GREMLIN Database
YDIU - UPF0061 protein YdiU
UniProt: P77649 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13980
Length: 478 (467)
Sequences: 2332 (1623)
Seq/√Len: 75.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
176_L200_A4.8371.00
235_T328_R4.7581.00
348_E395_R4.6751.00
342_D399_R4.1251.00
290_A317_Y3.9861.00
142_I236_V3.9781.00
18_T114_Y3.8691.00
230_I290_A3.8541.00
452_N455_S3.4821.00
197_A215_Y3.1861.00
353_M363_T3.1651.00
358_S363_T3.1201.00
349_L363_T3.0401.00
339_Q402_Q2.9201.00
95_L101_T2.8791.00
31_I440_M2.8651.00
429_Q433_E2.7461.00
296_R299_Q2.7321.00
137_M257_Y2.7291.00
207_H221_D2.6811.00
127_T150_I2.6461.00
421_L449_A2.5751.00
51_G55_W2.4541.00
37_L171_V2.4511.00
198_D215_Y2.4201.00
19_A65_S2.3741.00
434_A442_E2.3491.00
283_F360_Y2.3271.00
248_M290_A2.2951.00
96_L100_T2.2661.00
380_R390_D2.2461.00
181_F250_L2.2181.00
421_L457_R2.1751.00
30_L52_A2.1401.00
369_L456_D2.1241.00
61_L64_M2.1121.00
243_M290_A2.1041.00
220_S316_S2.0901.00
200_A250_L2.0901.00
189_E192_K2.0901.00
349_L353_M2.0851.00
34_N131_S2.0781.00
132_L423_L2.0761.00
291_L318_Q2.0731.00
368_S415_Q2.0471.00
413_L417_V2.0221.00
26_N155_S2.0061.00
111_L117_M1.9971.00
8_R199_F1.9911.00
37_L40_T1.9831.00
389_F393_F1.9741.00
96_L102_M1.9521.00
197_A304_F1.9511.00
228_S324_H1.9411.00
420_A456_D1.9091.00
223_V313_A1.8891.00
53_G59_A1.8831.00
297_L300_T1.8811.00
330_R338_E1.8801.00
445_R460_D1.8711.00
89_I109_A1.8711.00
69_Q180_H1.8521.00
22_P89_I1.8451.00
218_W222_V1.8411.00
158_Y162_A1.8291.00
236_V332_K1.8241.00
201_I215_Y1.7801.00
36_E451_R1.7671.00
427_L430_R1.7481.00
135_E146_R1.7361.00
324_H327_E1.7161.00
178_F248_M1.7141.00
149_S169_M1.6811.00
24_P121_R1.6801.00
264_D465_P1.6771.00
431_A442_E1.6651.00
25_L58_E1.6451.00
202_R209_A1.6401.00
268_P354_A1.6401.00
132_L443_L1.6391.00
29_R152_T1.6371.00
48_F51_G1.6361.00
333_L349_L1.6331.00
434_A439_D1.6181.00
67_L90_L1.6111.00
16_T184_F1.6010.99
219_F298_A1.5980.99
431_A446_L1.5740.99
381_D386_R1.5720.99
194_R198_D1.5690.99
42_S97_A1.5680.99
224_A320_V1.5610.99
40_T102_M1.5520.99
7_T11_D1.5480.99
205_W221_D1.5450.99
178_F226_T1.5410.99
362_R366_M1.5400.99
220_S313_A1.5390.99
226_T290_A1.5360.99
324_H328_R1.5340.99
34_N37_L1.5180.99
230_I243_M1.5150.99
406_S409_E1.5120.99
449_A457_R1.5120.99
219_F310_L1.5060.99
227_A231_A1.5020.99
239_A263_L1.4970.99
156_P162_A1.4740.99
104_W169_M1.4680.99
311_N315_D1.4650.99
70_V183_H1.4580.99
