251.00
58_A311_C1.3141.00
287_C335_I1.3141.00
44_M424_K1.3121.00
293_D296_N1.2991.00
355_M363_L1.2971.00
24_A40_A1.2931.00
71_E76_G1.2901.00
254_R257_Q1.2901.00
232_K260_Q1.2881.00
217_V247_E1.2871.00
173_A236_C1.2811.00
7_I25_V1.2781.00
209_H279_E1.2711.00
385_D428_R1.2701.00
375_Q384_K1.2691.00
194_D198_E1.2561.00
253_T308_E1.2541.00
50_V393_P1.2481.00
366_T370_D1.2481.00
52_S389_V1.2341.00
184_L241_C1.2321.00
246_P299_G1.2221.00
228_L255_A1.2181.00
78_R405_E1.2171.00
6_I40_A1.2171.00
52_S55_M1.2101.00
110_D113_K1.1991.00
272_V344_V1.1901.00
51_V388_F1.1891.00
199_E203_E1.1781.00
231_A260_Q1.1781.00
336_A408_H1.1741.00
399_L404_L1.1661.00
427_L432_I1.1661.00
19_R35_Q1.1601.00
229_Y233_V1.1581.00
135_H175_K1.1541.00
34_G38_G1.1531.00
347_D352_K1.1441.00
390_F424_K1.1341.00
274_D277_Q1.1301.00
110_D114_G1.1291.00
55_M364_M1.1271.00
62_I88_M1.1231.00
189_N222_E1.1201.00
138_D181_Q1.1191.00
264_C309_I1.1171.00
56_V369_A1.1111.00
376_Q385_D1.1101.00
5_L42_E1.1061.00
180_G373_G1.1051.00
99_T105_I1.0931.00
298_K302_E1.0931.00
175_K179_L1.0921.00
12_V19_R1.0921.00
7_I51_V1.0871.00
40_A43_V1.0831.00
13_I50_V1.0831.00
302_E306_N1.0811.00
104_S107_L1.0801.00
304_L363_L1.0781.00
22_D34_G1.0781.00
347_D416_R1.0731.00
347_D419_G1.0721.00
302_E305_F1.0681.00
20_V47_S1.0661.00
109_F113_K1.0621.00
357_L393_P1.0571.00
173_A183_V1.0561.00
10_G388_F1.0541.00
77_T116_L1.0521.00
126_L172_G1.0501.00
16_N379_R1.0501.00
224_I240_V1.0491.00
7_I426_I1.0471.00
72_G115_K1.0451.00
119_D377_K1.0371.00
111_A114_G1.0361.00
58_A368_A1.0341.00
12_V380_I1.0291.00
203_E207_T1.0201.00
46_A51_V1.0181.00
243_V248_G1.0171.00
62_I77_T1.0041.00
245_S248_G1.0021.00
21_V35_Q0.9931.00
7_I388_F0.9931.00
299_G303_K0.9861.00
24_A37_L0.9821.00
119_D122_Q0.9821.00
360_F364_M0.9821.00
326_G330_K0.9721.00
72_G75_T0.9681.00
390_F426_I0.9671.00
171_K174_Q0.9651.00
32_A37_L0.9651.00
168_Q171_K0.9641.00
198_E202_R0.9601.00
340_S399_L0.9561.00
369_A378_G0.9561.00
228_L260_Q0.9511.00
388_F426_I0.9491.00
341_C364_M0.9481.00
81_A425_T0.9481.00
101_D104_S0.9471.00
199_E202_R0.9461.00
343_D397_Y0.9451.00
346_F351_Q0.9441.00
136_E139_E0.9411.00
286_K331_A0.9401.00
165_N191_L0.9401.00
237_R261_D0.9381.00
118_I427_L0.9371.00
249_V303_K0.9371.00
253_T257_Q0.9311.00
13_I18_A0.9271.00
11_T50_V0.9271.00
275_T293_D0.9201.00
55_M85_I0.9191.00
274_D297_Q0.9121.00
89_I123_L0.9101.00
312_L345_M0.9081.00
131_I135_H0.9041.00
250_E253_T0.9021.00
174_Q178_E0.8941.00
227_V238_L0.8911.00
58_A313_V0.8891.00
277_Q285_A0.8881.00
25_V426_I0.8831.00
378_G387_D0.8831.00
107_L110_D0.8821.00
58_A89_I0.8811.00
182_P237_R0.8801.00
14_L17_E0.8801.00
