GREMLIN Database
YFEW - UPF0214 protein YfeW
UniProt: P77619 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG14164
Length: 434 (334)
Sequences: 7756 (6052)
Seq/√Len: 331.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
119_E230_S3.8251.00
221_Q229_E3.7821.00
65_D386_H3.4651.00
228_E233_R3.4201.00
125_D152_S3.0581.00
118_S327_N2.9581.00
126_D130_K2.9501.00
123_H126_D2.9481.00
115_K226_Y2.8761.00
112_A226_Y2.8161.00
240_T302_S2.7221.00
96_T255_A2.7171.00
44_D72_K2.6581.00
226_Y230_S2.6331.00
115_K230_S2.6331.00
100_L302_S2.6071.00
92_A98_Y2.5901.00
222_P225_R2.5081.00
118_S330_T2.4191.00
327_N330_T2.3881.00
215_V226_Y2.3551.00
77_A90_V2.3291.00
73_A94_T2.2881.00
111_F310_L2.2711.00
126_D131_Y2.1961.00
213_F217_S2.1331.00
134_G217_S2.1191.00
113_L211_L2.1121.00
71_R305_G2.0631.00
219_T226_Y2.0601.00
48_S52_D2.0541.00
78_K88_Q2.0541.00
76_A89_P2.0011.00
70_Y74_W1.9821.00
61_L308_A1.9581.00
78_K87_E1.9571.00
333_M336_T1.9161.00
113_L122_L1.9081.00
213_F216_E1.8811.00
229_E233_R1.8761.00
115_K119_E1.8571.00
328_A332_K1.7711.00
227_V232_Y1.7441.00
44_D74_W1.7441.00
225_R229_E1.7191.00
239_H253_Q1.7101.00
311_M388_T1.7041.00
224_D294_V1.6911.00
44_D48_S1.6791.00
237_L240_T1.6581.00
221_Q226_Y1.6391.00
49_Q53_V1.6391.00
151_I214_I1.6151.00
311_M379_T1.6071.00
159_G207_D1.6071.00
127_R130_K1.6001.00
106_M310_L1.5941.00
112_A227_V1.5921.00
116_L215_V1.5521.00
152_S338_S1.5471.00
57_S92_A1.5421.00
152_S346_L1.5411.00
153_D158_S1.5241.00
102_S105_K1.5071.00
107_Y300_L1.4961.00
121_K218_V1.4871.00
221_Q230_S1.4681.00
221_Q225_R1.4671.00
382_D385_N1.4671.00
150_R153_D1.4521.00
223_L296_G1.4431.00
76_A88_Q1.4341.00
195_Y200_K1.4241.00
63_I308_A1.4171.00
232_Y237_L1.4161.00
110_N208_Y1.4151.00
77_A96_T1.4001.00
180_D183_Q1.4001.00
45_R49_Q1.3991.00
223_L227_V1.3881.00
117_M124_P1.3741.00
115_K325_L1.3661.00
60_L391_M1.3651.00
44_D70_Y1.3591.00
104_T300_L1.3551.00
110_N155_L1.3501.00
153_D198_G1.3471.00
112_A215_V1.3431.00
237_L306_D1.3361.00
232_Y300_L1.3301.00
63_I68_I1.3251.00
59_N92_A1.3241.00
156_H338_S1.3231.00
317_G332_K1.3181.00
212_G296_G1.3151.00
314_M335_T1.3101.00
92_A96_T1.3061.00
59_N304_T1.3041.00
312_Q315_L1.3011.00
114_Q124_P1.3001.00
103_N379_T1.2981.00
117_M122_L1.2881.00
242_F300_L1.2881.00
182_G186_E1.2821.00
205_D297_H1.2821.00
116_L219_T1.2811.00
113_L215_V1.2811.00
345_G350_V1.2781.00
61_L68_I1.2771.00
365_S385_N1.2761.00
152_S333_M1.2751.00
95_G305_G1.2731.00
71_R94_T1.2591.00
63_I388_T1.2541.00
103_N307_I1.2531.00
240_T306_D1.2511.00
61_L304_T1.2501.00
47_I58_V1.2331.00
204_S207_D1.2301.00
196_Q199_S1.2291.00
367_Q384_V1.2211.00
107_Y310_L1.2201.00
113_L155_L1.2161.00
