GREMLIN Database
HCAD - 3-phenylpropionate/cinnamic acid dioxygenase ferredoxin--NAD(+) reductase component
UniProt: P77650 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13460
Length: 400 (354)
Sequences: 30073 (20935)
Seq/√Len: 1112.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
148_V230_A4.3321.00
36_D80_T3.9541.00
260_D264_R3.6361.00
171_T204_L3.4211.00
146_S169_K3.2831.00
89_R269_A3.0951.00
169_K202_R3.0391.00
193_L197_Q2.9941.00
90_E98_S2.7811.00
211_H221_T2.7551.00
213_V221_T2.6521.00
18_A105_F2.5831.00
252_D258_V2.5371.00
5_T32_H2.4711.00
113_R240_S2.4611.00
5_T102_D2.4271.00
85_G88_T2.3991.00
4_K32_H2.3481.00
118_L211_H2.3381.00
101_W104_L2.3251.00
208_A223_Q2.2891.00
111_A242_N2.2561.00
103_Q269_A2.2521.00
175_L208_A2.2461.00
148_V173_I2.2341.00
34_F99_W2.2001.00
111_A244_Q2.1991.00
14_A273_G2.1721.00
148_V220_L2.1411.00
6_I22_L2.1231.00
7_I99_W2.1131.00
221_T227_T2.0911.00
146_S231_D2.0071.00
219_E227_T2.0031.00
32_H76_H1.9921.00
86_R267_D1.9871.00
7_I34_F1.9771.00
105_F306_M1.9521.00
204_L226_E1.9421.00
111_A240_S1.9391.00
92_V98_S1.9301.00
210_E223_Q1.9251.00
177_A206_N1.8491.00
207_N224_S1.8451.00
210_E221_T1.8401.00
333_D338_D1.8121.00
146_S171_T1.7901.00
302_A306_M1.7871.00
171_T202_R1.7661.00
254_A278_I1.7591.00
7_I91_L1.7081.00
271_F305_A1.6911.00
178_T189_Q1.6791.00
86_R270_I1.6781.00
147_V163_A1.6761.00
245_L248_E1.6461.00
264_R268_P1.5951.00
103_Q271_F1.5841.00
8_I19_A1.5721.00
164_T169_K1.5681.00
132_G135_A1.5661.00
157_L172_V1.5651.00
204_L207_N1.5501.00
219_E229_Q1.5471.00
105_F273_G1.5451.00
39_H42_Y1.5401.00
303_A307_L1.5321.00
108_T276_V1.5311.00
353_F363_A1.5311.00
213_V219_E1.5261.00
252_D266_C1.5141.00
4_K74_H1.5001.00
90_E100_H1.4911.00
21_S304_A1.4661.00
83_T92_V1.4571.00
147_V168_C1.4571.00
11_G35_S1.4401.00
164_T201_V1.4381.00
299_A303_A1.4311.00
130_H133_D1.4301.00
186_P190_R1.4221.00
365_T370_R1.4221.00
186_P336_G1.4201.00
7_I101_W1.4131.00
222_L228_L1.4071.00
152_A174_E1.4041.00
195_R198_Q1.4021.00
7_I32_H1.3771.00
50_S53_L1.3761.00
76_H97_E1.3711.00
174_E205_L1.3611.00
338_D354_N1.3571.00
131_A135_A1.3551.00
80_T94_T1.3361.00
103_Q306_M1.3331.00
6_I105_F1.3331.00
193_L203_I1.3291.00
32_H99_W1.3211.00
301_I305_A1.3191.00
213_V227_T1.3171.00
83_T248_E1.3171.00
214_D219_E1.3151.00
165_Q199_A1.3031.00
193_L205_L1.2951.00
194_Q197_Q1.2851.00
254_A258_V1.2841.00
67_W71_N1.2771.00
152_A179_V1.2761.00
14_A295_A1.2531.00
133_D136_R1.2511.00
147_V232_V1.2491.00
257_I272_A1.2441.00
45_P50_S1.2441.00
335_R352_W1.2371.00
146_S229_Q1.2331.00
145_R231_D1.2321.00
370_R373_R1.2321.00
4_K103_Q1.2231.00
264_R269_A1.2101.00
126_F140_V1.2081.00
93_L96_G1.2051.00
150_I233_V1.1961.00
173_I228_L1.1951.00
185_P352_W1.1911.00
207_N222_L1.1881.00
178_T186_P1.1871.00
46_P50_S1.1861.00
