GREMLIN Database
YPDE - Aminopeptidase YpdE
UniProt: P77585 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG14152
Length: 345 (322)
Sequences: 2618 (1740)
Seq/√Len: 96.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
132_Y136_M4.8661.00
12_A25_I3.4861.00
159_R315_D3.1501.00
321_Q324_Q2.7571.00
81_V125_V2.7121.00
15_I84_V2.6961.00
7_K11_E2.6501.00
238_Q241_N2.6181.00
129_A135_V2.6061.00
176_T179_R2.5521.00
258_L298_V2.5031.00
100_T147_T2.4901.00
269_I328_A2.4571.00
10_S162_G2.4191.00
60_C195_S2.4021.00
74_S80_D2.3931.00
57_V330_I2.3011.00
27_L31_D2.2411.00
79_I99_I2.2411.00
56_K191_W2.1741.00
48_R189_E2.1641.00
16_A84_V2.1501.00
27_L39_F2.1391.00
272_P321_Q2.1161.00
180_E327_S2.0711.00
264_T268_E2.0341.00
79_I146_V2.0211.00
262_V298_V2.0111.00
184_A331_Q1.9901.00
243_P321_Q1.9741.00
328_A331_Q1.9691.00
65_E163_K1.9631.00
109_G125_V1.9591.00
262_V329_L1.9341.00
26_L171_C1.9311.00
75_R132_Y1.9311.00
133_D137_Q1.9251.00
70_V146_V1.9211.00
320_L324_Q1.9191.00
133_D136_M1.9181.00
127_I140_I1.9131.00
8_A29_E1.9031.00
8_A25_I1.9021.00
158_Q317_R1.8931.00
98_R106_K1.8711.00
28_E31_D1.8701.00
18_S145_R1.8681.00
213_S292_G1.8411.00
178_L192_L1.8381.00
48_R191_W1.8041.00
14_A22_V1.7661.00
56_K189_E1.7181.00
160_V165_F1.7101.00
127_I135_V1.6631.00
210_R292_G1.6551.00
314_A319_I1.6501.00
74_S78_A1.6461.00
97_V125_V1.6351.00
61_A174_L1.6291.00
99_I125_V1.6271.00
36_E48_R1.6161.00
247_L275_A1.6001.00
169_L319_I1.5971.00
8_A28_E1.5731.00
23_R63_M1.5621.00
27_L45_V1.5321.00
44_S207_T1.5201.00
141_R144_D1.4921.00
58_M288_V1.4891.00
34_Q47_I1.4881.00
60_C284_D1.4781.00
245_L273_L1.4741.00
81_V123_M1.4581.00
87_V148_F1.4491.00
14_A168_R1.4471.00
265_V269_I1.4391.00
206_Q287_A1.4281.00
180_E324_Q1.4181.00
4_S7_K1.4151.00
141_R267_A1.4111.00
69_M82_L1.4000.99
29_E32_R1.3950.99
37_V45_V1.3690.99
171_C194_A1.3630.99
29_E179_R1.3540.99
108_P153_Q1.3530.99
21_E106_K1.3520.99
154_V316_C1.3460.99
198_E308_H1.3390.99
30_A175_V1.3370.99
59_I330_I1.3330.99
129_A138_A1.3310.99
4_S8_A1.3230.99
58_M193_V1.3230.99
70_V79_I1.3130.99
58_M208_A1.3010.99
81_V146_V1.2890.99
173_L322_M1.2850.99
263_E273_L1.2740.99
136_M141_R1.2730.99
26_L194_A1.2720.99
114_D117_G1.2710.99
26_L175_V1.2670.99
114_D118_N1.2590.99
73_I135_V1.2540.99
7_K152_F1.2510.99
304_T307_G1.2420.99
58_M214_P1.2410.99
261_W329_L1.2400.99
38_R211_A1.2320.99
177_L327_S1.2250.99
158_Q315_D1.2170.99
15_I67_G1.2170.99
24_Q28_E1.2150.98
199_E308_H1.2140.98
177_L323_Q1.2080.98
179_R183_D1.2060.98
68_F92_R1.1900.98
10_S152_F1.1850.98
285_G297_T1.1780.98
