GREMLIN Database
YFCS - Probable fimbrial chaperone YfcS
UniProt: P77599 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG14122
Length: 250 (215)
Sequences: 2801 (2129)
Seq/√Len: 145.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
98_G102_I3.3881.00
180_I200_V3.2511.00
65_I140_L3.2041.00
178_Y202_E3.0101.00
40_N43_D2.9681.00
172_N206_T2.9501.00
109_R204_K2.9211.00
202_E205_T2.9021.00
112_M200_V2.8881.00
32_P138_I2.8281.00
105_L113_F2.6361.00
37_L46_I2.5991.00
170_T208_P2.5811.00
59_Y119_E2.5051.00
170_T206_T2.5031.00
37_L115_F2.4941.00
223_N229_M2.4851.00
37_L96_V2.4351.00
158_H162_L2.3451.00
141_F200_V2.3371.00
42_S145_K2.3141.00
161_T172_N2.2761.00
171_V209_L2.2531.00
141_F178_Y2.1131.00
58_P87_D2.0781.00
64_W116_N2.0101.00
66_E137_R1.9861.00
40_N46_I1.9291.00
163_T170_T1.8861.00
118_R135_Q1.8771.00
63_S94_V1.8411.00
77_L96_V1.8361.00
147_L177_Y1.8111.00
112_M141_F1.8091.00
106_P111_S1.7781.00
179_V221_Y1.6971.00
79_V94_V1.6921.00
58_P85_R1.6671.00
66_E116_N1.6651.00
32_P117_V1.6651.00
87_D90_M1.6551.00
168_A208_P1.6441.00
165_S170_T1.6261.00
116_N137_R1.5981.00
162_L171_V1.5821.00
39_F46_I1.5201.00
149_K153_K1.5101.00
65_I75_S1.5071.00
183_N220_T1.4981.00
154_S179_V1.4741.00
41_E107_A1.4691.00
61_A84_Q1.3891.00
48_V115_F1.3841.00
157_Q162_L1.3801.00
223_N227_A1.3761.00
160_V163_T1.3711.00
112_M180_I1.3691.00
49_T91_N1.3591.00
45_S95_K1.3551.00
106_P109_R1.3401.00
77_L140_L1.3331.00
67_D71_N1.3291.00
201_I207_V1.3161.00
150_V153_K1.3071.00
163_T172_N1.2851.00
32_P48_V1.2691.00
56_K89_M1.2621.00
50_L86_I1.2301.00
185_S218_V1.2251.00
37_L138_I1.2251.00
124_S129_T1.2241.00
54_D119_E1.2221.00
180_I221_Y1.2171.00
182_S228_R1.2081.00
176_P204_K1.2041.00
115_F140_L1.1991.00
98_G103_N1.1991.00
98_G142_W1.1961.00
94_V115_F1.1811.00
169_F211_V1.1791.00
34_R48_V1.1731.00
98_G104_K1.1651.00
41_E145_K1.1631.00
160_V171_V1.1380.99
165_S208_P1.1270.99
79_V96_V1.1220.99
31_T34_R1.1180.99
124_S131_Q1.1170.99
149_K177_Y1.1170.99
160_V179_V1.1030.99
67_D73_I1.1020.99
221_Y229_M1.0910.99
41_E142_W1.0840.99
11_G16_A1.0750.99
96_V140_L1.0640.99
164_R168_A1.0510.99
33_D49_T1.0410.99
114_Y137_R1.0400.99
119_E134_L1.0380.99
30_V86_I1.0340.99
29_S119_E1.0240.99
162_L219_L1.0180.99
64_W137_R1.0110.99
221_Y231_L1.0100.99
181_I201_I1.0090.99
181_I221_Y1.0040.99
159_K174_P1.0020.99
51_R91_N0.9910.99
79_V115_F0.9720.98
66_E70_G0.9710.98
32_P50_L0.9710.98
157_Q160_V0.9630.98
151_S154_S0.9510.98
154_S221_Y0.9500.98
39_F97_Q0.9470.98
16_A19_L0.9420.98
36_R143_R0.9410.98
149_K154_S0.9390.98
84_Q92_G0.9350.98
12_A20_S0.9350.98
30_V61_A0.9310.98
23_S27_L0.9290.98
160_V181_I0.9260.98
172_N204_K0.9210.98
185_S189_N0.9200.98
64_W118_R0.9090.97
54_D57_L0.9010.97
165_S168_A0.8980.97
65_I79_V0.8960.97
92_G118_R0.8830.97
63_S79_V0.8820.97
39_F77_L0.8790.97
178_Y203_P0.8750.97
108_D204_K0.8740.97
54_D59_Y0.8740.97
112_M178_Y0.8680.97
220_T228_R0.8640.96
114_Y118_R0.8600.96
94_V117_V0.8580.96
139_K222_V0.8490.96
153_K158_H0.8460.96
24_L27_L0.8360.96
33_D91_N0.8330.96
157_Q179_V0.8280.96
105_L109_R0.8250.95
86_I91_N0.8180.95
84_Q94_V0.8160.95
22_T26_A0.8110.95
108_D143_R0.8110.95
220_T230_P0.8110.95
37_L48_V0.8040.95
13_M16_A0.8020.95
66_E114_Y0.7990.95
18_L23_S0.7980.95
49_T83_V0.7960.94
113_F142_W0.7880.94
110_E143_R0.7850.94
92_G119_E0.7820.94
128_N137_R0.7790.94
86_I90_M0.7780.94
15_L18_L0.7770.94
116_N135_Q0.7730.94
29_S59_Y0.7640.93
31_T53_N0.7620.93
39_F98_G0.7620.93
65_I120_I0.7600.93
168_A210_N0.7580.93
62_Q118_R0.7570.93
