GREMLIN Database
ARCM - Carbamate kinase-like protein YahI
UniProt: P77624 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13593
Length: 316 (298)
Sequences: 1302 (847)
Seq/√Len: 49.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
138_D142_D6.3141.00
262_T287_E6.2371.00
256_V261_M4.2011.00
4_L46_D3.7331.00
242_C252_A3.6801.00
244_H249_Q3.6101.00
137_S140_Q3.3711.00
240_K254_D3.2871.00
253_L256_V3.2761.00
37_V47_I2.9591.00
50_T220_T2.9331.00
79_A211_D2.8831.00
202_T208_Q2.5731.00
263_R267_E2.5561.00
265_M276_L2.4611.00
244_H269_H2.4561.00
292_E312_H2.3701.00
240_K252_A2.3401.00
60_D85_T2.3081.00
35_D100_R2.2451.00
138_D161_Y2.2351.00
296_T304_A2.2161.00
192_A219_S2.2111.00
143_E147_A2.1901.00
94_Q111_T2.1781.00
169_E284_T2.0641.00
6_V229_A2.0591.00
222_L226_E2.0531.00
300_C303_A2.0441.00
151_W163_R1.9920.99
7_V37_V1.9780.99
286_L293_V1.9760.99
192_A223_L1.9600.99
243_I251_Q1.9330.99
233_V301_L1.9330.99
235_T301_L1.8880.99
117_E201_R1.8580.99
127_H154_V1.8340.99
117_E172_R1.8050.99
303_A308_E1.7950.99
38_L97_L1.7610.99
220_T232_L1.7450.99
142_D146_K1.7390.99
258_I283_L1.7280.99
239_E242_C1.7220.98
120_K202_T1.7150.98
172_R226_E1.6850.98
62_R136_F1.6600.98
296_T309_T1.6570.98
243_I269_H1.6550.98
239_E309_T1.6310.98
135_F159_R1.5950.97
264_Y267_E1.5940.97
286_L289_G1.5710.97
261_M313_I1.5690.97
257_D260_T1.5680.97
262_T266_Q1.5660.97
21_Q25_H1.5530.97
231_I294_I1.5240.97
221_A225_R1.5050.96
228_H291_K1.4920.96
145_Q153_F1.4620.96
39_E302_P1.4620.96
244_H251_Q1.4610.96
46_D186_G1.4590.96
218_L280_I1.4550.96
5_V45_Y1.4450.95
202_T206_D1.4320.95
225_R284_T1.4270.95
48_V227_I1.4270.95
131_P154_V1.3870.94
78_L82_V1.3810.94
272_P276_L1.3660.94
39_E42_A1.3640.94
172_R201_R1.3590.94
181_A185_Q1.3580.94
172_R176_A1.3370.93
117_E174_V1.3370.93
80_N92_L1.3260.93
246_G250_Q1.3210.93
108_K177_P1.3180.93
180_K184_Q1.3140.93
251_Q260_T1.3030.92
63_R88_G1.3010.92
176_A227_I1.2920.92
142_D161_Y1.2880.92
240_K309_T1.2640.91
110_V178_A1.2560.91
192_A220_T1.2400.90
98_N109_A1.2370.90
221_A284_T1.2340.90
294_I304_A1.2320.90
244_H247_K1.2280.90
62_R134_A1.2240.90
178_A187_F1.2010.89
63_R84_D1.1930.88
131_P135_F1.1830.88
282_S293_V1.1790.88
260_T263_R1.1740.88
115_Q207_Y1.1690.87
95_Q115_Q1.1690.87
91_Y209_S1.1660.87
279_I293_V1.1650.87
262_T280_I1.1630.87
41_L188_V1.1610.87
242_C250_Q1.1590.87
48_V183_I1.1570.87