240_G315_D1.1770.98
217_A288_V1.1760.98
99_I146_V1.1760.98
5_L25_I1.1750.98
13_D100_T1.1700.98
72_S80_D1.1690.98
177_L326_L1.1650.98
223_A244_M1.1580.98
13_D98_R1.1580.98
23_R39_F1.1490.98
261_W265_V1.1440.98
130_R134_E1.1440.98
169_L314_A1.1420.98
16_A67_G1.1420.98
97_V111_L1.1320.98
219_V285_G1.1300.98
218_I262_V1.1290.98
323_Q327_S1.1280.98
79_I127_I1.1140.97
83_P89_M1.1110.97
131_S134_E1.1070.97
191_W212_V1.0900.97
51_E185_E1.0830.97
102_R144_D1.0810.97
222_T307_G1.0790.97
115_R118_N1.0650.97
30_A47_I1.0650.97
267_A273_L1.0590.96
300_M322_M1.0560.96
53_T189_E1.0540.96
102_R260_A1.0510.96
263_E275_A1.0510.96
245_L259_T1.0450.96
63_M171_C1.0390.96
327_S331_Q1.0390.96
98_R149_D1.0370.96
193_V208_A1.0370.96
172_Y319_I1.0360.96
96_P149_D1.0320.96
99_I144_D1.0320.96
112_D115_R1.0310.96
24_Q27_L1.0260.96
81_V111_L1.0240.96
33_L179_R1.0210.96
243_P322_M1.0210.96
101_T104_E1.0150.95
96_P153_Q1.0150.95
172_Y323_Q1.0140.95
84_V145_R1.0060.95
46_L193_V1.0040.95
12_A21_E0.9970.95
317_R320_L0.9960.95
176_T180_E0.9960.95
25_I29_E0.9930.95
174_L220_L0.9870.95
223_A276_D0.9810.94
166_D308_H0.9790.94
162_G165_F0.9740.94
259_T263_E0.9730.94
135_V140_I0.9710.94
176_T319_I0.9660.94
58_M212_V0.9650.94
26_L63_M0.9590.94
112_D116_Q0.9590.94
5_L175_V0.9590.94
243_P325_L0.9570.94
271_V325_L0.9560.94
55_P188_A0.9560.94
20_Q257_K0.9550.94
223_A301_G0.9540.94
134_E137_Q0.9500.93
5_L29_E0.9490.93
30_A178_L0.9480.93
161_M313_I0.9460.93
243_P300_M0.9410.93
40_D44_S0.9390.93
155_L161_M0.9380.93
257_K296_P0.9360.93
209_T288_V0.9350.93
260_A264_T0.9320.93
97_V109_G0.9300.93
23_R45_V0.9280.93
242_G318_D0.9210.92
113_G118_N0.9200.92
181_L186_L0.9190.92
246_V276_D0.9130.92
30_A194_A0.9130.92
113_G116_Q0.9060.92
219_V288_V0.9010.92
255_P296_P0.8960.91
174_L192_L0.8930.91
57_V188_A0.8930.91
213_S293_T0.8910.91
79_I135_V0.8910.91
286_G289_H0.8880.91
56_K215_D0.8860.91
52_S55_P0.8860.91
166_D198_E0.8850.91
246_V278_F0.8840.91
21_E100_T0.8820.91
54_G189_E0.8680.90
281_G307_G0.8650.90
173_L323_Q0.8640.90
159_R165_F0.8640.90
11_E152_F0.8600.90
218_I326_L0.8540.89
167_D170_G0.8540.89
43_G196_S0.8520.89
227_K305_R0.8510.89
18_S100_T0.8510.89
245_L298_V0.8490.89
82_L248_S0.8420.89
47_I194_A0.8400.88
92_R111_L0.8380.88
89_M92_R0.8350.88
108_P149_D0.8310.88
48_R56_K0.8310.88
35_K47_I0.8280.88
15_I145_R0.8270.88
96_P311_A0.8260.88
222_T304_T0.8260.88
252_L299_V0.8210.87
220_L326_L0.8200.87
86_N308_H0.8160.87
49_L178_L0.8160.87
27_L37_V0.8120.87
78_A229_F0.8120.87
63_M194_A0.8100.87
263_E267_A0.8090.87
242_G274_Q0.8060.86
