GREMLIN Database
ASTC - Succinylornithine transaminase
UniProt: P77581 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13999
Length: 406 (374)
Sequences: 20745 (12309)
Seq/√Len: 636.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
65_N69_S4.2631.00
210_R214_N3.9791.00
361_A395_A3.8791.00
32_R40_E3.5361.00
173_I208_G3.3731.00
314_W387_T3.2891.00
89_K297_E3.0961.00
27_R34_W3.0501.00
234_E240_H2.8241.00
303_E306_N2.8131.00
314_W383_E2.7771.00
59_E301_T2.6761.00
307_G311_R2.5741.00
62_E66_E2.5691.00
382_S385_E2.5371.00
44_F389_G2.3601.00
169_A175_S2.3281.00
89_K300_N2.3251.00
294_K297_E2.3071.00
208_G211_E2.2891.00
318_R390_L2.2711.00
59_E298_L2.2001.00
59_E294_K2.1991.00
326_Y394_A2.1941.00
32_R385_E2.1841.00
211_E215_R2.1691.00
361_A399_H2.1651.00
26_V36_Q2.1601.00
57_H298_L2.1511.00
357_E360_K2.1501.00
310_Q383_E2.1241.00
357_E399_H2.0821.00
177_S215_R2.0441.00
34_W40_E2.0351.00
130_G183_S1.9681.00
318_R387_T1.9651.00
89_K293_G1.9431.00
86_L292_A1.9371.00
363_V392_R1.9011.00
188_I221_I1.8541.00
98_R267_E1.8331.00
316_V320_N1.8221.00
357_E361_A1.8091.00
61_R65_N1.8041.00
313_D317_E1.8021.00
388_T392_R1.7971.00
35_D39_K1.7851.00
130_G166_R1.7741.00
177_S181_D1.7601.00
267_E271_R1.7551.00
39_K362_G1.7261.00
298_L302_P1.7261.00
26_V70_K1.7181.00
81_E85_R1.7111.00
97_D267_E1.7031.00
88_K92_D1.7021.00
64_L291_V1.6941.00
330_S344_N1.6921.00
176_A209_L1.6771.00
135_K169_A1.6631.00
187_V213_C1.6581.00
326_Y398_E1.6521.00
32_R388_T1.6511.00
102_C261_G1.6451.00
189_V209_L1.6421.00
171_N202_S1.6351.00
318_R321_T1.6161.00
316_V334_G1.6081.00
64_L68_A1.5931.00
109_N249_T1.5881.00
29_E58_P1.5801.00
93_A300_N1.5711.00
234_E309_K1.5511.00
250_T262_A1.5431.00
311_R314_W1.4981.00
180_I218_A1.4861.00
255_G260_V1.4771.00
119_F269_C1.4761.00
311_R386_V1.4751.00
134_F205_F1.4661.00
40_E388_T1.4651.00
31_S385_E1.4591.00
168_A179_L1.4501.00
316_V339_I1.4451.00
66_E70_K1.4411.00
204_A207_Q1.4351.00
94_T264_L1.4321.00
222_F238_Y1.4291.00
89_K92_D1.4251.00
174_N178_A1.4241.00
87_A101_F1.4191.00
177_S208_G1.4091.00
31_S380_N1.4081.00
318_R391_D1.4071.00
357_E396_A1.4061.00
85_R293_G1.3941.00
132_V184_T1.3851.00
250_T264_L1.3751.00
320_N323_N1.3721.00
99_V264_L1.3651.00
111_A263_L1.3601.00
210_R220_L1.3561.00
131_I186_A1.3551.00
294_K298_L1.3531.00
35_D41_Y1.3521.00
210_R213_C1.3491.00
361_A396_A1.3401.00
307_G310_Q1.3391.00
58_P62_E1.3381.00
358_A365_V1.3351.00
318_R394_A1.3311.00
293_G297_E1.3211.00
133_A167_H1.3121.00
113_L131_I1.3081.00
314_W318_R1.3041.00
260_V289_S1.3031.00
25_P33_L1.2991.00
181_D216_H1.2961.00
234_E239_M1.2931.00
112_A249_T1.2921.00
394_A398_E1.2871.00
235_L239_M1.2731.00
306_N310_Q1.2721.00
254_L260_V1.2721.00
57_H302_P1.2671.00
174_N177_S1.2631.00
116_A221_I1.2621.00
91_I99_V1.2621.00
381_V386_V1.2611.00
238_Y248_L1.2581.00
85_R297_E1.2561.00
119_F272_V1.2551.00
27_R70_K1.2491.00
187_V209_L1.2491.00
148_A165_I1.2471.00
322_I394_A1.2461.00
189_V206_L1.2461.00
311_R383_E1.2451.00
