YFBT - ECOLI - GREMLIN Contacts

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YFBT - Sugar phosphatase YfbT

UniProt:	P77625	Sequences: MRCKGFLFDLDGTLVDSLPAVERAWSNWARRHGLAPEEVLAFIHGKQAITSLRHFMAGKSEADIAAEFTRLEHIEATETEGITALPGAIALLSHLNKAGIPWAIVTSGSMPVARARHKIAGLPAPEVFVTAERVKRGKPEPDAYLLGAQLLGLAPQECVVVEDAPAGVLSGLAAGCHVIAVNAPADTPRLNEVDLVLHSLEQITVTKQPNGDVIIQ	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG14104
Length:	216 (201)
Sequences:	28631 (22551)
Seq/√Len:	1590.6

ECOLI - YFBT YNIC PGMB GPH YRFG YJJG YIEH YIGB YQAB YIHX
BACSU - YHCW PPAX PGMB YSAA YFNB
HALSA - Q9HQE2 Q9HSS2 Q9HP74 Q9HMC4
SULSO - Q97ZU6 Q7LXL6 Q7LX46 Q97WT6 Q97YZ1 Q97X58

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
4_K	157_E	4.092	1.00
136_R	140_E	2.876	1.00
118_K	123_P	2.868	1.00
146_L	150_L	2.839	1.00
110_M	114_R	2.555	1.00
171_G	178_V	2.539	1.00
5_G	153_L	2.423	1.00
93_S	124_A	2.385	1.00
162_E	167_G	2.370	1.00
89_I	93_S	2.317	1.00
101_P	126_E	2.293	1.00
3_C	177_H	2.281	1.00
146_L	149_Q	2.264	1.00
110_M	133_R	2.241	1.00
103_A	127_V	2.233	1.00
136_R	142_D	2.139	1.00
8_F	102_W	2.102	1.00
198_H	202_Q	2.093	1.00
105_V	143_A	2.087	1.00
148_A	158_C	2.069	1.00
127_V	150_L	2.036	1.00
106_T	113_A	2.028	1.00
168_V	178_V	2.026	1.00
172_L	194_D	1.971	1.00
154_A	157_E	1.918	1.00
94_H	98_A	1.890	1.00
169_L	173_A	1.887	1.00
96_N	124_A	1.785	1.00
6_F	100_I	1.769	1.00
177_H	194_D	1.747	1.00
31_R	70_R	1.726	1.00
96_N	126_E	1.701	1.00
160_V	171_G	1.682	1.00
148_A	176_C	1.666	1.00
159_V	179_I	1.655	1.00
114_R	123_P	1.601	1.00
102_W	125_P	1.592	1.00
5_G	151_L	1.582	1.00
7_L	147_G	1.574	1.00
7_L	160_V	1.520	1.00
88_A	200_L	1.516	1.00
153_L	158_C	1.514	1.00
182_N	198_H	1.511	1.00
148_A	155_P	1.507	1.00
7_L	105_V	1.493	1.00
50_T	53_R	1.392	1.00
6_F	95_L	1.391	1.00
6_F	161_V	1.391	1.00
85_L	183_A	1.348	1.00
103_A	151_L	1.345	1.00
165_P	169_L	1.338	1.00
94_H	97_K	1.331	1.00
179_I	197_L	1.321	1.00
13_T	161_V	1.303	1.00
63_D	66_A	1.302	1.00
182_N	196_V	1.290	1.00
14_L	88_A	1.281	1.00
91_L	200_L	1.279	1.00
179_I	195_L	1.267	1.00
66_A	70_R	1.265	1.00
10_L	15_V	1.249	1.00
114_R	118_K	1.242	1.00
87_G	90_A	1.232	1.00
199_S	202_Q	1.227	1.00
10_L	113_A	1.207	1.00
27_N	31_R	1.204	1.00
144_Y	160_V	1.197	1.00
10_L	104_I	1.188	1.00
129_V	150_L	1.188	1.00
37_E	41_A	1.165	1.00
141_P	145_L	1.163	1.00
32_H	70_R	1.154	1.00
23_R	27_N	1.154	1.00
113_A	130_T	1.141	1.00
129_V	147_G	1.133	1.00
7_L	158_C	1.130	1.00
5_G	158_C	1.130	1.00
144_Y	170_S	1.129	1.00
90_A	201_E	1.113	1.00
84_A	122_L	1.101	1.00
158_C	176_C	1.100	1.00
187_T	191_N	1.089	1.00
70_R	73_H	1.088	1.00
96_N	102_W	1.084	1.00
5_G	101_P	1.082	1.00
67_E	71_L	1.079	1.00