51_E187_P0.8050.86
197_S202_L0.8050.86
113_G117_G0.8010.86
61_A167_D0.8010.86
241_N272_P0.8000.86
202_L287_A0.7990.86
37_V47_I0.7980.86
38_R48_R0.7970.86
221_D276_D0.7970.86
68_F146_V0.7910.85
224_C307_G0.7910.85
226_A236_H0.7910.85
12_A22_V0.7900.85
20_Q24_Q0.7890.85
93_Q123_M0.7870.85
88_R91_A0.7850.85
86_N198_E0.7840.85
160_V316_C0.7830.85
176_T323_Q0.7810.85
180_E323_Q0.7790.84
6_L172_Y0.7760.84
302_P322_M0.7740.84
166_D199_E0.7720.84
101_T139_G0.7670.83
282_G286_G0.7660.83
324_Q328_A0.7630.83
251_S286_G0.7560.83
57_V190_V0.7560.83
107_I127_I0.7560.83
7_K154_V0.7550.83
99_I127_I0.7520.82
249_D281_G0.7520.82
104_E107_I0.7500.82
98_R108_P0.7500.82
65_E164_A0.7500.82
237_R244_M0.7500.82
119_D122_A0.7440.82
254_A299_V0.7340.81
210_R293_T0.7300.80
71_R82_L0.7290.80
291_T295_V0.7260.80
62_H198_E0.7260.80
223_A237_R0.7240.80
288_V295_V0.7240.80
22_V63_M0.7230.80
127_I138_A0.7230.80
317_R321_Q0.7220.80
109_G127_I0.7220.80
202_L286_G0.7190.79
201_G282_G0.7180.79
158_Q163_K0.7180.79
165_F314_A0.7140.79
136_M267_A0.7110.79
152_F162_G0.7110.79
167_D222_T0.7090.78
86_N282_G0.7090.78
172_Y176_T0.7080.78
254_A259_T0.7060.78
219_V222_T0.7020.78
94_L310_A0.6980.77
30_A34_Q0.6970.77
12_A29_E0.6970.77
173_L319_I0.6970.77
219_V297_T0.6960.77
304_T314_A0.6960.77
218_I298_V0.6950.77
6_L165_F0.6950.77
173_L177_L0.6940.77
26_L45_V0.6930.77
307_G312_S0.6910.77
52_S189_E0.6900.76
250_K282_G0.6890.76
25_I28_E0.6880.76
262_V300_M0.6880.76
246_V299_V0.6870.76
107_I140_I0.6860.76
211_A293_T0.6800.75
51_E189_E0.6770.75
154_V158_Q0.6750.75
78_A124_R0.6720.75
239_I303_A0.6720.75
264_T267_A0.6690.74
319_I323_Q0.6670.74
190_V330_I0.6620.73
159_R163_K0.6610.73
186_L190_V0.6580.73
249_D286_G0.6550.73
158_Q165_F0.6530.72
34_Q37_V0.6510.72
265_V328_A0.6500.72
173_L220_L0.6500.72
86_N199_E0.6470.72
256_P260_A0.6460.72
79_I107_I0.6450.72
197_S200_V0.6450.72
155_L313_I0.6430.71
141_R263_E0.6430.71
180_E184_A0.6410.71
276_D301_G0.6410.71
74_S124_R0.6350.70
41_G215_D0.6300.70
201_G249_D0.6250.69
254_A281_G0.6240.69
205_G209_T0.6230.69
281_G299_V0.6220.69
266_A325_L0.6210.69
159_R164_A0.6210.69
33_L182_H0.6180.68
269_I324_Q0.6150.68
44_S193_V0.6140.68
177_L330_I0.6130.68
18_S21_E0.6120.68
249_D299_V0.6110.67
68_F81_V0.6090.67
34_Q178_L0.6080.67
102_R264_T0.6080.67
174_L177_L0.6050.67
209_T291_T0.6050.67
181_L190_V0.6050.67
15_I147_T0.6030.66
57_V216_V0.6020.66
13_D21_E0.5980.66
216_V258_L0.5980.66
66_V312_S0.5970.66
60_C219_V0.5970.66
265_V329_L0.5950.65
10_S163_K0.5950.65
45_V175_V0.5950.65
219_V326_L0.5930.65
