GREMLIN Database
YCJW - Uncharacterized HTH-type transcriptional regulator YcjW
UniProt: P77615 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13920
Length: 332 (315)
Sequences: 36073 (26309)
Seq/√Len: 1482.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
168_F207_Q3.3731.00
183_H246_E3.1851.00
11_V43_E3.1441.00
269_A272_Q3.0961.00
174_L277_V2.6641.00
124_G310_L2.6241.00
202_V206_K2.5911.00
183_H275_A2.5451.00
281_N296_D2.5041.00
161_Y313_L2.4211.00
172_I211_A2.3411.00
31_P35_E2.2691.00
232_L265_E2.2441.00
39_R43_E2.2331.00
90_K93_E2.2121.00
35_E39_R2.1861.00
90_K308_E2.1471.00
236_R266_K2.1471.00
176_D208_S2.1021.00
305_Q308_E2.0811.00
169_G173_A2.0791.00
179_I212_H2.0731.00
172_I207_Q2.0641.00
172_I208_S2.0371.00
236_R262_A2.0081.00
91_A307_C1.9871.00
22_V37_V1.9871.00
170_D279_Y1.9391.00
34_R38_L1.9121.00
168_F203_N1.9111.00
86_A303_G1.8791.00
178_L247_A1.8751.00
171_S175_T1.8721.00
90_K304_Q1.8721.00
176_D180_E1.8691.00
23_L41_I1.8651.00
6_Y16_K1.8641.00
263_A274_L1.8621.00
231_A258_S1.8241.00
240_S266_K1.8141.00
312_R317_K1.8121.00
171_S249_F1.7831.00
175_T205_Y1.7741.00
89_A300_Q1.7531.00
176_D212_H1.7451.00
177_A181_S1.7441.00
11_V40_A1.7101.00
172_I176_D1.7091.00
12_A40_A1.7021.00
232_L262_A1.6801.00
235_A259_I1.6731.00
268_I273_Q1.6521.00
188_C251_T1.6511.00
187_A245_P1.6451.00
64_M122_I1.6351.00
86_A300_Q1.6281.00
298_P301_E1.6271.00
250_A259_I1.6061.00
269_A273_Q1.6031.00
90_K94_E1.5831.00
262_A266_K1.5801.00
150_I306_S1.5661.00
185_N217_R1.5581.00
38_L42_E1.5311.00
169_G172_I1.5281.00
264_A289_T1.5171.00
185_N244_L1.5041.00
222_V237_Q1.5041.00
94_E311_F1.5011.00
177_A180_E1.5011.00
203_N207_Q1.4981.00
22_V41_I1.4931.00
179_I208_S1.4851.00
301_E305_Q1.4811.00
166_D169_G1.4611.00
262_A265_E1.4601.00
8_I40_A1.4591.00
61_D123_K1.4301.00
38_L41_I1.4261.00
277_V293_G1.4171.00
301_E304_Q1.4121.00
206_K210_A1.4061.00
200_D203_N1.4041.00
305_Q323_I1.3961.00
90_K307_C1.3791.00
217_R220_W1.3741.00
263_A268_I1.3431.00
208_S211_A1.3421.00
185_N246_E1.3381.00
175_T179_I1.3311.00
236_R265_E1.3311.00
235_A248_V1.3291.00
311_F315_S1.3261.00
232_L261_R1.3261.00
232_L236_R1.3181.00
11_V44_L1.3141.00
187_A238_L1.3031.00
63_I91_A1.3021.00
175_T208_S1.3001.00
6_Y10_R1.2941.00
171_S204_G1.2761.00
308_E312_R1.2751.00
7_D10_R1.2741.00
31_P34_R1.2721.00
175_T204_G1.2691.00
138_A142_K1.2641.00
61_D96_F1.2631.00
36_K40_A1.2581.00
30_S33_A1.2491.00
236_R240_S1.2421.00
204_G208_S1.2411.00
183_H247_A1.2361.00
235_A263_A1.2311.00
40_A43_E1.2241.00