49_I	53_R	1.076	1.00
11_D	17_S	1.076	1.00
69_T	73_H	1.071	1.00
142_D	146_L	1.063	1.00
93_S	97_K	1.062	1.00
144_Y	176_C	1.059	1.00
3_C	159_V	1.045	1.00
64_I	67_E	1.037	1.00
92_L	125_P	1.023	1.00
145_L	149_Q	1.022	1.00
28_W	32_H	1.013	1.00
23_R	26_S	1.011	1.00
26_S	30_R	1.007	1.00
27_N	30_R	1.005	1.00
188_P	191_N	0.997	1.00
172_L	178_V	0.994	1.00
110_M	130_T	0.991	1.00
145_L	174_A	0.986	1.00
46_K	50_T	0.980	1.00
105_V	147_G	0.979	1.00
68_F	72_E	0.978	1.00
77_T	80_E	0.961	1.00
10_L	108_G	0.960	1.00
89_I	124_A	0.957	1.00
147_G	151_L	0.957	1.00
127_V	151_L	0.954	1.00
50_T	54_H	0.953	1.00
61_E	64_I	0.951	1.00
115_A	119_I	0.944	1.00
160_V	176_C	0.940	1.00
5_G	103_A	0.939	1.00
115_A	118_K	0.934	1.00
166_A	169_L	0.930	1.00
168_V	193_V	0.927	1.00
110_M	132_E	0.914	1.00
29_A	34_L	0.911	1.00
67_E	70_R	0.911	1.00
180_A	190_L	0.909	1.00
90_A	93_S	0.906	1.00
142_D	145_L	0.906	1.00
104_I	125_P	0.905	1.00
186_D	189_R	0.901	1.00
53_R	57_A	0.893	1.00
47_Q	50_T	0.890	1.00
38_E	42_F	0.888	1.00
23_R	81_G	0.884	1.00
84_A	89_I	0.880	1.00
11_D	108_G	0.877	1.00
177_H	195_L	0.861	1.00
134_V	146_L	0.860	1.00
87_G	199_S	0.859	1.00
135_K	142_D	0.856	1.00
7_L	151_L	0.854	1.00
144_Y	162_E	0.852	1.00
106_T	130_T	0.852	1.00
102_W	124_A	0.852	1.00
65_A	69_T	0.850	1.00
129_V	146_L	0.850	1.00
85_L	181_V	0.849	1.00
145_L	155_P	0.846	1.00
22_E	26_S	0.843	1.00
11_D	106_T	0.843	1.00
187_T	198_H	0.839	1.00
54_H	57_A	0.836	1.00
161_V	179_I	0.835	1.00
46_K	54_H	0.834	1.00
113_A	116_R	0.828	1.00
155_P	176_C	0.827	1.00
10_L	116_R	0.824	1.00
95_L	102_W	0.822	1.00
7_L	176_C	0.819	1.00
69_T	72_E	0.810	1.00
4_K	100_I	0.809	1.00
95_L	100_I	0.807	1.00
40_L	43_I	0.801	1.00
159_V	177_H	0.796	1.00
15_V	116_R	0.795	1.00
48_A	51_S	0.794	1.00
85_L	88_A	0.792	1.00
63_D	67_E	0.791	1.00
103_A	147_G	0.790	1.00
73_H	76_A	0.788	1.00
48_A	52_L	0.785	1.00
170_S	174_A	0.784	1.00
130_T	133_R	0.782	1.00
61_E	65_A	0.781	1.00
168_V	180_A	0.779	1.00
197_L	203_I	0.778	1.00
108_G	113_A	0.774	1.00
19_P	83_T	0.774	1.00
6_F	159_V	0.773	1.00
24_A	28_W	0.766	1.00
60_S	63_D	0.766	1.00
178_V	194_D	0.764	1.00
117_H	123_P	0.761	1.00
49_I	65_A	0.760	1.00
27_N	77_T	0.758	1.00
44_H	47_Q	0.757	1.00
92_L	124_A	0.749	1.00
87_G	201_E	0.749	1.00
180_A	196_V	0.747	1.00
153_L	157_E	0.747	1.00
15_V	120_A	0.744	1.00
143_A	147_G	0.744	1.00
4_K	101_P	0.743	1.00
53_R	64_I	0.743	1.00
189_R	192_E	0.735	1.00
64_I	68_F	0.729	1.00
3_C	100_I	0.729	1.00
127_V	147_G	0.727	1.00
21_V	25_W	0.726	1.00
66_A	69_T	0.725	1.00
52_L	56_M	0.724	1.00
26_S	37_E	0.723	1.00
39_V	42_F	0.714	1.00
74_I	78_E	0.705	1.00
188_P	192_E	0.705	1.00
133_R	150_L	0.700	1.00
114_R	128_F	0.699	1.00