61_A86_I0.7560.93
29_S53_N0.7540.93
17_L20_S0.7540.93
169_F184_A0.7510.93
68_E114_Y0.7430.92
36_R139_K0.7400.92
83_V91_N0.7350.92
14_T17_L0.7340.92
66_E128_N0.7330.92
185_S190_G0.7280.91
180_I198_P0.7210.91
169_F217_P0.7210.91
77_L111_S0.7200.91
133_A162_L0.7170.91
186_A217_P0.7160.91
111_S142_W0.7140.91
198_P209_L0.7140.91
97_Q203_P0.7090.90
50_L61_A0.7090.90
59_Y118_R0.7030.90
181_I219_L0.7010.90
114_Y139_K0.7010.90
158_H164_R0.6990.90
109_R144_P0.6970.90
116_N139_K0.6960.89
164_R213_M0.6960.89
187_Q191_N0.6950.89
162_L184_A0.6940.89
117_V138_I0.6930.89
182_S222_V0.6850.89
38_I143_R0.6850.89
160_V164_R0.6830.89
139_K143_R0.6810.88
164_R167_Q0.6800.88
53_N122_P0.6800.88
25_S28_A0.6780.88
86_I92_G0.6780.88
150_V154_S0.6750.88
171_V201_I0.6720.88
30_V59_Y0.6690.88
17_L24_L0.6680.87
12_A15_L0.6680.87
187_Q216_V0.6660.87
34_R37_L0.6650.87
32_P53_N0.6640.87
63_S117_V0.6610.87
185_S192_P0.6600.87
14_T24_L0.6570.87
77_L142_W0.6560.87
197_S210_N0.6550.86
181_I227_A0.6540.86
31_T136_T0.6530.86
96_V115_F0.6530.86
157_Q175_T0.6520.86
114_Y180_I0.6480.86
68_E112_M0.6470.86
11_G18_L0.6450.86
184_A209_L0.6410.85
107_A146_A0.6400.85
67_D74_T0.6400.85
21_A25_S0.6360.85
59_Y63_S0.6310.84
78_T97_Q0.6250.84
119_E133_A0.6230.84
65_I113_F0.6230.84
12_A19_L0.6210.83
18_L21_A0.6150.83
201_I205_T0.6130.83
146_A149_K0.6120.82
139_K180_I0.6070.82
15_L19_L0.6070.82
40_N141_F0.6060.82
23_S26_A0.6010.81
69_K72_K0.5960.81
108_D111_S0.5930.80
67_D75_S0.5900.80
82_P120_I0.5870.80
121_P133_A0.5860.80
11_G14_T0.5860.80
165_S210_N0.5850.80
24_L230_P0.5820.79
58_P122_P0.5820.79
16_A27_L0.5810.79
60_L177_Y0.5770.79
178_Y205_T0.5770.79
116_N128_N0.5700.78
68_E137_R0.5690.78
133_A137_R0.5650.77
163_T183_N0.5620.77
95_K121_P0.5610.77
35_T143_R0.5590.76
157_Q221_Y0.5590.76
36_R144_P0.5590.76
32_P136_T0.5570.76
20_S23_S0.5530.76
54_D118_R0.5520.76
60_L118_R0.5500.75
105_L111_S0.5450.75
39_F43_D0.5450.75
22_T27_L0.5440.75
119_E180_I0.5430.74
47_S132_I0.5420.74
186_A216_V0.5410.74
36_R224_D0.5400.74
63_S92_G0.5390.74
43_D103_N0.5370.74
128_N131_Q0.5360.73
24_L210_N0.5360.73
114_Y117_V0.5350.73
13_M25_S0.5350.73
59_Y86_I0.5330.73
181_I184_A0.5320.73
11_G24_L0.5320.73
54_D114_Y0.5310.73
50_L122_P0.5300.73
14_T18_L0.5300.73
63_S84_Q0.5290.73
153_K159_K0.5280.72
67_D70_G0.5260.72
134_L198_P0.5240.72
183_N187_Q0.5230.72
64_W136_T0.5230.72
12_A17_L0.5230.72
199_L209_L0.5230.72
25_S192_P0.5210.71
75_S80_L0.5210.71
207_V210_N0.5210.71
42_S130_L0.5190.71
32_P60_L0.5190.71
38_I139_K0.5190.71
130_L137_R0.5170.71
114_Y135_Q0.5150.71
168_A211_V0.5150.71
188_K193_A0.5140.70
184_A211_V0.5140.70
143_R177_Y0.5130.70
12_A16_A0.5120.70
188_K191_N0.5110.70
119_E135_Q0.5090.70
169_F208_P0.5080.69
19_L23_S0.5080.69
34_R115_F0.5080.69
171_V181_I0.5070.69
80_L95_K0.5070.69
82_P97_Q0.5060.69
21_A28_A0.5060.69
134_L137_R0.5050.69
107_A126_K0.5040.69
105_L108_D0.5030.69
24_L56_K0.5030.69
145_K148_E0.5020.69
114_Y134_L0.5010.68
60_L82_P0.5010.68
131_Q134_L0.5000.68
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2xg5A 1 0.856 100 0.171 Contact Map
3gfuC 1 0.824 100 0.203 Contact Map
3q48A 1 0.752 100 0.211 Contact Map
2co7B 1 0.78 100 0.216 Contact Map
1klfA 1 0.796 100 0.227 Contact Map
1l4iA 2 0.756 100 0.233 Contact Map
4djmA 1 0.796 100 0.26 Contact Map
4ay0A 2 0.748 100 0.262 Contact Map
4ncdA 2 0.772 100 0.301 Contact Map
1mspA 3 0.44 85.6 0.93 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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