ARCM - ECOLI - GREMLIN Contacts

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ARCM - Carbamate kinase-like protein YahI

UniProt:	P77624	Sequences: MKELVVVAIGGNSIIKDNASQSIEHQAEAVKAVADTVLEMLASDYDIVLTHGNGPQVGLDLRRAEIAHKREGLPLTPLANCVADTQGGIGYLIQQALNNRLARHGEKKAVTVVTQVEVDKNDPGFAHPTKPIGAFFSDSQRDELQKANPDWCFVEDAGRGYRRVVASPEPKRIVEAPAIKALIQQGFVVIGAGGGGIPVVRTDAGDYQSVDAVIDKDLSTALLAREIHADILVITTGVEKVCIHFGKPQQQALDRVDIATMTRYMQEGHFPPGSMLPKIIASLTFLEQGGKEVIITTPECLPAALRGETGTHIIKT	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG13593
Length:	316 (298)
Sequences:	1302 (847)
Seq/√Len:	49.1

ECOLI - ARCM ARCL ARCC
HALSA - ARCC

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
138_D	142_D	6.314	1.00
262_T	287_E	6.237	1.00
256_V	261_M	4.201	1.00
4_L	46_D	3.733	1.00
242_C	252_A	3.680	1.00
244_H	249_Q	3.610	1.00
137_S	140_Q	3.371	1.00
240_K	254_D	3.287	1.00
253_L	256_V	3.276	1.00
37_V	47_I	2.959	1.00
50_T	220_T	2.933	1.00
79_A	211_D	2.883	1.00
202_T	208_Q	2.573	1.00
263_R	267_E	2.556	1.00
265_M	276_L	2.461	1.00
244_H	269_H	2.456	1.00
292_E	312_H	2.370	1.00
240_K	252_A	2.340	1.00
60_D	85_T	2.308	1.00
35_D	100_R	2.245	1.00
138_D	161_Y	2.235	1.00
296_T	304_A	2.216	1.00
192_A	219_S	2.211	1.00
143_E	147_A	2.190	1.00
94_Q	111_T	2.178	1.00
169_E	284_T	2.064	1.00
6_V	229_A	2.059	1.00
222_L	226_E	2.053	1.00
300_C	303_A	2.044	1.00
151_W	163_R	1.992	0.99
7_V	37_V	1.978	0.99
286_L	293_V	1.976	0.99
192_A	223_L	1.960	0.99
243_I	251_Q	1.933	0.99
233_V	301_L	1.933	0.99
235_T	301_L	1.888	0.99
117_E	201_R	1.858	0.99
127_H	154_V	1.834	0.99
117_E	172_R	1.805	0.99
303_A	308_E	1.795	0.99
38_L	97_L	1.761	0.99
220_T	232_L	1.745	0.99
142_D	146_K	1.739	0.99
258_I	283_L	1.728	0.99
239_E	242_C	1.722	0.98
120_K	202_T	1.715	0.98
172_R	226_E	1.685	0.98
62_R	136_F	1.660	0.98
296_T	309_T	1.657	0.98
243_I	269_H	1.655	0.98
239_E	309_T	1.631	0.98
135_F	159_R	1.595	0.97
264_Y	267_E	1.594	0.97
286_L	289_G	1.571	0.97
261_M	313_I	1.569	0.97
257_D	260_T	1.568	0.97
262_T	266_Q	1.566	0.97
21_Q	25_H	1.553	0.97
231_I	294_I	1.524	0.97
221_A	225_R	1.505	0.96
228_H	291_K	1.492	0.96
145_Q	153_F	1.462	0.96
39_E	302_P	1.462	0.96
244_H	251_Q	1.461	0.96
46_D	186_G	1.459	0.96
218_L	280_I	1.455	0.96
5_V	45_Y	1.445	0.95
202_T	206_D	1.432	0.95
225_R	284_T	1.427	0.95