173_A176_D1.2221.00
126_I306_S1.2221.00
168_F172_I1.2201.00
176_D211_A1.2161.00
260_Y276_V1.2151.00
225_G230_T1.2101.00
21_R26_Q1.2091.00
8_I12_A1.2041.00
40_A44_L1.2031.00
101_Q113_C1.2011.00
101_Q117_I1.2001.00
64_M117_I1.1981.00
5_I16_K1.1921.00
87_I307_C1.1871.00
91_A98_V1.1841.00
237_Q241_Q1.1751.00
184_Q246_E1.1701.00
8_I44_L1.1671.00
65_V87_I1.1601.00
177_A293_G1.1571.00
33_A36_K1.1571.00
300_Q304_Q1.1541.00
87_I126_I1.1531.00
168_F200_D1.1491.00
205_Y209_L1.1461.00
189_L259_I1.1251.00
94_E308_E1.1251.00
115_S139_Q1.1181.00
208_S212_H1.1091.00
258_S262_A1.1081.00
174_L249_F1.1031.00
229_E233_K1.1021.00
168_F204_G1.1011.00
253_S294_G1.0981.00
186_I209_L1.0891.00
65_V98_V1.0871.00
62_A97_D1.0861.00
62_A99_I1.0831.00
234_A237_Q1.0821.00
39_R42_E1.0821.00
35_E38_L1.0801.00
188_C202_V1.0791.00
207_Q211_A1.0771.00
5_I19_V1.0701.00
22_V29_I1.0691.00
248_V259_I1.0641.00
303_G307_C1.0581.00
25_K34_R1.0581.00
88_T92_E1.0471.00
305_Q309_L1.0451.00
227_T230_T1.0421.00
179_I214_I1.0411.00
203_N206_K1.0351.00
185_N243_P1.0301.00
111_Q115_S1.0281.00
51_L54_A1.0171.00
49_N55_L1.0161.00
205_Y249_F1.0131.00
180_E212_H1.0131.00
253_S278_G1.0121.00
92_E109_D1.0071.00
96_F311_F1.0061.00
242_S245_P1.0021.00
216_V219_E1.0001.00
250_A255_K0.9991.00
304_Q308_E0.9941.00
94_E315_S0.9911.00
233_K237_Q0.9861.00
250_A256_L0.9821.00
228_H261_R0.9781.00
41_I44_L0.9731.00
231_A235_A0.9701.00
193_L223_D0.9701.00
230_T233_K0.9701.00
209_L214_I0.9661.00
222_V234_A0.9651.00
310_L314_I0.9621.00
186_I247_A0.9611.00
196_H200_D0.9571.00
199_V203_N0.9561.00
206_K216_V0.9521.00
260_Y270_I0.9461.00
12_A19_V0.9441.00
115_S119_Q0.9331.00
235_A239_L0.9291.00
169_G326_A0.9291.00
260_Y288_L0.9281.00
181_S275_A0.9261.00
109_D112_K0.9241.00
161_Y309_L0.9221.00
174_L295_I0.9201.00
93_E304_Q0.9191.00
165_T298_P0.9161.00
49_N52_A0.9071.00
126_I310_L0.9061.00
309_L323_I0.9051.00
184_Q214_I0.9011.00
25_K38_L0.8971.00
89_A304_Q0.8961.00
85_H89_A0.8911.00
84_L88_T0.8871.00
175_T209_L0.8851.00
179_I184_Q0.8831.00
48_P53_R0.8831.00
52_A55_L0.8801.00
87_I303_G0.8741.00
134_E138_A0.8711.00
163_V309_L0.8701.00
233_K236_R0.8641.00
65_V84_L0.8591.00
63_I126_I0.8551.00
194_D199_V0.8551.00
22_V38_L0.8481.00
248_V274_L0.8471.00
268_I274_L0.8451.00
309_L312_R0.8401.00
83_V150_I0.8361.00
263_A276_V0.8301.00
187_A248_V0.8281.00
278_G294_G0.8271.00
264_A291_A0.8271.00
239_L262_A0.8271.00
60_F123_K0.8241.00
191_A226_Y0.8211.00
162_S322_N0.8211.00
220_W241_Q0.8211.00
298_P325_V0.8201.00
253_S281_N0.8171.00
190_H202_V0.8171.00
