GREMLIN Database
ANSP - L-asparagine permease
UniProt: P77610 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13776
Length: 499 (430)
Sequences: 24744 (15998)
Seq/√Len: 771.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
156_G360_L4.5901.00
342_F354_A4.5001.00
402_R406_A3.5951.00
345_K354_A3.2461.00
394_A430_L3.2311.00
71_G265_G3.0781.00
248_D251_T3.0021.00
251_T255_K2.8841.00
31_G247_K2.8401.00
334_A344_A2.7421.00
342_F345_K2.7091.00
347_S353_Y2.6881.00
246_C252_M2.5841.00
36_Q259_S2.4661.00
149_L364_V2.4641.00
32_N259_S2.4571.00
111_G333_M2.4171.00
293_T296_S2.3191.00
95_V336_G2.3181.00
397_I429_T2.2861.00
157_T161_I2.2841.00
188_G274_L2.2731.00
160_M353_Y2.2611.00
331_R335_M2.2211.00
460_L464_G2.1441.00
153_T364_V2.1391.00
458_G461_L2.1331.00
357_L361_V2.1201.00
186_V190_V2.1041.00
35_V246_C2.0871.00
175_L179_L2.0741.00
156_G356_I2.0731.00
293_T297_K2.0401.00
32_N252_M2.0391.00
302_Y306_I2.0361.00
255_K259_S2.0081.00
164_K168_E2.0021.00
99_R107_A1.9941.00
99_R104_E1.9821.00
343_M358_A1.9761.00
32_N36_Q1.9531.00
149_L367_V1.9401.00
462_V466_F1.9321.00
153_T360_L1.9141.00
245_E328_R1.9021.00
55_R63_L1.8951.00
148_A367_V1.8861.00
244_G335_M1.8771.00
102_L398_V1.8731.00
458_G462_V1.8701.00
398_V430_L1.8591.00
80_A397_I1.8561.00
31_G34_Q1.8501.00
73_F432_F1.8341.00
115_F359_T1.8281.00
34_Q171_F1.8281.00
424_F428_L1.8281.00
427_W431_L1.8171.00
83_E404_R1.8161.00
431_L435_S1.8151.00
337_G341_S1.7921.00
248_D252_M1.7871.00
102_L402_R1.7811.00
26_Y346_M1.7791.00
98_A110_A1.7731.00
452_A455_P1.7521.00
72_L76_F1.7401.00
448_T451_I1.7091.00
143_P146_V1.6971.00
122_G363_Y1.6881.00
36_Q263_R1.6771.00
402_R405_K1.6731.00
296_S304_G1.6601.00
450_T453_A1.6561.00
66_V225_L1.6531.00
103_G106_A1.6521.00
160_M357_L1.6321.00
110_A395_F1.6301.00
341_S344_A1.6201.00
258_N262_W1.6151.00
152_L363_Y1.6141.00
72_L428_L1.5661.00
126_I319_L1.5651.00
179_L183_T1.5651.00
88_R100_E1.5581.00
454_L458_G1.5531.00
102_L106_A1.5431.00
452_A456_I1.5391.00
345_K353_Y1.5261.00
435_S439_L1.5211.00
451_I454_L1.5151.00
129_V151_A1.5151.00
156_G357_L1.5131.00
326_T359_T1.5021.00
463_I467_G1.5001.00
349_Q353_Y1.4981.00
347_S351_V1.4961.00
204_G207_L1.4751.00
76_F428_L1.4711.00
39_A260_V1.4661.00
30_M34_Q1.4631.00
161_I349_Q1.4591.00
449_Y452_A1.4561.00
180_A310_V1.4541.00
149_L153_T1.4531.00
185_L270_G1.4391.00
70_C229_V1.4331.00
133_M147_F1.4311.00
189_T274_L1.4311.00
32_N255_K1.4301.00
98_A395_F1.4201.00
262_W266_L1.4151.00
27_H350_H1.4051.00
330_L355_G1.4041.00
252_M255_K1.4001.00
331_R346_M1.3991.00
401_M427_W1.3971.00
449_Y453_A1.3961.00
464_G468_V1.3931.00
354_A358_A1.3911.00
152_L360_L1.3881.00
289_S293_T1.3871.00
461_L464_G1.3821.00
126_I152_L1.3761.00
34_Q167_A1.3731.00