232_Q328_R1.4560.99
239_A270_F1.4460.99
176_L181_F1.4350.99
221_D225_R1.4240.99
56_G151_V1.4130.99
173_P253_L1.4130.99
31_I124_L1.4120.99
234_Q321_L1.4120.99
305_V310_L1.4040.99
151_V169_M1.3960.99
201_I218_W1.3750.98
433_E437_K1.3660.98
263_L270_F1.3600.98
20_L113_P1.3470.98
12_E16_T1.3420.98
365_R368_S1.3300.98
161_T436_E1.3090.98
216_R313_A1.3080.98
221_D224_A1.3040.98
231_A328_R1.3020.98
219_F223_V1.3000.98
17_Y67_L1.2820.97
18_T113_P1.2780.97
123_V163_E1.2670.97
337_T403_D1.2670.97
200_A218_W1.2640.97
325_Y329_M1.2620.97
224_A324_H1.2600.97
435_A440_M1.2510.97
282_S285_N1.2460.97
144_T257_Y1.2360.97
42_S96_L1.2340.97
219_F314_L1.2320.97
214_K218_W1.2320.97
322_L343_N1.2320.97
15_E192_K1.2300.97
326_G330_R1.2290.97
428_A450_L1.2260.97
157_V165_G1.2250.97
442_E461_Y1.2240.97
291_L295_Q1.2230.97
52_A55_W1.2230.97
69_Q105_H1.2230.97
194_R215_Y1.2220.97
35_T49_K1.2200.97
136_A140_L1.2160.97
430_R442_E1.2160.97
184_F192_K1.2130.96
39_N45_S1.2070.96
193_V300_T1.1950.96
90_L103_D1.1950.96
32_W131_S1.1900.96
32_W443_L1.1820.96
381_D384_I1.1820.96
102_M171_V1.1800.96
423_L428_A1.1780.96
211_D217_L1.1770.96
360_Y364_F1.1740.96
412_Q416_S1.1720.96
329_M360_Y1.1720.96
63_G66_P1.1680.96
447_H450_L1.1660.96
431_A443_L1.1630.96
407_D410_R1.1620.96
351_S355_R1.1610.95
88_G105_H1.1580.95
127_T168_L1.1520.95
230_I317_Y1.1510.95
133_A260_F1.1490.95
449_A461_Y1.1440.95
23_T121_R1.1410.95
369_L415_Q1.1370.95
445_R461_Y1.1310.95
326_G343_N1.1260.95
122_A166_A1.1240.95
222_V297_L1.1180.94
410_R413_L1.1160.94
229_L243_M1.1130.94
405_V413_L1.1110.94
181_F197_A1.1080.94
447_H451_R1.1070.94
33_H48_F1.1030.94
275_S474_V1.1010.94
298_A310_L1.0990.94
31_I443_L1.0910.94
72_S79_W1.0850.94
66_P91_L1.0680.93
224_A316_S1.0660.93
239_A272_C1.0530.92
208_L214_K1.0510.92
93_E101_T1.0480.92
399_R403_D1.0420.92
16_T192_K1.0360.92
182_E186_Y1.0350.92
100_T173_P1.0340.92
387_A391_D1.0340.92
103_D175_H1.0330.92
365_R456_D1.0320.92
452_N457_R1.0320.92
218_W250_L1.0320.92
332_K361_T1.0240.91
124_L128_I1.0230.91
312_E315_D1.0220.91
147_A168_L1.0210.91
198_D201_I1.0160.91
82_Q183_H1.0150.91
228_S320_V1.0060.91
22_P60_L1.0050.91
411_Q415_Q1.0020.91
20_L67_L1.0000.90
263_L266_Y0.9990.90
23_T89_I0.9990.90
381_D385_D0.9980.90
44_P48_F0.9960.90
413_L416_S0.9950.90
209_A214_K0.9930.90
152_T440_M0.9880.90
285_N288_A0.9880.90
336_M403_D0.9860.90
217_L221_D0.9850.90
469_G472_L0.9840.90
222_V301_L0.9840.90
191_E194_R0.9820.90