13_I361_G0.8771.00
106_E140_V0.8771.00
251_E254_R0.8761.00
170_F234_A0.8751.00
362_K370_D0.8741.00
297_Q301_W0.8721.00
17_E358_P0.8691.00
314_S341_C0.8691.00
218_F222_E0.8671.00
336_A404_L0.8651.00
351_Q394_N0.8641.00
320_P323_M0.8571.00
134_L179_L0.8561.00
218_F233_V0.8551.00
6_I43_V0.8551.00
342_M346_F0.8521.00
229_Y232_K0.8501.00
166_D226_R0.8481.00
50_V391_I0.8431.00
21_V380_I0.8331.00
55_M341_C0.8321.00
9_N47_S0.8321.00
81_A427_L0.8311.00
24_A31_A0.8291.00
102_R106_E0.8271.00
87_T387_D0.8251.00
169_F185_V0.8251.00
190_A194_D0.8231.00
14_L18_A0.8231.00
147_C172_G0.8211.00
365_A368_A0.8201.00
135_H139_E0.8161.00
421_R435_I0.8151.00
6_I22_D0.8131.00
161_F166_D0.8131.00
90_E108_K0.8111.00
347_D351_Q0.8071.00
411_S414_V0.8041.00
346_F357_L0.8011.00
217_V293_D0.8011.00
277_Q416_R0.8011.00
367_N371_I0.8001.00
132_D135_H0.7981.00
62_I338_L0.7960.99
301_W349_A0.7960.99
70_W319_C0.7940.99
103_A106_E0.7940.99
170_F174_Q0.7930.99
131_I140_V0.7910.99
231_A261_D0.7900.99
363_L367_N0.7890.99
166_D189_N0.7880.99
255_A260_Q0.7880.99
22_D36_D0.7880.99
143_V173_A0.7870.99
51_V426_I0.7850.99
56_V87_T0.7850.99
269_H335_I0.7840.99
19_R33_I0.7840.99
167_W171_K0.7820.99
56_V377_K0.7810.99
263_T371_I0.7810.99
24_A34_G0.7800.99
180_G237_R0.7790.99
342_M391_I0.7750.99
119_D427_L0.7740.99
55_M389_V0.7740.99
323_M332_W0.7730.99
89_I372_F0.7700.99
77_T117_T0.7690.99
23_I33_I0.7690.99
49_L424_K0.7680.99
11_T18_A0.7680.99
13_I358_P0.7670.99
69_H323_M0.7660.99
295_E298_K0.7640.99
321_P325_A0.7630.99
312_L363_L0.7630.99
379_R382_P0.7590.99
276_D294_L0.7580.99
389_V422_I0.7570.99
9_N20_V0.7570.99
74_E117_T0.7530.99
326_G332_W0.7530.99
377_K387_D0.7520.99
434_D437_Q0.7520.99
123_L144_G0.7510.99
49_L394_N0.7490.99
266_S300_M0.7490.99
355_M359_M0.7480.99
64_E68_S0.7460.99
286_K289_P0.7450.99
235_G261_D0.7440.99
141_G145_F0.7410.99
283_T331_A0.7390.99
28_G428_R0.7390.99
22_D38_G0.7390.99
174_Q202_R0.7390.99
102_R136_E0.7380.99
246_P250_E0.7370.99
145_F181_Q0.7370.99
74_E115_K0.7360.99
5_L431_V0.7350.99
15_E18_A0.7350.99
337_G340_S0.7300.99
44_M431_V0.7290.99
303_K308_E0.7290.99
8_K45_D0.7280.99
314_S318_P0.7280.99
132_D137_L0.7240.99
78_R117_T0.7230.99
221_V251_E0.7230.99
135_H140_V0.7200.99
242_H315_D0.7190.99
305_F359_M0.7190.99
174_Q199_E0.7190.99
376_Q384_K0.7180.99
171_K175_K0.7150.99
33_I380_I0.7140.99
391_I422_I0.7120.99
141_G144_G0.7100.99
166_D191_L0.7080.99
397_Y422_I0.7060.99
80_A88_M0.7050.99
221_V225_R0.7000.99
241_C265_E0.7000.99
173_A177_G0.7000.99
134_L137_L0.6970.99
146_K149_V0.6950.99
201_K329_M0.6950.99
166_D170_F0.6940.99
342_M360_F0.6930.99
98_A125_G0.6920.99
169_F173_A0.6910.99