48_V	227_I	1.427	0.95
131_P	154_V	1.387	0.94
78_L	82_V	1.381	0.94
272_P	276_L	1.366	0.94
39_E	42_A	1.364	0.94
172_R	201_R	1.359	0.94
181_A	185_Q	1.358	0.94
172_R	176_A	1.337	0.93
117_E	174_V	1.337	0.93
80_N	92_L	1.326	0.93
246_G	250_Q	1.321	0.93
108_K	177_P	1.318	0.93
180_K	184_Q	1.314	0.93
251_Q	260_T	1.303	0.92
63_R	88_G	1.301	0.92
176_A	227_I	1.292	0.92
142_D	161_Y	1.288	0.92
240_K	309_T	1.264	0.91
110_V	178_A	1.256	0.91
192_A	220_T	1.240	0.90
98_N	109_A	1.237	0.90
221_A	284_T	1.234	0.90
294_I	304_A	1.232	0.90
244_H	247_K	1.228	0.90
62_R	134_A	1.224	0.90
178_A	187_F	1.201	0.89
63_R	84_D	1.193	0.88
131_P	135_F	1.183	0.88
282_S	293_V	1.179	0.88
260_T	263_R	1.174	0.88
115_Q	207_Y	1.169	0.87
95_Q	115_Q	1.169	0.87
91_Y	209_S	1.166	0.87
279_I	293_V	1.165	0.87
262_T	280_I	1.163	0.87
41_L	188_V	1.161	0.87
242_C	250_Q	1.159	0.87
48_V	183_I	1.157	0.87
233_V	294_I	1.153	0.87
101_L	109_A	1.150	0.86
271_P	276_L	1.147	0.86
14_I	59_L	1.143	0.86
231_I	292_E	1.139	0.86
239_E	300_C	1.137	0.86
94_Q	115_Q	1.137	0.86
135_F	155_E	1.136	0.86
60_D	63_R	1.131	0.86
101_L	188_V	1.125	0.85
242_C	245_F	1.122	0.85
183_I	227_I	1.112	0.85
296_T	300_C	1.112	0.85
179_I	191_G	1.111	0.85
141_R	150_D	1.099	0.84
119_D	171_K	1.093	0.84
262_T	283_L	1.080	0.83
15_I	25_H	1.080	0.83
27_A	96_A	1.078	0.83
15_I	88_G	1.074	0.82
155_E	159_R	1.063	0.82
136_F	144_L	1.061	0.82
85_T	88_G	1.058	0.81
156_D	159_R	1.056	0.81
145_Q	151_W	1.056	0.81
141_R	145_Q	1.050	0.81
144_L	153_F	1.046	0.81
145_Q	161_Y	1.037	0.80
64_A	84_D	1.034	0.80
91_Y	95_Q	1.033	0.80
222_L	225_R	1.024	0.79
84_D	88_G	1.023	0.79
106_E	177_P	1.022	0.79
243_I	253_L	1.016	0.79
21_Q	59_L	1.014	0.79
15_I	63_R	1.012	0.78
80_N	88_G	1.003	0.78
23_I	80_N	1.000	0.78
136_F	153_F	0.997	0.77
43_S	306_R	0.990	0.77
4_L	45_Y	0.989	0.77
255_R	312_H	0.984	0.77
178_A	181_A	0.978	0.76
47_I	188_V	0.974	0.76
15_I	79_A	0.967	0.75
135_F	156_D	0.966	0.75
142_D	145_Q	0.960	0.75
46_D	107_K	0.959	0.75
241_V	295_I	0.957	0.74
302_P	306_R	0.956	0.74
23_I	79_A	0.953	0.74
5_V	40_M	0.948	0.74
54_G	273_G	0.945	0.74
91_Y	115_Q	0.944	0.73
82_V	116_V	0.944	0.73
169_E	280_I	0.942	0.73
5_V	298_P	0.940	0.73
23_I	76_T	0.936	0.73
173_I	223_L	0.935	0.73
171_K	222_L	0.929	0.72
23_I	92_L	0.927	0.72
4_L	183_I	0.913	0.71
258_I	262_T	0.910	0.71