29_E56_A1.2421.00
322_I390_L1.2391.00
247_L265_A1.2381.00
204_A241_Y1.2371.00
109_N188_I1.2351.00
62_E65_N1.2181.00
64_L287_L1.2121.00
241_Y335_L1.2041.00
173_I212_L1.1971.00
254_L262_A1.1851.00
260_V292_A1.1841.00
102_C263_L1.1811.00
53_L298_L1.1781.00
92_D300_N1.1751.00
120_A185_C1.1741.00
240_H335_L1.1731.00
63_A294_K1.1731.00
98_R271_R1.1711.00
222_F243_V1.1671.00
385_E388_T1.1671.00
56_A61_R1.1521.00
244_T266_T1.1511.00
297_E301_T1.1401.00
207_Q211_E1.1371.00
101_F289_S1.1301.00
177_S212_L1.1221.00
61_R69_S1.1211.00
358_A392_R1.1131.00
61_R68_A1.1091.00
120_A127_H1.1051.00
391_D395_A1.0991.00
219_L269_C1.0981.00
128_K217_N1.0961.00
65_N68_A1.0921.00
148_A188_I1.0871.00
32_R42_I1.0871.00
309_K313_D1.0871.00
363_V389_G1.0831.00
317_E321_T1.0761.00
230_G305_L1.0751.00
207_Q242_G1.0741.00
247_L263_L1.0731.00
383_E387_T1.0651.00
95_F244_T1.0561.00
236_Y250_T1.0511.00
29_E40_E1.0491.00
169_A172_D1.0411.00
170_Y201_A1.0381.00
106_A145_T1.0371.00
31_S42_I1.0361.00
358_A396_A1.0301.00
86_L293_G1.0271.00
358_A363_V1.0261.00
305_L308_V1.0221.00
388_T391_D1.0211.00
298_L301_T1.0151.00
177_S211_E1.0091.00
361_A392_R1.0071.00
180_I184_T1.0031.00
256_G295_V1.0011.00
213_C218_A1.0001.00
115_L263_L0.9991.00
26_V81_E0.9961.00
192_I335_L0.9961.00
387_T391_D0.9861.00
113_L148_A0.9821.00
177_S216_H0.9761.00
166_R179_L0.9731.00
26_V38_G0.9711.00
233_G239_M0.9671.00
133_A188_I0.9611.00
96_A264_L0.9571.00
93_A235_L0.9531.00
53_L295_V0.9501.00
147_S162_P0.9451.00
29_E34_W0.9421.00
130_G181_D0.9361.00
108_A249_T0.9361.00
191_P222_F0.9331.00
134_F170_Y0.9311.00
307_G383_E0.9281.00
60_L291_V0.9261.00
24_I36_Q0.9251.00
209_L220_L0.9221.00
26_V34_W0.9211.00
353_Q357_E0.9181.00
89_K93_A0.9171.00
299_I304_M0.9151.00
52_A253_A0.9131.00
323_N329_F0.9121.00
299_I305_L0.9101.00
384_E387_T0.9101.00
330_S342_V0.9091.00
290_A294_K0.9041.00
175_S178_A0.9041.00
211_E214_N0.9031.00
42_I385_E0.9021.00
130_G184_T0.9021.00
134_F201_A0.8971.00
206_L241_Y0.8961.00
203_N207_Q0.8941.00
356_Q360_K0.8901.00
229_V299_I0.8861.00
129_S183_S0.8851.00
51_N256_G0.8841.00
212_L216_H0.8801.00
24_I84_L0.8801.00
342_V371_N0.8791.00
62_E69_S0.8771.00
129_S164_D0.8761.00
59_E62_E0.8741.00
59_E297_E0.8721.00
186_A221_I0.8721.00
31_S382_S0.8691.00
306_N309_K0.8641.00
200_P335_L0.8621.00
304_M308_V0.8621.00
44_F381_V0.8611.00
42_I388_T0.8581.00
66_E69_S0.8551.00
91_I96_A0.8501.00
346_D350_Q0.8501.00
106_A142_T0.8501.00
240_H309_K0.8441.00
53_L60_L0.8441.00
95_F248_L0.8371.00
340_G372_V0.8361.00
320_N324_H0.8341.00
112_A221_I0.8301.00
168_A175_S0.8291.00
115_L265_A0.8241.00
168_A176_A0.8241.00
204_A208_G0.8191.00
318_R386_V0.8191.00
331_E342_V0.8181.00
312_H316_V0.8151.00
66_E290_A0.8151.00
93_A296_L0.8131.00
116_A186_A0.8121.00
119_F219_L0.8081.00
130_G164_D0.8021.00
217_N268_E0.8001.00
337_L381_V0.7981.00
258_F288_A0.7971.00
116_A219_L0.7971.00
338_L376_A0.7961.00
381_V389_G0.7921.00
229_V296_L0.7911.00
103_N107_E0.7881.00
36_Q81_E0.7861.00