149_V152_C0.6910.99
343_D421_R0.6900.99
184_L372_F0.6890.99
149_V227_V0.6880.99
248_G252_V0.6870.99
161_F169_F0.6870.99
249_V308_E0.6860.98
89_I121_A0.6860.98
180_G261_D0.6860.98
318_P323_M0.6860.98
112_A122_Q0.6850.98
206_V209_H0.6840.98
99_T104_S0.6830.98
349_A354_G0.6830.98
296_N299_G0.6830.98
336_A410_V0.6830.98
5_L41_K0.6820.98
137_L140_V0.6810.98
339_Q405_E0.6800.98
240_V243_V0.6780.98
298_K301_W0.6770.98
249_V309_I0.6720.98
21_V34_G0.6710.98
222_E225_R0.6700.98
131_I134_L0.6700.98
401_N404_L0.6670.98
99_T108_K0.6670.98
11_T19_R0.6660.98
340_S343_D0.6650.98
60_T85_I0.6640.98
87_T119_D0.6610.98
59_H242_H0.6570.98
143_V146_K0.6560.98
56_V368_A0.6560.98
403_D414_V0.6560.98
16_N366_T0.6550.98
350_V355_M0.6550.98
304_L309_I0.6530.98
70_W323_M0.6500.98
256_R308_E0.6490.98
397_Y403_D0.6490.98
346_F350_V0.6490.98
419_G422_I0.6480.98
132_D136_E0.6470.98
44_M390_F0.6460.98
348_E353_R0.6460.98
205_R210_D0.6460.98
137_L141_G0.6450.98
422_I425_T0.6440.98
67_R70_W0.6440.98
8_K37_L0.6440.98
305_F308_E0.6430.98
140_V145_F0.6420.98
343_D422_I0.6410.98
404_L414_V0.6410.98
205_R209_H0.6410.98
123_L149_V0.6370.98
105_I109_F0.6360.98
178_E181_Q0.6360.98
14_L19_R0.6360.98
42_E424_K0.6360.98
225_R254_R0.6350.98
366_T379_R0.6340.97
81_A117_T0.6310.97
346_F391_I0.6310.97
301_W354_G0.6290.97
17_E381_A0.6280.97
209_H213_A0.6270.97
111_A115_K0.6270.97
31_A382_P0.6270.97
224_I243_V0.6260.97
80_A338_L0.6260.97
346_F393_P0.6260.97
340_S404_L0.6260.97
206_V210_D0.6260.97
140_V143_V0.6250.97
162_R165_N0.6250.97
345_M349_A0.6240.97
140_V144_G0.6240.97
64_E111_A0.6230.97
282_G290_P0.6220.97
237_R371_I0.6210.97
240_V252_V0.6200.97
399_L411_S0.6200.97
207_T210_D0.6190.97
346_F360_F0.6190.97
106_E109_F0.6180.97
58_A371_I0.6170.97
131_I141_G0.6170.97
243_V264_C0.6160.97
119_D387_D0.6150.97
16_N381_A0.6150.97
133_R137_L0.6130.97
128_S131_I0.6120.97
243_V309_I0.6100.97
201_K204_G0.6090.97
344_V418_I0.6090.97
57_D60_T0.6070.97
77_T88_M0.6050.97
70_W320_P0.6050.97
287_C291_I0.6040.97
68_S72_G0.6040.97
9_N22_D0.6020.97
401_N409_K0.6010.97
103_A107_L0.6010.97
62_I90_E0.6010.97
123_L184_L0.6000.97
188_E192_I0.6000.97
24_A36_D0.5990.96
116_L120_A0.5990.96
342_M364_M0.5980.96
335_I412_P0.5970.96
82_K339_Q0.5960.96
348_E416_R0.5950.96
60_T338_L0.5930.96
217_V221_V0.5910.96
138_D141_G0.5880.96
231_A236_C0.5880.96
144_G147_C0.5870.96
52_S365_A0.5870.96
319_C323_M0.5860.96
296_N303_K0.5830.96
136_E140_V0.5820.96
67_R96_L0.5810.96
189_N226_R0.5790.96
134_L145_F0.5790.96
87_T369_A0.5780.96
269_H287_C0.5770.96
315_D318_P0.5770.96
176_L236_C0.5760.96
5_L44_M0.5760.96
61_H242_H0.5750.96
211_Y288_S0.5750.96