233_V294_I1.1530.87
101_L109_A1.1500.86
271_P276_L1.1470.86
14_I59_L1.1430.86
231_I292_E1.1390.86
239_E300_C1.1370.86
94_Q115_Q1.1370.86
135_F155_E1.1360.86
60_D63_R1.1310.86
101_L188_V1.1250.85
242_C245_F1.1220.85
183_I227_I1.1120.85
296_T300_C1.1120.85
179_I191_G1.1110.85
141_R150_D1.0990.84
119_D171_K1.0930.84
262_T283_L1.0800.83
15_I25_H1.0800.83
27_A96_A1.0780.83
15_I88_G1.0740.82
155_E159_R1.0630.82
136_F144_L1.0610.82
85_T88_G1.0580.81
156_D159_R1.0560.81
145_Q151_W1.0560.81
141_R145_Q1.0500.81
144_L153_F1.0460.81
145_Q161_Y1.0370.80
64_A84_D1.0340.80
91_Y95_Q1.0330.80
222_L225_R1.0240.79
84_D88_G1.0230.79
106_E177_P1.0220.79
243_I253_L1.0160.79
21_Q59_L1.0140.79
15_I63_R1.0120.78
80_N88_G1.0030.78
23_I80_N1.0000.78
136_F153_F0.9970.77
43_S306_R0.9900.77
4_L45_Y0.9890.77
255_R312_H0.9840.77
178_A181_A0.9780.76
47_I188_V0.9740.76
15_I79_A0.9670.75
135_F156_D0.9660.75
142_D145_Q0.9600.75
46_D107_K0.9590.75
241_V295_I0.9570.74
302_P306_R0.9560.74
23_I79_A0.9530.74
5_V40_M0.9480.74
54_G273_G0.9450.74
91_Y115_Q0.9440.73
82_V116_V0.9440.73
169_E280_I0.9420.73
5_V298_P0.9400.73
23_I76_T0.9360.73
173_I223_L0.9350.73
171_K222_L0.9290.72
23_I92_L0.9270.72
4_L183_I0.9130.71
258_I262_T0.9100.71
30_V93_I0.9080.71
94_Q190_I0.9080.71
116_V220_T0.9070.70
15_I23_I0.8970.70
59_L88_G0.8950.69
228_H289_G0.8930.69
59_L63_R0.8930.69
94_Q113_V0.8920.69
294_I312_H0.8910.69
115_Q174_V0.8890.69
15_I59_L0.8890.69
9_I13_S0.8830.68
254_D312_H0.8830.68
67_A72_G0.8820.68
34_A96_A0.8800.68
73_L92_L0.8710.67
28_E31_K0.8700.67
124_G129_T0.8670.67
120_K200_V0.8650.67
131_P271_P0.8590.66
263_R266_Q0.8560.66
60_D81_C0.8550.66
23_I63_R0.8530.66
22_S25_H0.8480.65
202_T205_G0.8460.65
64_A73_L0.8450.65
30_V96_A0.8440.65
49_L93_I0.8440.65
174_V207_Y0.8400.64
246_G286_L0.8400.64
179_I192_A0.8360.64
13_S235_T0.8340.64
64_A85_T0.8340.64
15_I26_Q0.8330.64
169_E218_L0.8310.64
265_M280_I0.8310.64
116_V219_S0.8280.63
154_V161_Y0.8260.63
144_L147_A0.8240.63
31_K96_A0.8220.63
34_A93_I0.8180.62
256_V264_Y0.8080.61
27_A92_L0.8060.61
9_I298_P0.7960.60
287_E290_G0.7950.60
298_P301_L0.7910.60
98_N207_Y0.7890.60
14_I89_I0.7860.59
235_T298_P0.7830.59
171_K176_A0.7810.59
14_I64_A0.7790.59
79_A91_Y0.7790.59
108_K187_F0.7730.58
59_L64_A0.7700.58
15_I85_T0.7680.58
99_N192_A0.7660.57
303_A306_R0.7600.57
41_L44_D0.7600.57
110_V187_F0.7600.57
15_I61_L0.7590.57