120_A217_N0.7841.00
44_F363_V0.7841.00
210_R243_V0.7831.00
346_D349_G0.7821.00
227_T338_L0.7801.00
280_T283_G0.7791.00
375_F393_F0.7791.00
317_E320_N0.7771.00
59_E63_A0.7701.00
305_L309_K0.7701.00
214_N244_T0.7691.00
238_Y243_V0.7691.00
235_L305_L0.7691.00
118_K277_T0.7651.00
85_R89_K0.7651.00
187_V218_A0.7591.00
90_L264_L0.7591.00
229_V254_L0.7581.00
30_G380_N0.7571.00
352_K356_Q0.7541.00
194_G226_Q0.7511.00
31_S378_A0.7511.00
86_L289_S0.7501.00
42_I389_G0.7461.00
82_P290_A0.7461.00
236_Y248_L0.7451.00
333_R342_V0.7441.00
314_W317_E0.7431.00
99_V262_A0.7431.00
113_L188_I0.7421.00
395_A399_H0.7371.00
208_G212_L0.7361.00
49_A376_A0.7361.00
310_Q314_W0.7341.00
229_V250_T0.7311.00
127_H183_S0.7301.00
134_F168_A0.7281.00
213_C220_L0.7261.00
104_S107_E0.7251.00
82_P293_G0.7251.00
345_A349_G0.7221.00
175_S179_L0.7221.00
191_P206_L0.7221.00
354_I393_F0.7201.00
232_T240_H0.7201.00
343_L354_I0.7191.00
235_L300_N0.7181.00
102_C108_A0.7181.00
354_I396_A0.7171.00
321_T324_H0.7171.00
214_N220_L0.7171.00
25_P28_G0.7171.00
176_A187_V0.7151.00
116_A247_L0.7131.00
332_V339_I0.7081.00
180_I212_L0.7061.00
322_I326_Y0.7041.00
60_L256_G0.7021.00
200_P334_G0.7011.00
308_V312_H0.7011.00
184_T218_A0.7011.00
229_V235_L0.7001.00
135_K167_H0.6961.00
114_K278_H0.6961.00
201_A204_A0.6941.00
250_T254_L0.6941.00
334_G339_I0.6941.00
63_A291_V0.6921.00
207_Q241_Y0.6911.00
79_T84_L0.6851.00
80_N83_V0.6821.00
89_K296_L0.6821.00
45_A366_L0.6821.00
274_T277_T0.6791.00
82_P86_L0.6791.00
342_V372_V0.6791.00
180_I216_H0.6781.00
268_E271_R0.6771.00
310_Q313_D0.6771.00
321_T394_A0.6761.00
83_V87_A0.6741.00
109_N145_T0.6731.00
115_L273_M0.6731.00
82_P289_S0.6731.00
194_G338_L0.6721.00
312_H334_G0.6721.00
389_G392_R0.6711.00
46_G376_A0.6711.00
189_V220_L0.6691.00
326_Y397_C0.6691.00
192_I232_T0.6671.00
266_T269_C0.6671.00
311_R337_L0.6671.00
138_F141_R0.6671.00
111_A278_H0.6661.00
42_I363_V0.6651.00
355_S367_I0.6651.00
93_A236_Y0.6621.00
70_K81_E0.6621.00
86_L260_V0.6621.00
64_L72_W0.6611.00
251_A261_G0.6601.00
39_K360_K0.6551.00
332_V341_C0.6541.00
94_T248_L0.6541.00
384_E388_T0.6541.00
96_A248_L0.6531.00
68_A287_L0.6521.00
354_I358_A0.6521.00
28_G71_F0.6501.00
265_A270_A0.6501.00
82_P85_R0.6481.00
220_L243_V0.6471.00
354_I373_V0.6471.00
56_A68_A0.6451.00
67_Q70_K0.6411.00
314_W386_V0.6401.00
375_F389_G0.6391.00
206_L222_F0.6341.00
120_A128_K0.6341.00
117_R160_P0.6341.00
323_N331_E0.6331.00
269_C272_V0.6331.00
307_G382_S0.6321.00
221_I247_L0.6291.00
390_L394_A0.6291.00
193_Q196_G0.6281.00
128_K218_A0.6281.00
230_G299_I0.6271.00
119_F268_E0.6251.00
72_W258_F0.6241.00
343_L397_C0.6221.00
112_A247_L0.6221.00
172_D175_S0.6211.00
396_A399_H0.6191.00
84_L88_K0.6141.00
315_F390_L0.6131.00
225_V249_T0.6131.00
307_G386_V0.6121.00
353_Q356_Q0.6121.00
105_G225_V0.6101.00
53_L304_M0.6081.00
24_I79_T0.6071.00
61_R258_F0.6071.00
33_L364_M0.6071.00
94_T236_Y0.6071.00
203_N335_L0.6061.00
323_N332_V0.6041.00
341_C393_F0.6041.00
