GREMLIN Database
YFBT - Sugar phosphatase YfbT
UniProt: P77625 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG14104
Length: 216 (201)
Sequences: 28631 (22551)
Seq/√Len: 1590.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
4_K157_E4.0921.00
136_R140_E2.8761.00
118_K123_P2.8681.00
146_L150_L2.8391.00
110_M114_R2.5551.00
171_G178_V2.5391.00
5_G153_L2.4231.00
93_S124_A2.3851.00
162_E167_G2.3701.00
89_I93_S2.3171.00
101_P126_E2.2931.00
3_C177_H2.2811.00
146_L149_Q2.2641.00
110_M133_R2.2411.00
103_A127_V2.2331.00
136_R142_D2.1391.00
8_F102_W2.1021.00
198_H202_Q2.0931.00
105_V143_A2.0871.00
148_A158_C2.0691.00
127_V150_L2.0361.00
106_T113_A2.0281.00
168_V178_V2.0261.00
172_L194_D1.9711.00
154_A157_E1.9181.00
94_H98_A1.8901.00
169_L173_A1.8871.00
96_N124_A1.7851.00
6_F100_I1.7691.00
177_H194_D1.7471.00
31_R70_R1.7261.00
96_N126_E1.7011.00
160_V171_G1.6821.00
148_A176_C1.6661.00
159_V179_I1.6551.00
114_R123_P1.6011.00
102_W125_P1.5921.00
5_G151_L1.5821.00
7_L147_G1.5741.00
7_L160_V1.5201.00
88_A200_L1.5161.00
153_L158_C1.5141.00
182_N198_H1.5111.00
148_A155_P1.5071.00
7_L105_V1.4931.00
50_T53_R1.3921.00
6_F95_L1.3911.00
6_F161_V1.3911.00
85_L183_A1.3481.00
103_A151_L1.3451.00
165_P169_L1.3381.00
94_H97_K1.3311.00
179_I197_L1.3211.00
13_T161_V1.3031.00
63_D66_A1.3021.00
182_N196_V1.2901.00
14_L88_A1.2811.00
91_L200_L1.2791.00
179_I195_L1.2671.00
66_A70_R1.2651.00
10_L15_V1.2491.00
114_R118_K1.2421.00
87_G90_A1.2321.00
199_S202_Q1.2271.00
10_L113_A1.2071.00
27_N31_R1.2041.00
144_Y160_V1.1971.00
10_L104_I1.1881.00
129_V150_L1.1881.00
37_E41_A1.1651.00
141_P145_L1.1631.00
32_H70_R1.1541.00
23_R27_N1.1541.00
113_A130_T1.1411.00
129_V147_G1.1331.00
7_L158_C1.1301.00
5_G158_C1.1301.00
144_Y170_S1.1291.00
90_A201_E1.1131.00
84_A122_L1.1011.00
158_C176_C1.1001.00
187_T191_N1.0891.00
70_R73_H1.0881.00
96_N102_W1.0841.00
5_G101_P1.0821.00
67_E71_L1.0791.00
49_I53_R1.0761.00
11_D17_S1.0761.00
69_T73_H1.0711.00
142_D146_L1.0631.00
93_S97_K1.0621.00
144_Y176_C1.0591.00
3_C159_V1.0451.00
64_I67_E1.0371.00
92_L125_P1.0231.00
145_L149_Q1.0221.00
28_W32_H1.0131.00
23_R26_S1.0111.00
26_S30_R1.0071.00
27_N30_R1.0051.00
188_P191_N0.9971.00
172_L178_V0.9941.00
110_M130_T0.9911.00
145_L174_A0.9861.00
46_K50_T0.9801.00
105_V147_G0.9791.00
68_F72_E0.9781.00
77_T80_E0.9611.00
10_L108_G0.9601.00
89_I124_A0.9571.00
147_G151_L0.9571.00
127_V151_L0.9541.00
50_T54_H0.9531.00
61_E64_I0.9511.00
115_A119_I0.9441.00
160_V176_C0.9401.00
5_G103_A0.9391.00
115_A118_K0.9341.00
166_A169_L0.9301.00
168_V193_V0.9271.00
110_M132_E0.9141.00
29_A34_L0.9111.00
67_E70_R0.9111.00
180_A190_L0.9091.00
90_A93_S0.9061.00
142_D145_L0.9061.00
104_I125_P0.9051.00
186_D189_R0.9011.00
53_R57_A0.8931.00
47_Q50_T0.8901.00
38_E42_F0.8881.00
23_R81_G0.8841.00
84_A89_I0.8801.00
11_D108_G0.8771.00
177_H195_L0.8611.00
134_V146_L0.8601.00
87_G199_S0.8591.00
135_K142_D0.8561.00
7_L151_L0.8541.00
144_Y162_E0.8521.00
106_T130_T0.8521.00
102_W124_A0.8521.00
65_A69_T0.8501.00
129_V146_L0.8501.00
85_L181_V0.8491.00
145_L155_P0.8461.00
22_E26_S0.8431.00
11_D106_T0.8431.00
187_T198_H0.8391.00
54_H57_A0.8361.00
161_V179_I0.8351.00
46_K54_H0.8341.00
113_A116_R0.8281.00
155_P176_C0.8271.00
10_L116_R0.8241.00
95_L102_W0.8221.00
7_L176_C0.8191.00