149_P153_F0.7550.56
15_I21_Q0.7540.56
50_T192_A0.7530.56
114_T173_I0.7530.56
82_V88_G0.7520.56
289_G292_E0.7510.56
218_L281_A0.7500.56
182_L189_V0.7480.56
303_A309_T0.7480.56
181_A187_F0.7460.55
64_A88_G0.7430.55
15_I92_L0.7400.55
36_T39_E0.7400.55
138_D155_E0.7400.55
132_I165_V0.7390.55
225_R289_G0.7370.54
49_L188_V0.7290.54
79_A92_L0.7290.54
83_A290_G0.7240.53
270_F279_I0.7230.53
261_M279_I0.7220.53
179_I223_L0.7210.53
41_L107_K0.7200.53
200_V210_V0.7180.52
172_R222_L0.7170.52
279_I313_I0.7130.52
66_I134_A0.7110.52
242_C254_D0.7110.52
15_I84_D0.7110.52
24_E28_E0.7090.52
61_L79_A0.7090.52
145_Q154_V0.7060.51
243_I248_P0.7040.51
25_H29_A0.7040.51
123_P126_A0.7020.51
60_D88_G0.6960.50
27_A95_Q0.6940.50
238_V245_F0.6920.50
251_Q254_D0.6900.50
180_K228_H0.6880.49
40_M301_L0.6870.49
297_T300_C0.6860.49
52_G215_D0.6830.49
45_Y230_D0.6790.49
135_F160_G0.6740.48
79_A88_G0.6740.48
12_N54_G0.6740.48
117_E120_K0.6730.48
190_I234_I0.6720.48
144_L149_P0.6720.48
21_Q79_A0.6720.48
117_E207_Y0.6700.48
300_C309_T0.6700.48
145_Q150_D0.6700.48
230_D291_K0.6680.47
67_A76_T0.6680.47
85_T113_V0.6660.47
63_R92_L0.6660.47
132_I161_Y0.6660.47
99_N205_G0.6650.47
12_N167_S0.6650.47
79_A134_A0.6640.47
76_T80_N0.6630.47
201_R207_Y0.6610.47
99_N204_A0.6600.47
11_G52_G0.6590.47
15_I64_A0.6580.46
145_Q149_P0.6540.46
11_G215_D0.6520.46
29_A78_L0.6510.46
32_A299_E0.6410.45
68_H71_E0.6400.45
42_A245_F0.6390.44
259_A287_E0.6380.44
42_A172_R0.6370.44
245_F268_G0.6340.44
67_A73_L0.6330.44
249_Q267_E0.6330.44
29_A92_L0.6330.44
110_V182_L0.6330.44
50_T116_V0.6320.44
78_L92_L0.6320.44
174_V199_V0.6300.44
99_N115_Q0.6300.44
98_N108_K0.6300.44
31_K99_N0.6290.43
257_D261_M0.6280.43
23_I88_G0.6280.43
7_V40_M0.6280.43
239_E297_T0.6260.43
143_E146_K0.6250.43
124_G281_A0.6230.43
22_S132_I0.6230.43
102_A105_G0.6210.43
65_E163_R0.6170.42
231_I301_L0.6150.42
39_E44_D0.6140.42
40_M305_L0.6140.42
153_F163_R0.6100.42
176_A226_E0.6090.42
241_V269_H0.6090.42
179_I214_I0.6090.42
215_D273_G0.6080.41
283_L287_E0.6050.41
260_T264_Y0.6040.41
93_I97_L0.6040.41
218_L284_T0.5990.41
14_I92_L0.5990.41
98_N115_Q0.5970.40
13_S298_P0.5960.40
37_V240_K0.5950.40
141_R161_Y0.5940.40
78_L211_D0.5940.40
21_Q29_A0.5940.40
88_G237_G0.5920.40
145_Q163_R0.5920.40
23_I77_P0.5910.40
29_A296_T0.5910.40
155_E158_G0.5900.40
99_N206_D0.5890.40
243_I264_Y0.5870.39
225_R288_Q0.5870.39