9_V106_I1.1831.00
110_A239_I1.1791.00
93_L99_W1.1781.00
85_G90_E1.1761.00
194_Q198_Q1.1741.00
207_N223_Q1.1711.00
82_K92_V1.1621.00
107_A273_G1.1621.00
49_K52_L1.1531.00
263_C302_A1.1521.00
25_Q304_A1.1461.00
214_D217_K1.1431.00
83_T89_R1.1411.00
8_I15_A1.1391.00
64_P67_W1.1291.00
106_I276_V1.1281.00
335_R339_W1.1201.00
263_C277_A1.1151.00
46_P49_K1.1081.00
262_A305_A1.1041.00
9_V81_I1.0991.00
135_A138_R1.0991.00
204_L228_L1.0941.00
173_I222_L1.0941.00
63_L67_W1.0941.00
195_R199_A1.0911.00
65_A69_Q1.0861.00
190_R193_L1.0851.00
131_A134_A1.0791.00
9_V108_T1.0771.00
66_N70_E1.0751.00
22_L303_A1.0661.00
134_A138_R1.0651.00
88_T98_S1.0561.00
129_R133_D1.0451.00
150_I235_Y1.0441.00
157_L324_Y1.0431.00
119_D122_G1.0431.00
273_G302_A1.0431.00
302_A305_A1.0421.00
272_A276_V1.0401.00
18_A302_A1.0401.00
5_T28_T1.0391.00
128_L134_A1.0381.00
327_N371_E1.0371.00
179_V205_L1.0321.00
351_I365_T1.0311.00
76_H99_W1.0311.00
49_K53_L1.0301.00
90_E93_L1.0271.00
45_P48_S1.0261.00
198_Q348_Q1.0241.00
261_E312_P1.0241.00
18_A273_G1.0231.00
34_F76_H1.0211.00
60_Q63_L1.0191.00
21_S25_Q1.0181.00
191_Y366_L1.0131.00
93_L97_E1.0111.00
250_N253_T1.0111.00
212_V233_V1.0051.00
259_I272_A1.0021.00
370_R374_P1.0011.00
328_L366_L0.9971.00
340_L343_G0.9961.00
6_I27_F0.9861.00
18_A299_A0.9841.00
145_R169_K0.9751.00
64_P68_W0.9751.00
140_V168_C0.9731.00
45_P49_K0.9711.00
244_Q247_R0.9711.00
207_N226_E0.9701.00
164_T199_A0.9691.00
15_A19_A0.9681.00
217_K229_Q0.9651.00
39_H43_E0.9651.00
83_T87_D0.9601.00
116_P120_A0.9571.00
83_T86_R0.9541.00
34_F81_I0.9541.00
82_K94_T0.9521.00
56_S59_L0.9521.00
197_Q202_R0.9501.00
265_T272_A0.9481.00
25_Q307_L0.9471.00
178_T193_L0.9441.00
68_W71_N0.9401.00
257_I276_V0.9391.00
48_S52_L0.9351.00
253_T258_V0.9321.00
86_R89_R0.9281.00
34_F93_L0.9231.00
144_E168_C0.9231.00
148_V228_L0.9171.00
304_A309_L0.9111.00
173_I207_N0.9111.00
46_P52_L0.9091.00
137_L232_V0.9051.00
259_I277_A0.9051.00
5_T100_H0.9041.00
104_L270_I0.9031.00
68_W73_V0.8981.00
174_E181_G0.8971.00
85_G89_R0.8971.00
40_L43_E0.8961.00
48_S53_L0.8911.00
258_V266_C0.8871.00
146_S168_C0.8821.00
150_I209_I0.8811.00
78_G95_N0.8811.00
63_L66_N0.8801.00
264_R305_A0.8781.00
21_S24_Q0.8741.00
117_L120_A0.8701.00
230_A233_V0.8681.00
32_H74_H0.8681.00
128_L131_A0.8651.00
191_Y195_R0.8651.00
45_P52_L0.8651.00
21_S300_Q0.8601.00
105_F302_A0.8581.00
50_S54_E0.8491.00
63_L68_W0.8451.00
245_L249_A0.8451.00
344_N347_T0.8441.00
156_G174_E0.8401.00
249_A253_T0.8401.00
190_R194_Q0.8391.00
19_A73_V0.8381.00
173_I204_L0.8351.00
130_H135_A0.8301.00
160_A172_V0.8301.00
112_A115_L0.8271.00
62_V66_N0.8241.00
172_V203_I0.8201.00
6_I306_M0.8151.00
244_Q248_E0.8141.00
263_C301_I0.8081.00
177_A186_P0.8011.00
271_F302_A0.8001.00
327_N369_G0.7981.00
22_L306_M0.7981.00
115_L235_Y0.7981.00