281_N285_S0.8111.00
124_G314_I0.8101.00
166_D324_T0.8081.00
106_P109_D0.8071.00
202_V221_I0.8031.00
209_L216_V0.8031.00
167_N201_R0.8011.00
185_N220_W0.8001.00
32_E35_E0.8001.00
214_I217_R0.7981.00
207_Q210_A0.7981.00
165_T297_V0.7931.00
14_V37_V0.7921.00
230_T234_A0.7891.00
50_K53_R0.7881.00
244_L268_I0.7871.00
139_Q142_K0.7861.00
89_A93_E0.7861.00
79_F299_T0.7841.00
178_L277_V0.7831.00
166_D326_A0.7811.00
86_A90_K0.7801.00
305_Q325_V0.7771.00
82_E300_Q0.7771.00
235_A262_A0.7761.00
307_C311_F0.7731.00
87_I98_V0.7721.00
62_A120_K0.7651.00
189_L250_A0.7601.00
224_G255_K0.7591.00
118_K143_Y0.7591.00
188_C249_F0.7591.00
246_E275_A0.7571.00
59_G123_K0.7561.00
86_A304_Q0.7561.00
84_L100_L0.7531.00
18_T21_R0.7521.00
17_S21_R0.7491.00
222_V238_L0.7481.00
32_E36_K0.7471.00
112_K115_S0.7401.00
21_R27_T0.7401.00
164_D324_T0.7401.00
239_L266_K0.7351.00
47_Q119_Q0.7311.00
68_T80_F0.7311.00
64_M125_I0.7301.00
173_A295_I0.7291.00
222_V241_Q0.7281.00
235_A238_L0.7251.00
253_S256_L0.7241.00
261_R291_A0.7241.00
138_A141_D0.7221.00
85_H88_T0.7211.00
173_A177_A0.7211.00
200_D204_G0.7191.00
261_R264_A0.7191.00
99_I122_I0.7151.00
141_D160_V0.7151.00
88_T98_V0.7151.00
63_I307_C0.7121.00
257_M288_L0.7101.00
312_R316_G0.7081.00
21_R28_N0.7071.00
161_Y321_Q0.7071.00
249_F277_V0.7061.00
153_V322_N0.7061.00
280_S297_V0.7051.00
164_D322_N0.7051.00
256_L278_G0.7041.00
109_D113_C0.7021.00
263_A270_I0.7001.00
124_G148_V0.6981.00
104_H109_D0.6951.00
149_V154_E0.6951.00
185_N215_A0.6891.00
172_I204_G0.6851.00
241_Q244_L0.6851.00
108_E112_K0.6801.00
22_V34_R0.6791.00
198_S226_Y0.6751.00
59_G315_S0.6741.00
126_I150_I0.6731.00
237_Q240_S0.6721.00
35_E42_E0.6721.00
141_D159_H0.6691.00
88_T102_T0.6681.00
231_A234_A0.6671.00
66_I113_C0.6661.00
141_D147_V0.6651.00
264_A290_P0.6651.00
235_A258_S0.6631.00
316_G319_S0.6621.00
186_I246_E0.6601.00
205_Y216_V0.6521.00
6_Y56_T0.6511.00
47_Q115_S0.6501.00
179_I209_L0.6501.00
140_L147_V0.6471.00
147_V160_V0.6461.00
118_K145_I0.6461.00
151_G197_V0.6371.00
226_Y251_T0.6371.00
148_V310_L0.6361.00
261_R265_E0.6351.00
188_C205_Y0.6351.00
99_I120_K0.6351.00
111_Q136_F0.6341.00
148_V313_L0.6271.00
42_E45_Q0.6241.00
114_E125_I0.6241.00
14_V33_A0.6231.00
124_G306_S0.6221.00
252_D280_S0.6221.00
28_N33_A0.6201.00
86_A299_T0.6181.00
85_H300_Q0.6181.00
312_R321_Q0.6161.00
214_I219_E0.6151.00
82_E299_T0.6141.00
136_F139_Q0.6131.00
178_L249_F0.6131.00
151_G167_N0.6121.00
202_V223_D0.6121.00
224_G230_T0.6081.00
172_I175_T0.6071.00
241_Q245_P0.6061.00