137_M254_T0.9820.90
122_A127_T0.9800.90
128_I440_M0.9780.89
448_E451_R0.9710.89
403_D410_R0.9710.89
32_W444_H0.9690.89
214_K217_L0.9670.89
198_D214_K0.9660.89
32_W447_H0.9660.89
47_L51_G0.9650.89
182_E296_R0.9640.89
81_G183_H0.9630.89
226_T230_I0.9620.89
133_A137_M0.9610.89
69_Q103_D0.9610.89
197_A218_W0.9570.88
53_G58_E0.9550.88
421_L456_D0.9480.88
231_A235_T0.9460.88
466_P469_G0.9450.88
157_V160_E0.9450.88
193_V303_P0.9410.88
26_N121_R0.9400.87
329_M346_L0.9360.87
101_T199_F0.9350.87
442_E445_R0.9340.87
288_A291_L0.9330.87
142_I232_Q0.9310.87
20_L89_I0.9310.87
460_D463_S0.9310.87
35_T45_S0.9290.87
205_W225_R0.9280.87
430_R460_D0.9240.87
80_A183_H0.9230.87
123_V126_S0.9160.86
50_N59_A0.9150.86
248_M293_N0.9140.86
37_L41_L0.9100.86
261_G474_V0.9060.85
132_L447_H0.9060.85
211_D214_K0.9050.85
121_R155_S0.9030.85
197_A201_I0.8970.85
97_A102_M0.8930.85
70_V82_Q0.8900.84
55_W169_M0.8890.84
93_E203_H0.8850.84
232_Q454_F0.8830.84
105_H167_M0.8830.84
160_E274_H0.8790.84
193_V197_A0.8750.83
267_E354_A0.8730.83
316_S320_V0.8690.83
143_P232_Q0.8690.83
31_I152_T0.8690.83
365_R415_Q0.8680.83
70_V184_F0.8680.83
128_I435_A0.8660.83
248_M294_L0.8650.83
176_L250_L0.8620.83
52_A151_V0.8610.82
48_F55_W0.8610.82
217_L220_S0.8590.82
341_E344_A0.8580.82
315_D318_Q0.8580.82
468_W472_L0.8570.82
201_I208_L0.8560.82
44_P47_L0.8560.82
468_W471_R0.8550.82
466_P471_R0.8540.82
216_R305_V0.8530.82
25_L56_G0.8530.82
10_R17_Y0.8520.82
358_S383_F0.8500.82
313_A316_S0.8490.82
243_M248_M0.8490.82
420_A455_S0.8450.81
474_V477_S0.8430.81
160_E163_E0.8430.81
145_T253_L0.8430.81
208_L221_D0.8420.81
52_A56_G0.8410.81
330_R403_D0.8410.81
60_L66_P0.8400.81
272_C275_S0.8400.81
25_L28_A0.8390.81
23_T26_N0.8360.81
291_L317_Y0.8360.81
330_R342_D0.8350.80
269_G284_D0.8330.80
208_L217_L0.8320.80
88_G255_L0.8290.80
355_R388_A0.8280.80
7_T10_R0.8280.80
379_L383_F0.8250.80
28_A58_E0.8230.79
254_T257_Y0.8230.79
184_F187_R0.8220.79
125_R163_E0.8210.79
181_F196_L0.8210.79
15_E189_E0.8200.79
105_H134_S0.8140.79
352_L356_E0.8130.79
330_R335_F0.8130.79
228_S232_Q0.8120.79
98_D102_M0.8110.78
342_D403_D0.8080.78
79_W187_R0.8070.78
201_I209_A0.8070.78
440_M443_L0.8060.78
33_H38_A0.8050.78
34_N135_E0.8040.78
427_L446_L0.8040.78
223_V227_A0.8030.78
350_F360_Y0.8020.78
331_Q417_V0.8000.78
55_W149_S0.7980.77
291_L314_L0.7980.77
421_L459_D0.7980.77
299_Q302_S0.7960.77
173_P251_L0.7950.77
164_P436_E0.7950.77
222_V250_L0.7940.77