88_G92_L0.5860.39
191_G304_A0.5850.39
9_I26_Q0.5840.39
113_V202_T0.5840.39
37_V49_L0.5810.39
41_L101_L0.5810.39
26_Q89_I0.5800.39
11_G167_S0.5800.39
132_I166_A0.5790.39
125_F210_V0.5790.39
61_L78_L0.5780.38
28_E32_A0.5750.38
33_V296_T0.5740.38
82_V107_K0.5730.38
21_Q61_L0.5730.38
159_R237_G0.5710.38
228_H255_R0.5690.38
166_A176_A0.5680.38
262_T267_E0.5680.38
116_V191_G0.5670.37
127_H272_P0.5660.37
138_D146_K0.5630.37
204_A306_R0.5620.37
97_L188_V0.5610.37
14_I61_L0.5610.37
98_N175_E0.5590.37
123_P259_A0.5580.37
94_Q175_E0.5570.36
63_R79_A0.5570.36
14_I88_G0.5560.36
30_V59_L0.5550.36
288_Q291_K0.5530.36
183_I186_G0.5530.36
234_I250_Q0.5520.36
54_G167_S0.5490.36
218_L225_R0.5480.36
40_M233_V0.5470.36
10_G13_S0.5470.36
14_I63_R0.5460.35
243_I270_F0.5450.35
5_V305_L0.5430.35
82_V237_G0.5410.35
45_Y74_P0.5400.35
76_T88_G0.5400.35
282_S313_I0.5390.35
59_L84_D0.5390.35
86_Q307_G0.5380.35
59_L92_L0.5360.35
85_T190_I0.5360.35
166_A211_D0.5350.34
59_L85_T0.5350.34
123_P248_P0.5340.34
29_A237_G0.5330.34
144_L151_W0.5330.34
24_E139_S0.5320.34
61_L163_R0.5310.34
76_T136_F0.5310.34
50_T191_G0.5310.34
151_W276_L0.5290.34
240_K256_V0.5270.34
107_K186_G0.5260.34
201_R205_G0.5260.34
48_V71_E0.5240.33
128_P166_A0.5240.33
294_I305_L0.5240.33
98_N102_A0.5240.33
15_I80_N0.5230.33
30_V92_L0.5230.33
300_C304_A0.5220.33
131_P155_E0.5190.33
64_A92_L0.5180.33
87_G113_V0.5180.33
134_A163_R0.5160.33
237_G301_L0.5160.33
254_D261_M0.5160.33
94_Q101_L0.5160.33
38_L101_L0.5150.33
140_Q143_E0.5140.33
244_H267_E0.5140.33
15_I237_G0.5140.33
258_I261_M0.5130.32
23_I82_V0.5120.32
158_G257_D0.5100.32
285_F289_G0.5100.32
87_G183_I0.5100.32
84_D92_L0.5100.32
12_N273_G0.5090.32
34_A97_L0.5080.32
65_E304_A0.5060.32
111_T190_I0.5040.32
8_A11_G0.5040.32
258_I287_E0.5020.31
81_C88_G0.5020.31
39_E100_R0.5000.31
235_T305_L0.5000.31
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1e19A 2 0.9873 100 0.485 Contact Map
2e9yA 2 0.9842 100 0.495 Contact Map
4jz8A 2 0.9905 100 0.512 Contact Map
2we5A 2 0.9684 100 0.517 Contact Map
4axsA 2 0.9114 100 0.517 Contact Map
2bufA 3 0.7943 100 0.715 Contact Map
3wwnA 2 0.7943 100 0.716 Contact Map
3l86A 1 0.7595 100 0.717 Contact Map
2ap9A 3 0.8133 100 0.721 Contact Map
2rd5A 3 0.8196 100 0.722 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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