GREMLIN Database
YAGL - Uncharacterized protein YagL
UniProt: P77607 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13551
Length: 232 (183)
Sequences: 7961 (6036)
Seq/√Len: 446.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
81_V104_E3.3741.00
96_L99_Q3.3351.00
201_L214_K3.0131.00
83_E96_L2.5201.00
50_T63_H2.5091.00
197_D201_L2.4831.00
48_F66_L2.4191.00
100_L111_L2.3751.00
63_H67_A2.3241.00
63_H82_I2.1521.00
206_F214_K2.0791.00
68_E72_K2.0681.00
178_R182_V1.9941.00
168_D171_N1.9391.00
201_L206_F1.9211.00
179_Y184_K1.8791.00
156_C167_I1.8771.00
124_E131_F1.8271.00
209_A213_K1.8091.00
63_H80_V1.8071.00
208_Q223_K1.8001.00
212_A222_V1.7781.00
54_S57_Q1.7741.00
159_F163_R1.7601.00
123_V159_F1.7521.00
64_H68_E1.7171.00
47_F104_E1.6761.00
169_I173_K1.6701.00
202_K226_W1.6651.00
79_H99_Q1.6481.00
126_L162_A1.6451.00
133_C138_M1.6301.00
223_K227_N1.6141.00
127_Q159_F1.5871.00
105_M111_L1.5731.00
47_F100_L1.5611.00
206_F210_E1.5521.00
130_L158_S1.5461.00
45_R109_D1.5351.00
132_F136_K1.5181.00
134_L155_S1.4901.00
46_S75_I1.4781.00
124_E128_N1.4711.00
48_F80_V1.4411.00
97_L129_I1.4391.00
142_S145_P1.4371.00
172_L176_K1.4261.00
155_S166_T1.4251.00
105_M138_M1.4071.00
151_P154_E1.4071.00
156_C163_R1.4011.00
207_T210_E1.3871.00
70_C77_P1.3841.00
120_G126_L1.3821.00
200_I204_G1.3801.00
197_D214_K1.3531.00
113_I140_I1.3441.00
67_A80_V1.3341.00
202_K211_I1.3181.00
177_S181_H1.2981.00
123_V127_Q1.2971.00
113_I142_S1.2941.00
175_T179_Y1.2811.00
117_S165_D1.2641.00
201_L211_I1.2631.00
209_A219_L1.2481.00
93_E98_R1.2271.00
90_V125_D1.2111.00
45_R76_L1.2081.00
219_L223_K1.1941.00
178_R181_H1.1841.00
85_V95_R1.1821.00
69_I73_F1.1811.00
67_A71_Q1.1441.00
65_S114_P1.1401.00
64_H178_R1.1391.00
106_N132_F1.1371.00
66_L112_V1.1321.00
131_F135_Q1.1181.00
197_D200_I1.1171.00
123_V162_A1.1161.00
97_L100_L1.1091.00
198_I211_I1.1061.00
114_P174_S1.1001.00
99_Q104_E1.1001.00
81_V100_L1.0951.00
101_I129_I1.0911.00
201_L204_G1.0651.00
50_T59_S1.0621.00
50_T80_V1.0601.00
130_L140_I1.0581.00
110_T141_Y1.0491.00
81_V96_L1.0421.00
202_K208_Q1.0371.00
46_S110_T1.0371.00
61_T114_P1.0121.00
110_T139_F0.9971.00
176_K186_L0.9881.00
70_C75_I0.9761.00
218_S221_T0.9711.00
65_S174_S0.9661.00
79_H104_E0.9651.00
48_F77_P0.9611.00
177_S180_R0.9591.00
117_S171_N0.9581.00
47_F81_V0.9561.00
89_E93_E0.9501.00
106_N136_K0.9441.00
50_T82_I0.9401.00
113_I119_L0.9361.00
77_P80_V0.9331.00
156_C164_Q0.9331.00
87_I121_R0.9251.00
198_I225_H0.9151.00
156_C160_L0.9121.00
68_E71_Q0.9121.00
61_T174_S0.9051.00
85_V89_E0.9011.00
198_I222_V0.8901.00
222_V225_H0.8891.00
119_L129_I0.8881.00
160_L163_R0.8831.00
111_L133_C0.8801.00
176_K180_R0.8771.00
180_R186_L0.8751.00
152_S170_H0.8741.00
116_L165_D0.8741.00
87_I120_G0.8731.00
65_S68_E0.8711.00
164_Q167_I0.8691.00
101_I132_F0.8661.00
44_M109_D0.8561.00
160_L164_Q0.8521.00
107_R137_E0.8471.00
97_L119_L0.8471.00
210_E214_K0.8441.00
52_C57_Q0.8341.00
50_T66_L0.8291.00
169_I172_L0.8251.00
59_S82_I0.8251.00
115_D144_H0.8241.00
52_C84_Q0.8191.00
115_D171_N0.8131.00
173_K176_K0.8131.00
139_F150_E0.8091.00