271_I275_S0.7930.77
25_L121_R0.7920.77
343_N347_N0.7920.77
380_R383_F0.7920.77
79_W186_Y0.7870.76
396_Y400_L0.7850.76
414_M418_N0.7850.76
227_A328_R0.7840.76
41_L171_V0.7820.76
194_R214_K0.7810.76
393_F397_R0.7780.76
263_L360_Y0.7760.75
269_G282_S0.7740.75
234_Q287_P0.7730.75
395_R398_G0.7720.75
27_N154_D0.7700.75
267_E284_D0.7700.75
33_H51_G0.7690.75
224_A228_S0.7690.75
291_L311_N0.7680.75
265_D470_K0.7660.74
302_S310_L0.7660.74
138_H146_R0.7630.74
345_L349_L0.7600.74
365_R369_L0.7580.74
373_H390_D0.7580.74
70_V80_A0.7520.73
105_H169_M0.7500.73
35_T39_N0.7500.73
8_R101_T0.7490.73
330_R339_Q0.7480.73
139_Y451_R0.7450.72
72_S80_A0.7440.72
391_D395_R0.7440.72
42_S100_T0.7440.72
405_V409_E0.7410.72
132_L428_A0.7410.72
137_M144_T0.7410.72
125_R477_S0.7380.72
13_L16_T0.7370.72
271_I274_H0.7340.71
239_A474_V0.7340.71
9_W13_L0.7310.71
294_L314_L0.7310.71
185_Y299_Q0.7290.71
23_T111_L0.7230.70
239_A271_I0.7200.70
234_Q325_Y0.7200.70
434_A441_T0.7190.70
409_E412_Q0.7190.70
105_H175_H0.7190.70
342_D345_L0.7180.70
201_I250_L0.7160.69
362_R382_E0.7160.69
230_I248_M0.7160.69
137_M332_K0.7130.69
192_K195_Q0.7080.69
13_L17_Y0.7070.68
329_M350_F0.7070.68
292_W296_R0.7070.68
208_L211_D0.7070.68
326_G346_L0.7060.68
330_R399_R0.7060.68
412_Q437_K0.7030.68
40_T98_D0.6990.68
467_D471_R0.6980.67
80_A255_L0.6970.67
464_R467_D0.6940.67
157_V163_E0.6910.67
394_A398_G0.6890.66
128_I432_I0.6890.66
361_T422_V0.6880.66
219_F294_L0.6870.66
70_V79_W0.6870.66
432_I440_M0.6860.66
172_A253_L0.6850.66
199_F203_H0.6850.66
230_I285_N0.6830.66
25_L165_G0.6830.66
40_T96_L0.6820.66
45_S48_F0.6820.66
12_E15_E0.6810.66
121_R124_L0.6810.66
25_L167_M0.6790.65
103_D168_L0.6770.65
133_A428_A0.6770.65
455_S458_D0.6760.65
397_R400_L0.6750.65
213_D217_L0.6750.65
9_W69_Q0.6740.65
232_Q235_T0.6690.64
77_G280_R0.6680.64
38_A48_F0.6680.64
301_L305_V0.6670.64
429_Q472_L0.6670.64
365_R420_A0.6660.64
239_A275_S0.6650.64
349_L358_S0.6650.64
356_E388_A0.6600.63
372_Q415_Q0.6590.63
320_V324_H0.6580.63
82_Q105_H0.6580.63
430_R434_A0.6560.63
370_T393_F0.6550.62
345_L399_R0.6550.62
30_L33_H0.6530.62
29_R438_G0.6520.62
133_A262_F0.6520.62
306_A309_A0.6520.62
7_T94_Q0.6510.62
151_V167_M0.6510.62
421_L462_V0.6460.61
458_D463_S0.6450.61
339_Q342_D0.6430.61
44_P51_G0.6430.61
383_F390_D0.6420.61
380_R385_D0.6410.61
200_A249_S0.6410.61
82_Q187_R0.6400.61
201_I383_F0.6390.61
185_Y188_R0.6390.61
270_F428_A0.6380.60
45_S51_G0.6370.60
81_G175_H0.6370.60