30_V	93_I	0.908	0.71
94_Q	190_I	0.908	0.71
116_V	220_T	0.907	0.70
15_I	23_I	0.897	0.70
59_L	88_G	0.895	0.69
228_H	289_G	0.893	0.69
59_L	63_R	0.893	0.69
94_Q	113_V	0.892	0.69
294_I	312_H	0.891	0.69
115_Q	174_V	0.889	0.69
15_I	59_L	0.889	0.69
9_I	13_S	0.883	0.68
254_D	312_H	0.883	0.68
67_A	72_G	0.882	0.68
34_A	96_A	0.880	0.68
73_L	92_L	0.871	0.67
28_E	31_K	0.870	0.67
124_G	129_T	0.867	0.67
120_K	200_V	0.865	0.67
131_P	271_P	0.859	0.66
263_R	266_Q	0.856	0.66
60_D	81_C	0.855	0.66
23_I	63_R	0.853	0.66
22_S	25_H	0.848	0.65
202_T	205_G	0.846	0.65
64_A	73_L	0.845	0.65
30_V	96_A	0.844	0.65
49_L	93_I	0.844	0.65
174_V	207_Y	0.840	0.64
246_G	286_L	0.840	0.64
179_I	192_A	0.836	0.64
13_S	235_T	0.834	0.64
64_A	85_T	0.834	0.64
15_I	26_Q	0.833	0.64
169_E	218_L	0.831	0.64
265_M	280_I	0.831	0.64
116_V	219_S	0.828	0.63
154_V	161_Y	0.826	0.63
144_L	147_A	0.824	0.63
31_K	96_A	0.822	0.63
34_A	93_I	0.818	0.62
256_V	264_Y	0.808	0.61
27_A	92_L	0.806	0.61
9_I	298_P	0.796	0.60
287_E	290_G	0.795	0.60
298_P	301_L	0.791	0.60
98_N	207_Y	0.789	0.60
14_I	89_I	0.786	0.59
235_T	298_P	0.783	0.59
171_K	176_A	0.781	0.59
14_I	64_A	0.779	0.59
79_A	91_Y	0.779	0.59
108_K	187_F	0.773	0.58
59_L	64_A	0.770	0.58
15_I	85_T	0.768	0.58
99_N	192_A	0.766	0.57
303_A	306_R	0.760	0.57
41_L	44_D	0.760	0.57
110_V	187_F	0.760	0.57
15_I	61_L	0.759	0.57
149_P	153_F	0.755	0.56
15_I	21_Q	0.754	0.56
50_T	192_A	0.753	0.56
114_T	173_I	0.753	0.56
82_V	88_G	0.752	0.56
289_G	292_E	0.751	0.56
218_L	281_A	0.750	0.56
182_L	189_V	0.748	0.56
303_A	309_T	0.748	0.56
181_A	187_F	0.746	0.55
64_A	88_G	0.743	0.55
15_I	92_L	0.740	0.55
36_T	39_E	0.740	0.55
138_D	155_E	0.740	0.55
132_I	165_V	0.739	0.55
225_R	289_G	0.737	0.54
49_L	188_V	0.729	0.54
79_A	92_L	0.729	0.54
83_A	290_G	0.724	0.53
270_F	279_I	0.723	0.53
261_M	279_I	0.722	0.53
179_I	223_L	0.721	0.53
41_L	107_K	0.720	0.53
200_V	210_V	0.718	0.52
172_R	222_L	0.717	0.52
279_I	313_I	0.713	0.52
66_I	134_A	0.711	0.52
242_C	254_D	0.711	0.52
15_I	84_D	0.711	0.52
24_E	28_E	0.709	0.52
61_L	79_A	0.709	0.52
145_Q	154_V	0.706	0.51
243_I	248_P	0.704	0.51
25_H	29_A	0.704	0.51
123_P	126_A	0.702	0.51
60_D	88_G	0.696	0.50
27_A	95_Q	0.694	0.50
238_V	245_F	0.692	0.50
251_Q	254_D	0.690	0.50
180_K	228_H	0.688	0.49
40_M	301_L	0.687	0.49
297_T	300_C	0.686	0.49