398_V402_R1.3711.00
159_N320_N1.3481.00
451_I455_P1.3401.00
101_F399_C1.3351.00
457_I460_L1.3321.00
305_S309_I1.3301.00
405_K423_P1.3231.00
296_S301_P1.3201.00
64_A273_V1.3151.00
155_V319_L1.3141.00
242_A324_Y1.3141.00
453_A456_I1.3111.00
78_L257_I1.3031.00
327_G356_I1.3001.00
78_L261_I1.2981.00
193_G196_Q1.2951.00
91_S244_G1.2951.00
142_V146_V1.2851.00
26_Y331_R1.2731.00
394_A434_L1.2631.00
412_A415_V1.2631.00
266_L270_G1.2631.00
448_T454_L1.2571.00
421_G425_T1.2571.00
96_S100_E1.2461.00
248_D255_K1.2421.00
178_V182_V1.2351.00
77_I397_I1.2291.00
457_I461_L1.2231.00
335_M344_A1.2211.00
129_V312_L1.2171.00
405_K408_K1.2161.00
205_F208_I1.2161.00
33_R37_M1.2051.00
434_L438_V1.1941.00
50_L128_A1.1921.00
423_P427_W1.1831.00
341_S345_K1.1821.00
140_G143_P1.1811.00
79_R258_N1.1771.00
90_S96_S1.1751.00
43_A264_I1.1691.00
424_F427_W1.1661.00
448_T452_A1.1621.00
158_M169_M1.1561.00
98_A106_A1.1561.00
112_W458_G1.1491.00
193_G197_P1.1491.00
188_G278_L1.1471.00
184_F188_G1.1441.00
145_W149_L1.1441.00
397_I430_L1.1421.00
455_P458_G1.1381.00
247_K252_M1.1371.00
62_A215_F1.1321.00
68_L269_V1.1321.00
80_A426_S1.1281.00
125_D318_S1.1271.00
115_F330_L1.1181.00
105_K465_W1.1171.00
190_V194_S1.1141.00
192_L277_M1.1121.00
35_V256_A1.1071.00
461_L465_W1.1071.00
168_E172_W1.1041.00
30_M167_A1.1031.00
408_K412_A1.0941.00
85_V97_Y1.0841.00
394_A433_L1.0831.00
189_T193_G1.0831.00
59_A62_A1.0811.00
354_A357_L1.0781.00
156_G160_M1.0761.00
462_V465_W1.0761.00
415_V418_K1.0721.00
458_G465_W1.0681.00
400_Q426_S1.0681.00
190_V195_G1.0661.00
169_M173_F1.0611.00
183_T187_V1.0611.00
40_I263_R1.0611.00
421_G424_F1.0611.00
301_P305_S1.0601.00
413_A416_S1.0591.00
30_M35_V1.0571.00
206_H209_T1.0491.00
29_A247_K1.0471.00
444_Y448_T1.0451.00
150_A154_I1.0421.00
90_S100_E1.0301.00
249_P254_P1.0291.00
154_I316_L1.0271.00
38_I242_A1.0261.00
330_L339_A1.0261.00
87_H413_A1.0261.00
194_S197_P1.0231.00
223_L435_S1.0221.00
62_A222_A1.0211.00
100_E407_I1.0171.00
422_A426_S1.0161.00
407_I412_A1.0151.00
81_L94_F1.0141.00
130_A147_F1.0141.00
39_A239_V1.0071.00
465_W468_V1.0071.00
273_V277_M1.0021.00
37_M171_F1.0021.00
448_T455_P1.0001.00
456_I460_L0.9951.00
361_V365_V0.9921.00
459_I463_I0.9911.00
192_L195_G0.9811.00
346_M350_H0.9811.00
163_V324_Y0.9801.00
76_F425_T0.9781.00
168_E171_F0.9741.00
40_I264_I0.9721.00
218_G221_P0.9711.00
182_V186_V0.9711.00
224_V228_G0.9691.00
146_V150_A0.9691.00
407_I413_A0.9661.00
203_T206_H0.9651.00
408_K415_V0.9651.00
173_F317_S0.9571.00
56_L63_L0.9561.00
87_H415_V0.9551.00
99_R336_G0.9501.00
259_S263_R0.9501.00
283_A297_K0.9491.00
133_M137_G0.9401.00
204_G209_T0.9391.00
438_V442_F0.9391.00
210_D213_G0.9361.00
430_L434_L0.9361.00
29_A164_K0.9351.00