374_L377_K0.5750.96
79_A338_L0.5740.96
87_T377_K0.5740.96
145_F148_F0.5730.95
312_L316_H0.5720.95
132_D140_V0.5720.95
273_L412_P0.5710.95
183_V236_C0.5710.95
424_K433_Y0.5680.95
164_V168_Q0.5660.95
32_A36_D0.5660.95
56_V378_G0.5640.95
433_Y436_E0.5640.95
63_S319_C0.5630.95
162_R223_A0.5630.95
63_S70_W0.5630.95
6_I37_L0.5630.95
200_A212_V0.5620.95
141_G146_K0.5620.95
161_F165_N0.5610.95
350_V357_L0.5600.95
282_G285_A0.5590.95
266_S271_F0.5580.95
224_I228_L0.5580.95
28_G430_D0.5580.95
161_F164_V0.5570.95
387_D427_L0.5570.95
7_I44_M0.5560.95
255_A259_G0.5550.95
15_E362_K0.5550.95
64_E72_G0.5540.95
272_V348_E0.5530.95
342_M389_V0.5520.94
314_S317_S0.5520.94
89_I374_L0.5490.94
108_K111_A0.5470.94
135_H179_L0.5450.94
249_V300_M0.5430.94
404_L411_S0.5430.94
404_L408_H0.5420.94
11_T21_V0.5420.94
55_M365_A0.5420.94
104_S108_K0.5420.94
284_L321_P0.5420.94
289_P292_R0.5420.94
349_A355_M0.5410.94
283_T286_K0.5380.94
343_D419_G0.5370.94
170_F218_F0.5370.94
222_E226_R0.5340.93
249_V264_C0.5330.93
15_E358_P0.5320.93
281_I284_L0.5320.93
100_V127_V0.5310.93
201_K206_V0.5310.93
56_V365_A0.5300.93
15_E366_T0.5300.93
86_T387_D0.5300.93
313_V316_H0.5300.93
316_H319_C0.5290.93
278_F328_I0.5290.93
210_D213_A0.5280.93
174_Q177_G0.5280.93
124_G137_L0.5280.93
314_S319_C0.5270.93
59_H265_E0.5270.93
87_T378_G0.5260.93
301_W305_F0.5260.93
305_F354_G0.5250.93
365_A377_K0.5250.93
271_F345_M0.5230.93
227_V231_A0.5220.93
173_A176_L0.5210.93
142_V146_K0.5210.93
167_W170_F0.5210.93
142_V145_F0.5210.93
211_Y215_R0.5200.93
318_P324_K0.5200.93
26_K41_K0.5170.92
162_R169_F0.5170.92
405_E433_Y0.5160.92
166_D169_F0.5150.92
14_L379_R0.5150.92
173_A230_L0.5150.92
215_R244_S0.5140.92
30_I33_I0.5130.92
402_D414_V0.5130.92
185_V238_L0.5120.92
170_F194_D0.5120.92
298_K354_G0.5120.92
201_K207_T0.5090.92
78_R82_K0.5090.92
277_Q280_E0.5090.92
131_I175_K0.5080.92
189_N230_L0.5070.92
212_V215_R0.5050.91
285_A291_I0.5050.91
288_S333_G0.5050.91
138_D145_F0.5050.91
118_I432_I0.5050.91
350_V356_S0.5040.91
144_G148_F0.5040.91
217_V245_S0.5040.91
392_Q420_A0.5020.91
200_A210_D0.5020.91
42_E430_D0.5020.91
238_L262_V0.5010.91
217_V296_N0.5000.91
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3e74A 3 0.9536 100 0.247 Contact Map
3dc8A 3 0.9691 100 0.26 Contact Map
2ftyA 3 0.9779 100 0.261 Contact Map
4lcqA 3 0.9801 100 0.276 Contact Map
4bknA 3 0.9823 100 0.286 Contact Map
2ftwA 3 0.9801 100 0.289 Contact Map
1gkrA 3 0.9801 100 0.289 Contact Map
2vm8A 3 0.9801 100 0.29 Contact Map
1gkpA 4 0.9757 100 0.291 Contact Map
3sfwA 3 0.9779 100 0.298 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0134 seconds.