59_N73_A1.2081.00
380_V389_I1.2051.00
51_V74_W1.2041.00
109_T296_G1.2021.00
153_D156_H1.1981.00
114_Q334_F1.1961.00
131_Y218_V1.1951.00
73_A92_A1.1881.00
101_A375_T1.1791.00
110_N347_G1.1751.00
93_T96_T1.1711.00
94_T305_G1.1601.00
304_T392_L1.1471.00
185_L213_F1.1451.00
127_R148_T1.1371.00
214_I218_V1.1271.00
212_G223_L1.1251.00
122_L218_V1.1171.00
105_K203_Y1.1161.00
47_I60_L1.1051.00
132_I217_S1.1051.00
117_M333_M1.1031.00
134_G186_E1.1001.00
114_Q330_T1.0981.00
235_L313_T1.0931.00
45_R48_S1.0851.00
57_S98_Y1.0821.00
103_N377_T1.0781.00
111_F326_F1.0771.00
365_S369_Y1.0711.00
183_Q186_E1.0681.00
78_K90_V1.0661.00
107_Y307_I1.0591.00
379_T390_V1.0531.00
309_V320_Y1.0521.00
59_N98_Y1.0481.00
114_Q117_M1.0451.00
126_D151_I1.0401.00
335_T369_Y1.0391.00
315_L381_I1.0361.00
215_V223_L1.0351.00
312_Q316_N1.0351.00
97_L253_Q1.0331.00
106_M379_T1.0331.00
128_I214_I1.0321.00
122_L214_I1.0321.00
148_T196_Q1.0281.00
279_W284_D1.0241.00
311_M381_I1.0191.00
237_L310_L1.0181.00
116_L121_K1.0121.00
215_V219_T1.0071.00
111_F314_M1.0071.00
48_S74_W1.0041.00
115_K231_I1.0001.00
195_Y202_I0.9921.00
314_M348_W0.9901.00
131_Y214_I0.9841.00
308_A388_T0.9821.00
307_I390_V0.9811.00
208_Y211_L0.9801.00
64_K67_Q0.9761.00
314_M369_Y0.9751.00
48_S72_K0.9711.00
112_A230_S0.9691.00
117_M330_T0.9681.00
64_K387_M0.9641.00
107_Y227_V0.9641.00
122_L151_I0.9621.00
116_L119_E0.9621.00
307_I392_L0.9611.00
183_Q187_M0.9581.00
239_H303_N0.9561.00
195_Y199_S0.9541.00
128_I154_L0.9531.00
102_S203_Y0.9521.00
112_A219_T0.9511.00
62_I389_I0.9441.00
326_F331_V0.9431.00
337_S343_T0.9371.00
228_E232_Y0.9361.00
236_G309_V0.9321.00
369_Y381_I0.9271.00
109_T212_G0.9171.00
86_M89_P0.9121.00
381_I388_T0.9101.00
97_L239_H0.9051.00
219_T222_P0.9001.00
107_Y237_L0.9001.00
344_F349_R0.8941.00
320_Y323_V0.8911.00
86_M258_E0.8881.00
58_V391_M0.8781.00
61_L390_V0.8711.00
129_A148_T0.8691.00
111_F115_K0.8681.00
329_E332_K0.8651.00
46_W50_Q0.8641.00
60_L72_K0.8601.00
98_Y392_L0.8561.00
56_P395_K0.8551.00
295_S298_A0.8531.00
131_Y151_I0.8521.00
68_I312_Q0.8491.00
239_H306_D0.8491.00
106_M311_M0.8481.00
101_A371_H0.8481.00
181_K185_L0.8471.00
317_G328_A0.8451.00
78_K89_P0.8401.00
332_K336_T0.8381.00
49_Q52_D0.8371.00
237_L309_V0.8361.00
245_L250_K0.8321.00
305_G309_V0.8311.00
115_K118_S0.8311.00
219_T230_S0.8281.00
77_A93_T0.8281.00
129_A136_A0.8261.00
186_E190_R0.8231.00
225_R228_E0.8201.00
66_N312_Q0.8171.00
157_H207_D0.8161.00
111_F231_I0.8161.00
334_F345_G0.8121.00
223_L242_F0.8121.00
181_K216_E0.8111.00
107_Y232_Y0.8101.00
97_L301_F0.8091.00
276_S279_W0.8071.00
232_Y240_T0.8061.00
100_L307_I0.8031.00
112_A231_I0.8021.00
309_V312_Q0.7981.00
370_G376_G0.7981.00