234_A389_I0.9301.00
147_F150_A0.9281.00
133_M312_L0.9231.00
33_R171_F0.9211.00
83_E86_L0.9111.00
170_E320_N0.9111.00
360_L364_V0.9101.00
153_T157_T0.9061.00
108_Y112_W0.9061.00
323_L360_L0.9031.00
178_V267_F0.9021.00
243_A253_V0.9021.00
450_T454_L0.9011.00
190_V193_G0.9001.00
455_P459_I0.8981.00
429_T433_L0.8981.00
295_F298_L0.8951.00
464_G467_G0.8931.00
106_A395_F0.8911.00
149_L368_F0.8891.00
77_I433_L0.8801.00
404_R408_K0.8801.00
449_Y456_I0.8771.00
34_Q168_E0.8751.00
160_M351_V0.8661.00
185_L189_T0.8651.00
435_S438_V0.8641.00
302_Y305_S0.8641.00
84_L400_Q0.8611.00
454_L457_I0.8521.00
238_M325_C0.8491.00
299_G303_I0.8491.00
185_L274_L0.8481.00
265_G269_V0.8471.00
448_T453_A0.8471.00
124_V382_L0.8441.00
215_F222_A0.8441.00
300_V303_I0.8421.00
353_Y357_L0.8391.00
112_W339_A0.8381.00
343_M354_A0.8361.00
92_G96_S0.8361.00
58_M61_P0.8351.00
453_A457_I0.8351.00
280_P297_K0.8351.00
414_D418_K0.8331.00
287_G293_T0.8311.00
155_V320_N0.8311.00
141_G144_Q0.8301.00
129_V315_A0.8301.00
205_F209_T0.8271.00
289_S292_V0.8251.00
157_T160_M0.8251.00
433_L436_V0.8241.00
423_P426_S0.8191.00
437_L440_M0.8181.00
75_F79_R0.8181.00
207_L210_D0.8181.00
103_G466_F0.8171.00
450_T455_P0.8161.00
290_P294_F0.8151.00
137_G140_G0.8141.00
444_Y449_Y0.8131.00
121_T124_V0.8111.00
42_G321_S0.8061.00
124_V231_F0.8051.00
283_A286_A0.8051.00
71_G233_F0.8041.00
206_H210_D0.8041.00
134_H144_Q0.8021.00
161_I165_W0.8011.00
453_A458_G0.8001.00
185_L271_S0.7991.00
64_A276_V0.7981.00
95_V332_S0.7961.00
459_I462_V0.7941.00
130_A148_A0.7921.00
86_L416_S0.7881.00
145_W367_V0.7881.00
347_S350_H0.7861.00
208_I211_N0.7851.00
192_L196_Q0.7831.00
426_S430_L0.7801.00
401_M405_K0.7791.00
280_P283_A0.7761.00
29_A163_V0.7751.00
32_N256_A0.7731.00
135_Y138_A0.7721.00
105_K109_V0.7721.00
449_Y455_P0.7691.00
394_A398_V0.7691.00
422_A425_T0.7681.00
167_A171_F0.7671.00
155_V323_L0.7601.00
284_Y287_G0.7601.00
413_A418_K0.7561.00
327_G355_G0.7531.00
98_A399_C0.7531.00
401_M426_S0.7521.00
286_A290_P0.7501.00
219_L222_A0.7501.00
191_F194_S0.7451.00
61_P276_V0.7441.00
29_A33_R0.7431.00
451_I456_I0.7401.00
203_T207_L0.7381.00
145_W148_A0.7371.00
160_M347_S0.7331.00
399_C403_L0.7291.00
191_F197_P0.7281.00
278_L294_F0.7261.00
36_Q256_A0.7261.00
26_Y29_A0.7231.00
334_A343_M0.7211.00
436_V440_M0.7201.00
339_A343_M0.7201.00
237_E241_T0.7171.00
207_L211_N0.7171.00
433_L437_L0.7161.00
426_S440_M0.7151.00
63_L272_V0.7131.00
361_V364_V0.7121.00
444_Y450_T0.7101.00
384_F388_G0.7101.00
165_W168_E0.7091.00
33_R168_E0.7081.00
415_V419_L0.7081.00
184_F295_F0.7071.00
460_L463_I0.7051.00
84_L97_Y0.7051.00
43_A260_V0.7051.00
348_R353_Y0.7041.00
114_Y118_W0.7041.00
189_T270_G0.7041.00
92_G95_V0.7021.00
448_T461_L0.7021.00