68_F	71_L	0.696	1.00
84_A	120_A	0.695	1.00
12_G	18_L	0.691	1.00
90_A	94_H	0.690	1.00
101_P	153_L	0.686	1.00
89_I	121_G	0.684	1.00
197_L	200_L	0.684	1.00
107_S	137_G	0.679	1.00
169_L	172_L	0.678	1.00
87_G	91_L	0.674	1.00
144_Y	167_G	0.673	1.00
141_P	173_A	0.672	1.00
155_P	158_C	0.671	1.00
27_N	74_I	0.670	1.00
183_A	200_L	0.667	1.00
161_V	203_I	0.667	1.00
113_A	128_F	0.663	1.00
102_W	126_E	0.660	1.00
39_V	43_I	0.659	1.00
22_E	40_L	0.656	1.00
62_A	66_A	0.655	1.00
4_K	153_L	0.655	1.00
16_D	83_T	0.652	1.00
38_E	41_A	0.649	1.00
3_C	157_E	0.647	1.00
30_R	35_A	0.646	1.00
16_D	19_P	0.644	1.00
143_A	170_S	0.640	1.00
15_V	82_I	0.640	1.00
47_Q	51_S	0.639	1.00
91_L	161_V	0.639	1.00
11_D	163_D	0.639	1.00
21_V	108_G	0.638	1.00
74_I	77_T	0.637	1.00
125_P	128_F	0.637	1.00
129_V	143_A	0.635	1.00
179_I	203_I	0.631	1.00
8_F	91_L	0.624	1.00
44_H	51_S	0.624	1.00
7_L	103_A	0.622	1.00
160_V	170_S	0.621	1.00
160_V	167_G	0.616	1.00
88_A	92_L	0.609	1.00
134_V	143_A	0.607	1.00
11_D	116_R	0.604	1.00
20_A	82_I	0.603	1.00
93_S	96_N	0.601	1.00
13_T	167_G	0.598	1.00
113_A	117_H	0.597	1.00
54_H	58_G	0.596	1.00
105_V	160_V	0.594	1.00
180_A	193_V	0.592	1.00
72_E	75_E	0.590	1.00
148_A	153_L	0.585	1.00
16_D	85_L	0.585	1.00
79_T	115_A	0.585	1.00
131_A	143_A	0.583	1.00
91_L	94_H	0.577	1.00
181_V	200_L	0.575	1.00
42_F	54_H	0.575	1.00
52_L	55_F	0.574	1.00
64_I	71_L	0.569	1.00
13_T	181_V	0.569	1.00
105_V	129_V	0.568	1.00
51_S	54_H	0.567	1.00
17_S	108_G	0.565	1.00
86_P	201_E	0.563	1.00
117_H	122_L	0.557	1.00
37_E	40_L	0.557	1.00
166_A	170_S	0.556	1.00
111_P	115_A	0.553	1.00
22_E	37_E	0.551	1.00
44_H	48_A	0.551	1.00
148_A	174_A	0.550	1.00
145_L	148_A	0.549	1.00
46_K	51_S	0.549	1.00
88_A	91_L	0.548	1.00
62_A	65_A	0.546	1.00
107_S	166_A	0.544	1.00
108_G	112_V	0.536	1.00
170_S	173_A	0.533	1.00
107_S	139_P	0.530	1.00
57_A	60_S	0.525	1.00
107_S	131_A	0.524	1.00
86_P	199_S	0.522	1.00
19_P	23_R	0.521	1.00
7_L	144_Y	0.517	1.00
127_V	130_T	0.513	1.00
23_R	77_T	0.511	1.00
144_Y	171_G	0.510	1.00
168_V	172_L	0.509	1.00
21_V	24_A	0.507	1.00
25_W	29_A	0.503	1.00
79_T	119_I	0.502	1.00
51_S	56_M	0.501	1.00
6_F	102_W	0.501	1.00
91_L	95_L	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4eekA	2	1	100	0.316	Contact Map
2hi0A	2	0.9722	100	0.317	Contact Map
2hdoA	1	0.9444	100	0.318	Contact Map
1te2A	2	0.9676	100	0.32	Contact Map
4uw9A	1	0.9213	100	0.326	Contact Map
3d6jA	1	0.9398	100	0.327	Contact Map
3s6jA	2	0.9722	100	0.328	Contact Map
3l5kA	1	0.9907	100	0.329	Contact Map
3nasA	2	0.9259	100	0.33	Contact Map
2om6A	2	0.9676	100	0.33	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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