69_T72_E0.8101.00
4_K100_I0.8091.00
95_L100_I0.8071.00
40_L43_I0.8011.00
159_V177_H0.7961.00
15_V116_R0.7951.00
48_A51_S0.7941.00
85_L88_A0.7921.00
63_D67_E0.7911.00
103_A147_G0.7901.00
73_H76_A0.7881.00
48_A52_L0.7851.00
170_S174_A0.7841.00
130_T133_R0.7821.00
61_E65_A0.7811.00
168_V180_A0.7791.00
197_L203_I0.7781.00
108_G113_A0.7741.00
19_P83_T0.7741.00
6_F159_V0.7731.00
24_A28_W0.7661.00
60_S63_D0.7661.00
178_V194_D0.7641.00
117_H123_P0.7611.00
49_I65_A0.7601.00
27_N77_T0.7581.00
44_H47_Q0.7571.00
92_L124_A0.7491.00
87_G201_E0.7491.00
180_A196_V0.7471.00
153_L157_E0.7471.00
15_V120_A0.7441.00
143_A147_G0.7441.00
4_K101_P0.7431.00
53_R64_I0.7431.00
189_R192_E0.7351.00
64_I68_F0.7291.00
3_C100_I0.7291.00
127_V147_G0.7271.00
21_V25_W0.7261.00
66_A69_T0.7251.00
52_L56_M0.7241.00
26_S37_E0.7231.00
39_V42_F0.7141.00
74_I78_E0.7051.00
188_P192_E0.7051.00
133_R150_L0.7001.00
114_R128_F0.6991.00
68_F71_L0.6961.00
84_A120_A0.6951.00
12_G18_L0.6911.00
90_A94_H0.6901.00
101_P153_L0.6861.00
89_I121_G0.6841.00
197_L200_L0.6841.00
107_S137_G0.6791.00
169_L172_L0.6781.00
87_G91_L0.6741.00
144_Y167_G0.6731.00
141_P173_A0.6721.00
155_P158_C0.6711.00
27_N74_I0.6701.00
183_A200_L0.6671.00
161_V203_I0.6671.00
113_A128_F0.6631.00
102_W126_E0.6601.00
39_V43_I0.6591.00
22_E40_L0.6561.00
62_A66_A0.6551.00
4_K153_L0.6551.00
16_D83_T0.6521.00
38_E41_A0.6491.00
3_C157_E0.6471.00
30_R35_A0.6461.00
16_D19_P0.6441.00
143_A170_S0.6401.00
15_V82_I0.6401.00
47_Q51_S0.6391.00
91_L161_V0.6391.00
11_D163_D0.6391.00
21_V108_G0.6381.00
74_I77_T0.6371.00
125_P128_F0.6371.00
129_V143_A0.6351.00
179_I203_I0.6311.00
8_F91_L0.6241.00
44_H51_S0.6241.00
7_L103_A0.6221.00
160_V170_S0.6211.00
160_V167_G0.6161.00
88_A92_L0.6091.00
134_V143_A0.6071.00
11_D116_R0.6041.00
20_A82_I0.6031.00
93_S96_N0.6011.00
13_T167_G0.5981.00
113_A117_H0.5971.00
54_H58_G0.5961.00
105_V160_V0.5941.00
180_A193_V0.5921.00
72_E75_E0.5901.00
148_A153_L0.5851.00
16_D85_L0.5851.00
79_T115_A0.5851.00
131_A143_A0.5831.00
91_L94_H0.5771.00
181_V200_L0.5751.00
42_F54_H0.5751.00
52_L55_F0.5741.00
64_I71_L0.5691.00
13_T181_V0.5691.00
105_V129_V0.5681.00
51_S54_H0.5671.00
17_S108_G0.5651.00
86_P201_E0.5631.00
117_H122_L0.5571.00
37_E40_L0.5571.00
166_A170_S0.5561.00
111_P115_A0.5531.00
22_E37_E0.5511.00
44_H48_A0.5511.00
148_A174_A0.5501.00
145_L148_A0.5491.00
46_K51_S0.5491.00
88_A91_L0.5481.00
62_A65_A0.5461.00
107_S166_A0.5441.00
108_G112_V0.5361.00
170_S173_A0.5331.00
107_S139_P0.5301.00
57_A60_S0.5251.00
107_S131_A0.5241.00
86_P199_S0.5221.00
19_P23_R0.5211.00
7_L144_Y0.5171.00
127_V130_T0.5131.00
23_R77_T0.5111.00
144_Y171_G0.5101.00
168_V172_L0.5091.00
21_V24_A0.5071.00
25_W29_A0.5031.00
79_T119_I0.5021.00
51_S56_M0.5011.00
6_F102_W0.5011.00
91_L95_L0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4eekA 2 1 100 0.316 Contact Map
2hi0A 2 0.9722 100 0.317 Contact Map
2hdoA 1 0.9444 100 0.318 Contact Map
1te2A 2 0.9676 100 0.32 Contact Map
4uw9A 1 0.9213 100 0.326 Contact Map
3d6jA 1 0.9398 100 0.327 Contact Map
3s6jA 2 0.9722 100 0.328 Contact Map
3l5kA 1 0.9907 100 0.329 Contact Map
3nasA 2 0.9259 100 0.33 Contact Map
2om6A 2 0.9676 100 0.33 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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