358_A393_F0.6031.00
193_Q199_V0.6011.00
311_R381_V0.6001.00
132_V176_A0.6001.00
115_L247_L0.6001.00
31_S381_V0.5981.00
229_V236_Y0.5951.00
313_D316_V0.5941.00
344_N350_Q0.5931.00
308_V379_L0.5901.00
152_P155_S0.5901.00
63_A66_E0.5901.00
67_Q82_P0.5891.00
91_I97_D0.5881.00
203_N241_Y0.5881.00
94_T250_T0.5881.00
45_A364_M0.5881.00
40_E392_R0.5861.00
238_Y245_P0.5851.00
152_P156_Q0.5841.00
52_A379_L0.5821.00
128_K183_S0.5811.00
363_V388_T0.5811.00
344_N349_G0.5781.00
60_L295_V0.5781.00
291_V294_K0.5781.00
315_F339_I0.5771.00
311_R382_S0.5761.00
356_Q359_A0.5751.00
28_G33_L0.5721.00
214_N268_E0.5721.00
95_F238_Y0.5701.00
392_R396_A0.5691.00
134_F209_L0.5691.00
212_L215_R0.5691.00
166_R184_T0.5681.00
68_A291_V0.5671.00
191_P227_T0.5661.00
381_V385_E0.5661.00
60_L294_K0.5661.00
117_R143_L0.5651.00
366_L369_G0.5621.00
46_G378_A0.5621.00
176_A208_G0.5611.00
26_V29_E0.5611.00
144_F162_P0.5601.00
132_V179_L0.5561.00
134_F189_V0.5561.00
91_I264_L0.5551.00
315_F386_V0.5551.00
93_A234_E0.5551.00
393_F397_C0.5541.00
23_F26_V0.5541.00
329_F397_C0.5541.00
191_P238_Y0.5531.00
63_A297_E0.5531.00
373_V393_F0.5531.00
318_R322_I0.5521.00
102_C107_E0.5501.00
300_N303_E0.5481.00
52_A299_I0.5471.00
308_V337_L0.5461.00
235_L296_L0.5441.00
251_A282_Y0.5431.00
209_L218_A0.5411.00
86_L101_F0.5400.99
392_R395_A0.5390.99
133_A165_I0.5390.99
174_N208_G0.5380.99
178_A181_D0.5370.99
329_F341_C0.5340.99
29_E32_R0.5330.99
333_R340_G0.5330.99
314_W390_L0.5320.99
195_E374_R0.5310.99
235_L299_I0.5310.99
27_R40_E0.5300.99
95_F266_T0.5300.99
351_A367_I0.5290.99
28_G51_N0.5280.99
341_C375_F0.5270.99
247_L269_C0.5270.99
91_I94_T0.5270.99
70_K82_P0.5270.99
67_Q71_F0.5270.99
181_D215_R0.5260.99
330_S350_Q0.5260.99
173_I177_S0.5230.99
323_N397_C0.5230.99
61_R256_G0.5220.99
380_N385_E0.5210.99
132_V168_A0.5210.99
113_L144_F0.5200.99
226_Q374_R0.5200.99
389_G393_F0.5190.99
42_I381_V0.5180.99
187_V214_N0.5170.99
25_P78_Y0.5160.99
363_V396_A0.5160.99
176_A205_F0.5150.99
200_P241_Y0.5150.99
328_L344_N0.5150.99
182_D216_H0.5150.99
170_Y193_Q0.5150.99
293_G300_N0.5120.99
355_S359_A0.5110.99
285_N288_A0.5100.99
315_F318_R0.5100.99
309_K312_H0.5070.99
25_P71_F0.5070.99
23_F359_A0.5070.99
53_L57_H0.5060.99
386_V389_G0.5060.99
58_P69_S0.5060.99
168_A205_F0.5050.99
333_R372_V0.5040.99
224_E237_A0.5040.99
296_L300_N0.5030.99
94_T99_V0.5020.99
219_L247_L0.5020.99
207_Q210_R0.5010.99
150_G167_H0.5010.99
226_Q338_L0.5010.99
141_R279_G0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1z7dA 2 0.9261 100 0.356 Contact Map
4uoxA 3 0.9877 100 0.358 Contact Map
3oksA 2 0.968 100 0.367 Contact Map
4atqA 7 0.9729 100 0.369 Contact Map
4nogA 2 0.9951 100 0.378 Contact Map
4ffcA 4 0.9754 100 0.378 Contact Map
4e3qA 3 0.9877 100 0.379 Contact Map
2oatA 3 0.9803 100 0.381 Contact Map
4a0gA 2 0.9828 100 0.385 Contact Map
1sffA 3 0.9754 100 0.385 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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