352_P355_G0.7021.00
68_L72_L0.7011.00
285_Q288_Q0.7011.00
119_A362_V0.7001.00
82_G86_L0.6991.00
401_M423_P0.6981.00
75_F258_N0.6971.00
450_T456_I0.6961.00
81_L396_I0.6961.00
455_P462_V0.6951.00
291_F295_F0.6931.00
263_R267_F0.6921.00
290_P295_F0.6911.00
458_G467_G0.6911.00
159_N356_I0.6911.00
212_G215_F0.6901.00
448_T462_V0.6901.00
52_A55_R0.6881.00
250_Q416_S0.6851.00
129_V316_L0.6841.00
121_T385_A0.6841.00
403_L407_I0.6831.00
153_T156_G0.6811.00
429_T432_F0.6801.00
120_M384_F0.6791.00
42_G322_G0.6791.00
52_A272_V0.6781.00
65_L69_I0.6751.00
177_K314_A0.6751.00
65_L222_A0.6721.00
254_P257_I0.6721.00
130_A133_M0.6701.00
400_Q404_R0.6691.00
427_W430_L0.6681.00
204_G208_I0.6681.00
123_I381_V0.6671.00
44_I47_G0.6651.00
126_I130_A0.6651.00
64_A68_L0.6641.00
274_L277_M0.6621.00
449_Y454_L0.6611.00
54_A379_E0.6611.00
152_L364_V0.6591.00
102_L105_K0.6581.00
460_L466_F0.6571.00
450_T457_I0.6571.00
162_G165_W0.6571.00
408_K413_A0.6571.00
65_L68_L0.6561.00
286_A289_S0.6561.00
130_A144_Q0.6551.00
62_A214_F0.6541.00
118_W322_G0.6541.00
152_L367_V0.6541.00
74_S236_I0.6531.00
205_F277_M0.6531.00
70_C230_V0.6511.00
343_M355_G0.6491.00
240_G257_I0.6481.00
342_F358_A0.6481.00
241_T325_C0.6481.00
117_N389_I0.6481.00
54_A58_M0.6471.00
131_L144_Q0.6471.00
191_F196_Q0.6471.00
133_M151_A0.6451.00
213_G216_P0.6431.00
387_L437_L0.6431.00
78_L236_I0.6421.00
84_L101_F0.6421.00
121_T125_D0.6411.00
48_L271_S0.6411.00
76_F429_T0.6391.00
87_H416_S0.6391.00
449_Y460_L0.6381.00
85_V240_G0.6381.00
134_H138_A0.6371.00
370_N377_V0.6351.00
64_A67_Y0.6331.00
192_L197_P0.6311.00
101_F403_L0.6311.00
388_G392_S0.6311.00
160_M356_I0.6311.00
448_T465_W0.6291.00
210_D214_F0.6281.00
187_V191_F0.6261.00
420_P424_F0.6241.00
219_L223_L0.6241.00
129_V133_M0.6231.00
462_V467_G0.6231.00
76_F80_A0.6231.00
444_Y451_I0.6221.00
102_L399_C0.6211.00
448_T456_I0.6201.00
36_Q39_A0.6201.00
326_T330_L0.6201.00
463_I466_F0.6191.00
101_F402_R0.6181.00
271_S275_L0.6181.00
263_R266_L0.6161.00
26_Y245_E0.6161.00
377_V380_I0.6161.00
244_G331_R0.6161.00
419_L422_A0.6151.00
91_S331_R0.6141.00
125_D128_A0.6131.00
365_V368_F0.6121.00
330_L358_A0.6121.00
422_A427_W0.6111.00
160_M349_Q0.6111.00
139_F143_P0.6091.00
87_H403_L0.6071.00
342_F346_M0.6061.00
283_A287_G0.6061.00
180_A306_I0.6051.00
159_N324_Y0.6021.00
39_A43_A0.6021.00
449_Y458_G0.6021.00
127_T381_V0.6011.00
421_G426_S0.5981.00
64_A269_V0.5981.00
26_Y328_R0.5971.00
461_L467_G0.5961.00
285_Q289_S0.5961.00
337_G344_A0.5951.00
306_I310_V0.5951.00
95_V99_R0.5951.00
44_I267_F0.5951.00
79_R420_P0.5941.00
135_Y308_N0.5931.00
40_I174_A0.5921.00
155_V316_L0.5901.00
234_A393_W0.5881.00
119_A359_T0.5881.00
165_W169_M0.5871.00
246_C253_V0.5861.00
176_I310_V0.5861.00