41_N45_R0.7971.00
276_S280_G0.7971.00
99_D301_F0.7961.00
209_M297_H0.7961.00
313_T325_L0.7961.00
61_L388_T0.7941.00
314_M334_F0.7941.00
124_P346_L0.7931.00
135_F149_L0.7901.00
56_P86_M0.7881.00
237_L302_S0.7871.00
280_G284_D0.7871.00
64_K69_V0.7841.00
57_S394_N0.7841.00
113_L214_I0.7831.00
100_L104_T0.7811.00
123_H131_Y0.7811.00
78_K256_A0.7781.00
308_A390_V0.7771.00
47_I51_V0.7771.00
365_S382_D0.7761.00
369_Y383_P0.7741.00
247_K250_K0.7711.00
315_L388_T0.7711.00
338_S346_L0.7691.00
311_M390_V0.7671.00
343_T350_V0.7671.00
47_I74_W0.7661.00
334_F348_W0.7661.00
309_V321_G0.7641.00
216_E219_T0.7581.00
147_N153_D0.7581.00
76_A91_K0.7561.00
194_E202_I0.7510.99
68_I71_R0.7500.99
364_A368_T0.7490.99
339_K342_A0.7450.99
116_L218_V0.7440.99
48_S51_V0.7410.99
123_H151_I0.7410.99
281_Q284_D0.7400.99
116_L226_Y0.7390.99
177_Y183_Q0.7360.99
42_Q45_R0.7350.99
114_Q348_W0.7350.99
127_R131_Y0.7340.99
224_D228_E0.7330.99
51_V58_V0.7320.99
78_K86_M0.7320.99
333_M338_S0.7270.99
149_L159_G0.7260.99
250_K253_Q0.7260.99
186_E189_K0.7240.99
76_A90_V0.7220.99
151_I218_V0.7210.99
227_V240_T0.7210.99
303_N306_D0.7200.99
182_G213_F0.7190.99
152_S156_H0.7180.99
335_T383_P0.7170.99
100_L377_T0.7150.99
257_T374_W0.7140.99
275_T280_G0.7130.99
155_L211_L0.7110.99
60_L70_Y0.7100.99
349_R370_G0.7100.99
97_L303_N0.7100.99
35_F40_L0.7040.99
316_N324_Q0.7010.99
324_Q328_A0.6950.99
71_R304_T0.6940.99
367_Q371_H0.6940.99
277_T281_Q0.6910.99
63_I312_Q0.6890.99
284_D287_A0.6850.99
240_T303_N0.6830.99
50_Q55_Y0.6810.99
90_V96_T0.6800.99
145_G196_Q0.6800.99
106_M348_W0.6790.99
117_M123_H0.6780.99
41_N44_D0.6750.99
278_L283_H0.6750.99
331_V335_T0.6740.99
163_A297_H0.6720.99
331_V334_F0.6720.99
101_A298_A0.6710.99
36_N40_L0.6700.99
132_I214_I0.6690.99
128_I149_L0.6680.99
376_G395_K0.6680.99
151_I211_L0.6670.99
231_I325_L0.6640.99
61_L71_R0.6640.99
304_T390_V0.6620.99
275_T279_W0.6590.99
113_L218_V0.6590.99
159_G204_S0.6560.99
36_N39_R0.6550.99
123_H152_S0.6450.98
330_T333_M0.6420.98
103_N106_M0.6420.98
348_W381_I0.6410.98
64_K386_H0.6400.98
348_W379_T0.6390.98
128_I135_F0.6350.98
382_D387_M0.6320.98
100_L103_N0.6310.98
241_V244_P0.6230.98
149_L153_D0.6210.98
128_I131_Y0.6190.98
181_K213_F0.6190.98
302_S307_I0.6180.98
58_V393_S0.6170.98
137_D147_N0.6170.98
302_S306_D0.6160.98
216_E222_P0.6120.98
282_V285_E0.6110.98
76_A86_M0.6100.98
76_A87_E0.6090.98
154_L159_G0.6090.98
39_R42_Q0.6040.98
125_D150_R0.6030.98
129_A133_P0.6030.98
317_G331_V0.6020.98
132_I213_F0.5970.97
222_P294_V0.5950.97
175_A179_Q0.5930.97
157_H346_L0.5920.97
77_A255_A0.5900.97
97_L250_K0.5880.97
313_T322_D0.5840.97
38_E41_N0.5830.97
332_K383_P0.5830.97
368_T371_H0.5820.97