26_L47_I0.5910.65
41_G296_P0.5900.65
35_K182_H0.5900.65
35_K49_L0.5890.65
197_S203_R0.5880.64
99_I140_I0.5870.64
169_L323_Q0.5850.64
50_N54_G0.5830.64
50_N189_E0.5830.64
59_I174_L0.5830.64
247_L259_T0.5830.64
237_R276_D0.5820.64
20_Q23_R0.5810.64
181_L330_I0.5810.64
72_S75_R0.5800.63
6_L160_V0.5800.63
55_P215_D0.5800.63
229_F235_N0.5770.63
299_V307_G0.5770.63
101_T144_D0.5770.63
217_A295_V0.5760.63
51_E54_G0.5750.63
21_E28_E0.5740.63
69_M84_V0.5740.63
39_F45_V0.5720.62
216_V329_L0.5710.62
221_D283_T0.5710.62
256_P296_P0.5700.62
62_H199_E0.5690.62
101_T107_I0.5690.62
35_K48_R0.5660.62
267_A270_G0.5660.62
51_E55_P0.5640.61
132_Y135_V0.5640.61
107_I129_A0.5620.61
249_D307_G0.5620.61
261_W264_T0.5620.61
46_L191_W0.5590.61
9_L22_V0.5580.60
6_L10_S0.5570.60
224_C276_D0.5570.60
158_Q164_A0.5550.60
222_T226_A0.5540.60
152_F160_V0.5520.60
162_G313_I0.5490.59
89_M120_V0.5490.59
38_R191_W0.5490.59
219_V223_A0.5490.59
224_C249_D0.5490.59
265_V271_V0.5470.59
283_T308_H0.5460.59
227_K239_I0.5460.59
59_I326_L0.5440.59
31_D37_V0.5440.59
242_G305_R0.5420.58
46_L208_A0.5410.58
260_A263_E0.5380.58
62_H308_H0.5380.58
148_F310_A0.5380.58
17_S145_R0.5380.58
18_S84_V0.5360.57
244_M301_G0.5340.57
282_G308_H0.5340.57
167_D198_E0.5330.57
130_R317_R0.5320.57
30_A37_V0.5320.57
100_T106_K0.5320.57
100_T146_V0.5310.57
75_R137_Q0.5300.57
195_S208_A0.5290.56
208_A288_V0.5280.56
204_G207_T0.5280.56
222_T276_D0.5270.56
170_G274_Q0.5240.56
23_R43_G0.5240.56
58_M217_A0.5230.56
202_L282_G0.5230.56
274_Q318_D0.5220.55
315_D319_I0.5220.55
83_P87_V0.5210.55
60_C258_L0.5200.55
59_I177_L0.5190.55
14_A163_K0.5170.55
11_E151_T0.5160.55
29_E175_V0.5160.55
158_Q316_C0.5160.55
71_R81_V0.5150.54
5_L176_T0.5130.54
246_V249_D0.5120.54
72_S142_P0.5120.54
108_P111_L0.5120.54
13_D106_K0.5110.54
245_L263_E0.5090.54
248_S254_A0.5090.54
35_K178_L0.5090.54
13_D147_T0.5080.53
5_L179_R0.5080.53
169_L302_P0.5070.53
216_V296_P0.5050.53
54_G188_A0.5040.53
128_G242_G0.5040.53
67_G84_V0.5020.53
7_K49_L0.5020.53
220_L223_A0.5000.52
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4wwvA 4 0.9942 100 0.423 Contact Map
1y0yA 5 0.9623 100 0.433 Contact Map
2wyrA 4 0.9217 100 0.442 Contact Map
2wznA 4 0.942 100 0.443 Contact Map
3vatA 4 0.9884 100 0.443 Contact Map
3wt4A 4 0.9478 100 0.443 Contact Map
2fvgA 1 0.887 100 0.444 Contact Map
2gljA 6 0.942 100 0.46 Contact Map
2glfA 4 0.9362 100 0.463 Contact Map
1y7eA 4 0.8638 100 0.47 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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