47_L50_S0.7931.00
150_I237_I0.7921.00
262_A310_P0.7911.00
129_R137_L0.7911.00
11_G33_L0.7901.00
18_A303_A0.7891.00
334_M337_D0.7891.00
27_F31_L0.7891.00
218_V233_V0.7841.00
66_N69_Q0.7811.00
149_I156_G0.7811.00
8_I18_A0.7811.00
113_R237_I0.7791.00
271_F306_M0.7771.00
264_R267_D0.7761.00
65_A77_S0.7721.00
267_D270_I0.7711.00
89_R93_L0.7661.00
355_L360_L0.7631.00
15_A107_A0.7611.00
184_A330_F0.7611.00
264_R271_F0.7591.00
27_F102_D0.7581.00
119_D211_H0.7561.00
135_A139_E0.7541.00
246_A249_A0.7521.00
61_Q64_P0.7491.00
49_K54_E0.7491.00
50_S57_P0.7481.00
128_L132_G0.7461.00
294_N298_Q0.7451.00
21_S303_A0.7451.00
20_A24_Q0.7441.00
161_A165_Q0.7441.00
188_V364_V0.7441.00
130_H134_A0.7431.00
132_G136_R0.7431.00
147_V234_I0.7411.00
78_G94_T0.7401.00
331_I363_A0.7391.00
184_A320_W0.7371.00
157_L196_H0.7371.00
129_R132_G0.7371.00
83_T88_T0.7361.00
216_E219_E0.7291.00
7_I104_L0.7291.00
118_L121_L0.7291.00
113_R116_P0.7281.00
176_A181_G0.7281.00
249_A267_D0.7281.00
188_V350_A0.7261.00
53_L57_P0.7261.00
101_W269_A0.7251.00
85_G92_V0.7241.00
46_P53_L0.7231.00
171_T230_A0.7221.00
179_V203_I0.7191.00
86_R101_W0.7181.00
138_R166_R0.7161.00
212_V218_V0.7151.00
342_R349_K0.7121.00
262_A312_P0.7091.00
333_D337_D0.7081.00
38_R78_G0.7081.00
212_V220_L0.7081.00
263_C305_A0.7071.00
146_S230_A0.7071.00
178_T190_R0.7041.00
4_K7_I0.7031.00
243_E253_T0.7001.00
50_S55_D0.6971.00
273_G299_A0.6971.00
179_V189_Q0.6961.00
52_L56_S0.6951.00
149_I160_A0.6941.00
297_N300_Q0.6941.00
222_L226_E0.6911.00
295_A299_A0.6911.00
259_I263_C0.6891.00
144_E231_D0.6861.00
192_L328_L0.6851.00
179_V193_L0.6841.00
118_L122_G0.6821.00
22_L307_L0.6811.00
195_R348_Q0.6801.00
320_W330_F0.6791.00
62_V67_W0.6771.00
149_I234_I0.6771.00
5_T99_W0.6771.00
4_K28_T0.6761.00
37_E44_R0.6761.00
321_S371_E0.6751.00
159_L234_I0.6751.00
22_L31_L0.6731.00
129_R134_A0.6721.00
187_P352_W0.6671.00
128_L133_D0.6661.00
20_A71_N0.6661.00
51_M55_D0.6651.00
192_L366_L0.6641.00
67_W72_N0.6631.00
54_E58_Q0.6621.00
63_L71_N0.6611.00
36_D242_N0.6601.00
49_K55_D0.6591.00
171_T228_L0.6581.00
78_G81_I0.6581.00
191_Y194_Q0.6581.00
255_N278_I0.6551.00
47_L51_M0.6531.00
146_S217_K0.6521.00
81_I91_L0.6511.00
304_A308_G0.6491.00
185_P364_V0.6491.00
22_L27_F0.6471.00
17_M296_N0.6441.00
204_L222_L0.6421.00
371_E374_P0.6411.00
48_S51_M0.6391.00
76_H81_I0.6391.00
15_A33_L0.6361.00
215_G219_E0.6361.00
84_L106_I0.6331.00
136_R140_V0.6321.00
209_I220_L0.6321.00
131_A138_R0.6301.00
369_G372_I0.6291.00
136_R139_E0.6281.00
132_G137_L0.6261.00
340_L344_N0.6251.00
251_L257_I0.6251.00
61_Q65_A0.6231.00
335_R354_N0.6231.00
51_M54_E0.6221.00
222_L225_G0.6181.00
196_H203_I0.6171.00
45_P51_M0.6161.00
196_H324_Y0.6161.00
42_Y45_P0.6161.00
67_W70_E0.6161.00
343_G350_A0.6151.00
45_P53_L0.6131.00
156_G236_G0.6131.00