70_C112_V0.8041.00
208_Q219_L0.8011.00
59_S84_Q0.7991.00
69_I112_V0.7991.00
198_I215_L0.7951.00
199_T202_K0.7931.00
141_Y148_R0.7921.00
61_T178_R0.7921.00
217_I222_V0.7881.00
200_I203_K0.7871.00
120_G129_I0.7861.00
211_I222_V0.7851.00
69_I143_Y0.7841.00
176_K179_Y0.7831.00
128_N132_F0.7781.00
225_H228_N0.7771.00
44_M139_F0.7701.00
212_A219_L0.7691.00
210_E213_K0.7651.00
88_K169_I0.7641.00
153_A156_C0.7631.00
211_I215_L0.7611.00
125_D128_N0.7601.00
61_T115_D0.7551.00
69_I141_Y0.7501.00
60_I64_H0.7421.00
100_L105_M0.7401.00
217_I225_H0.7361.00
49_Y83_E0.7361.00
116_L142_S0.7331.00
122_T125_D0.7331.00
82_I96_L0.7321.00
196_R200_I0.7311.00
122_T131_F0.7261.00
185_K190_E0.7251.00
45_R78_E0.7221.00
139_F148_R0.7171.00
196_R199_T0.7151.00
205_G211_I0.7151.00
208_Q212_A0.7141.00
212_A216_S0.7041.00
220_S224_R0.7011.00
172_L175_T0.6991.00
159_F166_T0.6931.00
171_N174_S0.6871.00
67_A77_P0.6851.00
64_H67_A0.6831.00
61_T65_S0.6811.00
199_T203_K0.6791.00
116_L158_S0.6751.00
100_L104_E0.6711.00
191_G194_Y0.6621.00
212_A217_I0.6581.00
99_Q102_H0.6541.00
44_M110_T0.6531.00
203_K206_F0.6460.99
114_P144_H0.6440.99
129_I133_C0.6390.99
157_L164_Q0.6340.99
199_T228_N0.6310.99
145_P161_I0.6290.99
46_S70_C0.6230.99
152_S167_I0.6180.99
208_Q222_V0.6180.99
198_I201_L0.6180.99
126_L158_S0.6120.99
221_T224_R0.6110.99
206_F211_I0.6070.99
170_H174_S0.6070.99
173_K177_S0.6070.99
179_Y186_L0.6060.99
98_R102_H0.6040.99
174_S178_R0.6000.99
202_K222_V0.5960.99
157_L161_I0.5920.99
105_M133_C0.5910.99
120_G125_D0.5910.99
97_L101_I0.5890.99
192_S215_L0.5890.99
156_C159_F0.5850.99
102_H107_R0.5840.99
198_I202_K0.5800.99
169_I176_K0.5780.99
153_A167_I0.5770.99
104_E107_R0.5770.99
188_R193_K0.5770.99
81_V99_Q0.5770.99
208_Q226_W0.5740.99
218_S223_K0.5730.99
188_R191_G0.5680.99
174_S177_S0.5670.99
157_L160_L0.5660.99
192_S225_H0.5630.99
123_V163_R0.5630.99
202_K207_T0.5620.99
207_T213_K0.5560.98
153_A157_L0.5550.98
161_I164_Q0.5550.98
222_V226_W0.5540.98
123_V166_T0.5480.98
212_A215_L0.5470.98
124_E127_Q0.5450.98
132_F135_Q0.5450.98
97_L125_D0.5440.98
47_F78_E0.5410.98
66_L143_Y0.5400.98
150_E154_E0.5350.98
198_I217_I0.5300.98
190_E193_K0.5260.98
127_Q131_F0.5250.98
176_K185_K0.5250.98
200_I214_K0.5240.98
197_D215_L0.5240.98
201_L205_G0.5200.98
90_V97_L0.5180.98
220_S223_K0.5180.98
58_E84_Q0.5180.98
46_S141_Y0.5170.98
192_S217_I0.5160.98
221_T225_H0.5110.97
120_G162_A0.5080.97
158_S162_A0.5060.97
200_I205_G0.5050.97
217_I221_T0.5040.97
46_S112_V0.5040.97
90_V120_G0.5020.97
185_K188_R0.5010.97
112_V141_Y0.5010.97
215_L222_V0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1gdtA 2 0.7716 100 0.316 Contact Map
2r0qC 3 0.7371 100 0.342 Contact Map
4bqqA 2 0.7759 100 0.352 Contact Map
3uj3X 2 0.5172 100 0.358 Contact Map
3g13A 2 0.6336 100 0.43 Contact Map
3guvA 2 0.5862 100 0.432 Contact Map
3lhkA 2 0.5948 100 0.518 Contact Map
2gm5A 4 0.5172 100 0.52 Contact Map
3bvpA 4 0.5474 100 0.526 Contact Map
3ilxA 2 0.5431 100 0.543 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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