19_V22_V0.6051.00
77_N254_L0.6041.00
186_I205_Y0.6041.00
260_Y264_A0.6031.00
19_V41_I0.6011.00
149_V160_V0.5991.00
36_K39_R0.5971.00
191_A198_S0.5961.00
83_V299_T0.5961.00
148_V163_V0.5941.00
125_I145_I0.5931.00
8_I19_V0.5911.00
263_A266_K0.5891.00
206_K221_I0.5881.00
63_I314_I0.5861.00
174_L247_A0.5851.00
63_I124_G0.5851.00
252_D255_K0.5841.00
96_F314_I0.5831.00
257_M282_E0.5831.00
249_F279_Y0.5821.00
21_R29_I0.5821.00
229_E232_L0.5821.00
285_S292_P0.5811.00
190_H223_D0.5791.00
261_R289_T0.5761.00
167_N200_D0.5741.00
177_A277_V0.5741.00
107_A111_Q0.5721.00
60_F97_D0.5681.00
187_A220_W0.5671.00
47_Q51_L0.5671.00
226_Y255_K0.5671.00
264_A269_A0.5661.00
286_F291_A0.5611.00
153_V162_S0.5601.00
285_S294_G0.5581.00
79_F83_V0.5581.00
228_H258_S0.5571.00
279_Y297_V0.5561.00
63_I96_F0.5551.00
96_F123_K0.5541.00
135_S138_A0.5541.00
62_A123_K0.5541.00
101_Q116_K0.5531.00
250_A278_G0.5531.00
309_L313_L0.5531.00
148_V306_S0.5461.00
165_T170_D0.5461.00
163_V305_Q0.5451.00
148_V309_L0.5431.00
185_N245_P0.5431.00
91_A311_F0.5421.00
91_A96_F0.5421.00
239_L263_A0.5411.00
268_I271_P0.5401.00
257_M284_L0.5391.00
53_R57_S0.5371.00
232_L235_A0.5361.00
219_E241_Q0.5351.00
300_Q303_G0.5351.00
19_V37_V0.5351.00
228_H284_L0.5341.00
87_I91_A0.5331.00
190_H221_I0.5311.00
156_Q159_H0.5301.00
270_I273_Q0.5301.00
198_S251_T0.5291.00
117_I122_I0.5271.00
14_V19_V0.5261.00
259_I263_A0.5261.00
122_I125_I0.5251.00
175_T212_H0.5251.00
25_K28_N0.5231.00
305_Q312_R0.5221.00
12_A22_V0.5221.00
115_S118_K0.5211.00
245_P268_I0.5211.00
139_Q143_Y0.5201.00
78_P254_L0.5191.00
149_V162_S0.5171.00
26_Q29_I0.5161.00
234_A238_L0.5141.00
232_L258_S0.5141.00
103_S110_L0.5131.00
313_L316_G0.5131.00
17_S26_Q0.5121.00
85_H104_H0.5111.00
245_P248_V0.5111.00
281_N294_G0.5091.00
29_I34_R0.5091.00
216_V221_I0.5071.00
90_K311_F0.5071.00
80_F128_L0.5071.00
235_A250_A0.5061.00
12_A37_V0.5061.00
202_V216_V0.5051.00
190_H193_L0.5021.00
7_D11_V0.5021.00
228_H254_L0.5011.00
189_L234_A0.5011.00
253_S282_E0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2hsgA 1 0.9699 100 0.048 Contact Map
3dbiA 2 0.8102 100 0.058 Contact Map
1qpzA 2 0.9759 100 0.068 Contact Map
2o20A 2 0.8133 100 0.069 Contact Map
3kjxA 2 0.9819 100 0.073 Contact Map
4o5aA 2 0.7892 100 0.073 Contact Map
3bilA 2 0.756 100 0.078 Contact Map
3e3mA 2 0.7892 100 0.08 Contact Map
3h5oA 2 0.7952 100 0.088 Contact Map
1jyeA 2 0.7892 100 0.089 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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