444_H448_E0.6370.60
9_W12_E0.6360.60
72_S183_H0.6360.60
344_A348_E0.6360.60
64_M92_G0.6360.60
104_W149_S0.6360.60
25_L153_S0.6350.60
28_A56_G0.6350.60
49_K52_A0.6350.60
369_L459_D0.6340.60
74_H182_E0.6330.60
134_S147_A0.6330.60
341_E399_R0.6330.60
58_E167_M0.6320.60
127_T184_F0.6320.60
416_S452_N0.6310.60
215_Y304_F0.6300.60
94_Q97_A0.6300.60
9_W180_H0.6300.60
163_E429_Q0.6280.59
449_A459_D0.6280.59
33_H36_E0.6280.59
25_L155_S0.6280.59
420_A457_R0.6250.59
125_R475_S0.6220.59
273_N477_S0.6210.58
72_S184_F0.6190.58
336_M405_V0.6180.58
294_L329_M0.6180.58
201_I214_K0.6170.58
359_D424_R0.6160.58
13_L195_Q0.6140.58
126_S273_N0.6140.58
239_A426_W0.6140.58
289_V293_N0.6130.57
319_Q327_E0.6120.57
366_M369_L0.6120.57
400_L410_R0.6120.57
260_F273_N0.6080.57
336_M342_D0.6080.57
352_L388_A0.6080.57
60_L67_L0.6070.57
461_Y465_P0.6070.57
390_D393_F0.6070.57
306_A310_L0.6060.57
380_R389_F0.6040.56
194_R197_A0.6030.56
368_S456_D0.6030.56
178_F297_L0.6020.56
235_T454_F0.6020.56
35_T46_S0.6020.56
125_R273_N0.6000.56
261_G270_F0.6000.56
153_S239_A0.5990.56
13_L192_K0.5980.56
464_R468_W0.5980.56
396_Y410_R0.5970.55
164_P438_G0.5970.55
268_P284_D0.5970.55
202_R221_D0.5950.55
207_H225_R0.5940.55
228_S328_R0.5940.55
172_A255_L0.5930.55
428_A432_I0.5930.55
33_H47_L0.5920.55
459_D462_V0.5920.55
235_T329_M0.5900.55
7_T63_G0.5900.55
245_T294_L0.5890.54
295_Q299_Q0.5890.54
288_A322_L0.5880.54
362_R464_R0.5870.54
330_R337_T0.5870.54
430_R445_R0.5870.54
465_P469_G0.5860.54
385_D390_D0.5850.54
199_F250_L0.5840.54
384_I389_F0.5830.54
270_F472_L0.5830.54
20_L68_A0.5830.54
328_R331_Q0.5830.54
197_A222_V0.5820.54
16_T70_V0.5810.53
168_L175_H0.5800.53
156_P164_P0.5800.53
386_R390_D0.5800.53
135_E138_H0.5800.53
219_F305_V0.5760.53
458_D462_V0.5760.53
266_Y400_L0.5750.53
319_Q322_L0.5750.53
319_Q323_T0.5750.53
93_E103_D0.5750.53
421_L455_S0.5750.53
153_S165_G0.5750.53
399_R410_R0.5730.52
10_R67_L0.5720.52
14_P19_A0.5710.52
370_T397_R0.5700.52
264_D284_D0.5690.52
94_Q104_W0.5670.52
16_T180_H0.5660.52
409_E413_L0.5660.52
452_N458_D0.5640.51
249_S297_L0.5640.51
87_R122_A0.5640.51
8_R203_H0.5630.51
132_L451_R0.5630.51
36_E39_N0.5630.51
226_T273_N0.5620.51
132_L254_T0.5610.51
32_W150_I0.5600.51
370_T373_H0.5600.51
349_L392_W0.5590.51
383_F389_F0.5590.51
60_L167_M0.5590.51
131_S147_A0.5580.51
368_S414_M0.5580.51
215_Y218_W0.5580.51
189_E193_V0.5580.51
208_L213_D0.5560.50
223_V320_V0.5550.50
280_R292_W0.5550.50