275_T281_Q0.5810.97
227_V242_F0.5800.97
237_L313_T0.5790.97
122_L131_Y0.5790.97
123_H130_K0.5780.97
216_E223_L0.5770.97
124_P152_S0.5760.97
149_L161_F0.5760.97
244_P247_K0.5760.97
97_L241_V0.5750.97
362_T385_N0.5740.97
95_G239_H0.5740.97
335_T348_W0.5730.97
129_A147_N0.5720.97
109_T227_V0.5710.97
187_M190_R0.5710.97
399_P404_Q0.5710.97
111_F325_L0.5700.97
181_K184_T0.5700.97
185_L189_K0.5700.97
158_S198_G0.5690.97
136_A146_K0.5680.97
365_S371_H0.5670.97
99_D371_H0.5660.96
60_L74_W0.5660.96
320_Y324_Q0.5640.96
238_T306_D0.5630.96
316_N323_V0.5600.96
99_D104_T0.5600.96
201_H344_F0.5590.96
278_L281_Q0.5590.96
43_M70_Y0.5580.96
59_N62_I0.5570.96
295_S299_G0.5550.96
128_I151_I0.5550.96
241_V245_L0.5530.96
104_T223_L0.5530.96
342_A349_R0.5520.96
127_R150_R0.5520.96
87_E90_V0.5510.96
400_V404_Q0.5510.96
235_L309_V0.5500.96
35_F69_V0.5490.96
87_E258_E0.5480.96
109_T211_L0.5460.96
182_G217_S0.5460.96
134_G213_F0.5450.96
157_H208_Y0.5430.96
46_W49_Q0.5430.96
101_A297_H0.5420.96
104_T242_F0.5420.96
278_L282_V0.5400.95
147_N196_Q0.5400.95
377_T392_L0.5400.95
154_L211_L0.5400.95
145_G149_L0.5390.95
277_T282_V0.5380.95
337_S350_V0.5380.95
254_I301_F0.5380.95
308_A312_Q0.5380.95
62_I69_V0.5360.95
103_N392_L0.5360.95
64_K385_N0.5360.95
228_E241_V0.5350.95
51_V54_G0.5350.95
257_T260_N0.5320.95
312_Q388_T0.5300.95
47_I391_M0.5290.95
330_T334_F0.5280.95
276_S281_Q0.5270.95
279_W285_E0.5270.95
241_V250_K0.5270.95
59_N96_T0.5270.95
371_H374_W0.5240.95
162_P194_E0.5240.95
105_K205_D0.5240.95
33_A37_V0.5230.95
280_G285_E0.5230.95
350_V363_L0.5220.95
122_L126_D0.5210.94
128_I132_I0.5210.94
128_I210_L0.5210.94
372_T378_V0.5200.94
310_L314_M0.5190.94
316_N320_Y0.5180.94
155_L208_Y0.5170.94
237_L303_N0.5170.94
179_Q183_Q0.5160.94
231_I235_L0.5160.94
164_D206_V0.5150.94
327_N331_V0.5130.94
136_A144_K0.5130.94
50_Q53_V0.5120.94
366_P369_Y0.5120.94
304_T308_A0.5110.94
109_T155_L0.5110.94
227_V231_I0.5090.94
155_L346_L0.5090.94
277_T280_G0.5090.94
279_W282_V0.5090.94
285_E400_V0.5080.94
34_G40_L0.5060.94
231_I234_P0.5040.93
242_F246_L0.5040.93
365_S368_T0.5030.93
95_G253_Q0.5030.93
313_T316_N0.5000.93
59_N71_R0.5000.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ivkA 4 0.8456 100 0.296 Contact Map
4p6bA 5 0.8134 100 0.296 Contact Map
2drwA 3 0.8134 100 0.317 Contact Map
2qmiA 5 0.8065 100 0.317 Contact Map
3zytA 3 0.8111 100 0.318 Contact Map
1ei5A 2 0.7788 100 0.321 Contact Map
4lclA 1 0.8364 100 0.323 Contact Map
1ci9A 1 0.8065 100 0.324 Contact Map
1yqsA 1 0.7788 100 0.325 Contact Map
3wrzA 1 0.7558 100 0.328 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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