52_G	215_D	0.683	0.49
45_Y	230_D	0.679	0.49
135_F	160_G	0.674	0.48
79_A	88_G	0.674	0.48
12_N	54_G	0.674	0.48
117_E	120_K	0.673	0.48
190_I	234_I	0.672	0.48
144_L	149_P	0.672	0.48
21_Q	79_A	0.672	0.48
117_E	207_Y	0.670	0.48
300_C	309_T	0.670	0.48
145_Q	150_D	0.670	0.48
230_D	291_K	0.668	0.47
67_A	76_T	0.668	0.47
85_T	113_V	0.666	0.47
63_R	92_L	0.666	0.47
132_I	161_Y	0.666	0.47
99_N	205_G	0.665	0.47
12_N	167_S	0.665	0.47
79_A	134_A	0.664	0.47
76_T	80_N	0.663	0.47
201_R	207_Y	0.661	0.47
99_N	204_A	0.660	0.47
11_G	52_G	0.659	0.47
15_I	64_A	0.658	0.46
145_Q	149_P	0.654	0.46
11_G	215_D	0.652	0.46
29_A	78_L	0.651	0.46
32_A	299_E	0.641	0.45
68_H	71_E	0.640	0.45
42_A	245_F	0.639	0.44
259_A	287_E	0.638	0.44
42_A	172_R	0.637	0.44
245_F	268_G	0.634	0.44
67_A	73_L	0.633	0.44
249_Q	267_E	0.633	0.44
29_A	92_L	0.633	0.44
110_V	182_L	0.633	0.44
50_T	116_V	0.632	0.44
78_L	92_L	0.632	0.44
174_V	199_V	0.630	0.44
99_N	115_Q	0.630	0.44
98_N	108_K	0.630	0.44
31_K	99_N	0.629	0.43
257_D	261_M	0.628	0.43
23_I	88_G	0.628	0.43
7_V	40_M	0.628	0.43
239_E	297_T	0.626	0.43
143_E	146_K	0.625	0.43
124_G	281_A	0.623	0.43
22_S	132_I	0.623	0.43
102_A	105_G	0.621	0.43
65_E	163_R	0.617	0.42
231_I	301_L	0.615	0.42
39_E	44_D	0.614	0.42
40_M	305_L	0.614	0.42
153_F	163_R	0.610	0.42
176_A	226_E	0.609	0.42
241_V	269_H	0.609	0.42
179_I	214_I	0.609	0.42
215_D	273_G	0.608	0.41
283_L	287_E	0.605	0.41
260_T	264_Y	0.604	0.41
93_I	97_L	0.604	0.41
218_L	284_T	0.599	0.41
14_I	92_L	0.599	0.41
98_N	115_Q	0.597	0.40
13_S	298_P	0.596	0.40
37_V	240_K	0.595	0.40
141_R	161_Y	0.594	0.40
78_L	211_D	0.594	0.40
21_Q	29_A	0.594	0.40
88_G	237_G	0.592	0.40
145_Q	163_R	0.592	0.40
23_I	77_P	0.591	0.40
29_A	296_T	0.591	0.40
155_E	158_G	0.590	0.40
99_N	206_D	0.589	0.40
243_I	264_Y	0.587	0.39
225_R	288_Q	0.587	0.39
88_G	92_L	0.586	0.39
191_G	304_A	0.585	0.39
9_I	26_Q	0.584	0.39
113_V	202_T	0.584	0.39
37_V	49_L	0.581	0.39
41_L	101_L	0.581	0.39
26_Q	89_I	0.580	0.39
11_G	167_S	0.580	0.39
132_I	166_A	0.579	0.39
125_F	210_V	0.579	0.39
61_L	78_L	0.578	0.38
28_E	32_A	0.575	0.38
33_V	296_T	0.574	0.38
82_V	107_K	0.573	0.38
21_Q	61_L	0.573	0.38
159_R	237_G	0.571	0.38
228_H	255_R	0.569	0.38
166_A	176_A	0.568	0.38
262_T	267_E	0.568	0.38
116_V	191_G	0.567	0.37
127_H	272_P	0.566	0.37
138_D	146_K	0.563	0.37