127_T175_H0.5540.50
133_A261_G0.5530.50
327_E331_Q0.5520.50
265_D268_P0.5520.50
33_H55_W0.5510.50
307_V335_F0.5500.50
275_S475_S0.5490.49
321_L326_G0.5490.49
415_Q455_S0.5490.49
182_E299_Q0.5480.49
141_G465_P0.5470.49
104_W171_V0.5460.49
340_K343_N0.5460.49
82_Q184_F0.5450.49
75_Q83_L0.5440.49
36_E40_T0.5440.49
236_V361_T0.5440.49
126_S477_S0.5430.49
358_S382_E0.5430.49
132_L431_A0.5430.49
81_G94_Q0.5420.49
17_Y199_F0.5410.48
7_T65_S0.5410.48
288_A318_Q0.5410.48
154_D271_I0.5400.48
8_R11_D0.5400.48
152_T164_P0.5390.48
133_A254_T0.5380.48
432_I472_L0.5370.48
143_P228_S0.5350.48
79_W82_Q0.5340.48
234_Q454_F0.5340.48
80_A88_G0.5340.48
184_F195_Q0.5330.47
7_T101_T0.5320.47
228_S231_A0.5320.47
127_T147_A0.5310.47
260_F477_S0.5310.47
466_P470_K0.5310.47
444_H447_H0.5300.47
121_R353_M0.5300.47
190_S303_P0.5300.47
219_F297_L0.5280.47
337_T402_Q0.5280.47
22_P58_E0.5270.47
31_I150_I0.5270.47
429_Q436_E0.5270.47
50_N53_G0.5260.47
235_T360_Y0.5260.47
461_Y464_R0.5250.46
323_T327_E0.5250.46
200_A251_L0.5240.46
215_Y219_F0.5240.46
200_A205_W0.5240.46
227_A235_T0.5230.46
383_F386_R0.5230.46
273_N475_S0.5220.46
23_T58_E0.5220.46
353_M358_S0.5210.46
231_A324_H0.5210.46
103_D253_L0.5210.46
180_H183_H0.5210.46
318_Q322_L0.5210.46
52_A60_L0.5200.46
349_L364_F0.5200.46
322_L326_G0.5200.46
88_G175_H0.5180.46
150_I443_L0.5170.45
26_N444_H0.5170.45
426_W430_R0.5160.45
368_S417_V0.5150.45
73_G83_L0.5150.45
58_E105_H0.5150.45
229_L364_F0.5140.45
261_G428_A0.5130.45
174_S204_Y0.5120.45
149_S167_M0.5120.45
448_E452_N0.5110.45
136_A139_Y0.5110.45
93_E168_L0.5080.44
74_H240_H0.5080.44
372_Q411_Q0.5060.44
127_T273_N0.5060.44
342_D400_L0.5030.44
356_E384_I0.5030.44
23_T109_A0.5030.44
104_W363_T0.5030.44
79_W299_Q0.5020.44
398_G401_Q0.5020.44
275_S423_L0.5020.44
410_R414_M0.5020.44
265_D357_R0.5010.43
444_H459_D0.5010.43
300_T303_P0.5010.43
23_T155_S0.5010.43
273_N474_V0.5000.43
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2o4tA 2 0.1862 44.5 0.982 Contact Map
3tm0A 1 0.3661 34.4 0.983 Contact Map
2ppqA 2 0.5523 32.4 0.983 Contact Map
1zarA 1 0.5021 32.1 0.983 Contact Map
3dxpA 2 0.5753 30.1 0.984 Contact Map
2olcA 3 0.5126 26.7 0.984 Contact Map
2pywA 2 0.7197 25.4 0.984 Contact Map
1zylA 1 0.6318 21.7 0.985 Contact Map
2hh6A 2 0.2218 21.4 0.985 Contact Map
4dcaA 1 0.5209 19.8 0.985 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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