65_A68_W0.6131.00
68_W75_L0.6121.00
115_L120_A0.6111.00
4_K76_H0.6101.00
160_A170_V0.6091.00
129_R135_A0.6081.00
275_D295_A0.6081.00
300_Q304_A0.6071.00
341_C345_P0.6061.00
134_A163_A0.6031.00
114_P235_Y0.6021.00
353_F360_L0.6011.00
53_L56_S0.6011.00
188_V366_L0.6011.00
86_R269_A0.5991.00
35_S75_L0.5991.00
342_R345_P0.5971.00
241_A256_G0.5971.00
134_A137_L0.5961.00
301_I313_L0.5961.00
160_A201_V0.5951.00
27_F307_L0.5931.00
23_R31_L0.5921.00
23_R73_V0.5911.00
334_M364_V0.5911.00
69_Q72_N0.5851.00
132_G138_R0.5841.00
153_G238_G0.5821.00
273_G306_M0.5811.00
17_M299_A0.5791.00
243_E276_V0.5781.00
148_V233_V0.5771.00
6_I303_A0.5771.00
143_P168_C0.5761.00
14_A107_A0.5761.00
256_G290_E0.5761.00
251_L266_C0.5741.00
17_M21_S0.5731.00
39_H132_G0.5711.00
161_A199_A0.5691.00
28_T31_L0.5691.00
178_T336_G0.5691.00
343_G349_K0.5671.00
338_D361_I0.5651.00
114_P120_A0.5641.00
159_L162_S0.5631.00
19_A33_L0.5631.00
189_Q193_L0.5621.00
101_W267_D0.5621.00
272_A277_A0.5621.00
165_Q325_S0.5611.00
17_M300_Q0.5601.00
187_P190_R0.5591.00
104_L269_A0.5591.00
243_E256_G0.5581.00
46_P51_M0.5561.00
308_G313_L0.5551.00
217_K231_D0.5551.00
54_E57_P0.5521.00
74_H77_S0.5521.00
126_F232_V0.5511.00
243_E247_R0.5501.00
365_T373_R0.5491.00
155_I236_G0.5491.00
81_I89_R0.5491.00
62_V65_A0.5481.00
83_T104_L0.5461.00
82_K86_R0.5461.00
180_M192_L0.5451.00
196_H201_V0.5441.00
256_G278_I0.5441.00
128_L137_L0.5441.00
329_Q370_R0.5431.00
163_A168_C0.5411.00
25_Q309_L0.5401.00
343_G346_E0.5371.00
251_L267_D0.5371.00
157_L203_I0.5361.00
253_T257_I0.5351.00
15_A35_S0.5341.00
355_L358_G0.5341.00
341_C344_N0.5331.00
46_P55_D0.5321.00
308_G312_P0.5311.00
120_A235_Y0.5311.00
265_T270_I0.5271.00
271_F309_L0.5261.00
82_K85_G0.5251.00
195_R366_L0.5251.00
61_Q68_W0.5241.00
81_I85_G0.5241.00
134_A140_V0.5211.00
81_I86_R0.5211.00
257_I265_T0.5201.00
115_L237_I0.5191.00
40_L75_L0.5171.00
45_P54_E0.5171.00
6_I103_Q0.5151.00
50_S56_S0.5131.00
126_F129_R0.5131.00
148_V171_T0.5121.00
157_L179_V0.5101.00
16_A33_L0.5091.00
342_R347_T0.5091.00
277_A298_Q0.5081.00
8_I107_A0.5061.00
174_E177_A0.5061.00
249_A266_C0.5051.00
18_A22_L0.5051.00
46_P56_S0.5021.00
214_D218_V0.5021.00
127_T133_D0.5011.00
253_T256_G0.5001.00
127_T130_H0.5001.00
261_E280_R0.5001.00
175_L181_G0.5001.00
351_I355_L0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1q1rA 1 0.9975 100 0.233 Contact Map
3lxdA 1 1 100 0.234 Contact Map
3fg2P 1 0.9925 100 0.243 Contact Map
2gqwA 2 0.97 100 0.251 Contact Map
3ef6A 1 0.99 100 0.261 Contact Map
3kljA 1 0.94 100 0.262 Contact Map
3iwaA 2 0.875 100 0.264 Contact Map
3icsA 2 0.995 100 0.277 Contact Map
3ntdA 2 0.9925 100 0.277 Contact Map
4fx9A 2 0.985 100 0.287 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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