204_A	306_R	0.562	0.37
97_L	188_V	0.561	0.37
14_I	61_L	0.561	0.37
98_N	175_E	0.559	0.37
123_P	259_A	0.558	0.37
94_Q	175_E	0.557	0.36
63_R	79_A	0.557	0.36
14_I	88_G	0.556	0.36
30_V	59_L	0.555	0.36
288_Q	291_K	0.553	0.36
183_I	186_G	0.553	0.36
234_I	250_Q	0.552	0.36
54_G	167_S	0.549	0.36
218_L	225_R	0.548	0.36
40_M	233_V	0.547	0.36
10_G	13_S	0.547	0.36
14_I	63_R	0.546	0.35
243_I	270_F	0.545	0.35
5_V	305_L	0.543	0.35
82_V	237_G	0.541	0.35
45_Y	74_P	0.540	0.35
76_T	88_G	0.540	0.35
282_S	313_I	0.539	0.35
59_L	84_D	0.539	0.35
86_Q	307_G	0.538	0.35
59_L	92_L	0.536	0.35
85_T	190_I	0.536	0.35
166_A	211_D	0.535	0.34
59_L	85_T	0.535	0.34
123_P	248_P	0.534	0.34
29_A	237_G	0.533	0.34
144_L	151_W	0.533	0.34
24_E	139_S	0.532	0.34
61_L	163_R	0.531	0.34
76_T	136_F	0.531	0.34
50_T	191_G	0.531	0.34
151_W	276_L	0.529	0.34
240_K	256_V	0.527	0.34
107_K	186_G	0.526	0.34
201_R	205_G	0.526	0.34
48_V	71_E	0.524	0.33
128_P	166_A	0.524	0.33
294_I	305_L	0.524	0.33
98_N	102_A	0.524	0.33
15_I	80_N	0.523	0.33
30_V	92_L	0.523	0.33
300_C	304_A	0.522	0.33
131_P	155_E	0.519	0.33
64_A	92_L	0.518	0.33
87_G	113_V	0.518	0.33
134_A	163_R	0.516	0.33
237_G	301_L	0.516	0.33
254_D	261_M	0.516	0.33
94_Q	101_L	0.516	0.33
38_L	101_L	0.515	0.33
140_Q	143_E	0.514	0.33
244_H	267_E	0.514	0.33
15_I	237_G	0.514	0.33
258_I	261_M	0.513	0.32
23_I	82_V	0.512	0.32
158_G	257_D	0.510	0.32
285_F	289_G	0.510	0.32
87_G	183_I	0.510	0.32
84_D	92_L	0.510	0.32
12_N	273_G	0.509	0.32
34_A	97_L	0.508	0.32
65_E	304_A	0.506	0.32
111_T	190_I	0.504	0.32
8_A	11_G	0.504	0.32
258_I	287_E	0.502	0.31
81_C	88_G	0.502	0.31
39_E	100_R	0.500	0.31
235_T	305_L	0.500	0.31

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
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HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1e19A	2	0.9873	100	0.485	Contact Map
2e9yA	2	0.9842	100	0.495	Contact Map
4jz8A	2	0.9905	100	0.512	Contact Map
2we5A	2	0.9684	100	0.517	Contact Map
4axsA	2	0.9114	100	0.517	Contact Map
2bufA	3	0.7943	100	0.715	Contact Map
3wwnA	2	0.7943	100	0.716	Contact Map
3l86A	1	0.7595	100	0.717	Contact Map
2ap9A	3	0.8133	100	0.721	Contact Map
2rd5A	3	0.8196	100	0.722	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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