284_Y290_P0.5861.00
223_L439_L0.5811.00
253_V257_I0.5781.00
438_V441_A0.5781.00
85_V253_V0.5761.00
58_M224_V0.5761.00
35_V242_A0.5761.00
389_I392_S0.5731.00
51_G382_L0.5731.00
414_D417_F0.5711.00
166_F324_Y0.5691.00
54_A57_Q0.5691.00
95_V111_G0.5671.00
390_I433_L0.5671.00
357_L360_L0.5671.00
328_R331_R0.5671.00
379_E382_L0.5671.00
353_Y356_I0.5661.00
151_A319_L0.5661.00
67_Y232_A0.5651.00
144_Q148_A0.5641.00
58_M225_L0.5631.00
113_M391_A0.5621.00
439_L443_D0.5611.00
79_R425_T0.5551.00
451_I462_V0.5551.00
171_F175_L0.5531.00
51_G54_A0.5521.00
271_S291_F0.5501.00
448_T459_I0.5501.00
292_V296_S0.5491.00
40_I43_A0.5481.00
176_I180_A0.5481.00
319_L322_G0.5481.00
182_V267_F0.5461.00
55_R59_A0.5461.00
211_N216_P0.5451.00
125_D319_L0.5451.00
323_L327_G0.5451.00
453_A464_G0.5431.00
128_A132_Y0.5421.00
458_G463_I0.5411.00
223_L227_Q0.5411.00
66_V69_I0.5411.00
26_Y91_S0.5391.00
270_G274_L0.5371.00
82_G257_I0.5361.00
174_A177_K0.5361.00
70_C233_F0.5361.00
346_M349_Q0.5351.00
215_F218_G0.5351.00
309_I313_T0.5351.00
52_A56_L0.5341.00
234_A237_E0.5331.00
221_P224_V0.5331.00
428_L431_L0.5321.00
48_L52_A0.5311.00
248_D254_P0.5301.00
63_L66_V0.5301.00
426_S433_L0.5291.00
460_L465_W0.5291.00
211_N282_S0.5281.00
98_A107_A0.5281.00
259_S262_W0.5281.00
433_L440_M0.5271.00
28_K247_K0.5261.00
113_M392_S0.5261.00
290_P298_L0.5251.00
79_R417_F0.5251.00
61_P64_A0.5241.00
52_A275_L0.5241.00
314_A317_S0.5241.00
404_R422_A0.5241.00
132_Y311_V0.5231.00
450_T465_W0.5211.00
156_G323_L0.5211.00
25_G28_K0.5181.00
88_R101_F0.5171.00
115_F119_A0.5171.00
94_F237_E0.5151.00
29_A350_H0.5141.00
301_P304_G0.5141.00
323_L359_T0.5141.00
305_S308_N0.5121.00
90_S244_G0.5111.00
295_F300_V0.5101.00
94_F396_I0.5101.00
294_F298_L0.5091.00
431_L434_L0.5091.00
24_E27_H0.5081.00
330_L334_A0.5081.00
358_A362_V0.5081.00
403_L408_K0.5081.00
458_G466_F0.5081.00
197_P277_M0.5071.00
61_P281_W0.5061.00
142_V147_F0.5061.00
462_V468_V0.5051.00
172_W175_L0.5041.00
87_H408_K0.5041.00
80_A429_T0.5041.00
41_G174_A0.5031.00
192_L274_L0.5031.00
376_R379_E0.5031.00
110_A392_S0.5031.00
107_A111_G0.5021.00
249_P252_M0.5011.00
197_P276_V0.5011.00
86_L250_Q0.5011.00
220_L224_V0.5011.00
234_A385_A0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3l1lA 2 0.8397 100 0.357 Contact Map
3giaA 1 0.8577 100 0.396 Contact Map
4djkA 2 0.8497 100 0.397 Contact Map
2jlnA 1 0.8717 99.3 0.844 Contact Map
3dh4A 3 0.8758 98.9 0.869 Contact Map
2xq2A 2 0.8758 98.9 0.871 Contact Map
4wgvA 2 0.7455 98.1 0.899 Contact Map
4xp4A 1 0.8798 97.6 0.91 Contact Map
4us3A 1 0.7896 97.2 0.917 Contact Map
2a65A 2 0.8637 97 0.918 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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